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The map label for this gene is kdsA

Identifier: 120610013

GI number: 120610013

Start: 1451707

End: 1452564

Strand: Reverse

Name: kdsA

Synonym: Aave_1326

Alternate gene names: 120610013

Gene position: 1452564-1451707 (Counterclockwise)

Preceding gene: 120610014

Following gene: 120610012

Centisome position: 27.14

GC content: 67.72

Gene sequence:

>858_bases
ATGAAACTCTGCGGCTTCGACGTCGGCCTCGACCGGCCCTTCTTCCTCATCGCGGGTCCCTGCGTCATCGAGTCCGAGCA
GCTGCAGATGGACGTGGCCGGCCGCCTGAAGGAAACCACGGCGGCGCTGGGCATCCCGTTCATCTTCAAGAGCAGCTTCG
ACAAGGCCAACCGGTCGTCGGGCACGAGCTTCCGCGGCCCCGGCCGCGAGAAGGGCCTGGAGATCCTGGCCAAGATCCGC
CGCGAACTGAACGTGCCCGTGCTGACCGACGTGCACACCGAGGACGACATCACCGAGGCCGCGAAGGTGGTGGACGTGCT
GCAGACGCCCGCGTTCCTGTGCCGCCAGACCGACTTCATCCGCGCCGTGGCGCAGTCGGGCAAGCCGGTCAACATCAAGA
AGGGCCAGTTCCTCGCACCCCACGACATGAAGAACGTCATCGACAAGGCCCGCGCCGCCGCGCGCGAGAAGGGCCTGCCG
GAAGACAGCTTCATGGCCTGCGAGCGCGGCGCGAGCTTCGGCTACAACAACCTCGTCTCCGACATGCGCGGCCTCGCCAT
CATGCGCGAGACGGGCGCGCCCGTGGTGTTCGACGCCACGCACAGCGTGCAGCTGCCGGGCGGCCAGGGCACCAGCAGCG
GCGGCCAGCGCGAGATGGTGCCGGTGCTGGCACGCGCGGCCGTGGCCGTGGGCGTGGCCGGCCTCTTCATGGAAACGCAC
CCCGATCCCTGCAACGCCCTCTCGGACGGGCCCAACGCAGTGCCGCTCAAGCACATGAAGGCGCTGCTGGAAACCCTCGT
CGCCCTGGATTCCGTCACCAAGCGGAATGGCTTTCTCGAAAACGACTTCGGAGCTTGA

Upstream 100 bases:

>100_bases
TCATCAAGGCGGCGATCGACCACCAGAAGAGCCGCCAGCCCACCCTGCCCGCCGCCGCTGCCTCCTGAGGCGTCGGCGCT
TTCCCCCCAAGGCACCTTCC

Downstream 100 bases:

>100_bases
GACATCCCATGAGCAGTGCCTACATCATCGCGTCCGTCACCGTCACCAACCCCGAACAGTACGAAGACTACCGCCGCCTC
AGCACGCAGGCCATGCAGGT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKLCGFDVGLDRPFFLIAGPCVIESEQLQMDVAGRLKETTAALGIPFIFKSSFDKANRSSGTSFRGPGREKGLEILAKIR
RELNVPVLTDVHTEDDITEAAKVVDVLQTPAFLCRQTDFIRAVAQSGKPVNIKKGQFLAPHDMKNVIDKARAAAREKGLP
EDSFMACERGASFGYNNLVSDMRGLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREMVPVLARAAVAVGVAGLFMETH
PDPCNALSDGPNAVPLKHMKALLETLVALDSVTKRNGFLENDFGA

Sequences:

>Translated_285_residues
MKLCGFDVGLDRPFFLIAGPCVIESEQLQMDVAGRLKETTAALGIPFIFKSSFDKANRSSGTSFRGPGREKGLEILAKIR
RELNVPVLTDVHTEDDITEAAKVVDVLQTPAFLCRQTDFIRAVAQSGKPVNIKKGQFLAPHDMKNVIDKARAAAREKGLP
EDSFMACERGASFGYNNLVSDMRGLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREMVPVLARAAVAVGVAGLFMETH
PDPCNALSDGPNAVPLKHMKALLETLVALDSVTKRNGFLENDFGA
>Mature_285_residues
MKLCGFDVGLDRPFFLIAGPCVIESEQLQMDVAGRLKETTAALGIPFIFKSSFDKANRSSGTSFRGPGREKGLEILAKIR
RELNVPVLTDVHTEDDITEAAKVVDVLQTPAFLCRQTDFIRAVAQSGKPVNIKKGQFLAPHDMKNVIDKARAAAREKGLP
EDSFMACERGASFGYNNLVSDMRGLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREMVPVLARAAVAVGVAGLFMETH
PDPCNALSDGPNAVPLKHMKALLETLVALDSVTKRNGFLENDFGA

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=279, Percent_Identity=45.8781362007168, Blast_Score=250, Evalue=8e-68,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_ACIAC (A1TLS9)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969691.1
- ProteinModelPortal:   A1TLS9
- SMR:   A1TLS9
- STRING:   A1TLS9
- GeneID:   4666964
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1326
- NMPDR:   fig|397945.5.peg.1167
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   GVFLECH
- PhylomeDB:   A1TLS9
- ProtClustDB:   PRK05198
- BioCyc:   AAVE397945:AAVE_1326-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30585; Mature: 30585

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCGFDVGLDRPFFLIAGPCVIESEQLQMDVAGRLKETTAALGIPFIFKSSFDKANRSS
CCCCCCCCCCCCCEEEEECCEEECHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
GTSFRGPGREKGLEILAKIRRELNVPVLTDVHTEDDITEAAKVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVAQSGKPVNIKKGQFLAPHDMKNVIDKARAAAREKGLPEDSFMACERGASFGYNNLVS
HHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHH
DMRGLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREMVPVLARAAVAVGVAGLFMETH
HHHHHHHHHCCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PDPCNALSDGPNAVPLKHMKALLETLVALDSVTKRNGFLENDFGA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLCGFDVGLDRPFFLIAGPCVIESEQLQMDVAGRLKETTAALGIPFIFKSSFDKANRSS
CCCCCCCCCCCCCEEEEECCEEECHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
GTSFRGPGREKGLEILAKIRRELNVPVLTDVHTEDDITEAAKVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAVAQSGKPVNIKKGQFLAPHDMKNVIDKARAAAREKGLPEDSFMACERGASFGYNNLVS
HHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHH
DMRGLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREMVPVLARAAVAVGVAGLFMETH
HHHHHHHHHCCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PDPCNALSDGPNAVPLKHMKALLETLVALDSVTKRNGFLENDFGA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA