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The map label for this gene is trpF [H]

Identifier: 120609903

GI number: 120609903

Start: 1338581

End: 1339351

Strand: Reverse

Name: trpF [H]

Synonym: Aave_1216

Alternate gene names: 120609903

Gene position: 1339351-1338581 (Counterclockwise)

Preceding gene: 120609904

Following gene: 120609902

Centisome position: 25.02

GC content: 68.61

Gene sequence:

>771_bases
ATGTCTTCGCCCATGCCTTCATCCGCCCCTGACACGCCCCTGCCGGAAAGCCGGCGCGGCGACGCTCCAGTTCCCCGCAC
GCGCATCAAGATCTGCGGCATCACCCGCGAGCAGGACCTGGACGCCGCCGTCCAGGCCGGAGCCGATGCGGTGGGATTCG
TGCTGTATCCGAAGAGCCAGCGCGCGGTGACCGTGCAGCGCGCCGCCGCGCTCGCGCGCCGCCTGCCCCCCTTCGTCACG
CCCGTGCTCCTGTTCGTGAATGCCGAAGCCGCCGAAGTGGCAGCCGCCTGCGACGAGATCCCCGGCGCCACCCTGCAGTT
CCATGGCGACGAAAGCCCCGCGGCCTGCCAGGAGGCCGCGGGCGCGGGACGGCGGCCCTTCGTTCGCGCAGCCCGCATTC
CCCTGGACGCGAACGCGCCGGCGTTCGACCTCGTACAATTCGCCCACCAATACTCACGCGCCCAGGCCATCCTGCTCGAC
GCCCATGTCGAAGGCTATGGCGGCGGCGGCAAGGCATTCAATTGGTCACTCCTTCCACCAAGCGTCGGCTCTCACCTCGT
TTTATCTGGTGGACTCACGCCTGCAAACGTGACCGATGGCATCTTGCAGGTGCGGCCGCGCGGCCTTTCGCTCGCGGTTG
ACGTCAGTTCCGGCGTGGAAGCCGAAGGCCCCGACGGCCGTCCGCTGCGGGGCATCAAGGACGCCGGCAAGATCCAACGC
TTCATCGCCGCCGTGCGCGCGGCCGATGGGCATTTTGCGAAGAACGATTGA

Upstream 100 bases:

>100_bases
TGATTGGCTGCCCTGACGGCAGGCCCCGCGGCTGAGCCGTGCATTGCCCGGCGCCCGGCGGGCCCGCTACGCGCCTGCGG
CAGCCCATCCGCATACCTTC

Downstream 100 bases:

>100_bases
TGCTTTCCTACCAACAGCCCGACGCTTCGGGCCACTTCGGCCGCTATGGCGGCAGTTTCGCGAGCGAGACGCTCACGCAT
GCCCTCACCGAGCTGCGCGA

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSSPMPSSAPDTPLPESRRGDAPVPRTRIKICGITREQDLDAAVQAGADAVGFVLYPKSQRAVTVQRAAALARRLPPFVT
PVLLFVNAEAAEVAAACDEIPGATLQFHGDESPAACQEAAGAGRRPFVRAARIPLDANAPAFDLVQFAHQYSRAQAILLD
AHVEGYGGGGKAFNWSLLPPSVGSHLVLSGGLTPANVTDGILQVRPRGLSLAVDVSSGVEAEGPDGRPLRGIKDAGKIQR
FIAAVRAADGHFAKND

Sequences:

>Translated_256_residues
MSSPMPSSAPDTPLPESRRGDAPVPRTRIKICGITREQDLDAAVQAGADAVGFVLYPKSQRAVTVQRAAALARRLPPFVT
PVLLFVNAEAAEVAAACDEIPGATLQFHGDESPAACQEAAGAGRRPFVRAARIPLDANAPAFDLVQFAHQYSRAQAILLD
AHVEGYGGGGKAFNWSLLPPSVGSHLVLSGGLTPANVTDGILQVRPRGLSLAVDVSSGVEAEGPDGRPLRGIKDAGKIQR
FIAAVRAADGHFAKND
>Mature_255_residues
SSPMPSSAPDTPLPESRRGDAPVPRTRIKICGITREQDLDAAVQAGADAVGFVLYPKSQRAVTVQRAAALARRLPPFVTP
VLLFVNAEAAEVAAACDEIPGATLQFHGDESPAACQEAAGAGRRPFVRAARIPLDANAPAFDLVQFAHQYSRAQAILLDA
HVEGYGGGGKAFNWSLLPPSVGSHLVLSGGLTPANVTDGILQVRPRGLSLAVDVSSGVEAEGPDGRPLRGIKDAGKIQRF
IAAVRAADGHFAKND

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=223, Percent_Identity=28.6995515695067, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320210, Length=236, Percent_Identity=28.8135593220339, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 26695; Mature: 26564

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPMPSSAPDTPLPESRRGDAPVPRTRIKICGITREQDLDAAVQAGADAVGFVLYPKSQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCC
RAVTVQRAAALARRLPPFVTPVLLFVNAEAAEVAAACDEIPGATLQFHGDESPAACQEAA
CEEHHHHHHHHHHHCCHHHHHHHHEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
GAGRRPFVRAARIPLDANAPAFDLVQFAHQYSRAQAILLDAHVEGYGGGGKAFNWSLLPP
CCCCCCCHHEECCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCEEEEEECCC
SVGSHLVLSGGLTPANVTDGILQVRPRGLSLAVDVSSGVEAEGPDGRPLRGIKDAGKIQR
CCCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
FIAAVRAADGHFAKND
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SSPMPSSAPDTPLPESRRGDAPVPRTRIKICGITREQDLDAAVQAGADAVGFVLYPKSQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCC
RAVTVQRAAALARRLPPFVTPVLLFVNAEAAEVAAACDEIPGATLQFHGDESPAACQEAA
CEEHHHHHHHHHHHCCHHHHHHHHEECCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHH
GAGRRPFVRAARIPLDANAPAFDLVQFAHQYSRAQAILLDAHVEGYGGGGKAFNWSLLPP
CCCCCCCHHEECCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCEEEEEECCC
SVGSHLVLSGGLTPANVTDGILQVRPRGLSLAVDVSSGVEAEGPDGRPLRGIKDAGKIQR
CCCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
FIAAVRAADGHFAKND
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA