Click here to switch to the map view.

The map label for this gene is trpB

Identifier: 120609902

GI number: 120609902

Start: 1337313

End: 1338581

Strand: Reverse

Name: trpB

Synonym: Aave_1215

Alternate gene names: 120609902

Gene position: 1338581-1337313 (Counterclockwise)

Preceding gene: 120609903

Following gene: 120609901

Centisome position: 25.01

GC content: 68.01

Gene sequence:

>1269_bases
ATGCTTTCCTACCAACAGCCCGACGCTTCGGGCCACTTCGGCCGCTATGGCGGCAGTTTCGCGAGCGAGACGCTCACGCA
TGCCCTCACCGAGCTGCGCGAGGCCTATGCCCGCTACCAGAACGACCCGGAGTTCCTGAAGGAATTCCACAGCGAACTCG
CGCACTTCGTGGGCCGGCCTTCGCCGATCTACCACGCCGCGCGCATGAGCCGCGAGATGGGCGGCGCGCAGATCTTCCTC
AAGCGGGAAGATCTCAACCACACGGGCGCGCACAAGATCAACAACGTGATCGGCCAGGCCATGCTCGCCCGCCGCATGGG
CAAGCCCCGCGTGATCGCCGAGACCGGCGCTGGCCAGCACGGCGTCGCCACGGCCACCATCTGCGCCCGCTACGGCCTGG
AATGCGTGGTGTACATGGGCGCGGAAGACGTGAAGCGCCAGAGCCCGAATGTCTATCGCATGAAGCTGCTGGGCGCCACC
GTGGTGCCCGTGGAGTCGGGCAGCCGCACGCTCAAGGATGCGCTCAACGAGGCCATGCGCGACTGGGTCGCGAACGTGGA
CAACACCTTCTACATCATCGGCACCGTGGCGGGCCCGCACCCCTACCCCATGATGGTGCGCGACTTCCAGAGCGTGATCG
GCACCGAATGCCTTGCCCAGATGCCCGGCATGCTGGCCGGGCAGCGCATCGCCGCCGAGCACCCGGACGCGGTGATCGCC
TGCGTGGGCGGCGGCAGCAATGCCATGGGCATCTTCCATCCCTACATCCCGCACGAGAAGACGCGCCTCATCGGCGTGGA
GGCGGCCGGCGAGGGGCTGGACAGCGGCAAGCACTCGGCATCGCTGCAGCGCGGCAGCGCGGGCGTGCTGCACGGCAACC
GCACGTTCATCCTGCAGGACGAGAACGGCCAGATCACCGAGACGCACAGCATCAGCGCCGGCCTCGACTACCCTGGCGTC
GGGCCCGAGCATGCCTGGCTGCAGGAGATCGGCCGCGCCGAGTACGTGGGCATCACCGACAGGGAAGCGCTCGACGCCTT
CCACTACCTCTGCCGCACCGAGGGCATCATCCCCGCGCTGGAGTCCAGCCATGCCGTGGCCTACGCGATGCAGCTCGCCA
GGACCCTGCGCACCGACCAGTCCATCCTCGTGAACCTTTCCGGCCGGGGCGACAAGGACATCGGCACGGTGGCGGATCTC
TCCGGCGTGGATTTCTACGACCGCCCGTCCATGCGGGGCCATGCCGTCAAGGGAGGGCCCGCGGCATGA

Upstream 100 bases:

>100_bases
CCGACGGCCGTCCGCTGCGGGGCATCAAGGACGCCGGCAAGATCCAACGCTTCATCGCCGCCGTGCGCGCGGCCGATGGG
CATTTTGCGAAGAACGATTG

Downstream 100 bases:

>100_bases
GCGCCGACATGACGACTTCCGCGTCCACGGCACCGCTGGCCGCCCAGGGGCGCATCGCGGCGACGTTCGCCGACCTGCAG
GCCCGCGGCCGCAAGGCCCT

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLSYQQPDASGHFGRYGGSFASETLTHALTELREAYARYQNDPEFLKEFHSELAHFVGRPSPIYHAARMSREMGGAQIFL
KREDLNHTGAHKINNVIGQAMLARRMGKPRVIAETGAGQHGVATATICARYGLECVVYMGAEDVKRQSPNVYRMKLLGAT
VVPVESGSRTLKDALNEAMRDWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLAQMPGMLAGQRIAAEHPDAVIA
CVGGGSNAMGIFHPYIPHEKTRLIGVEAAGEGLDSGKHSASLQRGSAGVLHGNRTFILQDENGQITETHSISAGLDYPGV
GPEHAWLQEIGRAEYVGITDREALDAFHYLCRTEGIIPALESSHAVAYAMQLARTLRTDQSILVNLSGRGDKDIGTVADL
SGVDFYDRPSMRGHAVKGGPAA

Sequences:

>Translated_422_residues
MLSYQQPDASGHFGRYGGSFASETLTHALTELREAYARYQNDPEFLKEFHSELAHFVGRPSPIYHAARMSREMGGAQIFL
KREDLNHTGAHKINNVIGQAMLARRMGKPRVIAETGAGQHGVATATICARYGLECVVYMGAEDVKRQSPNVYRMKLLGAT
VVPVESGSRTLKDALNEAMRDWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLAQMPGMLAGQRIAAEHPDAVIA
CVGGGSNAMGIFHPYIPHEKTRLIGVEAAGEGLDSGKHSASLQRGSAGVLHGNRTFILQDENGQITETHSISAGLDYPGV
GPEHAWLQEIGRAEYVGITDREALDAFHYLCRTEGIIPALESSHAVAYAMQLARTLRTDQSILVNLSGRGDKDIGTVADL
SGVDFYDRPSMRGHAVKGGPAA
>Mature_422_residues
MLSYQQPDASGHFGRYGGSFASETLTHALTELREAYARYQNDPEFLKEFHSELAHFVGRPSPIYHAARMSREMGGAQIFL
KREDLNHTGAHKINNVIGQAMLARRMGKPRVIAETGAGQHGVATATICARYGLECVVYMGAEDVKRQSPNVYRMKLLGAT
VVPVESGSRTLKDALNEAMRDWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLAQMPGMLAGQRIAAEHPDAVIA
CVGGGSNAMGIFHPYIPHEKTRLIGVEAAGEGLDSGKHSASLQRGSAGVLHGNRTFILQDENGQITETHSISAGLDYPGV
GPEHAWLQEIGRAEYVGITDREALDAFHYLCRTEGIIPALESSHAVAYAMQLARTLRTDQSILVNLSGRGDKDIGTVADL
SGVDFYDRPSMRGHAVKGGPAA

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=390, Percent_Identity=53.3333333333333, Blast_Score=419, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321412, Length=388, Percent_Identity=53.8659793814433, Blast_Score=447, Evalue=1e-126,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_ACIAC (A1TLG8)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969580.1
- ProteinModelPortal:   A1TLG8
- SMR:   A1TLG8
- STRING:   A1TLG8
- GeneID:   4665425
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1215
- NMPDR:   fig|397945.5.peg.1064
- eggNOG:   COG0133
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- PhylomeDB:   A1TLG8
- ProtClustDB:   PRK04346
- BioCyc:   AAVE397945:AAVE_1215-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 45657; Mature: 45657

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYQQPDASGHFGRYGGSFASETLTHALTELREAYARYQNDPEFLKEFHSELAHFVGRP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
SPIYHAARMSREMGGAQIFLKREDLNHTGAHKINNVIGQAMLARRMGKPRVIAETGAGQH
CHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GVATATICARYGLECVVYMGAEDVKRQSPNVYRMKLLGATVVPVESGSRTLKDALNEAMR
CHHHHHHHHHCCCEEEEEECCHHHHHCCCCEEEEEEECCEEEEECCCCHHHHHHHHHHHH
DWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLAQMPGMLAGQRIAAEHPDAVIA
HHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCCEEEE
CVGGGSNAMGIFHPYIPHEKTRLIGVEAAGEGLDSGKHSASLQRGSAGVLHGNRTFILQD
EECCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEEECCEEEEEEC
ENGQITETHSISAGLDYPGVGPEHAWLQEIGRAEYVGITDREALDAFHYLCRTEGIIPAL
CCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCCC
ESSHAVAYAMQLARTLRTDQSILVNLSGRGDKDIGTVADLSGVDFYDRPSMRGHAVKGGP
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCC
AA
CC
>Mature Secondary Structure
MLSYQQPDASGHFGRYGGSFASETLTHALTELREAYARYQNDPEFLKEFHSELAHFVGRP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
SPIYHAARMSREMGGAQIFLKREDLNHTGAHKINNVIGQAMLARRMGKPRVIAETGAGQH
CHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GVATATICARYGLECVVYMGAEDVKRQSPNVYRMKLLGATVVPVESGSRTLKDALNEAMR
CHHHHHHHHHCCCEEEEEECCHHHHHCCCCEEEEEEECCEEEEECCCCHHHHHHHHHHHH
DWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLAQMPGMLAGQRIAAEHPDAVIA
HHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCCEEEE
CVGGGSNAMGIFHPYIPHEKTRLIGVEAAGEGLDSGKHSASLQRGSAGVLHGNRTFILQD
EECCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEEECCEEEEEEC
ENGQITETHSISAGLDYPGVGPEHAWLQEIGRAEYVGITDREALDAFHYLCRTEGIIPAL
CCCCEEEECCCCCCCCCCCCCCCHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCCC
ESSHAVAYAMQLARTLRTDQSILVNLSGRGDKDIGTVADLSGVDFYDRPSMRGHAVKGGP
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA