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The map label for this gene is xdhA [H]

Identifier: 120609819

GI number: 120609819

Start: 1238427

End: 1240898

Strand: Reverse

Name: xdhA [H]

Synonym: Aave_1129

Alternate gene names: 120609819

Gene position: 1240898-1238427 (Counterclockwise)

Preceding gene: 120609820

Following gene: 120609816

Centisome position: 23.18

GC content: 72.29

Gene sequence:

>2472_bases
ATGAACCGGCGCGACGACACCCTGCCCACCAGTACCGCCCCCGAAGGCCCCCTGAGCCGCGACGCGGATGCGGACCCGGT
GGCGGCACGCGCAGACGCGGAAGGCGCGGCCGGCCCGATGGCCGGCGAGGCCCCGCCGCCCGGCCTGGACGGCACGCCGC
ACAGCGCACGCCGCGCCGTGGGCGTTTCCCAGATCCACGAAAGCGCCCGCGCCCAGGTGGCGGGTACGGCGCAGTACATC
GACGACCTGCCCGAATGGAAGGGCACGCTGCACGCGGCGCCCATCCTCTCGCCCGTGGCGCACGGCCGCCTGCGCGGCGT
GGATGCCGCGGCGGCCCGCGCCCTGGCCGGCGTGCGCGACATCGTGCTGGCGGCCGACGTGCCGGGCGATCCGGTGCTCG
CCGCCTTCGCGCACGACGAGCCGGTGTTCGCGCGGGACACGGTGCAGTTCGCGGGCCAGGTGGTCGGCCTCGTGCTGGCC
GACACCGTGGCGCAGGCGCGCCGCGCCGCGCGGCTGGTCCAGCTGGACATCGAGGAACTGCCGCCCGTGCTCTCGGTGCA
CGAGGCGCTGGCGCAGGAGAGCTACGTGCTGCCGCCCGTCACCGTGCGCCGCGGCGATGCGGCCGCGGCCCTGGCCGCGG
CGCCGCACCGCCTGCAGGGCACGCTCGAAGTGGGCGGCCAGGAGCATTTCTACCTGGAAGGCCAGATCGCCTACGTCCTG
CCGCAGGAGCAGGGCCAGTGGCAGGTGCATTCGAGCACCCAGCACCCGGGCGAGGTGCAGCACTGGGTGGCGCATGCGCT
GGGCATCGACAGCCACCGCGTCACCGTGTCCTGCCGCCGCATGGGCGGGGGCTTCGGCGGCAAGGAGACGCAGGCCGGCC
ACATGGCCGTGTGGGCCGCGGTGGCCGCGCACAAGACGGGTCGCCCCGTGAAGCTGCGGCTGGACCGCGACGACGACTTC
ATGGTCACTGGCAAGCGCCATCCCTTCGCCTACGACTGGGACGTGGGCTTCGACGGCACCGGCCGCATCCGGGGCCTGCG
GCTGCGCATGGCGGTGAACTGCGGCTTCTCGGCCGACCTCTCCGGCCCGGTGGCCGACCGCGCGGTCTTCCATTGCGACA
ACGCGTACTTCCTCGAGAACGTGGAGATCGCCTCCTACCGCTGCAGGACCCATCTCCAGAGCCACACGGCCTTCCGCGGC
TTCGGCGGGCCGCAGGGCGTGATCGCGATCGAGACCATCCTCGGCGACGTGGCGCGTGCGCTCGGGCTCGATCCACTCGA
CGTGCGCATGGCCAACCTCTACGGACTGGAGGACCGCAACGTCACGCACTACCAGATGGCCGTGGAAGACAACGTGCTGC
ACGACCTGCTGCCCCGGCTGGAGCAGTCCTCCCGGTACCGCCAGCGGCGCGAGGCCGTGAATGCCTGGAACGCCCGCCAC
CCGACGCTCAAGCGCGGCCTCGCCGTCACCCCGGTGAAGTTCGGCATCAGCTTCACGGCCACGCTCTTCAACCAGGCCGG
CGCGCTGGTGCACGTCTATACCGACGGCAGCGTGCAGGTGAACCACGGCGGCACCGAGATGGGCCAGGGCCTGCACACCA
AGGTGGCGCAGATCGTGGCCGACGAACTGGGCGTGCCTCTGGCGCACGTGCTGGTCACGGCCAGCGACACCAGCAAGGTA
CCCAATGCCAGCGCCACCGCGGCATCCAGCGGCACCGACCTCAACGGCCGGGCCGCGCAGTTCGCCGCGCGCCACGTGCG
CGACAACCTCGCGGCCTTCGTCGCGGGCCTGGACCACTGCGGCGCGGGCGCGGTGCATTTCGAGAACGGCCGGATCACTT
CGCCGAAACGCTCGCATGCGTGGCGCGACGTGGTGCAGGCCGCGTATGCCAACCGCATCCAGCTCTGGAGCGACGGCTTC
TACCGCACGCCCAAGATCCACTACGACAAGACGACGCTCACCGGGCGCCCGTTCTACTACTTCGCCTACGGCGCGGCCTG
CACCGAGGTGGCGATCGACACGCTCACCGGCGAAAGCCGCGTGCTCGCCGTGGATATCCTCCACGACGCGGGCCGCAGCA
TCAACCCCGCCATCGACGTCGGCCAGATCGAGGGCGGCTTCGTGCAGGGCATGGGCTGGCTGACCACCGAGCAACTCGTC
TGGGACGACCGGGGCCGGCTCGCGACGCACGCGCCCAGCACCTACAAGATCCCCGCCACGGGCGACATCCCGGCCCACTT
CCGGGTGGACCTGTGGCACGAGGCCAACCGCGAGGACAACGTGGGCGGCAGCAAGGCCGTGGGCGAACCGCCCTTCATGC
TGGCCGTGAGCGTCTATGAAGCGCTGCGGGATGCCGTGGCCGCGGCACGTGCGGATGCACCGGAGGGCGCTTCGGCGGAC
GGGCCGGTGCGCCTGGTGGCGCCGGCCACCGCCGAGAACGTGCTGCGCGCGCTGGGTGGCGTGGCGGACTGA

Upstream 100 bases:

>100_bases
GGCGCTGCTGGCTGGAGAGCCCGGAACGCCCCGCAGGAACCGGCGCCCTGCCCGTATCGCTCGAACAACTCGTGCCGGTG
GCGCAGGCGGAGGAACAGGC

Downstream 100 bases:

>100_bases
CCGCGGCGCAATCCCTCAGGGAGCCGCCGGGCCGGCGCGCCGCGCGGAACGCAGCTGCCACGCCCGGGCCTCCGCCTCCC
GGCCGTGGATCTGCAGATAC

Product: molybdopterin-binding aldehyde oxidase and xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 823; Mature: 823

Protein sequence:

>823_residues
MNRRDDTLPTSTAPEGPLSRDADADPVAARADAEGAAGPMAGEAPPPGLDGTPHSARRAVGVSQIHESARAQVAGTAQYI
DDLPEWKGTLHAAPILSPVAHGRLRGVDAAAARALAGVRDIVLAADVPGDPVLAAFAHDEPVFARDTVQFAGQVVGLVLA
DTVAQARRAARLVQLDIEELPPVLSVHEALAQESYVLPPVTVRRGDAAAALAAAPHRLQGTLEVGGQEHFYLEGQIAYVL
PQEQGQWQVHSSTQHPGEVQHWVAHALGIDSHRVTVSCRRMGGGFGGKETQAGHMAVWAAVAAHKTGRPVKLRLDRDDDF
MVTGKRHPFAYDWDVGFDGTGRIRGLRLRMAVNCGFSADLSGPVADRAVFHCDNAYFLENVEIASYRCRTHLQSHTAFRG
FGGPQGVIAIETILGDVARALGLDPLDVRMANLYGLEDRNVTHYQMAVEDNVLHDLLPRLEQSSRYRQRREAVNAWNARH
PTLKRGLAVTPVKFGISFTATLFNQAGALVHVYTDGSVQVNHGGTEMGQGLHTKVAQIVADELGVPLAHVLVTASDTSKV
PNASATAASSGTDLNGRAAQFAARHVRDNLAAFVAGLDHCGAGAVHFENGRITSPKRSHAWRDVVQAAYANRIQLWSDGF
YRTPKIHYDKTTLTGRPFYYFAYGAACTEVAIDTLTGESRVLAVDILHDAGRSINPAIDVGQIEGGFVQGMGWLTTEQLV
WDDRGRLATHAPSTYKIPATGDIPAHFRVDLWHEANREDNVGGSKAVGEPPFMLAVSVYEALRDAVAAARADAPEGASAD
GPVRLVAPATAENVLRALGGVAD

Sequences:

>Translated_823_residues
MNRRDDTLPTSTAPEGPLSRDADADPVAARADAEGAAGPMAGEAPPPGLDGTPHSARRAVGVSQIHESARAQVAGTAQYI
DDLPEWKGTLHAAPILSPVAHGRLRGVDAAAARALAGVRDIVLAADVPGDPVLAAFAHDEPVFARDTVQFAGQVVGLVLA
DTVAQARRAARLVQLDIEELPPVLSVHEALAQESYVLPPVTVRRGDAAAALAAAPHRLQGTLEVGGQEHFYLEGQIAYVL
PQEQGQWQVHSSTQHPGEVQHWVAHALGIDSHRVTVSCRRMGGGFGGKETQAGHMAVWAAVAAHKTGRPVKLRLDRDDDF
MVTGKRHPFAYDWDVGFDGTGRIRGLRLRMAVNCGFSADLSGPVADRAVFHCDNAYFLENVEIASYRCRTHLQSHTAFRG
FGGPQGVIAIETILGDVARALGLDPLDVRMANLYGLEDRNVTHYQMAVEDNVLHDLLPRLEQSSRYRQRREAVNAWNARH
PTLKRGLAVTPVKFGISFTATLFNQAGALVHVYTDGSVQVNHGGTEMGQGLHTKVAQIVADELGVPLAHVLVTASDTSKV
PNASATAASSGTDLNGRAAQFAARHVRDNLAAFVAGLDHCGAGAVHFENGRITSPKRSHAWRDVVQAAYANRIQLWSDGF
YRTPKIHYDKTTLTGRPFYYFAYGAACTEVAIDTLTGESRVLAVDILHDAGRSINPAIDVGQIEGGFVQGMGWLTTEQLV
WDDRGRLATHAPSTYKIPATGDIPAHFRVDLWHEANREDNVGGSKAVGEPPFMLAVSVYEALRDAVAAARADAPEGASAD
GPVRLVAPATAENVLRALGGVAD
>Mature_823_residues
MNRRDDTLPTSTAPEGPLSRDADADPVAARADAEGAAGPMAGEAPPPGLDGTPHSARRAVGVSQIHESARAQVAGTAQYI
DDLPEWKGTLHAAPILSPVAHGRLRGVDAAAARALAGVRDIVLAADVPGDPVLAAFAHDEPVFARDTVQFAGQVVGLVLA
DTVAQARRAARLVQLDIEELPPVLSVHEALAQESYVLPPVTVRRGDAAAALAAAPHRLQGTLEVGGQEHFYLEGQIAYVL
PQEQGQWQVHSSTQHPGEVQHWVAHALGIDSHRVTVSCRRMGGGFGGKETQAGHMAVWAAVAAHKTGRPVKLRLDRDDDF
MVTGKRHPFAYDWDVGFDGTGRIRGLRLRMAVNCGFSADLSGPVADRAVFHCDNAYFLENVEIASYRCRTHLQSHTAFRG
FGGPQGVIAIETILGDVARALGLDPLDVRMANLYGLEDRNVTHYQMAVEDNVLHDLLPRLEQSSRYRQRREAVNAWNARH
PTLKRGLAVTPVKFGISFTATLFNQAGALVHVYTDGSVQVNHGGTEMGQGLHTKVAQIVADELGVPLAHVLVTASDTSKV
PNASATAASSGTDLNGRAAQFAARHVRDNLAAFVAGLDHCGAGAVHFENGRITSPKRSHAWRDVVQAAYANRIQLWSDGF
YRTPKIHYDKTTLTGRPFYYFAYGAACTEVAIDTLTGESRVLAVDILHDAGRSINPAIDVGQIEGGFVQGMGWLTTEQLV
WDDRGRLATHAPSTYKIPATGDIPAHFRVDLWHEANREDNVGGSKAVGEPPFMLAVSVYEALRDAVAAARADAPEGASAD
GPVRLVAPATAENVLRALGGVAD

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=765, Percent_Identity=41.3071895424837, Blast_Score=613, Evalue=1e-175,
Organism=Homo sapiens, GI71773480, Length=757, Percent_Identity=36.8560105680317, Blast_Score=482, Evalue=1e-136,
Organism=Escherichia coli, GI1789230, Length=748, Percent_Identity=28.3422459893048, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789246, Length=755, Percent_Identity=26.3576158940397, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1786478, Length=658, Percent_Identity=26.1398176291793, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17540638, Length=762, Percent_Identity=38.8451443569554, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17539860, Length=777, Percent_Identity=29.2149292149292, Blast_Score=323, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI32566215, Length=745, Percent_Identity=29.1275167785235, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI17737937, Length=798, Percent_Identity=40.2255639097744, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24647193, Length=766, Percent_Identity=31.9843342036554, Blast_Score=339, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24647199, Length=760, Percent_Identity=32.6315789473684, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24647201, Length=765, Percent_Identity=30.9803921568627, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24647195, Length=762, Percent_Identity=30.8398950131234, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24647197, Length=762, Percent_Identity=30.8398950131234, Blast_Score=281, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 87941; Mature: 87941

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRDDTLPTSTAPEGPLSRDADADPVAARADAEGAAGPMAGEAPPPGLDGTPHSARRAV
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
GVSQIHESARAQVAGTAQYIDDLPEWKGTLHAAPILSPVAHGRLRGVDAAAARALAGVRD
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEHHHHHHHHHHCHHCCCHHHHHHHHHHHHH
IVLAADVPGDPVLAAFAHDEPVFARDTVQFAGQVVGLVLADTVAQARRAARLVQLDIEEL
EEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHC
PPVLSVHEALAQESYVLPPVTVRRGDAAAALAAAPHRLQGTLEVGGQEHFYLEGQIAYVL
CCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHCCCHHHCEEEEECCCEEEEECCEEEEEE
PQEQGQWQVHSSTQHPGEVQHWVAHALGIDSHRVTVSCRRMGGGFGGKETQAGHMAVWAA
ECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHH
VAAHKTGRPVKLRLDRDDDFMVTGKRHPFAYDWDVGFDGTGRIRGLRLRMAVNCGFSADL
HHHHCCCCCEEEEECCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCCC
SGPVADRAVFHCDNAYFLENVEIASYRCRTHLQSHTAFRGFGGPQGVIAIETILGDVARA
CCCCCCCEEEEECCEEEEECCEEHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHH
LGLDPLDVRMANLYGLEDRNVTHYQMAVEDNVLHDLLPRLEQSSRYRQRREAVNAWNARH
HCCCHHHEEEHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTLKRGLAVTPVKFGISFTATLFNQAGALVHVYTDGSVQVNHGGTEMGQGLHTKVAQIVA
CHHHCCCEECEEEECCCHHHHHHHCCCCEEEEEECCEEEECCCCHHHCCCHHHHHHHHHH
DELGVPLAHVLVTASDTSKVPNASATAASSGTDLNGRAAQFAARHVRDNLAAFVAGLDHC
HHHCCCEEHEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GAGAVHFENGRITSPKRSHAWRDVVQAAYANRIQLWSDGFYRTPKIHYDKTTLTGRPFYY
CCCCEEECCCEECCCHHHHHHHHHHHHHHHCCEEEECCCCEECCEEEECCEEECCCCEEE
FAYGAACTEVAIDTLTGESRVLAVDILHDAGRSINPAIDVGQIEGGFVQGMGWLTTEQLV
EEECHHHHHHHHHHCCCCCEEEEEEEEHHCCCCCCCCEECCCCCCCEEECCCCEEEHHEE
WDDRGRLATHAPSTYKIPATGDIPAHFRVDLWHEANREDNVGGSKAVGEPPFMLAVSVYE
ECCCCCEEECCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
ALRDAVAAARADAPEGASADGPVRLVAPATAENVLRALGGVAD
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCC
>Mature Secondary Structure
MNRRDDTLPTSTAPEGPLSRDADADPVAARADAEGAAGPMAGEAPPPGLDGTPHSARRAV
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
GVSQIHESARAQVAGTAQYIDDLPEWKGTLHAAPILSPVAHGRLRGVDAAAARALAGVRD
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEHHHHHHHHHHCHHCCCHHHHHHHHHHHHH
IVLAADVPGDPVLAAFAHDEPVFARDTVQFAGQVVGLVLADTVAQARRAARLVQLDIEEL
EEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHC
PPVLSVHEALAQESYVLPPVTVRRGDAAAALAAAPHRLQGTLEVGGQEHFYLEGQIAYVL
CCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHCCCHHHCEEEEECCCEEEEECCEEEEEE
PQEQGQWQVHSSTQHPGEVQHWVAHALGIDSHRVTVSCRRMGGGFGGKETQAGHMAVWAA
ECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHH
VAAHKTGRPVKLRLDRDDDFMVTGKRHPFAYDWDVGFDGTGRIRGLRLRMAVNCGFSADL
HHHHCCCCCEEEEECCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEEECCCCCCC
SGPVADRAVFHCDNAYFLENVEIASYRCRTHLQSHTAFRGFGGPQGVIAIETILGDVARA
CCCCCCCEEEEECCEEEEECCEEHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHH
LGLDPLDVRMANLYGLEDRNVTHYQMAVEDNVLHDLLPRLEQSSRYRQRREAVNAWNARH
HCCCHHHEEEHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTLKRGLAVTPVKFGISFTATLFNQAGALVHVYTDGSVQVNHGGTEMGQGLHTKVAQIVA
CHHHCCCEECEEEECCCHHHHHHHCCCCEEEEEECCEEEECCCCHHHCCCHHHHHHHHHH
DELGVPLAHVLVTASDTSKVPNASATAASSGTDLNGRAAQFAARHVRDNLAAFVAGLDHC
HHHCCCEEHEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GAGAVHFENGRITSPKRSHAWRDVVQAAYANRIQLWSDGFYRTPKIHYDKTTLTGRPFYY
CCCCEEECCCEECCCHHHHHHHHHHHHHHHCCEEEECCCCEECCEEEECCEEECCCCEEE
FAYGAACTEVAIDTLTGESRVLAVDILHDAGRSINPAIDVGQIEGGFVQGMGWLTTEQLV
EEECHHHHHHHHHHCCCCCEEEEEEEEHHCCCCCCCCEECCCCCCCEEECCCCEEEHHEE
WDDRGRLATHAPSTYKIPATGDIPAHFRVDLWHEANREDNVGGSKAVGEPPFMLAVSVYE
ECCCCCEEECCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
ALRDAVAAARADAPEGASADGPVRLVAPATAENVLRALGGVAD
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]