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The map label for this gene is aroK

Identifier: 120609696

GI number: 120609696

Start: 1100031

End: 1100582

Strand: Direct

Name: aroK

Synonym: Aave_1002

Alternate gene names: 120609696

Gene position: 1100031-1100582 (Clockwise)

Preceding gene: 120609695

Following gene: 120609697

Centisome position: 20.55

GC content: 67.57

Gene sequence:

>552_bases
TTGCGCGGACCCCAACTGAGCATCCACCTCATCGGCCTTCCAGGCTCGGGTAAATCCACCGTCGGGCGACATCTCGCCCG
GCGGCTGGGCCTGCCCTTCATCGATTCGGACCACGTGATCGAGCAGCGCATCGGCGGCTCGATCCGTGGTTTTTTCGATC
GTGAAGGCGAAGCCGCCTTCCGTGACCTGGAGGAGGAGGTCATCCTCGAGCTGACGGAGGCGAACGTGCCGCCCCAGGTG
CTGGCCACGGGCGGCGGGGTCGTGATACGTCCCGGCAACCGGACACGCCTGCGTGAGCGGGGCACGGTCGTTTACCTCAA
CGCTTCGCCGGAGGAAATCTTCCGGCACATCCGCCACGACCAGACGCGGCCCCTGCTGCAGGTGGGTTCGCCGCTGGACC
GGCTCCGCGAACTGCAGCGCGAGAGGGACCCGCTCTACCGGGAGGCGGCCCATTTCGTCATCTCGCCGGAGCGCGGCAAG
AACGTGGCGGCCCTGGTCCAGCACATCGCCATGCAGCTGGAGCTGGCAGGCATCCGTCCGCCATCCCCATGA

Upstream 100 bases:

>100_bases
GCACGTTCTTCAGCTTCTTCACGGGGGCACCGTCTTCCGACATGACGAACGCGCAGGTGCCTCCCGCCTCGCAGGTCAGT
CCTTTCGGCAGCATCAACAA

Downstream 100 bases:

>100_bases
AGACCTGACGGAAGCCGATAGACTCCACGGCATGACTGCCGACGCATTTTCCGTTCGAGACACCGACCGGTCCCTTCCGT
CCTCCCATACCGGCGCCGCC

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MRGPQLSIHLIGLPGSGKSTVGRHLARRLGLPFIDSDHVIEQRIGGSIRGFFDREGEAAFRDLEEEVILELTEANVPPQV
LATGGGVVIRPGNRTRLRERGTVVYLNASPEEIFRHIRHDQTRPLLQVGSPLDRLRELQRERDPLYREAAHFVISPERGK
NVAALVQHIAMQLELAGIRPPSP

Sequences:

>Translated_183_residues
MRGPQLSIHLIGLPGSGKSTVGRHLARRLGLPFIDSDHVIEQRIGGSIRGFFDREGEAAFRDLEEEVILELTEANVPPQV
LATGGGVVIRPGNRTRLRERGTVVYLNASPEEIFRHIRHDQTRPLLQVGSPLDRLRELQRERDPLYREAAHFVISPERGK
NVAALVQHIAMQLELAGIRPPSP
>Mature_183_residues
MRGPQLSIHLIGLPGSGKSTVGRHLARRLGLPFIDSDHVIEQRIGGSIRGFFDREGEAAFRDLEEEVILELTEANVPPQV
LATGGGVVIRPGNRTRLRERGTVVYLNASPEEIFRHIRHDQTRPLLQVGSPLDRLRELQRERDPLYREAAHFVISPERGK
NVAALVQHIAMQLELAGIRPPSP

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=166, Percent_Identity=45.7831325301205, Blast_Score=123, Evalue=7e-30,
Organism=Escherichia coli, GI1786587, Length=151, Percent_Identity=35.7615894039735, Blast_Score=88, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=152, Percent_Identity=27.6315789473684, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_ACIAC (A1TKW2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969374.1
- ProteinModelPortal:   A1TKW2
- SMR:   A1TKW2
- STRING:   A1TKW2
- GeneID:   4666908
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1002
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- PhylomeDB:   A1TKW2
- BioCyc:   AAVE397945:AAVE_1002-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 20418; Mature: 20418

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 37-37 BINDING 61-61 BINDING 85-85 BINDING 123-123 BINDING 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGPQLSIHLIGLPGSGKSTVGRHLARRLGLPFIDSDHVIEQRIGGSIRGFFDREGEAAF
CCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHH
RDLEEEVILELTEANVPPQVLATGGGVVIRPGNRTRLRERGTVVYLNASPEEIFRHIRHD
HHHHHHHHHHHHCCCCCHHEEECCCCEEEECCCCCHHHHCCCEEEEECCHHHHHHHHHCC
QTRPLLQVGSPLDRLRELQRERDPLYREAAHFVISPERGKNVAALVQHIAMQLELAGIRP
CCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCC
PSP
CCC
>Mature Secondary Structure
MRGPQLSIHLIGLPGSGKSTVGRHLARRLGLPFIDSDHVIEQRIGGSIRGFFDREGEAAF
CCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHH
RDLEEEVILELTEANVPPQVLATGGGVVIRPGNRTRLRERGTVVYLNASPEEIFRHIRHD
HHHHHHHHHHHHCCCCCHHEEECCCCEEEECCCCCHHHHCCCEEEEECCHHHHHHHHHCC
QTRPLLQVGSPLDRLRELQRERDPLYREAAHFVISPERGKNVAALVQHIAMQLELAGIRP
CCCCHHHHCCHHHHHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCCC
PSP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA