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The map label for this gene is parC [H]

Identifier: 120610029

GI number: 120610029

Start: 1467854

End: 1470211

Strand: Direct

Name: parC [H]

Synonym: Aave_1342

Alternate gene names: 120610029

Gene position: 1467854-1470211 (Clockwise)

Preceding gene: 120610028

Following gene: 120610030

Centisome position: 27.42

GC content: 69.97

Gene sequence:

>2358_bases
ATGAGCGACAACGACCAACCCACCCTCGACTTCTCCCAGCCCGAGTCCGGCGACCACCTGGGCCTGGCCGGCTACGCGCA
GCGCGCCTACCTGGAGTACGCGCTCTCCGTGGTGAAGGGCCGCGCGCTGCCGGACGTGTGCGACGGCATGAAGCCGGTGC
AGCGCCGCATCCTCTTCGCGATGGAACGCATGGGCCTGGCCTACGGCGGGCCGACCCGCAACGTGCCGGCCAAGCCCGTG
AAAAGCGCCCGCGTGGTCGGCGACGTGCTGGGCCGCTTCCATCCGCACGGCGACCAGTCGGCCTACGACGCGCTGGTGCG
GCTCGCGCAGGATTTCAGTCAGCGTTATCCGCTCATCGACGGCCAGGGCAACTTCGGCAGCCGCGACGGCGACGGCGCCG
CGGCCATGCGCTACACGGAGGCGCGGCTCACGCGCATCGCCAGCCTGCTGCTCGACGAGATCGACCAGGGCACGGTCGAT
TTCGTGCCCAACTACGACGGCTCCACCGAGGAGCCGCGCCAGTTGCCCGCGCGCCTGCCGTTCGCGCTGCTCAACGGCGC
GAGCGGCATCGCCGTGGGCCTGGCCACCGAGATCCCGAGCCACAACCTGCGCGAGATCGCCGACGCCTGCGTGGCGCTGG
TGAAGAACCCGAAGCTCGCCGACGAGGAGCTGGCCGCGCTGGTGCCGGGCCCGGACTATCCGGGCGGCGGCCAGATCATC
AGCAGCCCGGGCGACATCCAGGACGCCTACCGCACGGGGCGCGGCAGCCTCAAGGTGCGCGCGCGCTGGAAAATCGAGGA
CCTGGCGCGCGGCCAGTGGCAGATGGTGGTGACCGAACTGCCGCCCGGCGTCTCCGCGCAGAAGGTGCTGGAAGAGATCG
AGGAGCTCACCAATCCCAAGGTGAAGGCCGGCAAGAAGGCGCTCTCGCAGGAGCAGACGCAGCTCAAGGCCACGGTGCTG
GGCGTGCTGGACGTGGTGCGCGACGAGTCGAGCAAGGACGCGCCCGTGCGCATCGTGTTCGAGCCCAAGACGGGCAGGGT
GCCGCAGCAGGAGCTGATCACCACGCTGCTGGCGCACACCAGCCTGGAGACCTCCGCGCCCATCAACCTGACCATGGTGG
GCCTGGACGGCAAGCCCGTGCAGAAGTCGCTGCGGCGCATGCTGGAGGAGTGGATCGCCTTCCGCCAGCAGACCATCACG
CGGCGCAGCCAGCATCGCCTCGCCAAGGTGCTGGACCGCATCCACATCCTCGAGGGGCGGCAGACCGTGCTGCTCAACAT
CGACGAGGTGATCGCCATCATCCGCGCGAGCGACGAGCCCAAGGCCGCGCTGATCGAGCGCTTCCGCCTGTCGGACCGGC
AGGCCGAGGACATCCTGGAAATCCGCCTGCGCCAGCTCGCGCGGCTCGAAGCCATCAAGATCGAGCAGGAACTCAAGGAA
CTGCGCGAGGAACAGGGCAAGCTCGAGGACATCCTCGCCAACCCTGCCTCGCTGCGCCGCCTCATGGTCAAGGAGATCGA
GGCGGACGCGAAGCAGTTCGCCGACGCGCGCCGCACCCTCATCCAGGCCGACAAGCGCGCCACGGCCGAGGTGAAGGTGG
TCGATGAGCCCGTGACGGTGGTGGTTTCGCAGAAGGGCTGGGTGCGCGCGCGCCAGGGCCACGGGCACGACGCCGGCACC
TTCGCCTTCAAGTCCGGCGACGCGCTCTACGGCACCTTCGAGTGCCGCACCGTCGATACGCTCATCGCCTTCGGCAGCAA
TGGTCGCGTGTATTCCGTGGCCGTTTCGCAACTGCCCGGCGCGCGCGGGGACGGGCAGCCCATCACCACGCTGATCGACC
TGGAGGCCGGCACGCAGCCGGTGCATTATTTCGCCGGCCCCGCGAACGCGGCGCTGCTGCTCGCCGGCTCGGGCGGCTAC
GGCTTCATCGCGGCCGTGGAGCACATGACGGCGCGCAACCGGGGTGGCAAGGCATTCGTCTCGCTGGGCGAGGGCGAGCA
GCTCTGCCGGCCGTCGCACGCGGCGTTCACCAGCGGCAGCCAGCCGCTCGCCCCGGCGACCCACGTGTGCTGCGCCTCGG
CGGGCGGACGCATCCTGACTTTCGAGATCACCGAGCTCAAGCAGATGGCCAATGGCGGCCGCGGCCTGATGCTCATCGAC
CTCGAGCCCAAGGATACGCTGGCGGGTGCCGCGGCGTACACGCGCAGCGTGCGCATCGCAGGCGTGGGCCGCGGCGGCAA
GGAGCGCGACGAGACGCTGGAGATCCGCAGCCTCAACAATGCGCGCTTCCCGCGCGGGCGCAAGGGCAAGGCGGCGGATC
TGGGCTTCAAGCCGAACGCCGTGCAGCGCGTCGAGTAA

Upstream 100 bases:

>100_bases
ATGGAGCTGGCGGCGCCCGTGGTCCAGGGCGCGCCCTGATCTTTCGAACGACACCGCGGCGCACCCTCCGCCGCGTTCCT
CTTTCCATTCTTTCCGACGC

Downstream 100 bases:

>100_bases
AGCCTGGCGAACACAGCTGCCGGAGGGGCCGCCAGGGCATGGCGGCCCTTTTTTGTTGCGCCGCCGCATCGCGACAGGAA
CATGGTGTTTATGCGGAGTG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MSDNDQPTLDFSQPESGDHLGLAGYAQRAYLEYALSVVKGRALPDVCDGMKPVQRRILFAMERMGLAYGGPTRNVPAKPV
KSARVVGDVLGRFHPHGDQSAYDALVRLAQDFSQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIASLLLDEIDQGTVD
FVPNYDGSTEEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREIADACVALVKNPKLADEELAALVPGPDYPGGGQII
SSPGDIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKVKAGKKALSQEQTQLKATVL
GVLDVVRDESSKDAPVRIVFEPKTGRVPQQELITTLLAHTSLETSAPINLTMVGLDGKPVQKSLRRMLEEWIAFRQQTIT
RRSQHRLAKVLDRIHILEGRQTVLLNIDEVIAIIRASDEPKAALIERFRLSDRQAEDILEIRLRQLARLEAIKIEQELKE
LREEQGKLEDILANPASLRRLMVKEIEADAKQFADARRTLIQADKRATAEVKVVDEPVTVVVSQKGWVRARQGHGHDAGT
FAFKSGDALYGTFECRTVDTLIAFGSNGRVYSVAVSQLPGARGDGQPITTLIDLEAGTQPVHYFAGPANAALLLAGSGGY
GFIAAVEHMTARNRGGKAFVSLGEGEQLCRPSHAAFTSGSQPLAPATHVCCASAGGRILTFEITELKQMANGGRGLMLID
LEPKDTLAGAAAYTRSVRIAGVGRGGKERDETLEIRSLNNARFPRGRKGKAADLGFKPNAVQRVE

Sequences:

>Translated_785_residues
MSDNDQPTLDFSQPESGDHLGLAGYAQRAYLEYALSVVKGRALPDVCDGMKPVQRRILFAMERMGLAYGGPTRNVPAKPV
KSARVVGDVLGRFHPHGDQSAYDALVRLAQDFSQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIASLLLDEIDQGTVD
FVPNYDGSTEEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREIADACVALVKNPKLADEELAALVPGPDYPGGGQII
SSPGDIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKVKAGKKALSQEQTQLKATVL
GVLDVVRDESSKDAPVRIVFEPKTGRVPQQELITTLLAHTSLETSAPINLTMVGLDGKPVQKSLRRMLEEWIAFRQQTIT
RRSQHRLAKVLDRIHILEGRQTVLLNIDEVIAIIRASDEPKAALIERFRLSDRQAEDILEIRLRQLARLEAIKIEQELKE
LREEQGKLEDILANPASLRRLMVKEIEADAKQFADARRTLIQADKRATAEVKVVDEPVTVVVSQKGWVRARQGHGHDAGT
FAFKSGDALYGTFECRTVDTLIAFGSNGRVYSVAVSQLPGARGDGQPITTLIDLEAGTQPVHYFAGPANAALLLAGSGGY
GFIAAVEHMTARNRGGKAFVSLGEGEQLCRPSHAAFTSGSQPLAPATHVCCASAGGRILTFEITELKQMANGGRGLMLID
LEPKDTLAGAAAYTRSVRIAGVGRGGKERDETLEIRSLNNARFPRGRKGKAADLGFKPNAVQRVE
>Mature_784_residues
SDNDQPTLDFSQPESGDHLGLAGYAQRAYLEYALSVVKGRALPDVCDGMKPVQRRILFAMERMGLAYGGPTRNVPAKPVK
SARVVGDVLGRFHPHGDQSAYDALVRLAQDFSQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIASLLLDEIDQGTVDF
VPNYDGSTEEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREIADACVALVKNPKLADEELAALVPGPDYPGGGQIIS
SPGDIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKVKAGKKALSQEQTQLKATVLG
VLDVVRDESSKDAPVRIVFEPKTGRVPQQELITTLLAHTSLETSAPINLTMVGLDGKPVQKSLRRMLEEWIAFRQQTITR
RSQHRLAKVLDRIHILEGRQTVLLNIDEVIAIIRASDEPKAALIERFRLSDRQAEDILEIRLRQLARLEAIKIEQELKEL
REEQGKLEDILANPASLRRLMVKEIEADAKQFADARRTLIQADKRATAEVKVVDEPVTVVVSQKGWVRARQGHGHDAGTF
AFKSGDALYGTFECRTVDTLIAFGSNGRVYSVAVSQLPGARGDGQPITTLIDLEAGTQPVHYFAGPANAALLLAGSGGYG
FIAAVEHMTARNRGGKAFVSLGEGEQLCRPSHAAFTSGSQPLAPATHVCCASAGGRILTFEITELKQMANGGRGLMLIDL
EPKDTLAGAAAYTRSVRIAGVGRGGKERDETLEIRSLNNARFPRGRKGKAADLGFKPNAVQRVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=196, Percent_Identity=31.6326530612245, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI19913406, Length=174, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1789396, Length=711, Percent_Identity=43.6005625879044, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1788562, Length=757, Percent_Identity=36.4597093791281, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=465, Percent_Identity=27.741935483871, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=196, Percent_Identity=32.6530612244898, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=362, Percent_Identity=24.3093922651934, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=193, Percent_Identity=31.0880829015544, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=195, Percent_Identity=32.8205128205128, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136538, Length=265, Percent_Identity=26.4150943396226, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85310; Mature: 85179

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNDQPTLDFSQPESGDHLGLAGYAQRAYLEYALSVVKGRALPDVCDGMKPVQRRILFA
CCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHH
MERMGLAYGGPTRNVPAKPVKSARVVGDVLGRFHPHGDQSAYDALVRLAQDFSQRYPLID
HHHHCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEC
GQGNFGSRDGDGAAAMRYTEARLTRIASLLLDEIDQGTVDFVPNYDGSTEEPRQLPARLP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHCC
FALLNGASGIAVGLATEIPSHNLREIADACVALVKNPKLADEELAALVPGPDYPGGGQII
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCCCEE
SSPGDIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPK
CCCCCHHHHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC
VKAGKKALSQEQTQLKATVLGVLDVVRDESSKDAPVRIVFEPKTGRVPQQELITTLLAHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
SLETSAPINLTMVGLDGKPVQKSLRRMLEEWIAFRQQTITRRSQHRLAKVLDRIHILEGR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QTVLLNIDEVIAIIRASDEPKAALIERFRLSDRQAEDILEIRLRQLARLEAIKIEQELKE
CEEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREEQGKLEDILANPASLRRLMVKEIEADAKQFADARRTLIQADKRATAEVKVVDEPVTV
HHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEE
VVSQKGWVRARQGHGHDAGTFAFKSGDALYGTFECRTVDTLIAFGSNGRVYSVAVSQLPG
EEECCCCEEECCCCCCCCCEEEEECCCEEEEEEEEEEEEEHEEECCCCCEEEEEHHHCCC
ARGDGQPITTLIDLEAGTQPVHYFAGPANAALLLAGSGGYGFIAAVEHMTARNRGGKAFV
CCCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEE
SLGEGEQLCRPSHAAFTSGSQPLAPATHVCCASAGGRILTFEITELKQMANGGRGLMLID
EECCCHHHCCCCCHHCCCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHHHCCCCEEEEEE
LEPKDTLAGAAAYTRSVRIAGVGRGGKERDETLEIRSLNNARFPRGRKGKAADLGFKPNA
CCCCHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
VQRVE
CCCCC
>Mature Secondary Structure 
SDNDQPTLDFSQPESGDHLGLAGYAQRAYLEYALSVVKGRALPDVCDGMKPVQRRILFA
CCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHH
MERMGLAYGGPTRNVPAKPVKSARVVGDVLGRFHPHGDQSAYDALVRLAQDFSQRYPLID
HHHHCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEC
GQGNFGSRDGDGAAAMRYTEARLTRIASLLLDEIDQGTVDFVPNYDGSTEEPRQLPARLP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHCC
FALLNGASGIAVGLATEIPSHNLREIADACVALVKNPKLADEELAALVPGPDYPGGGQII
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCCCEE
SSPGDIQDAYRTGRGSLKVRARWKIEDLARGQWQMVVTELPPGVSAQKVLEEIEELTNPK
CCCCCHHHHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCC
VKAGKKALSQEQTQLKATVLGVLDVVRDESSKDAPVRIVFEPKTGRVPQQELITTLLAHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
SLETSAPINLTMVGLDGKPVQKSLRRMLEEWIAFRQQTITRRSQHRLAKVLDRIHILEGR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QTVLLNIDEVIAIIRASDEPKAALIERFRLSDRQAEDILEIRLRQLARLEAIKIEQELKE
CEEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREEQGKLEDILANPASLRRLMVKEIEADAKQFADARRTLIQADKRATAEVKVVDEPVTV
HHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEE
VVSQKGWVRARQGHGHDAGTFAFKSGDALYGTFECRTVDTLIAFGSNGRVYSVAVSQLPG
EEECCCCEEECCCCCCCCCEEEEECCCEEEEEEEEEEEEEHEEECCCCCEEEEEHHHCCC
ARGDGQPITTLIDLEAGTQPVHYFAGPANAALLLAGSGGYGFIAAVEHMTARNRGGKAFV
CCCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEE
SLGEGEQLCRPSHAAFTSGSQPLAPATHVCCASAGGRILTFEITELKQMANGGRGLMLID
EECCCHHHCCCCCHHCCCCCCCCCCHHHHHHHCCCCEEEEEEHHHHHHHHCCCCEEEEEE
LEPKDTLAGAAAYTRSVRIAGVGRGGKERDETLEIRSLNNARFPRGRKGKAADLGFKPNA
CCCCHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCC
VQRVE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]