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The map label for this gene is hemL

Identifier: 120609592

GI number: 120609592

Start: 975608

End: 976921

Strand: Reverse

Name: hemL

Synonym: Aave_0898

Alternate gene names: 120609592

Gene position: 976921-975608 (Counterclockwise)

Preceding gene: 120609593

Following gene: 120609591

Centisome position: 18.25

GC content: 71.16

Gene sequence:

>1314_bases
ATGACACCCAGCACTGACCTCAACCTTCCCCTCTTCGAACGCGCCAAGGCGCTCATCCCCGGCGGCGTCAACTCGCCCGT
GCGCGCCTTCCGCGCGGTGGGCGGCACGCCCCGCTTCGTGCAGCGCGCCCAGGGCGCCTACTTCTGGGACGCCAACGGCC
AGCGCTTCATCGACTACATCGGCTCCTGGGGTCCCATGATCCTGGGCCACGGCCATCCGGCCGTGCTGGAAGCGGTGCAG
AAGGCCGCGCTCGACGGCTTCAGCTTCGGCGCGCCCACCGAGCGCGAGGTCGAGCTGGCCGAGGAGATCCTCCGCCACGT
GCCGTCCATGGAGATGATCCGCCTGGTCAGTTCCGGCACCGAGGCCGGCATGAGCGCCATCCGGCTCGCGCGCGGCGCCA
CGGGCCGCAGCAGGATCATCAAGTTCAACGGCTGCTACCACGGCCATGCCGACGCGCTGCTGGTCAAGGCCGGCTCGGGC
CTGGCCACCTTCGGCCACGCCACCAGCGCCGGGGTGCCGGCCGAGGTGGTACAGCACACGCTCGTGCTGGAATACAACGA
CATCGCCCAGCTCGAAGAGGCCTTCGCTCTGCACGGCAGCGAGATCGCCGGGCTCATGATCGAGCCCATCGCCGGCAACA
TGAACTTCGTGCGCGCCAGCGTGCCCTTCATGCGGCGCTGCCGCGAGCTCTGCACGCAGCACGGCGCACTGCTGGTGTTC
GACGAGGTGATGACGGGCTTCCGCGTGGCGCTCGGCAGCGCGCAGAGCGTCTATGCCCGCGACATCCCGGGCTTCCAGCC
CGACATCACCGTGCTCGGCAAGGTGATCGGCGGCGGCATGCCGCTCGCGGCGTTCGGCGGACCGCGCGCGATCATGGAGC
AGCTGGCCCCGCTCGGGCCGGTGTACCAGGCCGGCACGCTTTCGGGCAACCCGGTGGCCACCGCCTGCGGCCTCGCCACG
CTGCGCGAGATCGCCCGCCCCGGCTTCTACGAGGCGCTGGGCGAGCGCACCCGCGCCCTGACCGGCGGGCTGGCCGACGC
GGCGCGCGCGGAAGGCCTGCCCTTCAGCGCGGACAGCGAAGGCGGCATGTTCGGCTTCTTCCTGCTGCCCGAGCTGCCCC
GGAACTATCCGACGGTGATGACCACGGACGGCGCGCGGTTCAACGCGCTCTTCCACGGGCTGCTGGACCGCGGCGTGTAC
ATCGCACCCGCGCTCTATGAGGCCGGTTTCGTGAGCAGCGCCCACAGCGCGCAGGACATCGACGAGACCATCGCCGCGGC
GCGCGAGGTGTTCCGCCTGGTCTCCGCGGGCTGA

Upstream 100 bases:

>100_bases
ATGTTCTGGGCCCAGCCGGACGACGATGACGACGACGAAGACCCCGACGACGGCCCCGGGACCGATCCCACGTCCACCGA
CGGCTTCGTGATGCCTCCCC

Downstream 100 bases:

>100_bases
CCCGGGCCGGACCCGGGCGCGCCGGGGCACGCTTCGGCTGCATGGCCGCCGCTTCGCGTGGCGGCAGCGGCGTGCCGGTT
CCGGAGCGCAGAGTGGATGC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTPSTDLNLPLFERAKALIPGGVNSPVRAFRAVGGTPRFVQRAQGAYFWDANGQRFIDYIGSWGPMILGHGHPAVLEAVQ
KAALDGFSFGAPTEREVELAEEILRHVPSMEMIRLVSSGTEAGMSAIRLARGATGRSRIIKFNGCYHGHADALLVKAGSG
LATFGHATSAGVPAEVVQHTLVLEYNDIAQLEEAFALHGSEIAGLMIEPIAGNMNFVRASVPFMRRCRELCTQHGALLVF
DEVMTGFRVALGSAQSVYARDIPGFQPDITVLGKVIGGGMPLAAFGGPRAIMEQLAPLGPVYQAGTLSGNPVATACGLAT
LREIARPGFYEALGERTRALTGGLADAARAEGLPFSADSEGGMFGFFLLPELPRNYPTVMTTDGARFNALFHGLLDRGVY
IAPALYEAGFVSSAHSAQDIDETIAAAREVFRLVSAG

Sequences:

>Translated_437_residues
MTPSTDLNLPLFERAKALIPGGVNSPVRAFRAVGGTPRFVQRAQGAYFWDANGQRFIDYIGSWGPMILGHGHPAVLEAVQ
KAALDGFSFGAPTEREVELAEEILRHVPSMEMIRLVSSGTEAGMSAIRLARGATGRSRIIKFNGCYHGHADALLVKAGSG
LATFGHATSAGVPAEVVQHTLVLEYNDIAQLEEAFALHGSEIAGLMIEPIAGNMNFVRASVPFMRRCRELCTQHGALLVF
DEVMTGFRVALGSAQSVYARDIPGFQPDITVLGKVIGGGMPLAAFGGPRAIMEQLAPLGPVYQAGTLSGNPVATACGLAT
LREIARPGFYEALGERTRALTGGLADAARAEGLPFSADSEGGMFGFFLLPELPRNYPTVMTTDGARFNALFHGLLDRGVY
IAPALYEAGFVSSAHSAQDIDETIAAAREVFRLVSAG
>Mature_436_residues
TPSTDLNLPLFERAKALIPGGVNSPVRAFRAVGGTPRFVQRAQGAYFWDANGQRFIDYIGSWGPMILGHGHPAVLEAVQK
AALDGFSFGAPTEREVELAEEILRHVPSMEMIRLVSSGTEAGMSAIRLARGATGRSRIIKFNGCYHGHADALLVKAGSGL
ATFGHATSAGVPAEVVQHTLVLEYNDIAQLEEAFALHGSEIAGLMIEPIAGNMNFVRASVPFMRRCRELCTQHGALLVFD
EVMTGFRVALGSAQSVYARDIPGFQPDITVLGKVIGGGMPLAAFGGPRAIMEQLAPLGPVYQAGTLSGNPVATACGLATL
REIARPGFYEALGERTRALTGGLADAARAEGLPFSADSEGGMFGFFLLPELPRNYPTVMTTDGARFNALFHGLLDRGVYI
APALYEAGFVSSAHSAQDIDETIAAAREVFRLVSAG

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=329, Percent_Identity=27.0516717325228, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI37574042, Length=317, Percent_Identity=29.6529968454259, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI24119277, Length=307, Percent_Identity=26.7100977198697, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI226442705, Length=317, Percent_Identity=29.0220820189274, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI284507298, Length=248, Percent_Identity=28.2258064516129, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI226442709, Length=286, Percent_Identity=29.3706293706294, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786349, Length=422, Percent_Identity=57.5829383886256, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1789016, Length=393, Percent_Identity=31.8066157760814, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788044, Length=304, Percent_Identity=30.9210526315789, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787560, Length=343, Percent_Identity=28.8629737609329, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=27.9742765273312, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI145693181, Length=312, Percent_Identity=27.5641025641026, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786991, Length=292, Percent_Identity=28.7671232876712, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=337, Percent_Identity=24.9258160237389, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=325, Percent_Identity=26.4615384615385, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=318, Percent_Identity=24.5283018867925, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=297, Percent_Identity=26.5993265993266, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_ACIAC (A1TKK8)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969270.1
- ProteinModelPortal:   A1TKK8
- STRING:   A1TKK8
- GeneID:   4666993
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0898
- NMPDR:   fig|397945.5.peg.780
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   NENAVRD
- PhylomeDB:   A1TKK8
- ProtClustDB:   PRK00062
- BioCyc:   AAVE397945:AAVE_0898-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46320; Mature: 46188

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSTDLNLPLFERAKALIPGGVNSPVRAFRAVGGTPRFVQRAQGAYFWDANGQRFIDYI
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCEEECCCCCHHHHHH
GSWGPMILGHGHPAVLEAVQKAALDGFSFGAPTEREVELAEEILRHVPSMEMIRLVSSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
EAGMSAIRLARGATGRSRIIKFNGCYHGHADALLVKAGSGLATFGHATSAGVPAEVVQHT
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCHHHHHHH
LVLEYNDIAQLEEAFALHGSEIAGLMIEPIAGNMNFVRASVPFMRRCRELCTQHGALLVF
HEEEEHHHHHHHHHHHHCCCHHCCEEEECCCCCCCEEECCCHHHHHHHHHHHHCCCEEEH
DEVMTGFRVALGSAQSVYARDIPGFQPDITVLGKVIGGGMPLAAFGGPRAIMEQLAPLGP
HHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCC
VYQAGTLSGNPVATACGLATLREIARPGFYEALGERTRALTGGLADAARAEGLPFSADSE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
GGMFGFFLLPELPRNYPTVMTTDGARFNALFHGLLDRGVYIAPALYEAGFVSSAHSAQDI
CCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCHHHH
DETIAAAREVFRLVSAG
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPSTDLNLPLFERAKALIPGGVNSPVRAFRAVGGTPRFVQRAQGAYFWDANGQRFIDYI
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHCCCEEECCCCCHHHHHH
GSWGPMILGHGHPAVLEAVQKAALDGFSFGAPTEREVELAEEILRHVPSMEMIRLVSSGT
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCC
EAGMSAIRLARGATGRSRIIKFNGCYHGHADALLVKAGSGLATFGHATSAGVPAEVVQHT
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCCEECCCCCCCCCCHHHHHHH
LVLEYNDIAQLEEAFALHGSEIAGLMIEPIAGNMNFVRASVPFMRRCRELCTQHGALLVF
HEEEEHHHHHHHHHHHHCCCHHCCEEEECCCCCCCEEECCCHHHHHHHHHHHHCCCEEEH
DEVMTGFRVALGSAQSVYARDIPGFQPDITVLGKVIGGGMPLAAFGGPRAIMEQLAPLGP
HHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHCCCHHHHHHHHCCCCC
VYQAGTLSGNPVATACGLATLREIARPGFYEALGERTRALTGGLADAARAEGLPFSADSE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCC
GGMFGFFLLPELPRNYPTVMTTDGARFNALFHGLLDRGVYIAPALYEAGFVSSAHSAQDI
CCEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCCHHHH
DETIAAAREVFRLVSAG
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA