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The map label for this gene is treA [H]

Identifier: 120608922

GI number: 120608922

Start: 240192

End: 241898

Strand: Direct

Name: treA [H]

Synonym: Aave_0217

Alternate gene names: 120608922

Gene position: 240192-241898 (Clockwise)

Preceding gene: 120608921

Following gene: 120608923

Centisome position: 4.49

GC content: 70.36

Gene sequence:

>1707_bases
ATGATCCCTGCCGCTCCTTCCTGCCGCACCCCGCTGCTGAGCCTGGTGCTCGGCCTGTTGCTCGGCACCGCCGGCACCAC
TGCCATGGCGGAGGCCGTGCCAGCGACGACGCTGACCGCGCCGGCGACGACGCTGACCGCGCCGGCACCGCCGCCGCAGA
CCCCCGACCTGGCCTACCCGGAACTGTTTCAGGCGGTGCAGCAGCACGAGCTGTTCGACGACCAGAAGCACTTCGTCGAT
GCGCTGCCGCTGCGTGACCCGGCGCTGATCAACGCCGACTATCTGGCGCAGCGCCAGCAACCCGGCTTCGACCTGCGCCG
CTTCGTCGCCGCCAACTTCGAGGAATCCGACCCGGTGCAGACCGGGGCGATCCGCCAGGACACCGGCTTGCGCGAACACA
TCGACGCGCTGTGGCCGCGGCTGGTGCGCCGCCAAGTGGAAGTGCCGCCCTACAGCAGCCTGCTGCCGCTGCCGCACCCC
TACGTGGTGCCGGGCGGGCGCTTCCGCGAGGTCTACTACTGGGATTCCTACTTCACCATGCTCGGCCTGGTGGAGAGCGG
CGAGCAAGAACACAGCCGGCAGATGCTGGACAACTTCGCCTACATGATCGACACCTACGGGCACATCCCCAACGGCAACC
GCACCTACTACCTGAGCCGTTCGCAGCCGCCGTTCTTCTCGTACATGGTGCAGTTGCAGGCCAAGGTGGAAGGCGATGCC
GCCTACGCGCGCTACCTGCCTCAGTTGCAGAAGGAATACGCGTACTGGATGGAAGGCGCGGAGACCTTGGCCCCAGGCAG
CGCGCATGCGCACGTGGTGCGGCTGGCCGACGGCAGTCTGCTCAACCGCTACTGGGACGCCCGCGACACACCGCGCCCGG
AAGCCTGGCTGCACGACGTGCGCACCGCTGCCGAGGCCAAGGACCGCCCCGCCGCCGAGGTCTACCGGGACCTGCGCGCT
GGCGCCGAGAGCGGCTGGGACTATTCCAGCCGCTGGCTCGGCGACCGCAAGACCCTGGCCAGCATCCGCACCACCGCCAT
CGTCCCGGTCGACCTGAACAGCCTGCTCTACCATTTGGAGACTACCCTGGCGCTCGCCTGCGCCAAGAACCCGGACGTGG
CCGGCTGCAACACCGACTACGCCGCCCTGGCCAGCGCGCGCAAGACCGCGATCGACAAGCACCTGTGGAGCGATGCCGGC
TACTACGCCGACTACGACTGGCAGCAGCGCCGGCTGCGCGGGCAGGTCACCGCGGCGGCGCTGTTCCCGCTGTTCGTCGG
CGCCGCCTCGCCGGCACGGGCCAAGCGCAGCGCCGACACCGTGCAGGCGCAGCTGCTGCGCCCCGGCGGCCTGGCGACTA
CGAGCCTGCACACCGGCCAGCAGTGGGACGAACCCAACGGCTGGGCGCCGCTGCAATGGATCGCCGTGGATGGCCTGCGC
CGCTACGGCCAGGACGCGCTGGCGCAGTGCATCGGCACCCGCTTCCTGACGCGGGTGCAGGCGCTGTTCGCGCAGCAGCA
CAAGCTGGTGGAGAAGTACGCGGTGGACGGGCAGGCCAAGGGCGGCGGCGGCGGCGAGTACGCCCTGCAGGACGGCTTCG
GCTGGACCAACGGCGTGACCTTGCTGCTGATGGACCTCTACGCGGCGCCCGCCGCCGCGCGGGCAGCGTCGCACGCGCAA
GCGCAGACGGAAGCGGTCGCGCCCTGA

Upstream 100 bases:

>100_bases
GCGTTGCGTCGTTCACCGGTGCGAGCCGGGCGGCGCGCGCCCATCGTCGTTTCGAACGTTTATCGTGCCGCACGCATCCT
GCTCTCTCTGGACCATAGAC

Downstream 100 bases:

>100_bases
ACCGCCGCCGGCGGCACCGCGGCCACGCCGCGTCCGCCAGGACCAGCGGTCGGCGCTGCCGCTACTGCGCTGGCGTCTCC
ACGGCAAGGCCCATCGCCGC

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MIPAAPSCRTPLLSLVLGLLLGTAGTTAMAEAVPATTLTAPATTLTAPAPPPQTPDLAYPELFQAVQQHELFDDQKHFVD
ALPLRDPALINADYLAQRQQPGFDLRRFVAANFEESDPVQTGAIRQDTGLREHIDALWPRLVRRQVEVPPYSSLLPLPHP
YVVPGGRFREVYYWDSYFTMLGLVESGEQEHSRQMLDNFAYMIDTYGHIPNGNRTYYLSRSQPPFFSYMVQLQAKVEGDA
AYARYLPQLQKEYAYWMEGAETLAPGSAHAHVVRLADGSLLNRYWDARDTPRPEAWLHDVRTAAEAKDRPAAEVYRDLRA
GAESGWDYSSRWLGDRKTLASIRTTAIVPVDLNSLLYHLETTLALACAKNPDVAGCNTDYAALASARKTAIDKHLWSDAG
YYADYDWQQRRLRGQVTAAALFPLFVGAASPARAKRSADTVQAQLLRPGGLATTSLHTGQQWDEPNGWAPLQWIAVDGLR
RYGQDALAQCIGTRFLTRVQALFAQQHKLVEKYAVDGQAKGGGGGEYALQDGFGWTNGVTLLLMDLYAAPAAARAASHAQ
AQTEAVAP

Sequences:

>Translated_568_residues
MIPAAPSCRTPLLSLVLGLLLGTAGTTAMAEAVPATTLTAPATTLTAPAPPPQTPDLAYPELFQAVQQHELFDDQKHFVD
ALPLRDPALINADYLAQRQQPGFDLRRFVAANFEESDPVQTGAIRQDTGLREHIDALWPRLVRRQVEVPPYSSLLPLPHP
YVVPGGRFREVYYWDSYFTMLGLVESGEQEHSRQMLDNFAYMIDTYGHIPNGNRTYYLSRSQPPFFSYMVQLQAKVEGDA
AYARYLPQLQKEYAYWMEGAETLAPGSAHAHVVRLADGSLLNRYWDARDTPRPEAWLHDVRTAAEAKDRPAAEVYRDLRA
GAESGWDYSSRWLGDRKTLASIRTTAIVPVDLNSLLYHLETTLALACAKNPDVAGCNTDYAALASARKTAIDKHLWSDAG
YYADYDWQQRRLRGQVTAAALFPLFVGAASPARAKRSADTVQAQLLRPGGLATTSLHTGQQWDEPNGWAPLQWIAVDGLR
RYGQDALAQCIGTRFLTRVQALFAQQHKLVEKYAVDGQAKGGGGGEYALQDGFGWTNGVTLLLMDLYAAPAAARAASHAQ
AQTEAVAP
>Mature_568_residues
MIPAAPSCRTPLLSLVLGLLLGTAGTTAMAEAVPATTLTAPATTLTAPAPPPQTPDLAYPELFQAVQQHELFDDQKHFVD
ALPLRDPALINADYLAQRQQPGFDLRRFVAANFEESDPVQTGAIRQDTGLREHIDALWPRLVRRQVEVPPYSSLLPLPHP
YVVPGGRFREVYYWDSYFTMLGLVESGEQEHSRQMLDNFAYMIDTYGHIPNGNRTYYLSRSQPPFFSYMVQLQAKVEGDA
AYARYLPQLQKEYAYWMEGAETLAPGSAHAHVVRLADGSLLNRYWDARDTPRPEAWLHDVRTAAEAKDRPAAEVYRDLRA
GAESGWDYSSRWLGDRKTLASIRTTAIVPVDLNSLLYHLETTLALACAKNPDVAGCNTDYAALASARKTAIDKHLWSDAG
YYADYDWQQRRLRGQVTAAALFPLFVGAASPARAKRSADTVQAQLLRPGGLATTSLHTGQQWDEPNGWAPLQWIAVDGLR
RYGQDALAQCIGTRFLTRVQALFAQQHKLVEKYAVDGQAKGGGGGEYALQDGFGWTNGVTLLLMDLYAAPAAARAASHAQ
AQTEAVAP

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=537, Percent_Identity=33.8919925512104, Blast_Score=250, Evalue=2e-66,
Organism=Escherichia coli, GI1787447, Length=547, Percent_Identity=54.4789762340037, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1789936, Length=525, Percent_Identity=51.2380952380952, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17542196, Length=542, Percent_Identity=31.7343173431734, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17565078, Length=566, Percent_Identity=31.2720848056537, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI25148109, Length=438, Percent_Identity=34.703196347032, Blast_Score=238, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI25141398, Length=539, Percent_Identity=30.7977736549165, Blast_Score=221, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI71987755, Length=432, Percent_Identity=29.1666666666667, Blast_Score=178, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6319473, Length=431, Percent_Identity=31.7865429234339, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320204, Length=450, Percent_Identity=29.3333333333333, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656680, Length=584, Percent_Identity=32.8767123287671, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24656675, Length=584, Percent_Identity=32.8767123287671, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24656661, Length=518, Percent_Identity=34.9420849420849, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI17933716, Length=518, Percent_Identity=34.9420849420849, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24656670, Length=518, Percent_Identity=34.9420849420849, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24656685, Length=507, Percent_Identity=34.5167652859961, Blast_Score=245, Evalue=8e-65,
Organism=Drosophila melanogaster, GI22024178, Length=539, Percent_Identity=28.5714285714286, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI45551104, Length=376, Percent_Identity=28.4574468085106, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28573474, Length=302, Percent_Identity=30.4635761589404, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 62629; Mature: 62629

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPAAPSCRTPLLSLVLGLLLGTAGTTAMAEAVPATTLTAPATTLTAPAPPPQTPDLAYP
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCEEECCCCCCCCCCCCCH
ELFQAVQQHELFDDQKHFVDALPLRDPALINADYLAQRQQPGFDLRRFVAANFEESDPVQ
HHHHHHHHHHHHCHHHHHHHHCCCCCCCEECHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
TGAIRQDTGLREHIDALWPRLVRRQVEVPPYSSLLPLPHPYVVPGGRFREVYYWDSYFTM
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCEEEEEEEHHHHHH
LGLVESGEQEHSRQMLDNFAYMIDTYGHIPNGNRTYYLSRSQPPFFSYMVQLQAKVEGDA
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCH
AYARYLPQLQKEYAYWMEGAETLAPGSAHAHVVRLADGSLLNRYWDARDTPRPEAWLHDV
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCHHHHHHCCCCCCCCHHHHHHHH
RTAAEAKDRPAAEVYRDLRAGAESGWDYSSRWLGDRKTLASIRTTAIVPVDLNSLLYHLE
HHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHEEEEECHHHHHHHHH
TTLALACAKNPDVAGCNTDYAALASARKTAIDKHLWSDAGYYADYDWQQRRLRGQVTAAA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LFPLFVGAASPARAKRSADTVQAQLLRPGGLATTSLHTGQQWDEPNGWAPLQWIAVDGLR
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHH
RYGQDALAQCIGTRFLTRVQALFAQQHKLVEKYAVDGQAKGGGGGEYALQDGFGWTNGVT
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHH
LLLMDLYAAPAAARAASHAQAQTEAVAP
HHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIPAAPSCRTPLLSLVLGLLLGTAGTTAMAEAVPATTLTAPATTLTAPAPPPQTPDLAYP
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCEEECCCCCCCCCCCCCH
ELFQAVQQHELFDDQKHFVDALPLRDPALINADYLAQRQQPGFDLRRFVAANFEESDPVQ
HHHHHHHHHHHHCHHHHHHHHCCCCCCCEECHHHHHHCCCCCHHHHHHHHCCCCCCCCCC
TGAIRQDTGLREHIDALWPRLVRRQVEVPPYSSLLPLPHPYVVPGGRFREVYYWDSYFTM
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCEEEEEEEHHHHHH
LGLVESGEQEHSRQMLDNFAYMIDTYGHIPNGNRTYYLSRSQPPFFSYMVQLQAKVEGDA
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCH
AYARYLPQLQKEYAYWMEGAETLAPGSAHAHVVRLADGSLLNRYWDARDTPRPEAWLHDV
HHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCHHHHHHCCCCCCCCHHHHHHHH
RTAAEAKDRPAAEVYRDLRAGAESGWDYSSRWLGDRKTLASIRTTAIVPVDLNSLLYHLE
HHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHEEEEECHHHHHHHHH
TTLALACAKNPDVAGCNTDYAALASARKTAIDKHLWSDAGYYADYDWQQRRLRGQVTAAA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LFPLFVGAASPARAKRSADTVQAQLLRPGGLATTSLHTGQQWDEPNGWAPLQWIAVDGLR
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHH
RYGQDALAQCIGTRFLTRVQALFAQQHKLVEKYAVDGQAKGGGGGEYALQDGFGWTNGVT
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHH
LLLMDLYAAPAAARAASHAQAQTEAVAP
HHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]