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The map label for this gene is hom [H]

Identifier: 120609925

GI number: 120609925

Start: 1362497

End: 1363831

Strand: Direct

Name: hom [H]

Synonym: Aave_1238

Alternate gene names: 120609925

Gene position: 1362497-1363831 (Clockwise)

Preceding gene: 120609924

Following gene: 120609926

Centisome position: 25.45

GC content: 69.36

Gene sequence:

>1335_bases
ATGAAACCGATCCAAGTGGGCCTGCTGGGCATTGGCACCGTCGGCAGCGGCGTGTTCAACGTGCTGCGACGCAACCAGGA
GGAAATCCGCCGCCGCGCGGGCCGCGGCATCGAGATCGCCATGGTGGCGGATCTCGACGTGGAGCGCGCCCGCGCCGTCG
CCGGAGACAGCGTGCAGGTGGTGAACGACGCGCGCGCCGTGATCGCCAACCCCGACATCGACATCGTCGTGGAGCTGATC
GGCGGCTACGGCGTGGCCAAGGCGCTGGTGATGGAAGCCATCGCGGCCGGCAAGCACGTGGTCACGGCCAACAAGGCCCT
GCTGGCGGTGCACGGCACCGAGATCTTCGCGGCCGCCTCGGCCAAGGGCGTCATGGTGGCCTTCGAGGCCGCGGTGGCCG
GCGGCATCCCGATCATCAAGGCGCTGCGCGAGGGCCTGACGGCCAACCGCATCCAGTGGATCGCGGGCATCATCAACGGC
ACGACGAACTTCATCCTTTCGGAGATGCGTGACAAGGGGCTCGACTTCGACGCGGTGCTCAAGGAGGCGCAGCGCCTGGG
TTACGCCGAGGCCGACCCGACCTTCGACATCGAGGGCGTGGACGCGGCGCACAAGGCCACGATCATGAGCGCGATCGCCT
TCGGCATCCCGGTGCAGTTCGACAAGGCGTACGTGGAAGGCATCACCAAGCTCGCCGCGGCGGACATCCGCTATGCCGAG
CAGCTCGGCTACCGCATCAAGCTGCTGGGCATCGCCAAGCGGCGCGAGGGCGGGGTGGAGTTGCGCGTGCATCCGAGTCT
GGTGCCGTCCAAGCGGCTGATCGCCAACGTGGAGGGCGCGATGAATGCCGTGGTGGTGCAGGCCGATGCGGTGGGCACCA
CGCTCTACTATGGCAAGGGCGCGGGCAGCGAGCCCACGGCCAGCGCCGTGATCGCCGACCTGGTGGACATCGCGCGCCTG
GCGGCGGCCGACCCTGAACACCGCGTGCCCCACCTGGCCTTCCAGCCGAACACGCTCGACGAGGCGCGCGATGCGCTGCC
CGTGCTGCCCATGGCCGAGGTGGTCACCAGCTACTACCTGCGCCTGCGCGTGGCCGACGAGGCCGGCGTGCTCGCCAAGG
TGACGGGGCTGCTGGCCGGCGCCGGCATCAGCATCGACGCCGTGCTGCAGCGCGAGGCCGACGAGGTGGGCGGCGAGGGC
GCCACGCACACCGACCTGATCATCCTCACGCACGACACGCGCGAGGGTACGATGAACGAAGCGATCGCGCAGATGCAGGC
CCTGCCCACGGTGCTGGGGCCGATCGTGCGTGTCCGCAAGGAGGAGCTGAACTGA

Upstream 100 bases:

>100_bases
GCGGCCGGGCGCGGCATGTCCTCTCTCCATCCAACCATCGCCGGCAGCGTTCATCCCTCTCGCGCGCTGCGGCACCATCT
GACTGACTGAGATACCGATC

Downstream 100 bases:

>100_bases
TGCGATACCTCTCCACACGCGGCCACGCGGACCGCAAGCGCTTCTGCGAGATCCTGCTCGAAGGCCTCGCGCCCGACGGC
GGGCTGTACCTGCCCGAGCA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MKPIQVGLLGIGTVGSGVFNVLRRNQEEIRRRAGRGIEIAMVADLDVERARAVAGDSVQVVNDARAVIANPDIDIVVELI
GGYGVAKALVMEAIAAGKHVVTANKALLAVHGTEIFAAASAKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFDAVLKEAQRLGYAEADPTFDIEGVDAAHKATIMSAIAFGIPVQFDKAYVEGITKLAAADIRYAE
QLGYRIKLLGIAKRREGGVELRVHPSLVPSKRLIANVEGAMNAVVVQADAVGTTLYYGKGAGSEPTASAVIADLVDIARL
AAADPEHRVPHLAFQPNTLDEARDALPVLPMAEVVTSYYLRLRVADEAGVLAKVTGLLAGAGISIDAVLQREADEVGGEG
ATHTDLIILTHDTREGTMNEAIAQMQALPTVLGPIVRVRKEELN

Sequences:

>Translated_444_residues
MKPIQVGLLGIGTVGSGVFNVLRRNQEEIRRRAGRGIEIAMVADLDVERARAVAGDSVQVVNDARAVIANPDIDIVVELI
GGYGVAKALVMEAIAAGKHVVTANKALLAVHGTEIFAAASAKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFDAVLKEAQRLGYAEADPTFDIEGVDAAHKATIMSAIAFGIPVQFDKAYVEGITKLAAADIRYAE
QLGYRIKLLGIAKRREGGVELRVHPSLVPSKRLIANVEGAMNAVVVQADAVGTTLYYGKGAGSEPTASAVIADLVDIARL
AAADPEHRVPHLAFQPNTLDEARDALPVLPMAEVVTSYYLRLRVADEAGVLAKVTGLLAGAGISIDAVLQREADEVGGEG
ATHTDLIILTHDTREGTMNEAIAQMQALPTVLGPIVRVRKEELN
>Mature_444_residues
MKPIQVGLLGIGTVGSGVFNVLRRNQEEIRRRAGRGIEIAMVADLDVERARAVAGDSVQVVNDARAVIANPDIDIVVELI
GGYGVAKALVMEAIAAGKHVVTANKALLAVHGTEIFAAASAKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFDAVLKEAQRLGYAEADPTFDIEGVDAAHKATIMSAIAFGIPVQFDKAYVEGITKLAAADIRYAE
QLGYRIKLLGIAKRREGGVELRVHPSLVPSKRLIANVEGAMNAVVVQADAVGTTLYYGKGAGSEPTASAVIADLVDIARL
AAADPEHRVPHLAFQPNTLDEARDALPVLPMAEVVTSYYLRLRVADEAGVLAKVTGLLAGAGISIDAVLQREADEVGGEG
ATHTDLIILTHDTREGTMNEAIAQMQALPTVLGPIVRVRKEELN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=282, Percent_Identity=25.531914893617, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=109, Percent_Identity=37.6146788990826, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46858; Mature: 46858

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIQVGLLGIGTVGSGVFNVLRRNQEEIRRRAGRGIEIAMVADLDVERARAVAGDSVQV
CCCEEEEEEEECHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEE
VNDARAVIANPDIDIVVELIGGYGVAKALVMEAIAAGKHVVTANKALLAVHGTEIFAAAS
ECCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECCEEEEECC
AKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDAVL
CCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQRLGYAEADPTFDIEGVDAAHKATIMSAIAFGIPVQFDKAYVEGITKLAAADIRYAE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
QLGYRIKLLGIAKRREGGVELRVHPSLVPSKRLIANVEGAMNAVVVQADAVGTTLYYGKG
HCCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCEEEEECCC
AGSEPTASAVIADLVDIARLAAADPEHRVPHLAFQPNTLDEARDALPVLPMAEVVTSYYL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHHHHE
RLRVADEAGVLAKVTGLLAGAGISIDAVLQREADEVGGEGATHTDLIILTHDTREGTMNE
EEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHH
AIAQMQALPTVLGPIVRVRKEELN
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPIQVGLLGIGTVGSGVFNVLRRNQEEIRRRAGRGIEIAMVADLDVERARAVAGDSVQV
CCCEEEEEEEECHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEE
VNDARAVIANPDIDIVVELIGGYGVAKALVMEAIAAGKHVVTANKALLAVHGTEIFAAAS
ECCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECCEEEEECC
AKGVMVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDAVL
CCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQRLGYAEADPTFDIEGVDAAHKATIMSAIAFGIPVQFDKAYVEGITKLAAADIRYAE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHH
QLGYRIKLLGIAKRREGGVELRVHPSLVPSKRLIANVEGAMNAVVVQADAVGTTLYYGKG
HCCCEEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCEEEEECCC
AGSEPTASAVIADLVDIARLAAADPEHRVPHLAFQPNTLDEARDALPVLPMAEVVTSYYL
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHHHHE
RLRVADEAGVLAKVTGLLAGAGISIDAVLQREADEVGGEGATHTDLIILTHDTREGTMNE
EEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHH
AIAQMQALPTVLGPIVRVRKEELN
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]