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The map label for this gene is nuoF1 [H]

Identifier: 120609955

GI number: 120609955

Start: 1391226

End: 1392584

Strand: Direct

Name: nuoF1 [H]

Synonym: Aave_1268

Alternate gene names: 120609955

Gene position: 1391226-1392584 (Clockwise)

Preceding gene: 120609954

Following gene: 120609956

Centisome position: 25.99

GC content: 67.18

Gene sequence:

>1359_bases
ATGACCACCGCAGCACAGATCCTCTCGCAGTTCCAGGCCACGGGCGTCCAGACCTGCTTCCACGACCGCCACATCGAGCC
GCAGATCTACGCGGGCCTCGACGGCACGAACTGGAGCATCAAGGACTACGAGGCGCGCGGCGGCTACCAGGCCCTGCGCA
AGATCCTGGGCGTCGACGGCGGCGAGCCGATGACGCAGGACCAGGTCATCGCCACCGTCAAGGAATCCGGCCTGCGCGGC
CGTGGCGGCGCGGGCTTCCCGACGGGCCTGAAGTGGAGCTTCATGCCCCGCTCGTTCCCGGGCCAGAAGTACCTCGTCTG
CAACTCCGACGAGGGCGAGCCGGGCACCTGCAAGGACCGCGACATCCTGCAGTTCAACCCGCACATCGTCATCGAGGGCA
TGATCATCGCGGCTTTCGCGATGGGCATCTCGGTGGGCTACAACTACATCCACGGCGAGATCTTCCAGACCTACGAGCGT
TTCGAGGCCGCGCTGGAAGAGGCGCGCGCCGCGGGCTACCTGGGCGACAACATCCTGGGCAGCAGCTTCAGCTTCCAGCT
GCATGCCGCCCACGGCTTCGGTGCCTACATCTGCGGCGAGGAAACCGCGCTGCTGGAATCGCTGGAAGGCAAGAAGGGCC
AGCCGCGCTTCAAGCCGCCGTTCCCTGCCAGCTTCGGCCTGTACGGCAAGCCCACCACGATCAACAACACCGAGACCTTC
GCGGCGGTGCCCTGGATCATCCGCAACGGCGGCGCGGCCTACCTGGCCTGCGGCAAGCCGAACAACGGCGGCACCAAGAT
CTTCTCGGTGTCCGGCGACGTGGAGAAGCCCGGCAACTACGAGATCCCGCTGGGCACGCCGTTCAGCAAGCTGCTGGAAC
TGGCCGGCGGCGTGCGCAAGGGCCGCCAGCTCAAGGCGGTGATCCCGGGCGGTTCGTCCGCGCCGGTGCTGCCCGCGTCC
ATCATCATGGAATGCACGATGGACTACGACTCCATCGCCAAGGCCGGCTCGATGCTGGGCTCGGGCGCCGTGATCGTCAT
GGACGACTCGCGCAGCATGGTCGAGAGCCTGCTGCGCCTGTCGTACTTCTATTCGCACGAATCCTGCGGCCAGTGCACGC
CCTGCCGCGAAGGCACGGGCTGGATGTGGCGCGTGATCGACCGCATCCAGCACGGCCTGGGCCGCGAAGGCGACCTGGAC
CTGCTCAATTCGGTGGCGGACAACATCCAGGGGCGCACCATCTGCGCCCTGGGCGACGCGGCGGCCATGCCGGTGCGGGC
GATGATCAAGCACTTCCGTCCGGAATTCGAGGCGCTGATCCGCAACAAGACGAGCCCCCAGGCTCCGGCCTCCGCCTGA

Upstream 100 bases:

>100_bases
CGCCCGTGATGCTGGTGAACGACCGCACGATGTGCAGCTTCATGGACAACGAGAAGCTCGACCAGCTCGTGGACGGCCTG
CGCCAGGCGGAGGGACAGGC

Downstream 100 bases:

>100_bases
TCGCGAGAAACGCATATGGTTGAAATCGAACTCGACGGGAAGAAGGTGGAAGTCGCCGAAGGCTGCATGGTGATGCATGC
GGCCGAGAAGGCGGGCACCT

Product: NADH-quinone oxidoreductase subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTTAAQILSQFQATGVQTCFHDRHIEPQIYAGLDGTNWSIKDYEARGGYQALRKILGVDGGEPMTQDQVIATVKESGLRG
RGGAGFPTGLKWSFMPRSFPGQKYLVCNSDEGEPGTCKDRDILQFNPHIVIEGMIIAAFAMGISVGYNYIHGEIFQTYER
FEAALEEARAAGYLGDNILGSSFSFQLHAAHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
AAVPWIIRNGGAAYLACGKPNNGGTKIFSVSGDVEKPGNYEIPLGTPFSKLLELAGGVRKGRQLKAVIPGGSSAPVLPAS
IIMECTMDYDSIAKAGSMLGSGAVIVMDDSRSMVESLLRLSYFYSHESCGQCTPCREGTGWMWRVIDRIQHGLGREGDLD
LLNSVADNIQGRTICALGDAAAMPVRAMIKHFRPEFEALIRNKTSPQAPASA

Sequences:

>Translated_452_residues
MTTAAQILSQFQATGVQTCFHDRHIEPQIYAGLDGTNWSIKDYEARGGYQALRKILGVDGGEPMTQDQVIATVKESGLRG
RGGAGFPTGLKWSFMPRSFPGQKYLVCNSDEGEPGTCKDRDILQFNPHIVIEGMIIAAFAMGISVGYNYIHGEIFQTYER
FEAALEEARAAGYLGDNILGSSFSFQLHAAHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
AAVPWIIRNGGAAYLACGKPNNGGTKIFSVSGDVEKPGNYEIPLGTPFSKLLELAGGVRKGRQLKAVIPGGSSAPVLPAS
IIMECTMDYDSIAKAGSMLGSGAVIVMDDSRSMVESLLRLSYFYSHESCGQCTPCREGTGWMWRVIDRIQHGLGREGDLD
LLNSVADNIQGRTICALGDAAAMPVRAMIKHFRPEFEALIRNKTSPQAPASA
>Mature_451_residues
TTAAQILSQFQATGVQTCFHDRHIEPQIYAGLDGTNWSIKDYEARGGYQALRKILGVDGGEPMTQDQVIATVKESGLRGR
GGAGFPTGLKWSFMPRSFPGQKYLVCNSDEGEPGTCKDRDILQFNPHIVIEGMIIAAFAMGISVGYNYIHGEIFQTYERF
EAALEEARAAGYLGDNILGSSFSFQLHAAHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFA
AVPWIIRNGGAAYLACGKPNNGGTKIFSVSGDVEKPGNYEIPLGTPFSKLLELAGGVRKGRQLKAVIPGGSSAPVLPASI
IMECTMDYDSIAKAGSMLGSGAVIVMDDSRSMVESLLRLSYFYSHESCGQCTPCREGTGWMWRVIDRIQHGLGREGDLDL
LNSVADNIQGRTICALGDAAAMPVRAMIKHFRPEFEALIRNKTSPQAPASA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=425, Percent_Identity=48.4705882352941, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI260656005, Length=425, Percent_Identity=48.4705882352941, Blast_Score=401, Evalue=1e-112,
Organism=Escherichia coli, GI1788620, Length=409, Percent_Identity=42.7872860635697, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17531727, Length=441, Percent_Identity=46.2585034013605, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19920794, Length=416, Percent_Identity=47.1153846153846, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI45550452, Length=430, Percent_Identity=45.1162790697674, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24653819, Length=376, Percent_Identity=37.7659574468085, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24653817, Length=352, Percent_Identity=36.0795454545455, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48761; Mature: 48630

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAAQILSQFQATGVQTCFHDRHIEPQIYAGLDGTNWSIKDYEARGGYQALRKILGVDG
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEECCCCCCHHHHHHHHHCCCC
GEPMTQDQVIATVKESGLRGRGGAGFPTGLKWSFMPRSFPGQKYLVCNSDEGEPGTCKDR
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCC
DILQFNPHIVIEGMIIAAFAMGISVGYNYIHGEIFQTYERFEAALEEARAAGYLGDNILG
CEEEECCCEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSFSFQLHAAHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
CCEEEEEEECCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAVPWIIRNGGAAYLACGKPNNGGTKIFSVSGDVEKPGNYEIPLGTPFSKLLELAGGVRK
EECCEEEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCCCC
GRQLKAVIPGGSSAPVLPASIIMECTMDYDSIAKAGSMLGSGAVIVMDDSRSMVESLLRL
CCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
SYFYSHESCGQCTPCREGTGWMWRVIDRIQHGLGREGDLDLLNSVADNIQGRTICALGDA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCH
AAMPVRAMIKHFRPEFEALIRNKTSPQAPASA
HHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTAAQILSQFQATGVQTCFHDRHIEPQIYAGLDGTNWSIKDYEARGGYQALRKILGVDG
CHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEECCCCCCHHHHHHHHHCCCC
GEPMTQDQVIATVKESGLRGRGGAGFPTGLKWSFMPRSFPGQKYLVCNSDEGEPGTCKDR
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCC
DILQFNPHIVIEGMIIAAFAMGISVGYNYIHGEIFQTYERFEAALEEARAAGYLGDNILG
CEEEECCCEEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SSFSFQLHAAHGFGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETF
CCEEEEEEECCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAVPWIIRNGGAAYLACGKPNNGGTKIFSVSGDVEKPGNYEIPLGTPFSKLLELAGGVRK
EECCEEEECCCEEEEEECCCCCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCCCC
GRQLKAVIPGGSSAPVLPASIIMECTMDYDSIAKAGSMLGSGAVIVMDDSRSMVESLLRL
CCEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
SYFYSHESCGQCTPCREGTGWMWRVIDRIQHGLGREGDLDLLNSVADNIQGRTICALGDA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCH
AAMPVRAMIKHFRPEFEALIRNKTSPQAPASA
HHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]