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The map label for this gene is dppA [H]

Identifier: 120610861

GI number: 120610861

Start: 2405068

End: 2406627

Strand: Direct

Name: dppA [H]

Synonym: Aave_2187

Alternate gene names: 120610861

Gene position: 2405068-2406627 (Clockwise)

Preceding gene: 120610860

Following gene: 120610862

Centisome position: 44.93

GC content: 67.44

Gene sequence:

>1560_bases
ATGCAGTCGCTGGCGCGCGGCGCCTCGCGCCGCGACGTGCTGGCCATGTTCCTCGCGGGGGGCATGCAGGCGTCCCTGGC
GGGCGGCCTGGCCACCATGGCCGCCAACGCGCATGCCCAGACGCCCCGGCGGGGAGGGCGCATCCGCGTGGCGGGCGCGA
CCGCGGCCGCCACCGACACGCTGGACCCCGCCAAGCAGTCCAACCAGACCGACTATTCGCGCGGCAACATGCTCTACAAC
GGGCTGTTCTCGCTGGATGGCAGCCTCACGCCACAGCCTGCGCTGGCCGAGTCGCACTCCACGGCCGATGCCAAGACCTG
GGTGTTCAAGCTGCGCAAGGGCGTGGTCTTCCATGACGGCAAGGCCCTGGCCCCCGAGGACGTGGTGTTCTCGCTCATGC
GGCACAAGGACCCCGCCACGGCCTCCAAGGCCAAGGTGCTGGCCGACCAGATCGAAAGCGTGAAGGTCTCCGGCCCCGGC
GAGGTCACGGTGGTGCTGTCGCAGCCCAACGCCGACCTGCCCGTGATCCTGGGCACCTTCCACTTCCACATCGTCAAGGA
CGGCACCACGGATTTCAATGCCGGCATCGGTACCGGCCCCTACAAGCTCAGGGAATTCAAGCCCGGCGTGCGCTCCCTGG
TGGTGCGCAACGACGCCTACTGGAAACCCGGCAAGCCCTACCTGGACGAGATCGAGTTCGTCGGCATCGGCGACGAGACC
GCGCGCGTGAACGCGCTGCTGTCCGGCGGCATGGACCTCGTCGCCTCGGTGAATCCCCGCGCGGTGGCCCGCGTCAAGGG
CACGCCCGGCTACGCGATCTTCACCACGCAGTCGGGGCAGTATTCCGACCTCATCCTGCGCAAGGACATGGGCCCGGGCG
CGAACCCGGACTTCGTCCTGGCGATGAAGCACCTGTTCGACCGCGAGCAGATGAAGAAGACCATCGCGCTCGACTACGCG
GTGCTGGGCAACGACCAGCCCATCGATCCGACCAACCGTTTCTACTTCGCGGGCCTGCCGCAGCGCACCTTCGATCTGGA
CAAGGCCAAGTTCCACCTGCAGAAGTCGGGCGTGACGGGCAAGGTCCCGGTGGTCACGTCGCCCGCGGCCATGTACTCCA
CCGAGATCGCGCTGCTGCTGCAGCAGGCGGGCCAGCGCATCGGCCTGGAGCTGGACGTCAAGCGCATGCCGGCCGACGGC
TACTGGTCCAACCATTGGCTGACCAACCCCGTGGGTTTCGGCAACGTGAACCCGCGCCCCAGCGCCGACACCCTGCTCAC
GCAGTTCTTCAAGTCCGACGCTGCATGGAACGAGTCGCGCTGGAAGAGCGCGCAGTTCGACCAGTTGCTGCTGGCCGCAC
GGGCCGAAACCGACCAGGCCAAGCGCAAGCAGATGTATGCCGACATGCAGACCATGATCCACCAGGAAGCGGGCATCGGC
ATCCCGCTGTTCCTCGCCAGCATCGACGGCCACTCGTCCAAGCTCAAGGGACTGTCGCCGATCCCGCTGGGCGGCATGAT
GGGCTATGCGTTCGCGGAGCACGTCTGGCTGGAGGCTTGA

Upstream 100 bases:

>100_bases
CGTCCCTTCCCTTTTTTTCCCAGGCCCCAAGGAGTCCACCATGAGCGACAAAATCCCCGAGTTCGACCGCCTCGTCGGCC
CTGCCGAAAGCCAGCGCGTG

Downstream 100 bases:

>100_bases
AACATAAGACACTCCCCCCTGAGCGGCTTCGCCGCTTCCGTGCGGCCGTCAGAGCCGGCAGCTCCCCGGGCACGTCCGGG
CCTGCGCAGGCAGGGGAGCG

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MQSLARGASRRDVLAMFLAGGMQASLAGGLATMAANAHAQTPRRGGRIRVAGATAAATDTLDPAKQSNQTDYSRGNMLYN
GLFSLDGSLTPQPALAESHSTADAKTWVFKLRKGVVFHDGKALAPEDVVFSLMRHKDPATASKAKVLADQIESVKVSGPG
EVTVVLSQPNADLPVILGTFHFHIVKDGTTDFNAGIGTGPYKLREFKPGVRSLVVRNDAYWKPGKPYLDEIEFVGIGDET
ARVNALLSGGMDLVASVNPRAVARVKGTPGYAIFTTQSGQYSDLILRKDMGPGANPDFVLAMKHLFDREQMKKTIALDYA
VLGNDQPIDPTNRFYFAGLPQRTFDLDKAKFHLQKSGVTGKVPVVTSPAAMYSTEIALLLQQAGQRIGLELDVKRMPADG
YWSNHWLTNPVGFGNVNPRPSADTLLTQFFKSDAAWNESRWKSAQFDQLLLAARAETDQAKRKQMYADMQTMIHQEAGIG
IPLFLASIDGHSSKLKGLSPIPLGGMMGYAFAEHVWLEA

Sequences:

>Translated_519_residues
MQSLARGASRRDVLAMFLAGGMQASLAGGLATMAANAHAQTPRRGGRIRVAGATAAATDTLDPAKQSNQTDYSRGNMLYN
GLFSLDGSLTPQPALAESHSTADAKTWVFKLRKGVVFHDGKALAPEDVVFSLMRHKDPATASKAKVLADQIESVKVSGPG
EVTVVLSQPNADLPVILGTFHFHIVKDGTTDFNAGIGTGPYKLREFKPGVRSLVVRNDAYWKPGKPYLDEIEFVGIGDET
ARVNALLSGGMDLVASVNPRAVARVKGTPGYAIFTTQSGQYSDLILRKDMGPGANPDFVLAMKHLFDREQMKKTIALDYA
VLGNDQPIDPTNRFYFAGLPQRTFDLDKAKFHLQKSGVTGKVPVVTSPAAMYSTEIALLLQQAGQRIGLELDVKRMPADG
YWSNHWLTNPVGFGNVNPRPSADTLLTQFFKSDAAWNESRWKSAQFDQLLLAARAETDQAKRKQMYADMQTMIHQEAGIG
IPLFLASIDGHSSKLKGLSPIPLGGMMGYAFAEHVWLEA
>Mature_519_residues
MQSLARGASRRDVLAMFLAGGMQASLAGGLATMAANAHAQTPRRGGRIRVAGATAAATDTLDPAKQSNQTDYSRGNMLYN
GLFSLDGSLTPQPALAESHSTADAKTWVFKLRKGVVFHDGKALAPEDVVFSLMRHKDPATASKAKVLADQIESVKVSGPG
EVTVVLSQPNADLPVILGTFHFHIVKDGTTDFNAGIGTGPYKLREFKPGVRSLVVRNDAYWKPGKPYLDEIEFVGIGDET
ARVNALLSGGMDLVASVNPRAVARVKGTPGYAIFTTQSGQYSDLILRKDMGPGANPDFVLAMKHLFDREQMKKTIALDYA
VLGNDQPIDPTNRFYFAGLPQRTFDLDKAKFHLQKSGVTGKVPVVTSPAAMYSTEIALLLQQAGQRIGLELDVKRMPADG
YWSNHWLTNPVGFGNVNPRPSADTLLTQFFKSDAAWNESRWKSAQFDQLLLAARAETDQAKRKQMYADMQTMIHQEAGIG
IPLFLASIDGHSSKLKGLSPIPLGGMMGYAFAEHVWLEA

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=549, Percent_Identity=24.5901639344262, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1787052, Length=524, Percent_Identity=23.6641221374046, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789887, Length=305, Percent_Identity=28.8524590163934, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787495, Length=278, Percent_Identity=24.1007194244604, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 56236; Mature: 56236

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLARGASRRDVLAMFLAGGMQASLAGGLATMAANAHAQTPRRGGRIRVAGATAAATDT
CCHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
LDPAKQSNQTDYSRGNMLYNGLFSLDGSLTPQPALAESHSTADAKTWVFKLRKGVVFHDG
CCCHHHCCCCCCCCCCEEEEEHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECC
KALAPEDVVFSLMRHKDPATASKAKVLADQIESVKVSGPGEVTVVLSQPNADLPVILGTF
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCCCEEEEEE
HFHIVKDGTTDFNAGIGTGPYKLREFKPGVRSLVVRNDAYWKPGKPYLDEIEFVGIGDET
EEEEEECCCCCCCCCCCCCCCHHHHCCCCHHEEEEECCCCCCCCCCCCCCEEEEECCCCH
ARVNALLSGGMDLVASVNPRAVARVKGTPGYAIFTTQSGQYSDLILRKDMGPGANPDFVL
HHHHHHHHCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCCEEEEEECCCCCCCCHHHH
AMKHLFDREQMKKTIALDYAVLGNDQPIDPTNRFYFAGLPQRTFDLDKAKFHLQKSGVTG
HHHHHHCHHHHHHHHHEEEEEECCCCCCCCCCCEEEECCCCHHCCCCHHHEEEEECCCCC
KVPVVTSPAAMYSTEIALLLQQAGQRIGLELDVKRMPADGYWSNHWLTNPVGFGNVNPRP
CCCEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECCCCCCCCCCCCC
SADTLLTQFFKSDAAWNESRWKSAQFDQLLLAARAETDQAKRKQMYADMQTMIHQEAGIG
CHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
IPLFLASIDGHSSKLKGLSPIPLGGMMGYAFAEHVWLEA
EEEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHEECC
>Mature Secondary Structure
MQSLARGASRRDVLAMFLAGGMQASLAGGLATMAANAHAQTPRRGGRIRVAGATAAATDT
CCHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCC
LDPAKQSNQTDYSRGNMLYNGLFSLDGSLTPQPALAESHSTADAKTWVFKLRKGVVFHDG
CCCHHHCCCCCCCCCCEEEEEHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECC
KALAPEDVVFSLMRHKDPATASKAKVLADQIESVKVSGPGEVTVVLSQPNADLPVILGTF
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCCCEEEEEE
HFHIVKDGTTDFNAGIGTGPYKLREFKPGVRSLVVRNDAYWKPGKPYLDEIEFVGIGDET
EEEEEECCCCCCCCCCCCCCCHHHHCCCCHHEEEEECCCCCCCCCCCCCCEEEEECCCCH
ARVNALLSGGMDLVASVNPRAVARVKGTPGYAIFTTQSGQYSDLILRKDMGPGANPDFVL
HHHHHHHHCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCCEEEEEECCCCCCCCHHHH
AMKHLFDREQMKKTIALDYAVLGNDQPIDPTNRFYFAGLPQRTFDLDKAKFHLQKSGVTG
HHHHHHCHHHHHHHHHEEEEEECCCCCCCCCCCEEEECCCCHHCCCCHHHEEEEECCCCC
KVPVVTSPAAMYSTEIALLLQQAGQRIGLELDVKRMPADGYWSNHWLTNPVGFGNVNPRP
CCCEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEECCCCCCCCCCCCC
SADTLLTQFFKSDAAWNESRWKSAQFDQLLLAARAETDQAKRKQMYADMQTMIHQEAGIG
CHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
IPLFLASIDGHSSKLKGLSPIPLGGMMGYAFAEHVWLEA
EEEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]