Click here to switch to the map view.

The map label for this gene is dut [H]

Identifier: 120610016

GI number: 120610016

Start: 1455682

End: 1456128

Strand: Direct

Name: dut [H]

Synonym: Aave_1329

Alternate gene names: 120610016

Gene position: 1455682-1456128 (Clockwise)

Preceding gene: 120610015

Following gene: 120610017

Centisome position: 27.19

GC content: 67.11

Gene sequence:

>447_bases
GTGAAAATCGACGTCAAGATCCTCGACGCGCGCATGGCGGAGCAGTTGCCCGCCTACGCCACGCCCGGCAGCGCCGGCCT
CGACCTGCGGGCCTGCCTGGACGCCCCCCTGACCCTGCAGCCCAATGCCTGGCAACTCGTACCCACAGGCATCGCCATCT
ACCTGAAGGATCCCGGCTACGCCGCGCTGATCCTGCCGCGCTCGGGCCTGGGCCACAAGCACGGCATCGTGCTCGGCAAC
CTGGTCGGCCTCATCGACAGCGACTACCAGGGGCAGTTGATGGTCAGCGCCTGGAACCGCAGCGACATTGCCTTCACCCT
GCAGCCGATGGAGCGTCTGGCCCAGCTCGTGATCGTGCCGGTGGTGCAGGCGCAGTTCCATGTGGTGCAGGAGTTTCCGG
CCACGGCGCGTGGTGAGAACGGTTACGGCTCCACGGGCAAGGTGTAG

Upstream 100 bases:

>100_bases
GCCCGCCGGCTGGTCACCGCCTGAAGCGCAGTCCCGGAGCACCCCCGGAGGCTGGCGCTCCAGGAGTGTTGCGCCCCTGC
ATCATCCATTGAAAGCATTT

Downstream 100 bases:

>100_bases
GTATCGTCCTATCCGTCCGGGGCGATGGTGCCTACGGCGGCCGCGGCCATCTCCCGTCGCGTACCGCGGCCGGCCCCATG
CTCCAATGGGTTGACCGGCG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MKIDVKILDARMAEQLPAYATPGSAGLDLRACLDAPLTLQPNAWQLVPTGIAIYLKDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMVSAWNRSDIAFTLQPMERLAQLVIVPVVQAQFHVVQEFPATARGENGYGSTGKV

Sequences:

>Translated_148_residues
MKIDVKILDARMAEQLPAYATPGSAGLDLRACLDAPLTLQPNAWQLVPTGIAIYLKDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMVSAWNRSDIAFTLQPMERLAQLVIVPVVQAQFHVVQEFPATARGENGYGSTGKV
>Mature_148_residues
MKIDVKILDARMAEQLPAYATPGSAGLDLRACLDAPLTLQPNAWQLVPTGIAIYLKDPGYAALILPRSGLGHKHGIVLGN
LVGLIDSDYQGQLMVSAWNRSDIAFTLQPMERLAQLVIVPVVQAQFHVVQEFPATARGENGYGSTGKV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=140, Percent_Identity=35.7142857142857, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI4503423, Length=140, Percent_Identity=35.7142857142857, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI70906441, Length=140, Percent_Identity=35.7142857142857, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=65.5405405405405, Blast_Score=204, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71988561, Length=133, Percent_Identity=37.593984962406, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319729, Length=133, Percent_Identity=35.3383458646617, Blast_Score=72, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24583610, Length=149, Percent_Identity=34.2281879194631, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19921126, Length=149, Percent_Identity=34.2281879194631, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15906; Mature: 15906

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDVKILDARMAEQLPAYATPGSAGLDLRACLDAPLTLQPNAWQLVPTGIAIYLKDPGY
CEEEEEEECHHHHHHCCCCCCCCCCCCEEHHHCCCCEEECCCCEEEEECCEEEEEECCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSAWNRSDIAFTLQPMERLAQLVIVP
EEEEEECCCCCCCCCEEEEHEEECCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQAQFHVVQEFPATARGENGYGSTGKV
HHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIDVKILDARMAEQLPAYATPGSAGLDLRACLDAPLTLQPNAWQLVPTGIAIYLKDPGY
CEEEEEEECHHHHHHCCCCCCCCCCCCEEHHHCCCCEEECCCCEEEEECCEEEEEECCCE
AALILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSAWNRSDIAFTLQPMERLAQLVIVP
EEEEEECCCCCCCCCEEEEHEEECCCCCCCCEEEEEECCCCCEEEEECHHHHHHHHHHHH
VVQAQFHVVQEFPATARGENGYGSTGKV
HHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA