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The map label for this gene is thrC [H]

Identifier: 120609926

GI number: 120609926

Start: 1363831

End: 1365276

Strand: Direct

Name: thrC [H]

Synonym: Aave_1239

Alternate gene names: 120609926

Gene position: 1363831-1365276 (Clockwise)

Preceding gene: 120609925

Following gene: 120609927

Centisome position: 25.48

GC content: 67.57

Gene sequence:

>1446_bases
ATGCGATACCTCTCCACACGCGGCCACGCGGACCGCAAGCGCTTCTGCGAGATCCTGCTCGAAGGCCTCGCGCCCGACGG
CGGGCTGTACCTGCCCGAGCATTACCCGCAGATCGACGACGCCGCGCTCACGCGGCTGCGCGCGGCCTACCACGAGCAGG
GCTACGCGGAGCTGGCGTTCCAGATCCTGTCGCTCTACATCGACGACATTCCGGCGGCCGACCTGAAGCGCCTGTGCGAG
AAGACGTACACCGCCGAGGTGTTCGGCACGGGCGAGATCGTGCCGCTGCGCCACCTGGAGAACAGCCTGTGGCTGGAGGC
GCTCTCCAACGGCCCCACGCTCGCGTTCAAGGACATGGCGATGCAGCTGCTGGGCAACCTGTTCGAGTACGAACTGGGCC
GGCGCGGCGAAGAGCTCAACATCCTGGGCGCGACCAGCGGCGATACCGGCAGCGCGGCCGAGTACGCGATGCGCGGCAAG
CGCGGCATCCGCGTGTTCATGACGAGCCCGCACGGCCGCATGAGCGCCTTCCAGCAGGCGCAGATGTTCAGCCTGCAGGA
CGCGAACATCTTCAACATCGCCATCGAAGGCGTGTTCGACGACTGCCAGGACATCGTCAAGGCCGTGAGCAACGACCTGG
AGTTCAAGCGCCGCTTCAAGATCGGCACGGTGAACTCGATCAACTGGGCGCGGCTGCTCGCCCAGGTGGTGTATTACTTC
GCGGGTTACGTGCAGGCCACCGAGTCGAACGACCAGAAGGTCAGCTTCACGGTGCCGTCGGGCAATTTCGGGAACGTGTG
CGCGGGCCACGTGGCGCGCATGATGGGCCTGCCCATCGACAAGCTCGTGGTGGCGACCAACGAGAACGACGTGCTCGACG
AGTTCTTCCGCACGGGCATCTACCGCGTGCGCGGCAGCGCCGATACGCACGAGACGTCCAGCCCGTCGATGGACATCAGC
AAGGCCAGCAATTTCGAGCGCTTCGTGTTCGACCTGCTGGGCCGCGACGCGGAGGCCACGCGCCGGCTGTTCGGCGAGGC
CGTGGTGCGCGAGGGCCGCTTCGACCTCAGCGGCGATCCGCGCTTCGCCGAGGCCGCGTCGCGCTACGGCTTCGTGAGCG
GGCGCAGCACGCACGCGGACCGCATCGCGACCATCCGCGACACCTTCCAGCGCTTCGGCATCACGATCGACACGCACACC
GCCGACGGGGTGAAGGTGGCGCGCGAGCACACCGAGCCGGGCGTGCCGATGCTGGTGCTGGAAACCGCCCTGCCGATCAA
GTTCGCCGAGACGATCCAGGAGGCTCTGGGCCATGCTCCCGAACGCCCCGCGAAGTTCGACGGCATCGAGCGCCTGCCCA
AGCGCGTGCAGGTGATGCCGGCCGACGTGGATCTGGTGAAGGCCTACATCACGCGCCACTGCGACGGGACCGCCGCAGCG
GCCTGA

Upstream 100 bases:

>100_bases
ACACGCGCGAGGGTACGATGAACGAAGCGATCGCGCAGATGCAGGCCCTGCCCACGGTGCTGGGGCCGATCGTGCGTGTC
CGCAAGGAGGAGCTGAACTG

Downstream 100 bases:

>100_bases
GCGCCGGGCAGGGTCCGGGTGACGCGCGCAGACGCGGGTTGCTTCGGCGCCGCGCGCGGCGCTCTTCCGGCCTCGGCACA
TCCACGGAGGGCATGCATGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRYLSTRGHADRKRFCEILLEGLAPDGGLYLPEHYPQIDDAALTRLRAAYHEQGYAELAFQILSLYIDDIPAADLKRLCE
KTYTAEVFGTGEIVPLRHLENSLWLEALSNGPTLAFKDMAMQLLGNLFEYELGRRGEELNILGATSGDTGSAAEYAMRGK
RGIRVFMTSPHGRMSAFQQAQMFSLQDANIFNIAIEGVFDDCQDIVKAVSNDLEFKRRFKIGTVNSINWARLLAQVVYYF
AGYVQATESNDQKVSFTVPSGNFGNVCAGHVARMMGLPIDKLVVATNENDVLDEFFRTGIYRVRGSADTHETSSPSMDIS
KASNFERFVFDLLGRDAEATRRLFGEAVVREGRFDLSGDPRFAEAASRYGFVSGRSTHADRIATIRDTFQRFGITIDTHT
ADGVKVAREHTEPGVPMLVLETALPIKFAETIQEALGHAPERPAKFDGIERLPKRVQVMPADVDLVKAYITRHCDGTAAA
A

Sequences:

>Translated_481_residues
MRYLSTRGHADRKRFCEILLEGLAPDGGLYLPEHYPQIDDAALTRLRAAYHEQGYAELAFQILSLYIDDIPAADLKRLCE
KTYTAEVFGTGEIVPLRHLENSLWLEALSNGPTLAFKDMAMQLLGNLFEYELGRRGEELNILGATSGDTGSAAEYAMRGK
RGIRVFMTSPHGRMSAFQQAQMFSLQDANIFNIAIEGVFDDCQDIVKAVSNDLEFKRRFKIGTVNSINWARLLAQVVYYF
AGYVQATESNDQKVSFTVPSGNFGNVCAGHVARMMGLPIDKLVVATNENDVLDEFFRTGIYRVRGSADTHETSSPSMDIS
KASNFERFVFDLLGRDAEATRRLFGEAVVREGRFDLSGDPRFAEAASRYGFVSGRSTHADRIATIRDTFQRFGITIDTHT
ADGVKVAREHTEPGVPMLVLETALPIKFAETIQEALGHAPERPAKFDGIERLPKRVQVMPADVDLVKAYITRHCDGTAAA
A
>Mature_481_residues
MRYLSTRGHADRKRFCEILLEGLAPDGGLYLPEHYPQIDDAALTRLRAAYHEQGYAELAFQILSLYIDDIPAADLKRLCE
KTYTAEVFGTGEIVPLRHLENSLWLEALSNGPTLAFKDMAMQLLGNLFEYELGRRGEELNILGATSGDTGSAAEYAMRGK
RGIRVFMTSPHGRMSAFQQAQMFSLQDANIFNIAIEGVFDDCQDIVKAVSNDLEFKRRFKIGTVNSINWARLLAQVVYYF
AGYVQATESNDQKVSFTVPSGNFGNVCAGHVARMMGLPIDKLVVATNENDVLDEFFRTGIYRVRGSADTHETSSPSMDIS
KASNFERFVFDLLGRDAEATRRLFGEAVVREGRFDLSGDPRFAEAASRYGFVSGRSTHADRIATIRDTFQRFGITIDTHT
ADGVKVAREHTEPGVPMLVLETALPIKFAETIQEALGHAPERPAKFDGIERLPKRVQVMPADVDLVKAYITRHCDGTAAA
A

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=443, Percent_Identity=35.2144469525959, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI149193323, Length=470, Percent_Identity=30.8510638297872, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1786185, Length=474, Percent_Identity=28.6919831223629, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319901, Length=468, Percent_Identity=41.025641025641, Blast_Score=322, Evalue=1e-88,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53418; Mature: 53418

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLSTRGHADRKRFCEILLEGLAPDGGLYLPEHYPQIDDAALTRLRAAYHEQGYAELAF
CCCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
QILSLYIDDIPAADLKRLCEKTYTAEVFGTGEIVPLRHLENSLWLEALSNGPTLAFKDMA
HHHHHHHHCCCHHHHHHHHHHHHCEEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHH
MQLLGNLFEYELGRRGEELNILGATSGDTGSAAEYAMRGKRGIRVFMTSPHGRMSAFQQA
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHH
QMFSLQDANIFNIAIEGVFDDCQDIVKAVSNDLEFKRRFKIGTVNSINWARLLAQVVYYF
HHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHH
AGYVQATESNDQKVSFTVPSGNFGNVCAGHVARMMGLPIDKLVVATNENDVLDEFFRTGI
HHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCCE
YRVRGSADTHETSSPSMDISKASNFERFVFDLLGRDAEATRRLFGEAVVREGRFDLSGDP
EEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
RFAEAASRYGFVSGRSTHADRIATIRDTFQRFGITIDTHTADGVKVAREHTEPGVPMLVL
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCCCCCCEEEE
ETALPIKFAETIQEALGHAPERPAKFDGIERLPKRVQVMPADVDLVKAYITRHCDGTAAA
HHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHCCCCCCCC
A
C
>Mature Secondary Structure
MRYLSTRGHADRKRFCEILLEGLAPDGGLYLPEHYPQIDDAALTRLRAAYHEQGYAELAF
CCCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
QILSLYIDDIPAADLKRLCEKTYTAEVFGTGEIVPLRHLENSLWLEALSNGPTLAFKDMA
HHHHHHHHCCCHHHHHHHHHHHHCEEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHH
MQLLGNLFEYELGRRGEELNILGATSGDTGSAAEYAMRGKRGIRVFMTSPHGRMSAFQQA
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEEECCCHHHHHHHHH
QMFSLQDANIFNIAIEGVFDDCQDIVKAVSNDLEFKRRFKIGTVNSINWARLLAQVVYYF
HHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHH
AGYVQATESNDQKVSFTVPSGNFGNVCAGHVARMMGLPIDKLVVATNENDVLDEFFRTGI
HHHHEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCCE
YRVRGSADTHETSSPSMDISKASNFERFVFDLLGRDAEATRRLFGEAVVREGRFDLSGDP
EEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
RFAEAASRYGFVSGRSTHADRIATIRDTFQRFGITIDTHTADGVKVAREHTEPGVPMLVL
CHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCCCCCCEEEE
ETALPIKFAETIQEALGHAPERPAKFDGIERLPKRVQVMPADVDLVKAYITRHCDGTAAA
HHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCHHHHHHHHHHHCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]