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The map label for this gene is hisI

Identifier: 120609741

GI number: 120609741

Start: 1152992

End: 1153417

Strand: Direct

Name: hisI

Synonym: Aave_1048

Alternate gene names: 120609741

Gene position: 1152992-1153417 (Clockwise)

Preceding gene: 120609740

Following gene: 120609742

Centisome position: 21.54

GC content: 63.85

Gene sequence:

>426_bases
ATGCTGCAGTGCAACAAAAAAGCGGAGAATGGGGCGATGAGCTGGCTCGATGAAGTGAAATGGGATGCGCAGGGCCTCGT
GCCCGTGATCGCGCAGGAAGCGGCCACGGGCGACGTGCTCATGTTCGCCTGGATGAACCGCGAGGCGCTGGCCAAAACGG
CAGAACTCGGTCGCGCGGTGTATTTCAGCCGCTCGCGCGGCAGGCTGTGGTTCAAGGGCGAGGAGTCCGGCCACGTGCAG
ACCGTGCACGAGATCCGGCTCGATTGCGACAACGACGTGGTGCTGCTCAAGGTGACCCAGCTGGGCCACGAGCCCGGCAT
CGCCTGCCACACCGGCCGGCACAGCTGCTTCTTCAGCGTGCTGAAGGACGGCGCCTGGCAGGCCGTCGATCCGGTCTTGA
AAGACCCCGAATCCATCTACAAGTGA

Upstream 100 bases:

>100_bases
ACTATGGCGAATACACGGTGGCGCAGGCCAAGGAACGCATGGCCGCACGGGGCATTCCCGTGCGCCTCTAGGGGCATTCC
CCCGGAGGACATCGTGGTTC

Downstream 100 bases:

>100_bases
CAGCGATGACCCACGATTCCCTTTCGCCCGTGGCCGCCCCGGCCGTGCATTCCGGCGACGCGCTCGCCCGGCTCGCCGCC
GTGATCGAGAGCCGCAAGCC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MLQCNKKAENGAMSWLDEVKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGEESGHVQ
TVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSVLKDGAWQAVDPVLKDPESIYK

Sequences:

>Translated_141_residues
MLQCNKKAENGAMSWLDEVKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGEESGHVQ
TVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSVLKDGAWQAVDPVLKDPESIYK
>Mature_141_residues
MLQCNKKAENGAMSWLDEVKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGEESGHVQ
TVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSVLKDGAWQAVDPVLKDPESIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=101, Percent_Identity=48.5148514851485, Blast_Score=98, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=78, Percent_Identity=41.025641025641, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_ACIAC (A1TL07)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969419.1
- STRING:   A1TL07
- GeneID:   4669545
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1048
- NMPDR:   fig|397945.5.peg.911
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   AAVE397945:AAVE_1048-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15772; Mature: 15772

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQCNKKAENGAMSWLDEVKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAV
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHEE
YFSRSRGRLWFKGEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSV
EEECCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEEECCCCCCCCEEECCCHHHHHHH
LKDGAWQAVDPVLKDPESIYK
HHCCCCHHHCHHHCCHHHHCC
>Mature Secondary Structure
MLQCNKKAENGAMSWLDEVKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAV
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHEE
YFSRSRGRLWFKGEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSV
EEECCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEEECCCCCCCCEEECCCHHHHHHH
LKDGAWQAVDPVLKDPESIYK
HHCCCCHHHCHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA