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The map label for this gene is dapA [H]

Identifier: 120610024

GI number: 120610024

Start: 1461823

End: 1462719

Strand: Reverse

Name: dapA [H]

Synonym: Aave_1337

Alternate gene names: 120610024

Gene position: 1462719-1461823 (Counterclockwise)

Preceding gene: 120610025

Following gene: 120610023

Centisome position: 27.33

GC content: 68.56

Gene sequence:

>897_bases
ATGACCTCTTCCAGCGCCACCCTCACCGGCAGCATCGTCGCCCTCGTCACCCCCATGCACGAGGACGGCAGCGTGGACTA
CCCCACCCTGCGCAAGCTGATCGACTGGCATGTCGCCGAAGGGACCGACTGCATCGGCGTGGTGGGCACCACCGGCGAAT
CGCCCACCGTCAACGTCGAGGAGCACTGCGAGATCATCCGCGTGGCCGTCGAGCAGGCCGCCAGGCGCGTGCCGATCATG
GCCGGCTGCGGCGCCAACTCCACGGCCGAGGCCATCGAACTGGCCCGCTTCGCCAAGAAGGTGGGCGCGGACAGCCAGCT
CCAGGTCGTTCCCTACTACAACAAGCCCACGCAGGAAGGGCAGTACCAGCACTTCAGGTCCATAGCCGAAGCCGTGGGCG
ACCTGCCCACCGTCCTCTACAACGTGCCCGGCCGCTCCGTCGCCGATATGCAGCACGACACCGTGCTGCGCCTCGCGCAG
GTGCCCGGCATCATCGGCATCAAGGAAGCCACAGGCAACATCGAGCGCGCGCAATGGCTGATCCGCGACGTGCCCGAAGG
CTTCGCCGTCTATTCGGGCGACGACCCGACAGCCGTGGCCCTGATGCTCTGCGGCGGGCAGGGCAACATCAGCGTGACCG
CCAACGTGGCCCCGCGCCTGATGCACGAACTCTGCGTGGCCGCCCTGGCCGGCGACGTGCGCCGGGCCATGGAGATCCAG
TTCCGCCTGATGCCTGTCCACAAGCACCTCTTCGTCGAGGCCAACCCCATTCCGGTGAAGTGGGCGATGCAGCGCATGGG
CCTGTGCGGCGGCACGATGCGCCTGCCCATGACGCCCCTCTCCCCCGGCAGCGAGCCCGTGGTGGAAGCCGCGCTGCGCT
CCGCTGGCCTGCTCTGA

Upstream 100 bases:

>100_bases
CCACCCCGCCATCCCCTCGTACCGCCACCCTCCGGTTAACCCCCGGGCGGGCCGGTTACACACTCGTTAGAATGCTCTTT
TACCGTTTTCCTTCGTGGAC

Downstream 100 bases:

>100_bases
AGCACGTCCGCCTCCGCCTGCGCCCGTCTTTCCCCACCGCAGCCAGCCTCCAGAGACTCCCTCAAAGGATTTTTGCGTGA
ACGCTATCAATCGCCTGGGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTSSSATLTGSIVALVTPMHEDGSVDYPTLRKLIDWHVAEGTDCIGVVGTTGESPTVNVEEHCEIIRVAVEQAARRVPIM
AGCGANSTAEAIELARFAKKVGADSQLQVVPYYNKPTQEGQYQHFRSIAEAVGDLPTVLYNVPGRSVADMQHDTVLRLAQ
VPGIIGIKEATGNIERAQWLIRDVPEGFAVYSGDDPTAVALMLCGGQGNISVTANVAPRLMHELCVAALAGDVRRAMEIQ
FRLMPVHKHLFVEANPIPVKWAMQRMGLCGGTMRLPMTPLSPGSEPVVEAALRSAGLL

Sequences:

>Translated_298_residues
MTSSSATLTGSIVALVTPMHEDGSVDYPTLRKLIDWHVAEGTDCIGVVGTTGESPTVNVEEHCEIIRVAVEQAARRVPIM
AGCGANSTAEAIELARFAKKVGADSQLQVVPYYNKPTQEGQYQHFRSIAEAVGDLPTVLYNVPGRSVADMQHDTVLRLAQ
VPGIIGIKEATGNIERAQWLIRDVPEGFAVYSGDDPTAVALMLCGGQGNISVTANVAPRLMHELCVAALAGDVRRAMEIQ
FRLMPVHKHLFVEANPIPVKWAMQRMGLCGGTMRLPMTPLSPGSEPVVEAALRSAGLL
>Mature_297_residues
TSSSATLTGSIVALVTPMHEDGSVDYPTLRKLIDWHVAEGTDCIGVVGTTGESPTVNVEEHCEIIRVAVEQAARRVPIMA
GCGANSTAEAIELARFAKKVGADSQLQVVPYYNKPTQEGQYQHFRSIAEAVGDLPTVLYNVPGRSVADMQHDTVLRLAQV
PGIIGIKEATGNIERAQWLIRDVPEGFAVYSGDDPTAVALMLCGGQGNISVTANVAPRLMHELCVAALAGDVRRAMEIQF
RLMPVHKHLFVEANPIPVKWAMQRMGLCGGTMRLPMTPLSPGSEPVVEAALRSAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=25.7839721254355, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI13540533, Length=306, Percent_Identity=24.8366013071895, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=52.7397260273973, Blast_Score=294, Evalue=4e-81,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=31.438127090301, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789620, Length=236, Percent_Identity=28.8135593220339, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786463, Length=289, Percent_Identity=32.5259515570934, Blast_Score=124, Evalue=8e-30,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31918; Mature: 31787

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSATLTGSIVALVTPMHEDGSVDYPTLRKLIDWHVAEGTDCIGVVGTTGESPTVNVE
CCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECHH
EHCEIIRVAVEQAARRVPIMAGCGANSTAEAIELARFAKKVGADSQLQVVPYYNKPTQEG
HHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
QYQHFRSIAEAVGDLPTVLYNVPGRSVADMQHDTVLRLAQVPGIIGIKEATGNIERAQWL
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
IRDVPEGFAVYSGDDPTAVALMLCGGQGNISVTANVAPRLMHELCVAALAGDVRRAMEIQ
HHHCCCCCEEECCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHE
FRLMPVHKHLFVEANPIPVKWAMQRMGLCGGTMRLPMTPLSPGSEPVVEAALRSAGLL
EEEEEEEEEEEEECCCCCHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSSSATLTGSIVALVTPMHEDGSVDYPTLRKLIDWHVAEGTDCIGVVGTTGESPTVNVE
CCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECHH
EHCEIIRVAVEQAARRVPIMAGCGANSTAEAIELARFAKKVGADSQLQVVPYYNKPTQEG
HHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
QYQHFRSIAEAVGDLPTVLYNVPGRSVADMQHDTVLRLAQVPGIIGIKEATGNIERAQWL
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
IRDVPEGFAVYSGDDPTAVALMLCGGQGNISVTANVAPRLMHELCVAALAGDVRRAMEIQ
HHHCCCCCEEECCCCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHE
FRLMPVHKHLFVEANPIPVKWAMQRMGLCGGTMRLPMTPLSPGSEPVVEAALRSAGLL
EEEEEEEEEEEEECCCCCHHHHHHHCCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA