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The map label for this gene is mutL

Identifier: 119946846

GI number: 119946846

Start: 3996896

End: 3998782

Strand: Reverse

Name: mutL

Synonym: Ping_3240

Alternate gene names: 119946846

Gene position: 3998782-3996896 (Counterclockwise)

Preceding gene: 119946847

Following gene: 119946845

Centisome position: 87.7

GC content: 43.14

Gene sequence:

>1887_bases
ATGCCTATTCAAATTTTAGCTGCTCGCCTGGCTAACCAAATTGCTGCGGGTGAGGTCGTTGAACGCCCGGCTTCGGTGGT
TAAAGAGCTGATTGAAAACAGCTTAGATGCCGGGGCGACAAAAATTGAGATCGATATTGAAAAGGGCGGCGCAAAATGTA
TCCGTGTCAAAGACAATGGTGCAGGCGTTTGTCAAGAACAGCTGACCCTGGCATTAAGCCGTCATGCAACCAGTAAAATA
AGCCATTTAGACGATCTCGAAGCGATTGTCAGCTTGGGTTTTCGCGGAGAAGCCTTAGCCAGTGTCAGCTCTGTCTCGCG
TCTGACATTTACTTCTAAACCCGCCGATCAGGAGCAGGCCTGGCAAGCGATCGCTGAAGGCCGGGATATGCAGGTGACTA
TTCAACCTGCCGCACATCCCCAGGGAACAACGGTGGAGGTTTTGGATCTGTTTTTTAATACCCCCGCCAGGCGGCGGTTT
TTAAAAACAGAAAAAACGGAATTTCAGCATATTGACGAGTTGATTCGGCGCATCGCATTAAGCCGTTTTGAAATTACTTT
TGTACTGAAACATAATCATAAAATTGTTCATCAGTATCGCGCCACACAAACACAAAGTCAGCAGGAAAAACGTCTTGCTT
CTATCTGCAGTGAAAGTTTTGTCAGCAGCGCCTTATATTTTCAAAATAGCGATAATGCGTTAAAAATATCCGGTTGGGTT
TCAGATAAGCTCTCCGCACGGTCATCAAACGATGTGCAGTACTGCTATATTAATGGCAGAGTGATCCGCGATAAATTAAT
TAACCATGCGATCAAGCAGGTTTATGCTTACTCCTTACCTCAGGGGAAATTCCCCGCTTATGTTATCTATATTGAATGTG
ATCCGGATCAAGTGGATGTAAATGTGCACCCCTCAAAACATGAGGTACGTTTTCATCAGGCGCGTTGGGTACATGATTTT
ATCGTCAGCACCTTAACGGTGACACTAAATGAATCCCCCTTGTCGGCATCAGAACCACAATCACAACCAAAACCAAGTGA
ACACGCTTATTTACCCGCCAACCGCGGGGAGGAAAAAACTGATTCTCAGTATGAGCCAAAAGAAAAAAATAAAAGTGCCG
GGCGGGTTAATGAGCAAACAGCAGCGCCATCTTCAGGTTATGCTAAGCGCGAAACAAACCCACAACTGGATCAGGCTAAA
ATGGCGGCCTATTGCGATTTTGTCGCGGAAGCTCACTTACCTTTCTCGGCAGACGAACAACAATCATCTACTTTATCTGA
TCTGACTTTTGCGACTGTCGTGTGTTTGATCGACAGGCAATATTTATTAATTAAGCTCAATGCAAAGCAGCAGCTGCTCA
ATATTGACTCGCCTTTTTTAGTGTTGTCCTTGGAAAACGTTGATTTAATGATTAAGCAAATGGAATTATTTGCTGCCTGG
TCCGATGGAGAAGTAATAGCACAACCTTTGTTATTACCCGTGCGTGTGGAGCTTGATGCGCTTTTATTGAAAACTAGCGA
AGACTTTAATGAGTTATTTATGCGCTTAGGTTTTGTTTTTAAAATACAGGGCAGCAAGCTGATTATTAGTAAAGTGCCCG
CGCTACTCAGGCAGGCACCGGTTGCGAAAATTATACCTGAGTTATTAACCTTTTTAAGTCAAACAGATAACAATATGGAT
GCACAACAGGTTAATCTCTTTTGTGTCTTTTTAGTCAACACATTAAAACAGCAGCAAGCAGAAAATATTAACTGGACTGA
GCAAAGTGCCAAAGCGCTTTTTGACTTATTACTTTCGTTGTTCTCGGAAAAGCTTAGTGACTGGCAGAAACAATTATTTA
GAGTGCCCGATTTATCATTATTAGTACAAGGTTTTTCACATGAATAA

Upstream 100 bases:

>100_bases
GATGTTATTAAAGAATTTAATAAACTCAGTTCAACTTTGCTTAGGGTTGGTCAAGTTTTAACCATTCCTGTTAGTTAATC
GATTTCGGATACCCGTTTTT

Downstream 100 bases:

>100_bases
CTATCCGACCGCCCTGTTTTTAATGGGGCCTACGGCTTCTGGAAAAACCGATTTAGCCATAAAATTAGCCTTGCAATGTG
ACTGTGAAATTATCAGTGTT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 628; Mature: 627

Protein sequence:

>628_residues
MPIQILAARLANQIAAGEVVERPASVVKELIENSLDAGATKIEIDIEKGGAKCIRVKDNGAGVCQEQLTLALSRHATSKI
SHLDDLEAIVSLGFRGEALASVSSVSRLTFTSKPADQEQAWQAIAEGRDMQVTIQPAAHPQGTTVEVLDLFFNTPARRRF
LKTEKTEFQHIDELIRRIALSRFEITFVLKHNHKIVHQYRATQTQSQQEKRLASICSESFVSSALYFQNSDNALKISGWV
SDKLSARSSNDVQYCYINGRVIRDKLINHAIKQVYAYSLPQGKFPAYVIYIECDPDQVDVNVHPSKHEVRFHQARWVHDF
IVSTLTVTLNESPLSASEPQSQPKPSEHAYLPANRGEEKTDSQYEPKEKNKSAGRVNEQTAAPSSGYAKRETNPQLDQAK
MAAYCDFVAEAHLPFSADEQQSSTLSDLTFATVVCLIDRQYLLIKLNAKQQLLNIDSPFLVLSLENVDLMIKQMELFAAW
SDGEVIAQPLLLPVRVELDALLLKTSEDFNELFMRLGFVFKIQGSKLIISKVPALLRQAPVAKIIPELLTFLSQTDNNMD
AQQVNLFCVFLVNTLKQQQAENINWTEQSAKALFDLLLSLFSEKLSDWQKQLFRVPDLSLLVQGFSHE

Sequences:

>Translated_628_residues
MPIQILAARLANQIAAGEVVERPASVVKELIENSLDAGATKIEIDIEKGGAKCIRVKDNGAGVCQEQLTLALSRHATSKI
SHLDDLEAIVSLGFRGEALASVSSVSRLTFTSKPADQEQAWQAIAEGRDMQVTIQPAAHPQGTTVEVLDLFFNTPARRRF
LKTEKTEFQHIDELIRRIALSRFEITFVLKHNHKIVHQYRATQTQSQQEKRLASICSESFVSSALYFQNSDNALKISGWV
SDKLSARSSNDVQYCYINGRVIRDKLINHAIKQVYAYSLPQGKFPAYVIYIECDPDQVDVNVHPSKHEVRFHQARWVHDF
IVSTLTVTLNESPLSASEPQSQPKPSEHAYLPANRGEEKTDSQYEPKEKNKSAGRVNEQTAAPSSGYAKRETNPQLDQAK
MAAYCDFVAEAHLPFSADEQQSSTLSDLTFATVVCLIDRQYLLIKLNAKQQLLNIDSPFLVLSLENVDLMIKQMELFAAW
SDGEVIAQPLLLPVRVELDALLLKTSEDFNELFMRLGFVFKIQGSKLIISKVPALLRQAPVAKIIPELLTFLSQTDNNMD
AQQVNLFCVFLVNTLKQQQAENINWTEQSAKALFDLLLSLFSEKLSDWQKQLFRVPDLSLLVQGFSHE
>Mature_627_residues
PIQILAARLANQIAAGEVVERPASVVKELIENSLDAGATKIEIDIEKGGAKCIRVKDNGAGVCQEQLTLALSRHATSKIS
HLDDLEAIVSLGFRGEALASVSSVSRLTFTSKPADQEQAWQAIAEGRDMQVTIQPAAHPQGTTVEVLDLFFNTPARRRFL
KTEKTEFQHIDELIRRIALSRFEITFVLKHNHKIVHQYRATQTQSQQEKRLASICSESFVSSALYFQNSDNALKISGWVS
DKLSARSSNDVQYCYINGRVIRDKLINHAIKQVYAYSLPQGKFPAYVIYIECDPDQVDVNVHPSKHEVRFHQARWVHDFI
VSTLTVTLNESPLSASEPQSQPKPSEHAYLPANRGEEKTDSQYEPKEKNKSAGRVNEQTAAPSSGYAKRETNPQLDQAKM
AAYCDFVAEAHLPFSADEQQSSTLSDLTFATVVCLIDRQYLLIKLNAKQQLLNIDSPFLVLSLENVDLMIKQMELFAAWS
DGEVIAQPLLLPVRVELDALLLKTSEDFNELFMRLGFVFKIQGSKLIISKVPALLRQAPVAKIIPELLTFLSQTDNNMDA
QQVNLFCVFLVNTLKQQQAENINWTEQSAKALFDLLLSLFSEKLSDWQKQLFRVPDLSLLVQGFSHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=315, Percent_Identity=36.5079365079365, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI4505911, Length=317, Percent_Identity=28.7066246056782, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI189458898, Length=317, Percent_Identity=28.7066246056782, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI189458896, Length=310, Percent_Identity=28.3870967741935, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=28.7390029325513, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI310128478, Length=341, Percent_Identity=28.7390029325513, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI263191589, Length=221, Percent_Identity=32.579185520362, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI310128480, Length=294, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI91992162, Length=337, Percent_Identity=23.4421364985163, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI91992160, Length=337, Percent_Identity=23.4421364985163, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1790612, Length=567, Percent_Identity=48.1481481481481, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=33.75, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=346, Percent_Identity=27.7456647398844, Blast_Score=126, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=357, Percent_Identity=34.453781512605, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=375, Percent_Identity=27.7333333333333, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=348, Percent_Identity=26.7241379310345, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=184, Percent_Identity=32.0652173913043, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136968, Length=313, Percent_Identity=33.8658146964856, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17136970, Length=181, Percent_Identity=35.9116022099448, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_PSYIN (A1SZL2)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944526.1
- ProteinModelPortal:   A1SZL2
- STRING:   A1SZL2
- GeneID:   4626338
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3240
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- PhylomeDB:   A1SZL2
- BioCyc:   PING357804:PING_3240-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70469; Mature: 70338

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQILAARLANQIAAGEVVERPASVVKELIENSLDAGATKIEIDIEKGGAKCIRVKDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
AGVCQEQLTLALSRHATSKISHLDDLEAIVSLGFRGEALASVSSVSRLTFTSKPADQEQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCHHHH
WQAIAEGRDMQVTIQPAAHPQGTTVEVLDLFFNTPARRRFLKTEKTEFQHIDELIRRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SRFEITFVLKHNHKIVHQYRATQTQSQQEKRLASICSESFVSSALYFQNSDNALKISGWV
HHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCC
SDKLSARSSNDVQYCYINGRVIRDKLINHAIKQVYAYSLPQGKFPAYVIYIECDPDQVDV
CHHHCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEE
NVHPSKHEVRFHQARWVHDFIVSTLTVTLNESPLSASEPQSQPKPSEHAYLPANRGEEKT
EECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCC
DSQYEPKEKNKSAGRVNEQTAAPSSGYAKRETNPQLDQAKMAAYCDFVAEAHLPFSADEQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
QSSTLSDLTFATVVCLIDRQYLLIKLNAKQQLLNIDSPFLVLSLENVDLMIKQMELFAAW
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHCCCCCEEEEEECCHHHHHHHHHHHEEC
SDGEVIAQPLLLPVRVELDALLLKTSEDFNELFMRLGFVFKIQGSKLIISKVPALLRQAP
CCCCHHHCCCEEEEEECHHHHEEECCCCHHHHHHHCCEEEEECCCEEHHHHHHHHHHHCC
VAKIIPELLTFLSQTDNNMDAQQVNLFCVFLVNTLKQQQAENINWTEQSAKALFDLLLSL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FSEKLSDWQKQLFRVPDLSLLVQGFSHE
HHHHHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure 
PIQILAARLANQIAAGEVVERPASVVKELIENSLDAGATKIEIDIEKGGAKCIRVKDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
AGVCQEQLTLALSRHATSKISHLDDLEAIVSLGFRGEALASVSSVSRLTFTSKPADQEQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCHHHH
WQAIAEGRDMQVTIQPAAHPQGTTVEVLDLFFNTPARRRFLKTEKTEFQHIDELIRRIAL
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SRFEITFVLKHNHKIVHQYRATQTQSQQEKRLASICSESFVSSALYFQNSDNALKISGWV
HHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCC
SDKLSARSSNDVQYCYINGRVIRDKLINHAIKQVYAYSLPQGKFPAYVIYIECDPDQVDV
CHHHCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEE
NVHPSKHEVRFHQARWVHDFIVSTLTVTLNESPLSASEPQSQPKPSEHAYLPANRGEEKT
EECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCEECCCCCCCCCC
DSQYEPKEKNKSAGRVNEQTAAPSSGYAKRETNPQLDQAKMAAYCDFVAEAHLPFSADEQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
QSSTLSDLTFATVVCLIDRQYLLIKLNAKQQLLNIDSPFLVLSLENVDLMIKQMELFAAW
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHCCCCCEEEEEECCHHHHHHHHHHHEEC
SDGEVIAQPLLLPVRVELDALLLKTSEDFNELFMRLGFVFKIQGSKLIISKVPALLRQAP
CCCCHHHCCCEEEEEECHHHHEEECCCCHHHHHHHCCEEEEECCCEEHHHHHHHHHHHCC
VAKIIPELLTFLSQTDNNMDAQQVNLFCVFLVNTLKQQQAENINWTEQSAKALFDLLLSL
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FSEKLSDWQKQLFRVPDLSLLVQGFSHE
HHHHHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA