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The map label for this gene is ndk

Identifier: 120610107

GI number: 120610107

Start: 1560900

End: 1561325

Strand: Direct

Name: ndk

Synonym: Aave_1420

Alternate gene names: 120610107

Gene position: 1560900-1561325 (Clockwise)

Preceding gene: 120610106

Following gene: 120610108

Centisome position: 29.16

GC content: 63.38

Gene sequence:

>426_bases
ATGGCTATCGAACGCACCCTCTCCATCATCAAGCCCGACGCAGTCGCCAAGAACGTGATCGGCCAGATCTACGCCCGCTT
CGAAGCCGCCGGCCTGAAGATCGCCGCCGCACGCATGGCCCACCTGTCGCGCCAGGAAGCCGAGCAGTTCTACGCCGTCC
ACAAGGAGCGTCCCTTCTTCAAGGACCTCGTGGATTTCATGATCTCCGGCCCCGTGATGATCCAGGTGCTCGAAGGCGAG
AACGCCATCCTGAAGAACCGTGAACTGATGGGCGCCACGGACCCGAAGAAGGCCGCTCCCGGCACCATCCGCGCCGACTT
CGCCGACAGCATCGACGCCAACGCCGTGCACGGTTCGGACGCTGCCGAAACGGCCCAGGTGGAAGTCTCCTTCTTCTTCC
CCGGCCTGAACATCTACGCACGCTGA

Upstream 100 bases:

>100_bases
GTCGCTGAGTGCCCTGCCACATTGTGGACAAGTCCTGCCGATTAGAATCGAGGGCTTTGTCCGCAGGGCAAAAGTCTTTC
TCACCATCCAAGGAAAAACC

Downstream 100 bases:

>100_bases
TCCCGCTGGCGGCCCGGCGCGGCGCCTGCGCCATGCCCCGGGCCCTGCCAGCCGGAACGGCTCCCCGACGATGACCAAGA
ACCTTCTCGACTTCGACCTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIAAARMAHLSRQEAEQFYAVHKERPFFKDLVDFMISGPVMIQVLEGE
NAILKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSDAAETAQVEVSFFFPGLNIYAR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIAAARMAHLSRQEAEQFYAVHKERPFFKDLVDFMISGPVMIQVLEGE
NAILKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSDAAETAQVEVSFFFPGLNIYAR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIAAARMAHLSRQEAEQFYAVHKERPFFKDLVDFMISGPVMIQVLEGEN
AILKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSDAAETAQVEVSFFFPGLNIYAR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=41.6666666666667, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=41.2213740458015, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=39.6946564885496, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=39.6946564885496, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=38.4615384615385, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=36.5671641791045, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=36.5671641791045, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.036496350365, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=34.5323741007194, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI148839372, Length=134, Percent_Identity=33.5820895522388, Blast_Score=73, Evalue=8e-14,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=34.5588235294118, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=59.3984962406015, Blast_Score=175, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=41.5384615384615, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=40.7692307692308, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=43.0769230769231, Blast_Score=126, Evalue=5e-30,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=34.0740740740741, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ACIAC (A1TM23)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969785.1
- ProteinModelPortal:   A1TM23
- SMR:   A1TM23
- STRING:   A1TM23
- GeneID:   4668842
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1420
- NMPDR:   fig|397945.5.peg.1245
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- PhylomeDB:   A1TM23
- ProtClustDB:   PRK00668
- BioCyc:   AAVE397945:AAVE_1420-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15425; Mature: 15294

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIAAARMAHLSRQEAEQFYAVHKERPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KDLVDFMISGPVMIQVLEGENAILKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAQVEVSFFFPGLNIYAR
CCCEEEEEEEEEECCCEEEEC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKIAAARMAHLSRQEAEQFYAVHKERPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
KDLVDFMISGPVMIQVLEGENAILKNRELMGATDPKKAAPGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
AAETAQVEVSFFFPGLNIYAR
CCCEEEEEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA