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The map label for this gene is hisD [H]

Identifier: 120609718

GI number: 120609718

Start: 1123524

End: 1124843

Strand: Direct

Name: hisD [H]

Synonym: Aave_1024

Alternate gene names: 120609718

Gene position: 1123524-1124843 (Clockwise)

Preceding gene: 120609717

Following gene: 120609719

Centisome position: 20.99

GC content: 69.55

Gene sequence:

>1320_bases
ATGAAATTAATAGCTGCTCCTGCCCGTCTCTCCACGGTATCCGCTACCTTCGAGGCCGATTTCGCGGCCCGCCTGCACTG
GTCCGCGGACACCGACGCCGCCATCGAGCAGCGCGTGGCCGACATTCTGACCGACGTGCAGGCGCGAGGCGATGCGGCCG
TGCTGGAGTACACGCAGCGCTTCGACGGGCTGCAGGCGGACTCCGTGGCGGCGCTGGAGCTTTCCCAGTCCGAACTGAAG
GCCGCCTTCGAGATGCTGCCGGCCGCGCAGCGCGAGGCGCTGGAAGCGGCGGCCCGCCGCGTGCGCAAATACCACGAAGC
GCAGAAGAAGGCGAGCGGCGAGAGCTGGAGCTACCGCGACGAAGACGGCACGCTGCTCGGCCAGAAGGTGACGCCGCTGG
ACCGCGTGGGCATCTACGTGCCCGGCGGCAAGGCGGCATACCCTTCCAGTGTGCTGATGAATGCCATTCCGGCCCACGTG
GCCGGCGTGCCGGACATCGTCATGGTGGTGCCCACGCCGCGCGGCGAGAAGAACCCGCTGGTGCTCGCGGCTGCCTACGT
GGCGGGCGTGAGCCGCGCCTTCGCCATCGGCGGTGCGCAGGCCGTGGCCGCGCTGGCCTATGGCACCGCTACCGTGCCCA
AGGTGGACAAGATCACCGGCCCCGGCAATGCCTACGTGGCCAGCGCCAAGAAGCGCGTGTTCGGCACGGTGGGCATCGAC
ATGATCGCCGGCCCCAGCGAGATCCTGGTGCTGGCCGACGGCACCACGCCGCCCGACTGGGTGGCGATGGACCTGTTCAG
CCAGGCCGAGCACGACGAACTGGCGCAGTCCATCCTGCTGTGCCCGGACGCCGCCTACATCGATGCCGTGCAGGCGTCCA
TCGACCGCCTGCTGCCCGAAATGCCGCGTGCGGAGATCATCGCCAAGAGCCTCACGGGCCGTGGCGCGCTGATCCTCACG
AAGGACATGGAAGAGGCCTGTGCCATCAGCAACCGCATCGCGCCCGAGCACCTGGAGGTGTCGAGCCGCGACCCGCACCG
CTGGGAGCCGCTGCTGCGCCATGCAGGCGCCATCTTCCTCGGGGCCTATACCTCCGAAAGCCTGGGCGACTACTGCGCGG
GCCCCAACCACGTGCTGCCCACCAGCGGCACCGCGCGGTTCTCGTCGCCGCTGGGCGTGTACGACTTCCAGAAGCGCAGC
AGCCTGATCGAGGTGAGCGAGCAGGGCGCGCAGGCCCTGGGCCGCATTGCCAGCGTGCTGGCGCACGGCGAGGGGCTGCA
GGCCCATGCGCGGGCTGCGGAGATGCGGTTGAAGGCCTAG

Upstream 100 bases:

>100_bases
GCCGCATCATCGATGCGTTCGCCCAGGCTACCGCTGCAGGCGCCCCGAAGTGAAAGTCGGGCGCGTGTGATACGAGAGAT
CGCTGCCATCCATTGATACT

Downstream 100 bases:

>100_bases
GGCGACGTCCAACAAACACCTCAATCCTGATCTGAGCGGAGAAACTGCTGTTGAAAGATCAAGGTTGAAGAAGAGTTGGA
TGTTGCGCCATAGGGTTTTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKLIAAPARLSTVSATFEADFAARLHWSADTDAAIEQRVADILTDVQARGDAAVLEYTQRFDGLQADSVAALELSQSELK
AAFEMLPAAQREALEAAARRVRKYHEAQKKASGESWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHV
AGVPDIVMVVPTPRGEKNPLVLAAAYVAGVSRAFAIGGAQAVAALAYGTATVPKVDKITGPGNAYVASAKKRVFGTVGID
MIAGPSEILVLADGTTPPDWVAMDLFSQAEHDELAQSILLCPDAAYIDAVQASIDRLLPEMPRAEIIAKSLTGRGALILT
KDMEEACAISNRIAPEHLEVSSRDPHRWEPLLRHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRS
SLIEVSEQGAQALGRIASVLAHGEGLQAHARAAEMRLKA

Sequences:

>Translated_439_residues
MKLIAAPARLSTVSATFEADFAARLHWSADTDAAIEQRVADILTDVQARGDAAVLEYTQRFDGLQADSVAALELSQSELK
AAFEMLPAAQREALEAAARRVRKYHEAQKKASGESWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHV
AGVPDIVMVVPTPRGEKNPLVLAAAYVAGVSRAFAIGGAQAVAALAYGTATVPKVDKITGPGNAYVASAKKRVFGTVGID
MIAGPSEILVLADGTTPPDWVAMDLFSQAEHDELAQSILLCPDAAYIDAVQASIDRLLPEMPRAEIIAKSLTGRGALILT
KDMEEACAISNRIAPEHLEVSSRDPHRWEPLLRHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRS
SLIEVSEQGAQALGRIASVLAHGEGLQAHARAAEMRLKA
>Mature_439_residues
MKLIAAPARLSTVSATFEADFAARLHWSADTDAAIEQRVADILTDVQARGDAAVLEYTQRFDGLQADSVAALELSQSELK
AAFEMLPAAQREALEAAARRVRKYHEAQKKASGESWSYRDEDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHV
AGVPDIVMVVPTPRGEKNPLVLAAAYVAGVSRAFAIGGAQAVAALAYGTATVPKVDKITGPGNAYVASAKKRVFGTVGID
MIAGPSEILVLADGTTPPDWVAMDLFSQAEHDELAQSILLCPDAAYIDAVQASIDRLLPEMPRAEIIAKSLTGRGALILT
KDMEEACAISNRIAPEHLEVSSRDPHRWEPLLRHAGAIFLGAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRS
SLIEVSEQGAQALGRIASVLAHGEGLQAHARAAEMRLKA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=43.0317848410758, Blast_Score=305, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=448, Percent_Identity=37.7232142857143, Blast_Score=272, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46543; Mature: 46543

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIAAPARLSTVSATFEADFAARLHWSADTDAAIEQRVADILTDVQARGDAAVLEYTQR
CCEEECCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FDGLQADSVAALELSQSELKAAFEMLPAAQREALEAAARRVRKYHEAQKKASGESWSYRD
HCCCCCCCEEHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
EDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVPDIVMVVPTPRGEKNPL
CCCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCE
VLAAAYVAGVSRAFAIGGAQAVAALAYGTATVPKVDKITGPGNAYVASAKKRVFGTVGID
EEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHEECCHH
MIAGPSEILVLADGTTPPDWVAMDLFSQAEHDELAQSILLCPDAAYIDAVQASIDRLLPE
EECCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
MPRAEIIAKSLTGRGALILTKDMEEACAISNRIAPEHLEVSSRDPHRWEPLLRHAGAIFL
CCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEE
GAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIEVSEQGAQALGRIASVL
EECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AHGEGLQAHARAAEMRLKA
HCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKLIAAPARLSTVSATFEADFAARLHWSADTDAAIEQRVADILTDVQARGDAAVLEYTQR
CCEEECCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FDGLQADSVAALELSQSELKAAFEMLPAAQREALEAAARRVRKYHEAQKKASGESWSYRD
HCCCCCCCEEHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEC
EDGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVPDIVMVVPTPRGEKNPL
CCCCEECCCCCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCE
VLAAAYVAGVSRAFAIGGAQAVAALAYGTATVPKVDKITGPGNAYVASAKKRVFGTVGID
EEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHEECCHH
MIAGPSEILVLADGTTPPDWVAMDLFSQAEHDELAQSILLCPDAAYIDAVQASIDRLLPE
EECCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
MPRAEIIAKSLTGRGALILTKDMEEACAISNRIAPEHLEVSSRDPHRWEPLLRHAGAIFL
CCHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCEEEE
GAYTSESLGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIEVSEQGAQALGRIASVL
EECCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AHGEGLQAHARAAEMRLKA
HCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA