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The map label for this gene is cbiC [H]

Identifier: 120608780

GI number: 120608780

Start: 78256

End: 78975

Strand: Direct

Name: cbiC [H]

Synonym: Aave_0070

Alternate gene names: 120608780

Gene position: 78256-78975 (Clockwise)

Preceding gene: 120608779

Following gene: 120608781

Centisome position: 1.46

GC content: 71.25

Gene sequence:

>720_bases
ATGAGCACGGTCAACACCGTCACCGAACAGCTCACGCGCGCCGGCCAGGCCATCGAGCACGACAGCTTCGCCATCATCGA
CGCCGAAGCCGGCCCGCATGCCTACACCGCGCAGCAGTGGCCGATCGTGCGCCGCATGATCCACGCCAATGCCGACTTCG
AATTCAACGGCCTGACCGACTTCCACCCCGAGGCGGTGGAGGCCGGCATGGCCGCCATGCTCCGCGGCGGCGCGCCGGTG
GTGGCAGACGTGGAGATGATCTGCTCGGGCCTGTCGCAGCCGCGCCTGGCCCACTTCGGCATGCGCACGCACCAGTTCAT
CAGCGACGCCGACGTGATCGCCCGGGCCCAGGCCGAGGACACCACGCGCGCCGTGCAGGCCATGCGCAAGGCGCACCGGC
TGGGGCTGCTGCAGGGCGCCGTCGTGGGCATCGGCAACGCACCCACGGCGCTCATCGAACTCGTGCGCCTGATCCGCGAA
GAGGGCGTGCGCCCGGCCCTCGTGGTGGGCATGCCGGTGGGCTTCGTCTCCGCCGCCGAATCCAAGGATTTGATGGCCGA
AGTGGCCGAGGTGCCCTGGATCGTGATCCGCGGCCGCAAGGGCGGCTCCACCCTGGTGGTGGCCGCGCTGCACGCGCTGC
TGGCGCTGGCCGAGGCGCGGCAGAAGCAACAACCGCAGCAGCCCGCACAGGGGCCGGCACGGAGCGCCACCGGAGGCTGA

Upstream 100 bases:

>100_bases
ACGCGCATGCGCACGGCCATGACCACGGGCATTCCCATTCCCATGGTCACGACCATCCCCAGCACGGCCACGCCGCACAC
CAGCCGGCCGGAGCCGCCGC

Downstream 100 bases:

>100_bases
ACCCGCCATGATGGAGAAAACCGTCCGCCGCGGCACGCGCACCGGCTTCACCACCGGGGCCTGCTCCGCCGCCGCCGCGC
GCGCCGCCGTGCTGGGCCTG

Product: precorrin-8X methylmutase

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSTVNTVTEQLTRAGQAIEHDSFAIIDAEAGPHAYTAQQWPIVRRMIHANADFEFNGLTDFHPEAVEAGMAAMLRGGAPV
VADVEMICSGLSQPRLAHFGMRTHQFISDADVIARAQAEDTTRAVQAMRKAHRLGLLQGAVVGIGNAPTALIELVRLIRE
EGVRPALVVGMPVGFVSAAESKDLMAEVAEVPWIVIRGRKGGSTLVVAALHALLALAEARQKQQPQQPAQGPARSATGG

Sequences:

>Translated_239_residues
MSTVNTVTEQLTRAGQAIEHDSFAIIDAEAGPHAYTAQQWPIVRRMIHANADFEFNGLTDFHPEAVEAGMAAMLRGGAPV
VADVEMICSGLSQPRLAHFGMRTHQFISDADVIARAQAEDTTRAVQAMRKAHRLGLLQGAVVGIGNAPTALIELVRLIRE
EGVRPALVVGMPVGFVSAAESKDLMAEVAEVPWIVIRGRKGGSTLVVAALHALLALAEARQKQQPQQPAQGPARSATGG
>Mature_238_residues
STVNTVTEQLTRAGQAIEHDSFAIIDAEAGPHAYTAQQWPIVRRMIHANADFEFNGLTDFHPEAVEAGMAAMLRGGAPVV
ADVEMICSGLSQPRLAHFGMRTHQFISDADVIARAQAEDTTRAVQAMRKAHRLGLLQGAVVGIGNAPTALIELVRLIREE
GVRPALVVGMPVGFVSAAESKDLMAEVAEVPWIVIRGRKGGSTLVVAALHALLALAEARQKQQPQQPAQGPARSATGG

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 25376; Mature: 25245

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVNTVTEQLTRAGQAIEHDSFAIIDAEAGPHAYTAQQWPIVRRMIHANADFEFNGLTD
CCHHHHHHHHHHHHCCHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCC
FHPEAVEAGMAAMLRGGAPVVADVEMICSGLSQPRLAHFGMRTHQFISDADVIARAQAED
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
TTRAVQAMRKAHRLGLLQGAVVGIGNAPTALIELVRLIREEGVRPALVVGMPVGFVSAAE
HHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
SKDLMAEVAEVPWIVIRGRKGGSTLVVAALHALLALAEARQKQQPQQPAQGPARSATGG
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STVNTVTEQLTRAGQAIEHDSFAIIDAEAGPHAYTAQQWPIVRRMIHANADFEFNGLTD
CHHHHHHHHHHHHCCHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCC
FHPEAVEAGMAAMLRGGAPVVADVEMICSGLSQPRLAHFGMRTHQFISDADVIARAQAED
CCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
TTRAVQAMRKAHRLGLLQGAVVGIGNAPTALIELVRLIREEGVRPALVVGMPVGFVSAAE
HHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
SKDLMAEVAEVPWIVIRGRKGGSTLVVAALHALLALAEARQKQQPQQPAQGPARSATGG
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]