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The map label for this gene is nuoH

Identifier: 120609957

GI number: 120609957

Start: 1394747

End: 1395823

Strand: Direct

Name: nuoH

Synonym: Aave_1270

Alternate gene names: 120609957

Gene position: 1394747-1395823 (Clockwise)

Preceding gene: 120609956

Following gene: 120609958

Centisome position: 26.06

GC content: 65.37

Gene sequence:

>1077_bases
ATGATCGACGCGCTCTACAACGGCGGGCTGAACCTCGTCGCGCAGTCCTGGTGGACGGGCGCCGTGTGGCCCGTGCTCTG
GAACCTGCTCAAGATCGTCGCCATCGTGGCGCCGCTCATGGGCGCGGTGGCCTACCTCACGCTCTGGGAGCGCAAGCTGC
TGGGCTTCATGCAGGTGCGCCACGGCCCCAACCGCGTGGGCCCGTTCGGGCTGCTGCAGCCGCTGGCCGACGGCCTGAAG
CTGCTCACCAAGGAAATCATCCAGCCCGCGGCGGCCAGCAAGGGCCTGTTCGTGCTGGGCCCGGTGATGGCCATCATGCC
CGCGCTCGCGGCCTGGGTGGCGATCCCCTTCGGTCCCGACGTGGCGCTGGCCAACGTGAACGCCGGCCTGCTGCTGATCA
TGGCGATCACCTCGATCGAGGTGTACGGCGTGATCATCGCCGGCTGGGCCTCGAACTCGAAGTACGCTTTCCTGGGCGCG
CTGCGCGCATCGGCCCAGATGGTGAGCTACGAGATCGCCATGGGCTTCTGCTTCCTCGTGGTCATCATGGTCTCGGGCAG
CATGAACCTCACGCAGATCGTGCTGAGCCAGGCGCAGGGCACGATGGCGAACGCCGGGCTGTCGTTCCTGTCCTGGAACT
GGCTGCCGCTGCTGCCGATCTTCATCGTCTATCTGATCTCCGGCGTCGCCGAAACCAACCGCCATCCGTTCGACGTGGTG
GAAGGCGAGGCGGAAATCGTGGCCGGCCACATGGTCGAGTACTCGGGCATGGGCTTCGCGATCTTCTTCCTGGCCGAATA
CGCCAGCATGTGGCTCGTGTCCATCCTGGGCGTGACCATGTTTCTGGGCGGCTGGCTGTCGCCGGTGGCGGCCCTGGACT
TCATCCCGGGCTGGATCTGGCTGGGCCTCAAGACCTTCCTCGTGGTGTCCATGTTCATCTGGATCCGCGCGACCTTCCCG
CGCTTCCGGTACGACCAGATCATGCGCCTGGGCTGGAAGATCTTCATTCCGGTCACCCTGGTGTGGCTGCTGATCGTGGG
CGGATGGCTGCTGTCGCCCTGGAACATCTGGAAATAA

Upstream 100 bases:

>100_bases
CCGCCATCTACCAGCTCGACAGCCTCGTGCGCCGCGCGCCCTCGCTGCAGCTGACGGCCGACGGCCGCCAGGCCACCGTC
GCCGTGGAAGGAGCCGCAGC

Downstream 100 bases:

>100_bases
GCGGGACACGACATCATGGCTGCTGTTGCTGCTGCTACGACATCTTTTTCCTTCAAGGACTTTTTCAAGAGCTTCATGCT
CGTGGAACTGGTCAAGGGCA

Product: respiratory-chain NADH dehydrogenase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MIDALYNGGLNLVAQSWWTGAVWPVLWNLLKIVAIVAPLMGAVAYLTLWERKLLGFMQVRHGPNRVGPFGLLQPLADGLK
LLTKEIIQPAAASKGLFVLGPVMAIMPALAAWVAIPFGPDVALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGA
LRASAQMVSYEIAMGFCFLVVIMVSGSMNLTQIVLSQAQGTMANAGLSFLSWNWLPLLPIFIVYLISGVAETNRHPFDVV
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILGVTMFLGGWLSPVAALDFIPGWIWLGLKTFLVVSMFIWIRATFP
RFRYDQIMRLGWKIFIPVTLVWLLIVGGWLLSPWNIWK

Sequences:

>Translated_358_residues
MIDALYNGGLNLVAQSWWTGAVWPVLWNLLKIVAIVAPLMGAVAYLTLWERKLLGFMQVRHGPNRVGPFGLLQPLADGLK
LLTKEIIQPAAASKGLFVLGPVMAIMPALAAWVAIPFGPDVALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGA
LRASAQMVSYEIAMGFCFLVVIMVSGSMNLTQIVLSQAQGTMANAGLSFLSWNWLPLLPIFIVYLISGVAETNRHPFDVV
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILGVTMFLGGWLSPVAALDFIPGWIWLGLKTFLVVSMFIWIRATFP
RFRYDQIMRLGWKIFIPVTLVWLLIVGGWLLSPWNIWK
>Mature_358_residues
MIDALYNGGLNLVAQSWWTGAVWPVLWNLLKIVAIVAPLMGAVAYLTLWERKLLGFMQVRHGPNRVGPFGLLQPLADGLK
LLTKEIIQPAAASKGLFVLGPVMAIMPALAAWVAIPFGPDVALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGA
LRASAQMVSYEIAMGFCFLVVIMVSGSMNLTQIVLSQAQGTMANAGLSFLSWNWLPLLPIFIVYLISGVAETNRHPFDVV
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILGVTMFLGGWLSPVAALDFIPGWIWLGLKTFLVVSMFIWIRATFP
RFRYDQIMRLGWKIFIPVTLVWLLIVGGWLLSPWNIWK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=303, Percent_Identity=42.9042904290429, Blast_Score=251, Evalue=6e-67,
Organism=Escherichia coli, GI1788618, Length=336, Percent_Identity=41.6666666666667, Blast_Score=255, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_ACIAC (A1TLM3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969635.1
- STRING:   A1TLM3
- GeneID:   4668624
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1270
- NMPDR:   fig|397945.5.peg.1114
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   SSHKAMF
- PhylomeDB:   A1TLM3
- ProtClustDB:   CLSK963012
- BioCyc:   AAVE397945:AAVE_1270-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39370; Mature: 39370

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12ba0cc4)-; HASH(0x12826c68)-; HASH(0x11c76e38)-; HASH(0x12bdba94)-; HASH(0x12bcc044)-; HASH(0x12bdbb0c)-; HASH(0x1244328c)-; HASH(0xd0207e8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDALYNGGLNLVAQSWWTGAVWPVLWNLLKIVAIVAPLMGAVAYLTLWERKLLGFMQVR
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGPNRVGPFGLLQPLADGLKLLTKEIIQPAAASKGLFVLGPVMAIMPALAAWVAIPFGPD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
VALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGALRASAQMVSYEIAMGFCFLV
EEEECCCCHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIMVSGSMNLTQIVLSQAQGTMANAGLSFLSWNWLPLLPIFIVYLISGVAETNRHPFDVV
HHHHCCCCHHHHHHHHHHCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHC
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILGVTMFLGGWLSPVAALDFIPGWIW
CCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLKTFLVVSMFIWIRATFPRFRYDQIMRLGWKIFIPVTLVWLLIVGGWLLSPWNIWK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MIDALYNGGLNLVAQSWWTGAVWPVLWNLLKIVAIVAPLMGAVAYLTLWERKLLGFMQVR
CCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGPNRVGPFGLLQPLADGLKLLTKEIIQPAAASKGLFVLGPVMAIMPALAAWVAIPFGPD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
VALANVNAGLLLIMAITSIEVYGVIIAGWASNSKYAFLGALRASAQMVSYEIAMGFCFLV
EEEECCCCHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VIMVSGSMNLTQIVLSQAQGTMANAGLSFLSWNWLPLLPIFIVYLISGVAETNRHPFDVV
HHHHCCCCHHHHHHHHHHCCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHC
EGEAEIVAGHMVEYSGMGFAIFFLAEYASMWLVSILGVTMFLGGWLSPVAALDFIPGWIW
CCCHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLKTFLVVSMFIWIRATFPRFRYDQIMRLGWKIFIPVTLVWLLIVGGWLLSPWNIWK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA