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The map label for this gene is fkpA [H]

Identifier: 120597410

GI number: 120597410

Start: 636046

End: 636828

Strand: Direct

Name: fkpA [H]

Synonym: Sputw3181_0579

Alternate gene names: 120597410

Gene position: 636046-636828 (Clockwise)

Preceding gene: 120597409

Following gene: 120597411

Centisome position: 13.51

GC content: 43.68

Gene sequence:

>783_bases
ATGAAAACACGTATACCAGCTTCTTTTATCCCCAAAAGCATTACAGTGGCGACCTGCGCCGCATTATTTGTTTCGGTAGC
CAGTTTTGCAGGCACAGGTCTGAAAACCGATGCAGATAAAACCTCCTACAGCATTGGTGCTTCTATTGGTAATTACATTT
CAGGCCAAGTCTACAACCAAGTTGAATTGGGCTCAGAGGTCAATGTCGACTTAGTTGTGCAAGGTTTTGTGGATGCGCTT
AAAGATAAACAGCAATTAACCGACGAAGAAGTGCTGACCTACCTGAACCAAAGAGCAGAACAACTCAATGCAGCAAGAGC
CGTCGTTGCTGAAAAACAAATGGCAGAAACCAAAAAGGCAAGTGCGGCATATCTTGCTGAAAATCAAAAAAAGTCTGGCG
TTAAAGTTACCGCCTCTGGTCTTCAATACGAAGTCTTAACCCAAGGTAAAGGTCATAAACCCAATCCAGAAGATGTGGTC
ACAGTGGAATATGTTGGCACTCTTATCAATGGGACTGAGTTTGAAAATACGGTTGGACGTAAAGAGCCTACTCGCTTTGC
ATTAATGTCAGTGATCCCCGGCTGGGAAGAGGGATTAAAGTTGATGCCTGTGGGGTCTAAATACCGTTTTGTGGTACCCG
CAAGCCTTGCCTATGGCGCTGAAGCTGTAGGCATTATCCCACCTGAGTCAGCACTTATCTTTGAAATTGAACTGAAAAAT
ATTGAGAAACCCAGCGAAATGAAAGAGATGAAAAATAAAAAGATGATGCCTGCACACGGTTAA

Upstream 100 bases:

>100_bases
ACAGAAAAACCTTAGTAACACACAAGGCCGATGTTTTATCGGTTTGGTTTGCAGGGCCAAAAGGCGAAACCCACAGGGTT
AACATTGTAGAGAACATAAT

Downstream 100 bases:

>100_bases
TCAGGCTCCTAAAACGAGTTGTTTGGAGAGTGAAATGGAGACTGGAATGGTGAGCTTAGGACTAGGCATTGGCATCAGTT
TACTGGTGTTTGTTGCTTAC

Product: peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKTRIPASFIPKSITVATCAALFVSVASFAGTGLKTDADKTSYSIGASIGNYISGQVYNQVELGSEVNVDLVVQGFVDAL
KDKQQLTDEEVLTYLNQRAEQLNAARAVVAEKQMAETKKASAAYLAENQKKSGVKVTASGLQYEVLTQGKGHKPNPEDVV
TVEYVGTLINGTEFENTVGRKEPTRFALMSVIPGWEEGLKLMPVGSKYRFVVPASLAYGAEAVGIIPPESALIFEIELKN
IEKPSEMKEMKNKKMMPAHG

Sequences:

>Translated_260_residues
MKTRIPASFIPKSITVATCAALFVSVASFAGTGLKTDADKTSYSIGASIGNYISGQVYNQVELGSEVNVDLVVQGFVDAL
KDKQQLTDEEVLTYLNQRAEQLNAARAVVAEKQMAETKKASAAYLAENQKKSGVKVTASGLQYEVLTQGKGHKPNPEDVV
TVEYVGTLINGTEFENTVGRKEPTRFALMSVIPGWEEGLKLMPVGSKYRFVVPASLAYGAEAVGIIPPESALIFEIELKN
IEKPSEMKEMKNKKMMPAHG
>Mature_260_residues
MKTRIPASFIPKSITVATCAALFVSVASFAGTGLKTDADKTSYSIGASIGNYISGQVYNQVELGSEVNVDLVVQGFVDAL
KDKQQLTDEEVLTYLNQRAEQLNAARAVVAEKQMAETKKASAAYLAENQKKSGVKVTASGLQYEVLTQGKGHKPNPEDVV
TVEYVGTLINGTEFENTVGRKEPTRFALMSVIPGWEEGLKLMPVGSKYRFVVPASLAYGAEAVGIIPPESALIFEIELKN
IEKPSEMKEMKNKKMMPAHG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=37.3831775700935, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=37.3831775700935, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=35.5140186915888, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI206725530, Length=93, Percent_Identity=39.7849462365591, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI17149844, Length=93, Percent_Identity=39.7849462365591, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI17149842, Length=93, Percent_Identity=39.7849462365591, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=38.5321100917431, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI87082390, Length=205, Percent_Identity=41.9512195121951, Blast_Score=134, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324194, Length=88, Percent_Identity=40.9090909090909, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=41.4893617021277, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=113, Percent_Identity=36.283185840708, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323566, Length=113, Percent_Identity=34.5132743362832, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281363946, Length=112, Percent_Identity=37.5, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17352457, Length=112, Percent_Identity=37.5, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24655568, Length=86, Percent_Identity=39.5348837209302, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28125; Mature: 28125

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRIPASFIPKSITVATCAALFVSVASFAGTGLKTDADKTSYSIGASIGNYISGQVYNQ
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCHH
VELGSEVNVDLVVQGFVDALKDKQQLTDEEVLTYLNQRAEQLNAARAVVAEKQMAETKKA
HHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAYLAENQKKSGVKVTASGLQYEVLTQGKGHKPNPEDVVTVEYVGTLINGTEFENTVGR
HHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCCCCCEEEHEEHHHHHCCCCCHHHCCC
KEPTRFALMSVIPGWEEGLKLMPVGSKYRFVVPASLAYGAEAVGIIPPESALIFEIELKN
CCCHHHHHHHHCCCHHHCCEEEECCCCEEEEEECHHHCCCCEEEECCCCCEEEEEEEECC
IEKPSEMKEMKNKKMMPAHG
CCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKTRIPASFIPKSITVATCAALFVSVASFAGTGLKTDADKTSYSIGASIGNYISGQVYNQ
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCCCCHH
VELGSEVNVDLVVQGFVDALKDKQQLTDEEVLTYLNQRAEQLNAARAVVAEKQMAETKKA
HHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAYLAENQKKSGVKVTASGLQYEVLTQGKGHKPNPEDVVTVEYVGTLINGTEFENTVGR
HHHHHHHCCCCCCEEEEECCCEEEEEECCCCCCCCCCCEEEHEEHHHHHCCCCCHHHCCC
KEPTRFALMSVIPGWEEGLKLMPVGSKYRFVVPASLAYGAEAVGIIPPESALIFEIELKN
CCCHHHHHHHHCCCHHHCCEEEECCCCEEEEEECHHHCCCCEEEECCCCCEEEEEEEECC
IEKPSEMKEMKNKKMMPAHG
CCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]