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The map label for this gene is thiD [H]

Identifier: 120609593

GI number: 120609593

Start: 976905

End: 977861

Strand: Reverse

Name: thiD [H]

Synonym: Aave_0899

Alternate gene names: 120609593

Gene position: 977861-976905 (Counterclockwise)

Preceding gene: 120609600

Following gene: 120609592

Centisome position: 18.27

GC content: 70.22

Gene sequence:

>957_bases
ATGACCACAGATTCCCCCTCCAAGCTCACCCCTCCCCCCTCCTCCGGCACCGACGACGACGGCGGGGTCCCCATCTGCGT
GATGGCCTTCAACGCCAGCGACCCCAGCGGCGCGGGCGGCCTGACGGGCGACATCGCCACCATCGCCTCGGTGGGCGGGC
ATGCGGTGGCCGTCGTGACCGGCGCGTACGTACGCGACACCGCGCAGGTGTTCGACCACTACGCGCTGGACGACGAGGCC
GTGGCGGAGCAGGCCCGCAGCGTGCTCGAGGACCTGACGGTGCAGGCGATCAAGGTCGGCTTCGTCGGCAGCCCCGAGAA
CCTCAGCGCCATCGCCTCCATCGCGTCCGACTACGACGACGTGCCGGTGATCGCCTACATGCCCAACCTGTCGTGGTGGC
GCGACGACCTCATCGACCAGTACCTCGACGCCTTCCAGGAACTGCTGCTGCCCCAGACCTCGGTGCTGGTGGGCAACTAC
AGCACGCTTTCGCGCTGGCTGCTGCCGGACTGGTCCAGCGACCGCAAGCCCTCCGCACGCGACCTCGCCATGGCCGCCTC
CGAACTCGGGGTGCCCTACCTGCTGGTCACCGGCATTCCCGCGCCCGAGCAGCACGTCGAGAACGTGCTCACCTCCGCGC
AGACCGTGCTCGGCACCACGCGCTTCGAGCTGTTCGACGCCACCTTCACCGGCGCCGGCGACACGCTGTCGGCGGCGCTC
GCCGCGCTCGTGGCCAGCGGCAACGACCTCGCCGAAGCGGCCAGCGAAGCGCTCACCTACCTCGACCGCTGCCTGGACGC
CGGCTTCCGGCCGGGCATGGGCCACATCCTGCCCGACCGGATGTTCTGGGCCCAGCCGGACGACGATGACGACGACGAAG
ACCCCGACGACGGCCCCGGGACCGATCCCACGTCCACCGACGGCTTCGTGATGCCTCCCCATGACACCCAGCACTGA

Upstream 100 bases:

>100_bases
CGTCACAGCTTAAGGGGCCTTCACATAGAATGCAACGATTGTATCTAGACATCACCGCGGGACGCAGCTTCCGTGCCAAC
CGTTACGCTGGTGCGGCGCA

Downstream 100 bases:

>100_bases
CCTCAACCTTCCCCTCTTCGAACGCGCCAAGGCGCTCATCCCCGGCGGCGTCAACTCGCCCGTGCGCGCCTTCCGCGCGG
TGGGCGGCACGCCCCGCTTC

Product: phosphomethylpyrimidine kinase type-1

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTTDSPSKLTPPPSSGTDDDGGVPICVMAFNASDPSGAGGLTGDIATIASVGGHAVAVVTGAYVRDTAQVFDHYALDDEA
VAEQARSVLEDLTVQAIKVGFVGSPENLSAIASIASDYDDVPVIAYMPNLSWWRDDLIDQYLDAFQELLLPQTSVLVGNY
STLSRWLLPDWSSDRKPSARDLAMAASELGVPYLLVTGIPAPEQHVENVLTSAQTVLGTTRFELFDATFTGAGDTLSAAL
AALVASGNDLAEAASEALTYLDRCLDAGFRPGMGHILPDRMFWAQPDDDDDDEDPDDGPGTDPTSTDGFVMPPHDTQH

Sequences:

>Translated_318_residues
MTTDSPSKLTPPPSSGTDDDGGVPICVMAFNASDPSGAGGLTGDIATIASVGGHAVAVVTGAYVRDTAQVFDHYALDDEA
VAEQARSVLEDLTVQAIKVGFVGSPENLSAIASIASDYDDVPVIAYMPNLSWWRDDLIDQYLDAFQELLLPQTSVLVGNY
STLSRWLLPDWSSDRKPSARDLAMAASELGVPYLLVTGIPAPEQHVENVLTSAQTVLGTTRFELFDATFTGAGDTLSAAL
AALVASGNDLAEAASEALTYLDRCLDAGFRPGMGHILPDRMFWAQPDDDDDDEDPDDGPGTDPTSTDGFVMPPHDTQH
>Mature_317_residues
TTDSPSKLTPPPSSGTDDDGGVPICVMAFNASDPSGAGGLTGDIATIASVGGHAVAVVTGAYVRDTAQVFDHYALDDEAV
AEQARSVLEDLTVQAIKVGFVGSPENLSAIASIASDYDDVPVIAYMPNLSWWRDDLIDQYLDAFQELLLPQTSVLVGNYS
TLSRWLLPDWSSDRKPSARDLAMAASELGVPYLLVTGIPAPEQHVENVLTSAQTVLGTTRFELFDATFTGAGDTLSAALA
ALVASGNDLAEAASEALTYLDRCLDAGFRPGMGHILPDRMFWAQPDDDDDDEDPDDGPGTDPTSTDGFVMPPHDTQH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=24.609375, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 33607; Mature: 33476

Theoretical pI: Translated: 3.73; Mature: 3.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDSPSKLTPPPSSGTDDDGGVPICVMAFNASDPSGAGGLTGDIATIASVGGHAVAVVT
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEH
GAYVRDTAQVFDHYALDDEAVAEQARSVLEDLTVQAIKVGFVGSPENLSAIASIASDYDD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCC
VPVIAYMPNLSWWRDDLIDQYLDAFQELLLPQTSVLVGNYSTLSRWLLPDWSSDRKPSAR
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHEECCHHHHHHHCCCCCCCCCCCCHH
DLAMAASELGVPYLLVTGIPAPEQHVENVLTSAQTVLGTTRFELFDATFTGAGDTLSAAL
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECEECCCCHHHHHHH
AALVASGNDLAEAASEALTYLDRCLDAGFRPGMGHILPDRMFWAQPDDDDDDEDPDDGPG
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCC
TDPTSTDGFVMPPHDTQH
CCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
TTDSPSKLTPPPSSGTDDDGGVPICVMAFNASDPSGAGGLTGDIATIASVGGHAVAVVT
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEH
GAYVRDTAQVFDHYALDDEAVAEQARSVLEDLTVQAIKVGFVGSPENLSAIASIASDYDD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCC
VPVIAYMPNLSWWRDDLIDQYLDAFQELLLPQTSVLVGNYSTLSRWLLPDWSSDRKPSAR
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHEECCHHHHHHHCCCCCCCCCCCCHH
DLAMAASELGVPYLLVTGIPAPEQHVENVLTSAQTVLGTTRFELFDATFTGAGDTLSAAL
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECEECCCCHHHHHHH
AALVASGNDLAEAASEALTYLDRCLDAGFRPGMGHILPDRMFWAQPDDDDDDEDPDDGPG
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCC
TDPTSTDGFVMPPHDTQH
CCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]