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The map label for this gene is hisD [H]

Identifier: 119945368

GI number: 119945368

Start: 2013100

End: 2014407

Strand: Reverse

Name: hisD [H]

Synonym: Ping_1656

Alternate gene names: 119945368

Gene position: 2014407-2013100 (Counterclockwise)

Preceding gene: 119945369

Following gene: 119945367

Centisome position: 44.18

GC content: 45.26

Gene sequence:

>1308_bases
ATGCAAACTAAGATGAGGACAGTTAACTGGTTAGATTTATCCAATAAGCAACAAGCACTACTGCTTACTCGTCCTGCAAT
GGCGGATTCTGCCGGACTGAAAACAACCGTCTCTGAAATCATTTCTGATGTTCGTATTAAAGGTGATCGCGCCCTTTTAG
ATTATACTAAACGTTTTGATAAATTAGATGGCGAAAACTTTACCATTTCAGAAGCGCAAATTCAGCAGGCAAGTGCACGT
TTAGGTGATGATATTAAAACAGCTATCCGCACCGCTTATAACCACGTGGTTATATTTCATAAGGCGCAAGTGCAGGATGT
AATCCGTGTTGAAACCATGCCGGGTGTGGTTTGTGAAATGCACACTCAAGCCATTGAATCAGTCGGTCTCTATATCCCAG
GTGGCAGTGCCCCACTGCCCTCAACGGTTATTATGACCGGAGCACCTGCGCAAATTGCCGGTTGCAGCCGCTTAGTACTG
TGTACGCCACCTCCCGTGGCCGATGAAATTTTATTTGCCGCCTCACTGTGCGGCGTAAACGAAATTTACACTGTAGGGGG
TGCACAGGCAATTGCCGCTTTAGCCTATGGCACAGACACCATTGCCTCTGTTGATAAAATTTTTGGTCCCGGCAATGCCT
ATGTTACGGAAGCAAAACGTCAGGTAAGTAATGATTTTGCCGGTGCCGCCATTGATATGCCGGCAGGTCCTTCGGAAGTA
CTGGTCATTGCAGATGAGAATGCTAATCCCACTTTTATCGCCGCAGACTTGCTCTCTCAAGCTGAGCATGGCCATGACTC
ACAATCTATATTAGTGACTCCAAGCCTTGCTGTTGCAGAGCAAACCGCCATTGAGATTAAGCAACAATTAGCTGTTTTAG
AACGTCGTGACATCGCAGAAAAGGCATTAGCACACAGTGTTAGTATCATTTGTAAAGATATCCAGCAGGCATGTGAAATT
TCCAATCGTTATGCCCCGGAGCACTTGATAGTTCAAACAGCCAATCCAAGAGCTTTACAGCCAAAACTTAAAAATGCCGG
TTCCATATTCTTAGGCGCCTGGACACCTGAGTCAGTGGGCGATTACGCCAGTGGGACAAACCATGTTTTACCTACTTATG
GTTATACCCGTACCTATTCAAGTTTAGGCTTAGCAGACTTTGTTAAACGTTATACTGTGCAGGAATTGACTGAAGACGGC
TTGCTTAATTTAGCCCCTACGGTGACCTGTCTTGCAGACGCAGAAGGGTTAACGGCGCATAAACGTGCTGTTACTATCCG
TGTAGATAAATTAAACAGTACAAAATAA

Upstream 100 bases:

>100_bases
TAAGCAAAGAAAACTTATTCTGGGAAACAATGGAGCAGCTTAAAACCTTAGGCGCGAGCTCTATTCTAGTGTTACCCATT
GAAAAAATGATGGAGTAGAT

Downstream 100 bases:

>100_bases
CAGTACAAAATAATCGCCTGTAATAAAGTTAACTTTTAATAATTTTGGGCAAATGTTGAGTGTTATAAAACAGGCACGCT
AACATTTGCCGCGGACATCA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MQTKMRTVNWLDLSNKQQALLLTRPAMADSAGLKTTVSEIISDVRIKGDRALLDYTKRFDKLDGENFTISEAQIQQASAR
LGDDIKTAIRTAYNHVVIFHKAQVQDVIRVETMPGVVCEMHTQAIESVGLYIPGGSAPLPSTVIMTGAPAQIAGCSRLVL
CTPPPVADEILFAASLCGVNEIYTVGGAQAIAALAYGTDTIASVDKIFGPGNAYVTEAKRQVSNDFAGAAIDMPAGPSEV
LVIADENANPTFIAADLLSQAEHGHDSQSILVTPSLAVAEQTAIEIKQQLAVLERRDIAEKALAHSVSIICKDIQQACEI
SNRYAPEHLIVQTANPRALQPKLKNAGSIFLGAWTPESVGDYASGTNHVLPTYGYTRTYSSLGLADFVKRYTVQELTEDG
LLNLAPTVTCLADAEGLTAHKRAVTIRVDKLNSTK

Sequences:

>Translated_435_residues
MQTKMRTVNWLDLSNKQQALLLTRPAMADSAGLKTTVSEIISDVRIKGDRALLDYTKRFDKLDGENFTISEAQIQQASAR
LGDDIKTAIRTAYNHVVIFHKAQVQDVIRVETMPGVVCEMHTQAIESVGLYIPGGSAPLPSTVIMTGAPAQIAGCSRLVL
CTPPPVADEILFAASLCGVNEIYTVGGAQAIAALAYGTDTIASVDKIFGPGNAYVTEAKRQVSNDFAGAAIDMPAGPSEV
LVIADENANPTFIAADLLSQAEHGHDSQSILVTPSLAVAEQTAIEIKQQLAVLERRDIAEKALAHSVSIICKDIQQACEI
SNRYAPEHLIVQTANPRALQPKLKNAGSIFLGAWTPESVGDYASGTNHVLPTYGYTRTYSSLGLADFVKRYTVQELTEDG
LLNLAPTVTCLADAEGLTAHKRAVTIRVDKLNSTK
>Mature_435_residues
MQTKMRTVNWLDLSNKQQALLLTRPAMADSAGLKTTVSEIISDVRIKGDRALLDYTKRFDKLDGENFTISEAQIQQASAR
LGDDIKTAIRTAYNHVVIFHKAQVQDVIRVETMPGVVCEMHTQAIESVGLYIPGGSAPLPSTVIMTGAPAQIAGCSRLVL
CTPPPVADEILFAASLCGVNEIYTVGGAQAIAALAYGTDTIASVDKIFGPGNAYVTEAKRQVSNDFAGAAIDMPAGPSEV
LVIADENANPTFIAADLLSQAEHGHDSQSILVTPSLAVAEQTAIEIKQQLAVLERRDIAEKALAHSVSIICKDIQQACEI
SNRYAPEHLIVQTANPRALQPKLKNAGSIFLGAWTPESVGDYASGTNHVLPTYGYTRTYSSLGLADFVKRYTVQELTEDG
LLNLAPTVTCLADAEGLTAHKRAVTIRVDKLNSTK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=425, Percent_Identity=57.6470588235294, Blast_Score=498, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=48.2100238663485, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46601; Mature: 46601

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKMRTVNWLDLSNKQQALLLTRPAMADSAGLKTTVSEIISDVRIKGDRALLDYTKRFD
CCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHH
KLDGENFTISEAQIQQASARLGDDIKTAIRTAYNHVVIFHKAQVQDVIRVETMPGVVCEM
HCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHCEEEEEEEHHHHHHHHECCCCCHHHHH
HTQAIESVGLYIPGGSAPLPSTVIMTGAPAQIAGCSRLVLCTPPPVADEILFAASLCGVN
HHHHHHHCCEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCC
EIYTVGGAQAIAALAYGTDTIASVDKIFGPGNAYVTEAKRQVSNDFAGAAIDMPAGPSEV
CEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCE
LVIADENANPTFIAADLLSQAEHGHDSQSILVTPSLAVAEQTAIEIKQQLAVLERRDIAE
EEEEECCCCCCEEHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
KALAHSVSIICKDIQQACEISNRYAPEHLIVQTANPRALQPKLKNAGSIFLGAWTPESVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHCCCCCEEEEECCCHHHC
DYASGTNHVLPTYGYTRTYSSLGLADFVKRYTVQELTEDGLLNLAPTVTCLADAEGLTAH
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCC
KRAVTIRVDKLNSTK
CEEEEEEEECCCCCC
>Mature Secondary Structure
MQTKMRTVNWLDLSNKQQALLLTRPAMADSAGLKTTVSEIISDVRIKGDRALLDYTKRFD
CCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHH
KLDGENFTISEAQIQQASARLGDDIKTAIRTAYNHVVIFHKAQVQDVIRVETMPGVVCEM
HCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHCEEEEEEEHHHHHHHHECCCCCHHHHH
HTQAIESVGLYIPGGSAPLPSTVIMTGAPAQIAGCSRLVLCTPPPVADEILFAASLCGVN
HHHHHHHCCEEECCCCCCCCCEEEEECCCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCC
EIYTVGGAQAIAALAYGTDTIASVDKIFGPGNAYVTEAKRQVSNDFAGAAIDMPAGPSEV
CEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCCE
LVIADENANPTFIAADLLSQAEHGHDSQSILVTPSLAVAEQTAIEIKQQLAVLERRDIAE
EEEEECCCCCCEEHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
KALAHSVSIICKDIQQACEISNRYAPEHLIVQTANPRALQPKLKNAGSIFLGAWTPESVG
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHCCCCCEEEEECCCHHHC
DYASGTNHVLPTYGYTRTYSSLGLADFVKRYTVQELTEDGLLNLAPTVTCLADAEGLTAH
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCEECCCCEEEEECCCCCCCC
KRAVTIRVDKLNSTK
CEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]