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The map label for this gene is yedX [C]

Identifier: 120609807

GI number: 120609807

Start: 1223308

End: 1223658

Strand: Direct

Name: yedX [C]

Synonym: Aave_1116

Alternate gene names: 120609807

Gene position: 1223308-1223658 (Clockwise)

Preceding gene: 120609804

Following gene: 120609809

Centisome position: 22.85

GC content: 67.81

Gene sequence:

>351_bases
ATGGGCCTCAGTACGCACGTTCTCGACACCATGCATGGCTGCCCGGCCGCGGGCATGGCGGTTTCGCTCTACGACACCGC
AGGCGGCCAGGCCCGGCTGCTCAAGGAACTGGTGCTCAACCAGGACGGTCGCACCGATGCGCCGCTCTTCGACAACGCCA
GCCTGCGTCCCGGCACCTACCGGCTGTCGTTCGAGGTGGGCGATTACTTTCGCGCGCGCGGCGTGGTGCTGCCCGAGCCG
AACTTCCTCGACCGCGTGAGCCTGGACTTCGGCGTCGCCCATGCCGACCAGCACTACCACGTGCCGCTGCTGGTCAGCCC
CTGGAGCTACTCGACCTACCGTGGCTCCTGA

Upstream 100 bases:

>100_bases
GGCTGCGCGGCGGTGAGTCAACCCGTTCAGTGGCCAAGGCCGGCCGGCCTGCCTTGACGACTGAAGTTTGAACCAACTGA
GACATATAAGGAGACGCCCC

Downstream 100 bases:

>100_bases
ACTGCCGAGCCCGGAGGCGTCAGAGCTGGCCCTCGGTCAGCGTGTCGAGCTGGAACCGGCCCGACTTGTGCCAGAGCCAG
GTGTCGGTATAGGTCACGCG

Product: transthyretin

Products: NA

Alternate protein names: HIU hydrolase; HIUHase [H]

Number of amino acids: Translated: 116; Mature: 115

Protein sequence:

>116_residues
MGLSTHVLDTMHGCPAAGMAVSLYDTAGGQARLLKELVLNQDGRTDAPLFDNASLRPGTYRLSFEVGDYFRARGVVLPEP
NFLDRVSLDFGVAHADQHYHVPLLVSPWSYSTYRGS

Sequences:

>Translated_116_residues
MGLSTHVLDTMHGCPAAGMAVSLYDTAGGQARLLKELVLNQDGRTDAPLFDNASLRPGTYRLSFEVGDYFRARGVVLPEP
NFLDRVSLDFGVAHADQHYHVPLLVSPWSYSTYRGS
>Mature_115_residues
GLSTHVLDTMHGCPAAGMAVSLYDTAGGQARLLKELVLNQDGRTDAPLFDNASLRPGTYRLSFEVGDYFRARGVVLPEPN
FLDRVSLDFGVAHADQHYHVPLLVSPWSYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=114, Percent_Identity=36.8421052631579, Blast_Score=80, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI115532920, Length=116, Percent_Identity=39.6551724137931, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115532922, Length=116, Percent_Identity=39.6551724137931, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115534555, Length=116, Percent_Identity=38.7931034482759, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 12726; Mature: 12595

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00768 TRANSTHYRETIN_1 ; PS00769 TRANSTHYRETIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLSTHVLDTMHGCPAAGMAVSLYDTAGGQARLLKELVLNQDGRTDAPLFDNASLRPGTY
CCCCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
RLSFEVGDYFRARGVVLPEPNFLDRVSLDFGVAHADQHYHVPLLVSPWSYSTYRGS
EEEEECCCCHHHCCEECCCCCCCCEEECCCCEEECCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GLSTHVLDTMHGCPAAGMAVSLYDTAGGQARLLKELVLNQDGRTDAPLFDNASLRPGTY
CCCCCHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
RLSFEVGDYFRARGVVLPEPNFLDRVSLDFGVAHADQHYHVPLLVSPWSYSTYRGS
EEEEECCCCHHHCCEECCCCCCCCEEECCCCEEECCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]