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The map label for this gene is hisG

Identifier: 119945369

GI number: 119945369

Start: 2014410

End: 2015306

Strand: Reverse

Name: hisG

Synonym: Ping_1657

Alternate gene names: 119945369

Gene position: 2015306-2014410 (Counterclockwise)

Preceding gene: 119945370

Following gene: 119945368

Centisome position: 44.2

GC content: 41.69

Gene sequence:

>897_bases
ATGCCAGAGCAACGTTTAAGAATTGCAATACAGAAGAAAGGTCGTTTAAGTGAAGATACCGTTAAGTTATTAAAAGCTTG
TGGTGTAAAAGTTAACCTCAATACCCAACGCTTAATTGCGCACAGTGACAATATGGCCATTGATATTCTGCGCGTGCGCG
ATGATGATATTCCAGGCTTAATAATGGATGGTGTGGTTGACCTTGGTTTTATCGGTCAAAATGTACTTGAAGAAGAAAAC
ATGATGCGGACAGTGGCAAAAGAGCCAACCGCACACAAAGTAGTTAAAGAACTCGCTTTTGGTGCCTGTCGTTTCTCCAT
TGCTGTTGATCAGGATTTTGATTATCAAGGTGCCAAATCACTGGCCAATTTACGCATTGCAACAACTTATGTTCATATCC
TTAAGCGCTTTATGGAAGAACAAAATATCCCTTACACATCTTGTATGTTAACTGGCTCTGTTGAAGTGGCTCCGCGTGCA
GGCCTTGCCGATGCAATTTGTGATCTGGTCTCAACCGGTGCAACGCTTGAAGCAAATGGTCTTAAAGAAGTTGAAGTTAT
CTATCGTTCAACCGCGGTTTTAATACAGCGCGCAGACCCCTTAAACCAACAAAAACAAGATTTAGTTAATCGTCTTTTAA
CCCGTATTGATGGTGTACAGTCAGCTAAAGAATGTAAATACATTATGTTACATGCACCAACGGCTAATTTAGAAGCAATC
AAATCGCTATTACCGGGTTCAGAGCAACCAACAGTCATGCAACTTTCAGGCAGCAGTGACCATGTCGCCCTGCACGTGGT
AAGCAAAGAAAACTTATTCTGGGAAACAATGGAGCAGCTTAAAACCTTAGGCGCGAGCTCTATTCTAGTGTTACCCATTG
AAAAAATGATGGAGTAG

Upstream 100 bases:

>100_bases
TGGGAGAATTTTTGCGTTCTTCCAGAGGTTACCAATAAAATAAACCCCCGGAAGTCCGCCTCCCGAGGGTTTTTTAGTTT
TTAAGACAAGGGAAATAAGA

Downstream 100 bases:

>100_bases
ATATGCAAACTAAGATGAGGACAGTTAACTGGTTAGATTTATCCAATAAGCAACAAGCACTACTGCTTACTCGTCCTGCA
ATGGCGGATTCTGCCGGACT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MPEQRLRIAIQKKGRLSEDTVKLLKACGVKVNLNTQRLIAHSDNMAIDILRVRDDDIPGLIMDGVVDLGFIGQNVLEEEN
MMRTVAKEPTAHKVVKELAFGACRFSIAVDQDFDYQGAKSLANLRIATTYVHILKRFMEEQNIPYTSCMLTGSVEVAPRA
GLADAICDLVSTGATLEANGLKEVEVIYRSTAVLIQRADPLNQQKQDLVNRLLTRIDGVQSAKECKYIMLHAPTANLEAI
KSLLPGSEQPTVMQLSGSSDHVALHVVSKENLFWETMEQLKTLGASSILVLPIEKMME

Sequences:

>Translated_298_residues
MPEQRLRIAIQKKGRLSEDTVKLLKACGVKVNLNTQRLIAHSDNMAIDILRVRDDDIPGLIMDGVVDLGFIGQNVLEEEN
MMRTVAKEPTAHKVVKELAFGACRFSIAVDQDFDYQGAKSLANLRIATTYVHILKRFMEEQNIPYTSCMLTGSVEVAPRA
GLADAICDLVSTGATLEANGLKEVEVIYRSTAVLIQRADPLNQQKQDLVNRLLTRIDGVQSAKECKYIMLHAPTANLEAI
KSLLPGSEQPTVMQLSGSSDHVALHVVSKENLFWETMEQLKTLGASSILVLPIEKMME
>Mature_297_residues
PEQRLRIAIQKKGRLSEDTVKLLKACGVKVNLNTQRLIAHSDNMAIDILRVRDDDIPGLIMDGVVDLGFIGQNVLEEENM
MRTVAKEPTAHKVVKELAFGACRFSIAVDQDFDYQGAKSLANLRIATTYVHILKRFMEEQNIPYTSCMLTGSVEVAPRAG
LADAICDLVSTGATLEANGLKEVEVIYRSTAVLIQRADPLNQQKQDLVNRLLTRIDGVQSAKECKYIMLHAPTANLEAIK
SLLPGSEQPTVMQLSGSSDHVALHVVSKENLFWETMEQLKTLGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=63.6054421768708, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6320896, Length=296, Percent_Identity=28.3783783783784, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PSYIN (A1SVD5)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_943049.1
- ProteinModelPortal:   A1SVD5
- SMR:   A1SVD5
- STRING:   A1SVD5
- GeneID:   4626936
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_1657
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   A1SVD5
- ProtClustDB:   PRK00489
- BioCyc:   PING357804:PING_1657-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32958; Mature: 32827

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQRLRIAIQKKGRLSEDTVKLLKACGVKVNLNTQRLIAHSDNMAIDILRVRDDDIPGL
CCCCCEEEEECCCCCCCHHHHHHHHHCCCEEECCHHEEEEECCCCEEEEEEECCCCCCCH
IMDGVVDLGFIGQNVLEEENMMRTVAKEPTAHKVVKELAFGACRFSIAVDQDFDYQGAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCCCCHHHH
LANLRIATTYVHILKRFMEEQNIPYTSCMLTGSVEVAPRAGLADAICDLVSTGATLEANG
HHHHHHHHHHHHHHHHHHHHCCCCEEHEEEECCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEVEVIYRSTAVLIQRADPLNQQKQDLVNRLLTRIDGVQSAKECKYIMLHAPTANLEAI
CHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHH
KSLLPGSEQPTVMQLSGSSDHVALHVVSKENLFWETMEQLKTLGASSILVLPIEKMME
HHHCCCCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
PEQRLRIAIQKKGRLSEDTVKLLKACGVKVNLNTQRLIAHSDNMAIDILRVRDDDIPGL
CCCCEEEEECCCCCCCHHHHHHHHHCCCEEECCHHEEEEECCCCEEEEEEECCCCCCCH
IMDGVVDLGFIGQNVLEEENMMRTVAKEPTAHKVVKELAFGACRFSIAVDQDFDYQGAKS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCCCCHHHH
LANLRIATTYVHILKRFMEEQNIPYTSCMLTGSVEVAPRAGLADAICDLVSTGATLEANG
HHHHHHHHHHHHHHHHHHHHCCCCEEHEEEECCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEVEVIYRSTAVLIQRADPLNQQKQDLVNRLLTRIDGVQSAKECKYIMLHAPTANLEAI
CHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHH
KSLLPGSEQPTVMQLSGSSDHVALHVVSKENLFWETMEQLKTLGASSILVLPIEKMME
HHHCCCCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA