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The map label for this gene is hisE

Identifier: 120609742

GI number: 120609742

Start: 1153423

End: 1153836

Strand: Direct

Name: hisE

Synonym: Aave_1049

Alternate gene names: 120609742

Gene position: 1153423-1153836 (Clockwise)

Preceding gene: 120609741

Following gene: 120609743

Centisome position: 21.55

GC content: 70.29

Gene sequence:

>414_bases
ATGACCCACGATTCCCTTTCGCCCGTGGCCGCCCCGGCCGTGCATTCCGGCGACGCGCTCGCCCGGCTCGCCGCCGTGAT
CGAGAGCCGCAAGCCCGCCAACGGCGGCGACGCCGACAAGAGCTACGTCGCGCGCCTGCTGCACAAGGGCCCGGACGCCT
TCCTCAAGAAGATCGGCGAAGAGGCCACCGAGGTGGTCATGGCCGCCAAGGACGTGGACCATGGCGCGGACGCCTCCAAG
CTCGTTTACGAGGTGGCCGACCTCTGGTTCCACTCCATGATCGCCCTGGCGCACTACGGCCTGGCGCCCGCCGACGTGGT
GGCCGAGCTGGAGCGCCGCGAAGGCACCAGCGGCATCGAGGAAAAGGCGCTGCGCAAGTCGCTGCAGCGCGCCGCCGAGG
AAGCCCAACCCTGA

Upstream 100 bases:

>100_bases
CCGGCCGGCACAGCTGCTTCTTCAGCGTGCTGAAGGACGGCGCCTGGCAGGCCGTCGATCCGGTCTTGAAAGACCCCGAA
TCCATCTACAAGTGACAGCG

Downstream 100 bases:

>100_bases
GGACCATCCCCATGAGCCGCAACGACATCACCGACATCGAGACCGACCAGCGTGCCGATTCCCTGAAGACCGTCGGCTGG
GTGAGCTACATCCTGCACCT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 137; Mature: 136

Protein sequence:

>137_residues
MTHDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEATEVVMAAKDVDHGADASK
LVYEVADLWFHSMIALAHYGLAPADVVAELERREGTSGIEEKALRKSLQRAAEEAQP

Sequences:

>Translated_137_residues
MTHDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEATEVVMAAKDVDHGADASK
LVYEVADLWFHSMIALAHYGLAPADVVAELERREGTSGIEEKALRKSLQRAAEEAQP
>Mature_136_residues
THDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEATEVVMAAKDVDHGADASKL
VYEVADLWFHSMIALAHYGLAPADVVAELERREGTSGIEEKALRKSLQRAAEEAQP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_ACIAC (A1TL08)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969420.1
- ProteinModelPortal:   A1TL08
- SMR:   A1TL08
- STRING:   A1TL08
- GeneID:   4669567
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1049
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   AAVE397945:AAVE_1049-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 14568; Mature: 14436

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGE
CCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
EATEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERREGTSGIE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHH
EKALRKSLQRAAEEAQP
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
THDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGE
CCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
EATEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERREGTSGIE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHH
EKALRKSLQRAAEEAQP
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA