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The map label for this gene is xdhB [H]

Identifier: 120609820

GI number: 120609820

Start: 1240895

End: 1242418

Strand: Reverse

Name: xdhB [H]

Synonym: Aave_1130

Alternate gene names: 120609820

Gene position: 1242418-1240895 (Counterclockwise)

Preceding gene: 120609821

Following gene: 120609819

Centisome position: 23.21

GC content: 73.69

Gene sequence:

>1524_bases
ATGACCGTTGCATCCCGACCGATCCGCTTCCTCCGCCGCGGCCAGCCCGTGACGCTGGCCCATGTTCCGCCCGACCGCAC
GCTGCTCGAAGTGCTGCGCGAGGACCTGGGCGACTGCGGCACCAAGGAGGGCTGCGGCGAGGGCGACTGCGGCGCCTGCA
CCGTGGTGCTGGGCTCGGAGGAAGGCGGCCGGCTGCGCCTGCGGGCCGTGAACAGCTGCATCCGCCTCGCGCACGCGATC
GACGGCATGGCGCTGTGGACGGTGGAAGACCTCGCGCAGGATCCGCTCATCCGGCGCGGCGCGCCCGCACCGCTGCATCC
CGCGCAGGAAGCCATGGTGCAGTGCCACGGATCGCAGTGCGGCTTCTGCACGCCGGGCTTCGTGATGAGCCTGTTCGGCA
TGTACCAGAACCATGTCTGCCAGGGCCGCGCCGTCACGCGCGAAATGGCCGTGGCGGAGCTTTCGGGCAACCTGTGCCGC
TGCACCGGCTACCGCCCGATCCTGGACGCCGCCGGGCGGATGGCCGAACTGCCGGCCCAGCCGGTGGACGAGGGCGCGGT
GCTGGAGCGGTTGCGGGAACTGCGAGCCCCCGTGGCGGCCCCCCAGGACGCAGCACCCAACTATCTGGCGCCGGAGACGC
TCGCTGGCCTGCTGGCCGCGCGTGCCGCCCATCCCGACGCGCAAATCGTCGCAGGCACCACCGACGTGGGCCTGTGGATC
ACCAAGCAGCACCGCCGCTTCGAGCGCGTGCTGGACGTCACCCGTGCCGAGGAGCTGCGGCGCATCGGTACCGTGGACGG
CCACCTTTCCATCGGTGCGGCGGCCACGCTGGACGACGCCTTCGCCGCCCTGGCCGCGCACTGGCCGGCGCTGCGGCGCT
TCGCCGAGCGCTTCGCCGGGCTGCCGGTGCGCAACGCGGGCACGCTGGGCGGCAACGTCGCCAACGGCTCGCCCATCGGC
GATTCGATGCCGGTGCTGATCGCGCTCGGCGCGCGCATCGTGCTGGCCAGCGTGCGCGGCGAACGCAGCCTGCCGCTGGA
AGACTTCTACACGGGCTACCGCCGCAACCTGCTGGCGCCGGACGAGATCGTCGCGCGCATCGACGTGCCCCTGCCCGCGC
CGGGCGACCGGCTGGCCGCCTACAAGGTGTCCAAGCGCTTCGACGACGACATCTCCGCCGTCTGCCTGGCCGTGCTGCTG
TCGGTGCGGGACGGCGCCGTGCAGTCCGCCCGCATCGGCGCGGGCGGCGTGGCCGCGGTGCCGGCGCGCGCACGCGGTGC
CGAGGCCGCGCTCGCCGGCCAGCCCTGGAGCGAGGCCGCCGCGCTGCGCGCGGGCGAAGCTCTGCAGGCGGAGTTCACCC
CCATTTCCGACATGCGCGCCAGCGGCGCCTACCGGCGCGCCGTGCTGGCCTCGCTGATGCGGCGCTGCTGGCTGGAGAGC
CCGGAACGCCCCGCAGGAACCGGCGCCCTGCCCGTATCGCTCGAACAACTCGTGCCGGTGGCGCAGGCGGAGGAACAGGC
ATGA

Upstream 100 bases:

>100_bases
GGTGGCAGGCGGTGCCGGGACCGGTTACGCTTCGAGTCCATGGCCCCCATGCCCCGTCCCGGCTGCCGGACGCCGGGGCG
CGCTCCAGAAAGCCCCGCGA

Downstream 100 bases:

>100_bases
ACCGGCGCGACGACACCCTGCCCACCAGTACCGCCCCCGAAGGCCCCCTGAGCCGCGACGCGGATGCGGACCCGGTGGCG
GCACGCGCAGACGCGGAAGG

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MTVASRPIRFLRRGQPVTLAHVPPDRTLLEVLREDLGDCGTKEGCGEGDCGACTVVLGSEEGGRLRLRAVNSCIRLAHAI
DGMALWTVEDLAQDPLIRRGAPAPLHPAQEAMVQCHGSQCGFCTPGFVMSLFGMYQNHVCQGRAVTREMAVAELSGNLCR
CTGYRPILDAAGRMAELPAQPVDEGAVLERLRELRAPVAAPQDAAPNYLAPETLAGLLAARAAHPDAQIVAGTTDVGLWI
TKQHRRFERVLDVTRAEELRRIGTVDGHLSIGAAATLDDAFAALAAHWPALRRFAERFAGLPVRNAGTLGGNVANGSPIG
DSMPVLIALGARIVLASVRGERSLPLEDFYTGYRRNLLAPDEIVARIDVPLPAPGDRLAAYKVSKRFDDDISAVCLAVLL
SVRDGAVQSARIGAGGVAAVPARARGAEAALAGQPWSEAAALRAGEALQAEFTPISDMRASGAYRRAVLASLMRRCWLES
PERPAGTGALPVSLEQLVPVAQAEEQA

Sequences:

>Translated_507_residues
MTVASRPIRFLRRGQPVTLAHVPPDRTLLEVLREDLGDCGTKEGCGEGDCGACTVVLGSEEGGRLRLRAVNSCIRLAHAI
DGMALWTVEDLAQDPLIRRGAPAPLHPAQEAMVQCHGSQCGFCTPGFVMSLFGMYQNHVCQGRAVTREMAVAELSGNLCR
CTGYRPILDAAGRMAELPAQPVDEGAVLERLRELRAPVAAPQDAAPNYLAPETLAGLLAARAAHPDAQIVAGTTDVGLWI
TKQHRRFERVLDVTRAEELRRIGTVDGHLSIGAAATLDDAFAALAAHWPALRRFAERFAGLPVRNAGTLGGNVANGSPIG
DSMPVLIALGARIVLASVRGERSLPLEDFYTGYRRNLLAPDEIVARIDVPLPAPGDRLAAYKVSKRFDDDISAVCLAVLL
SVRDGAVQSARIGAGGVAAVPARARGAEAALAGQPWSEAAALRAGEALQAEFTPISDMRASGAYRRAVLASLMRRCWLES
PERPAGTGALPVSLEQLVPVAQAEEQA
>Mature_506_residues
TVASRPIRFLRRGQPVTLAHVPPDRTLLEVLREDLGDCGTKEGCGEGDCGACTVVLGSEEGGRLRLRAVNSCIRLAHAID
GMALWTVEDLAQDPLIRRGAPAPLHPAQEAMVQCHGSQCGFCTPGFVMSLFGMYQNHVCQGRAVTREMAVAELSGNLCRC
TGYRPILDAAGRMAELPAQPVDEGAVLERLRELRAPVAAPQDAAPNYLAPETLAGLLAARAAHPDAQIVAGTTDVGLWIT
KQHRRFERVLDVTRAEELRRIGTVDGHLSIGAAATLDDAFAALAAHWPALRRFAERFAGLPVRNAGTLGGNVANGSPIGD
SMPVLIALGARIVLASVRGERSLPLEDFYTGYRRNLLAPDEIVARIDVPLPAPGDRLAAYKVSKRFDDDISAVCLAVLLS
VRDGAVQSARIGAGGVAAVPARARGAEAALAGQPWSEAAALRAGEALQAEFTPISDMRASGAYRRAVLASLMRRCWLESP
ERPAGTGALPVSLEQLVPVAQAEEQA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=486, Percent_Identity=31.8930041152263, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI71773480, Length=534, Percent_Identity=26.7790262172285, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1789231, Length=279, Percent_Identity=29.3906810035842, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=36.8098159509202, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789232, Length=160, Percent_Identity=34.375, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=184, Percent_Identity=40.2173913043478, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32566215, Length=410, Percent_Identity=26.0975609756098, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17539860, Length=165, Percent_Identity=41.2121212121212, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI17737937, Length=528, Percent_Identity=33.3333333333333, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24647201, Length=507, Percent_Identity=27.6134122287968, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24647199, Length=518, Percent_Identity=29.5366795366795, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24647197, Length=334, Percent_Identity=34.1317365269461, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24647195, Length=334, Percent_Identity=34.1317365269461, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24647193, Length=543, Percent_Identity=28.1767955801105, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 53769; Mature: 53638

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVASRPIRFLRRGQPVTLAHVPPDRTLLEVLREDLGDCGTKEGCGEGDCGACTVVLGSE
CCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
EGGRLRLRAVNSCIRLAHAIDGMALWTVEDLAQDPLIRRGAPAPLHPAQEAMVQCHGSQC
CCCEEHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCCCC
GFCTPGFVMSLFGMYQNHVCQGRAVTREMAVAELSGNLCRCTGYRPILDAAGRMAELPAQ
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCHHHHHCCHHHHCCCC
PVDEGAVLERLRELRAPVAAPQDAAPNYLAPETLAGLLAARAAHPDAQIVAGTTDVGLWI
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEE
TKQHRRFERVLDVTRAEELRRIGTVDGHLSIGAAATLDDAFAALAAHWPALRRFAERFAG
EHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPVRNAGTLGGNVANGSPIGDSMPVLIALGARIVLASVRGERSLPLEDFYTGYRRNLLAP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
DEIVARIDVPLPAPGDRLAAYKVSKRFDDDISAVCLAVLLSVRDGAVQSARIGAGGVAAV
HHHHEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEC
PARARGAEAALAGQPWSEAAALRAGEALQAEFTPISDMRASGAYRRAVLASLMRRCWLES
CCCCCCCCHHCCCCCHHHHHHHHCCCHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCC
PERPAGTGALPVSLEQLVPVAQAEEQA
CCCCCCCCCCCCCHHHHCCHHHHCCCC
>Mature Secondary Structure 
TVASRPIRFLRRGQPVTLAHVPPDRTLLEVLREDLGDCGTKEGCGEGDCGACTVVLGSE
CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECC
EGGRLRLRAVNSCIRLAHAIDGMALWTVEDLAQDPLIRRGAPAPLHPAQEAMVQCHGSQC
CCCEEHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCHHHCCCCCCCCHHHHHHHHHCCCCC
GFCTPGFVMSLFGMYQNHVCQGRAVTREMAVAELSGNLCRCTGYRPILDAAGRMAELPAQ
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEECCCCHHHHHCCHHHHCCCC
PVDEGAVLERLRELRAPVAAPQDAAPNYLAPETLAGLLAARAAHPDAQIVAGTTDVGLWI
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEE
TKQHRRFERVLDVTRAEELRRIGTVDGHLSIGAAATLDDAFAALAAHWPALRRFAERFAG
EHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPVRNAGTLGGNVANGSPIGDSMPVLIALGARIVLASVRGERSLPLEDFYTGYRRNLLAP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
DEIVARIDVPLPAPGDRLAAYKVSKRFDDDISAVCLAVLLSVRDGAVQSARIGAGGVAAV
HHHHEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEC
PARARGAEAALAGQPWSEAAALRAGEALQAEFTPISDMRASGAYRRAVLASLMRRCWLES
CCCCCCCCHHCCCCCHHHHHHHHCCCHHHCCCCCHHHHHHCHHHHHHHHHHHHHHHHCCC
PERPAGTGALPVSLEQLVPVAQAEEQA
CCCCCCCCCCCCCHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]