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The map label for this gene is cobL [H]

Identifier: 120608782

GI number: 120608782

Start: 80113

End: 81456

Strand: Direct

Name: cobL [H]

Synonym: Aave_0072

Alternate gene names: 120608782

Gene position: 80113-81456 (Clockwise)

Preceding gene: 120608781

Following gene: 120608783

Centisome position: 1.5

GC content: 72.62

Gene sequence:

>1344_bases
ATGACCACCACGAACCTGCTCGAAAAAGACCCCCAGCCCTGCCGCGTGATCGGCGTGCTGGACGATGGCGCCGCCAGCCT
GAGCGCCACCGCGCTCGCGCTGCTGCGCCGCGCCGACCTGGTGATCGGCGGCACGCGCACCCTGGCGCTGCTGGAGGACG
ACATTGCCCCGCAGGCCGTGCGGCGCGATCTGACCGGCTGCCTCTCGTCCGTGCCCGGCTGGATCGCCGAGGCCCGCGCC
GCCCACCAGGCCTGCGTGGTGCTGGCCACGGGCGACCCGCTCTGCCACGGCATCGCCAGCTACCTGGCCTCGCGCCTGTG
CATCCAGGCGCTGGAGGTGATGCCCAACGTCTCCACCCTGCAGCTCGCCTGCGCCCGGCTGGGCCTGGCCTGGCAGGACG
CGCGCATCGTCTCCGTGCATGCGAAGGATGCCGGCGAATGGACCGTGGGCGCTGAACCTGCGCACGGCCTCTACGCGCTG
GCCCAGGCCGTGCGCCAGCACGACCGCCTGGCCGTGCTCACCAGCCCCGACAACACACCCGCGCGCATCGCGCGCCTGCT
GGTGGCCGAAGGCCTGGGCGACGATTTCCAGATCAGCGTGGCCGAGCGCCTGTGCACGCCCGACGAGCGCGTGTGGGCCG
ACATGGCTCCGGCCGCTGCCGCCGCGCAGGACTTCGCCGACCCCAACGTCGTGCTGCTGGTGCGCACGCGCCAGCGGCCC
GACGCGGTGCGCTTCGGCCTGCCCGATGCGGCCTACCACCAGCGCCAGCCGGACAAGGGCCTGATCACCAAGCAGGAGGT
GCGCGCCGTCTCGCTCGCACGCATGCAGTTGCGTGCCGCCAGCCGCGTGTGGGACATCGGCGCCGGCAGCGGCTCGGTGG
GGCTGGAGGCCGCGCGCCTGTGCCCGCAGGGCCATGTCTGGGCGATGGAGAAGAACGAGGGCGACGTGGAGATCGCGCGC
CGCAACGTGCGCGATTTCGGTGTCTCCAACCACACGCTGGTGCACGGCAAGGCGCCCGAGGGGCTGGATGCCTGGCCCGA
TCCGGACGCCGTCTTCATCGGCGGCTCGGGCGGCGAGCTGGCCGAGCTGATCGCGCTGTGCCTGAAACGCCTGCGCCCCG
GCGGCTGGCTGGTGATGAATTTCGTCACGCTGGAGAACTTGGCTGCCGCCACCCAGGCCCTGCAGGCTGCAGGCGCCGCG
TGGGACGTGCTGCAGCTGCAGGCGGCGCGCAGCAAACCCATCCTGCACATGCACCGCATGGCGGCCGAGAACCCGGTGTG
GATCGTCTGCGCGCAGGCGGGCAGCGTCGGGACTGCTGCCGTCGCCGTGGAGGAGGGCGCATGA

Upstream 100 bases:

>100_bases
ACCGCTACGGCGACCGCTTCCACCTCACCGTGCTGGTCTGCGATTTCGACGGCAGCAAGATCACCGAAGCCGCCTCCGGG
CCGGCTGCCACCGCATGACG

Downstream 100 bases:

>100_bases
CCGCCGAGCACACCACCATCACGAGCGCGCCGCGGCCGCAGGACACGCACACTCCGCCGACGCGGGGCCCGCTGGGCCGC
CTCATCGGCGTTTCGCTCGG

Product: precorrin-6Y C5,15-methyltransferase

Products: NA

Alternate protein names: Precorrin-6 methyltransferase; Precorrin-6Y methylase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTTTNLLEKDPQPCRVIGVLDDGAASLSATALALLRRADLVIGGTRTLALLEDDIAPQAVRRDLTGCLSSVPGWIAEARA
AHQACVVLATGDPLCHGIASYLASRLCIQALEVMPNVSTLQLACARLGLAWQDARIVSVHAKDAGEWTVGAEPAHGLYAL
AQAVRQHDRLAVLTSPDNTPARIARLLVAEGLGDDFQISVAERLCTPDERVWADMAPAAAAAQDFADPNVVLLVRTRQRP
DAVRFGLPDAAYHQRQPDKGLITKQEVRAVSLARMQLRAASRVWDIGAGSGSVGLEAARLCPQGHVWAMEKNEGDVEIAR
RNVRDFGVSNHTLVHGKAPEGLDAWPDPDAVFIGGSGGELAELIALCLKRLRPGGWLVMNFVTLENLAAATQALQAAGAA
WDVLQLQAARSKPILHMHRMAAENPVWIVCAQAGSVGTAAVAVEEGA

Sequences:

>Translated_447_residues
MTTTNLLEKDPQPCRVIGVLDDGAASLSATALALLRRADLVIGGTRTLALLEDDIAPQAVRRDLTGCLSSVPGWIAEARA
AHQACVVLATGDPLCHGIASYLASRLCIQALEVMPNVSTLQLACARLGLAWQDARIVSVHAKDAGEWTVGAEPAHGLYAL
AQAVRQHDRLAVLTSPDNTPARIARLLVAEGLGDDFQISVAERLCTPDERVWADMAPAAAAAQDFADPNVVLLVRTRQRP
DAVRFGLPDAAYHQRQPDKGLITKQEVRAVSLARMQLRAASRVWDIGAGSGSVGLEAARLCPQGHVWAMEKNEGDVEIAR
RNVRDFGVSNHTLVHGKAPEGLDAWPDPDAVFIGGSGGELAELIALCLKRLRPGGWLVMNFVTLENLAAATQALQAAGAA
WDVLQLQAARSKPILHMHRMAAENPVWIVCAQAGSVGTAAVAVEEGA
>Mature_446_residues
TTTNLLEKDPQPCRVIGVLDDGAASLSATALALLRRADLVIGGTRTLALLEDDIAPQAVRRDLTGCLSSVPGWIAEARAA
HQACVVLATGDPLCHGIASYLASRLCIQALEVMPNVSTLQLACARLGLAWQDARIVSVHAKDAGEWTVGAEPAHGLYALA
QAVRQHDRLAVLTSPDNTPARIARLLVAEGLGDDFQISVAERLCTPDERVWADMAPAAAAAQDFADPNVVLLVRTRQRPD
AVRFGLPDAAYHQRQPDKGLITKQEVRAVSLARMQLRAASRVWDIGAGSGSVGLEAARLCPQGHVWAMEKNEGDVEIARR
NVRDFGVSNHTLVHGKAPEGLDAWPDPDAVFIGGSGGELAELIALCLKRLRPGGWLVMNFVTLENLAAATQALQAAGAAW
DVLQLQAARSKPILHMHRMAAENPVWIVCAQAGSVGTAAVAVEEGA

Specific function: Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X [H]

COG id: COG2242

COG function: function code H; Precorrin-6B methylase 2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012818
- InterPro:   IPR014008
- InterPro:   IPR006365 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.132 [H]

Molecular weight: Translated: 47444; Mature: 47313

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTNLLEKDPQPCRVIGVLDDGAASLSATALALLRRADLVIGGTRTLALLEDDIAPQAV
CCCCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCEEECCCEEEEEECCCCCHHHH
RRDLTGCLSSVPGWIAEARAAHQACVVLATGDPLCHGIASYLASRLCIQALEVMPNVSTL
HHHHHHHHHHCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
QLACARLGLAWQDARIVSVHAKDAGEWTVGAEPAHGLYALAQAVRQHDRLAVLTSPDNTP
HHHHHHHCCCCCCCEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCH
ARIARLLVAEGLGDDFQISVAERLCTPDERVWADMAPAAAAAQDFADPNVVLLVRTRQRP
HHHHHHHHHHCCCCCEEEEHHHHHCCCCHHHHHHHCHHHHHHHHCCCCCEEEEEECCCCC
DAVRFGLPDAAYHQRQPDKGLITKQEVRAVSLARMQLRAASRVWDIGAGSGSVGLEAARL
CCEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHH
CPQGHVWAMEKNEGDVEIARRNVRDFGVSNHTLVHGKAPEGLDAWPDPDAVFIGGSGGEL
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCHH
AELIALCLKRLRPGGWLVMNFVTLENLAAATQALQAAGAAWDVLQLQAARSKPILHMHRM
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
AAENPVWIVCAQAGSVGTAAVAVEEGA
CCCCCEEEEEECCCCCCEEEEEEECCC
>Mature Secondary Structure 
TTTNLLEKDPQPCRVIGVLDDGAASLSATALALLRRADLVIGGTRTLALLEDDIAPQAV
CCCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCEEECCCEEEEEECCCCCHHHH
RRDLTGCLSSVPGWIAEARAAHQACVVLATGDPLCHGIASYLASRLCIQALEVMPNVSTL
HHHHHHHHHHCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHH
QLACARLGLAWQDARIVSVHAKDAGEWTVGAEPAHGLYALAQAVRQHDRLAVLTSPDNTP
HHHHHHHCCCCCCCEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCH
ARIARLLVAEGLGDDFQISVAERLCTPDERVWADMAPAAAAAQDFADPNVVLLVRTRQRP
HHHHHHHHHHCCCCCEEEEHHHHHCCCCHHHHHHHCHHHHHHHHCCCCCEEEEEECCCCC
DAVRFGLPDAAYHQRQPDKGLITKQEVRAVSLARMQLRAASRVWDIGAGSGSVGLEAARL
CCEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHH
CPQGHVWAMEKNEGDVEIARRNVRDFGVSNHTLVHGKAPEGLDAWPDPDAVFIGGSGGEL
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCHH
AELIALCLKRLRPGGWLVMNFVTLENLAAATQALQAAGAAWDVLQLQAARSKPILHMHRM
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHH
AAENPVWIVCAQAGSVGTAAVAVEEGA
CCCCCEEEEEECCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]