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The map label for this gene is degS [H]

Identifier: 120609813

GI number: 120609813

Start: 1229360

End: 1230763

Strand: Reverse

Name: degS [H]

Synonym: Aave_1122

Alternate gene names: 120609813

Gene position: 1230763-1229360 (Counterclockwise)

Preceding gene: 120609816

Following gene: 120609812

Centisome position: 22.99

GC content: 72.08

Gene sequence:

>1404_bases
ATGCAACTGCGGCTGAAACTCCTGCTGCTTTCCACCCTGCCCATCCTGGTGGCCCTCGGCTGCGTGGCCGCGACGGCCCG
GCACCAGACCCTGAAGCTGGCGCAGCAGGAGCGCGAACTGGTGGAGACGGCCTACCTGCACAGCAAGGAAACCGAACTGC
GCCACTACGTGCAACTGGCCCAGAGCGCGCTCGCACGCGTCGCCGCCGAAGAGGCCGACCCCGTGCAGCGCCAGCGGCAG
GCCCTGGCCCTGCTCTCGCGCATGCAGTTCGGCAAGGACGGCTATTTCTTCGTCTATGACCGCGAGGGCAACGTGCTGCT
GGACGCCCGGCAGATGGGCCTGTCGGGCGTGGACCTGTGCGATCCGGGCGATCCGCGCAGCGAAGCGCCCGCGAACCGCA
TCCTGGCCACGGCGCGCCAGGGCGGCGGGATGGTGCGCTACGACTGGCAGAAGCCCTCCTCGCAGCTCATGGCGCCCAAG
CTGGCCTACGTGACCACCCTGCCCGGCTGGGAGTGGATCCTGGGCACGGGGCTGTACCTGGACGACGTGCAGCAAACGCT
GCGCCACATCGACCGGGCCGCGCAGGAGAACATCGACGGCACGCGGCAGCGCATCTATGGCATCGCGGCCCTGTGCATCG
TGCTGATCGGCCTGGCGGGGCTGGCGCTCAACCTGAGCGACCACCGCGTGGCCAGCGCCAAGCTGCGCCGGCTCGCGCAG
CGGGTGGTGAGCTCGCAGGAGGAAGAGCGGGTGCGGGTGGCGCGCGAGCTGCACGACGGGGTGGTGCAGGTGCTGGTGTC
CTCGAAATTCCTGCTGGAGACGGCGCAGGTGCAGTGGGCCGCGCGCGCAGCCCACGCGCCGCGCGACATGCTCGACCATG
GGCTGGAGCGGCTCAACGATGCCCTGCTGGAGATCCGGCGCGTGTCCCACGGGCTGCGCCCCGCGCTGCTCGACGACCTC
GGGCTCGCGCCCGCGCTCGCGCTGATGGCGCAGGAGGTGGAGGAGCAGGGAGCGTTCAGCGTGCGGTTCGTGCTGCGCGG
GCCGGCCGGGCCCCTGCCCACCAGCCACGGCACGGCGCTGTTCCGCATTGCCCAGGAGGCGATCACCAATGCCCGCATGC
ATGCGGGAGCCAGCCAGGTGGAGGTGGCGCTGCGCTTCACGCGCTGGCGGGTGAGCCTGTCGGTGCGCGACGACGGGCGC
GGCTTCGACGTGCAGCGCGTGCAGCGCGACGGCCAGGGCGGCATCGGCCTGCGCAACATGCGCGAGCGCATCGAAGGACT
GGGCGGCCGCTTCGCCATCGCATCGGGCCGCGGCGGCACGCGCATCCTGGCGGTGCTCGACCGCCGGGACGCGCCCGCCG
CCGGGCTGTCCGCCGGCATCGAACCCTCGCAGGTGCCCGCATGA

Upstream 100 bases:

>100_bases
GTTGTCACGCCCGCATGGAATACCGGCACTGACCCCCATACCGCTTTGCCGGACTTTCCGGTATCAGGCGGATAGTTATC
CCCCACTCGCGAGACAGACC

Downstream 100 bases:

>100_bases
ACGCCGACCCCGGCCAGACCCCGATCCGCGTCCTGCTGGTGGACGACCATCCGCTGGTGCGCGACGGCGTGCGCATGCGC
CTGGACGCCACGCCCCACAT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MQLRLKLLLLSTLPILVALGCVAATARHQTLKLAQQERELVETAYLHSKETELRHYVQLAQSALARVAAEEADPVQRQRQ
ALALLSRMQFGKDGYFFVYDREGNVLLDARQMGLSGVDLCDPGDPRSEAPANRILATARQGGGMVRYDWQKPSSQLMAPK
LAYVTTLPGWEWILGTGLYLDDVQQTLRHIDRAAQENIDGTRQRIYGIAALCIVLIGLAGLALNLSDHRVASAKLRRLAQ
RVVSSQEEERVRVARELHDGVVQVLVSSKFLLETAQVQWAARAAHAPRDMLDHGLERLNDALLEIRRVSHGLRPALLDDL
GLAPALALMAQEVEEQGAFSVRFVLRGPAGPLPTSHGTALFRIAQEAITNARMHAGASQVEVALRFTRWRVSLSVRDDGR
GFDVQRVQRDGQGGIGLRNMRERIEGLGGRFAIASGRGGTRILAVLDRRDAPAAGLSAGIEPSQVPA

Sequences:

>Translated_467_residues
MQLRLKLLLLSTLPILVALGCVAATARHQTLKLAQQERELVETAYLHSKETELRHYVQLAQSALARVAAEEADPVQRQRQ
ALALLSRMQFGKDGYFFVYDREGNVLLDARQMGLSGVDLCDPGDPRSEAPANRILATARQGGGMVRYDWQKPSSQLMAPK
LAYVTTLPGWEWILGTGLYLDDVQQTLRHIDRAAQENIDGTRQRIYGIAALCIVLIGLAGLALNLSDHRVASAKLRRLAQ
RVVSSQEEERVRVARELHDGVVQVLVSSKFLLETAQVQWAARAAHAPRDMLDHGLERLNDALLEIRRVSHGLRPALLDDL
GLAPALALMAQEVEEQGAFSVRFVLRGPAGPLPTSHGTALFRIAQEAITNARMHAGASQVEVALRFTRWRVSLSVRDDGR
GFDVQRVQRDGQGGIGLRNMRERIEGLGGRFAIASGRGGTRILAVLDRRDAPAAGLSAGIEPSQVPA
>Mature_467_residues
MQLRLKLLLLSTLPILVALGCVAATARHQTLKLAQQERELVETAYLHSKETELRHYVQLAQSALARVAAEEADPVQRQRQ
ALALLSRMQFGKDGYFFVYDREGNVLLDARQMGLSGVDLCDPGDPRSEAPANRILATARQGGGMVRYDWQKPSSQLMAPK
LAYVTTLPGWEWILGTGLYLDDVQQTLRHIDRAAQENIDGTRQRIYGIAALCIVLIGLAGLALNLSDHRVASAKLRRLAQ
RVVSSQEEERVRVARELHDGVVQVLVSSKFLLETAQVQWAARAAHAPRDMLDHGLERLNDALLEIRRVSHGLRPALLDDL
GLAPALALMAQEVEEQGAFSVRFVLRGPAGPLPTSHGTALFRIAQEAITNARMHAGASQVEVALRFTRWRVSLSVRDDGR
GFDVQRVQRDGQGGIGLRNMRERIEGLGGRFAIASGRGGTRILAVLDRRDAPAAGLSAGIEPSQVPA

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=200, Percent_Identity=30, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788812, Length=199, Percent_Identity=30.1507537688442, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082311, Length=229, Percent_Identity=30.5676855895196, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51234; Mature: 51234

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLKLLLLSTLPILVALGCVAATARHQTLKLAQQERELVETAYLHSKETELRHYVQLA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QSALARVAAEEADPVQRQRQALALLSRMQFGKDGYFFVYDREGNVLLDARQMGLSGVDLC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCCCCCC
DPGDPRSEAPANRILATARQGGGMVRYDWQKPSSQLMAPKLAYVTTLPGWEWILGTGLYL
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHCCCHHHEEEECCCCHHHHHCCCHH
DDVQQTLRHIDRAAQENIDGTRQRIYGIAALCIVLIGLAGLALNLSDHRVASAKLRRLAQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
RVVSSQEEERVRVARELHDGVVQVLVSSKFLLETAQVQWAARAAHAPRDMLDHGLERLND
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ALLEIRRVSHGLRPALLDDLGLAPALALMAQEVEEQGAFSVRFVLRGPAGPLPTSHGTAL
HHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHH
FRIAQEAITNARMHAGASQVEVALRFTRWRVSLSVRDDGRGFDVQRVQRDGQGGIGLRNM
HHHHHHHHHHHHHHCCHHHHHHHHEEEEEEEEEEEECCCCCCCHHHHHHCCCCCCCHHHH
RERIEGLGGRFAIASGRGGTRILAVLDRRDAPAAGLSAGIEPSQVPA
HHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQLRLKLLLLSTLPILVALGCVAATARHQTLKLAQQERELVETAYLHSKETELRHYVQLA
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
QSALARVAAEEADPVQRQRQALALLSRMQFGKDGYFFVYDREGNVLLDARQMGLSGVDLC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCCCCCC
DPGDPRSEAPANRILATARQGGGMVRYDWQKPSSQLMAPKLAYVTTLPGWEWILGTGLYL
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHCCCHHHEEEECCCCHHHHHCCCHH
DDVQQTLRHIDRAAQENIDGTRQRIYGIAALCIVLIGLAGLALNLSDHRVASAKLRRLAQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHH
RVVSSQEEERVRVARELHDGVVQVLVSSKFLLETAQVQWAARAAHAPRDMLDHGLERLND
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ALLEIRRVSHGLRPALLDDLGLAPALALMAQEVEEQGAFSVRFVLRGPAGPLPTSHGTAL
HHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHH
FRIAQEAITNARMHAGASQVEVALRFTRWRVSLSVRDDGRGFDVQRVQRDGQGGIGLRNM
HHHHHHHHHHHHHHCCHHHHHHHHEEEEEEEEEEEECCCCCCCHHHHHHCCCCCCCHHHH
RERIEGLGGRFAIASGRGGTRILAVLDRRDAPAAGLSAGIEPSQVPA
HHHHHCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]