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The map label for this gene is hemL

Identifier: 119944626

GI number: 119944626

Start: 1083138

End: 1084415

Strand: Reverse

Name: hemL

Synonym: Ping_0865

Alternate gene names: 119944626

Gene position: 1084415-1083138 (Counterclockwise)

Preceding gene: 119944632

Following gene: 119944625

Centisome position: 23.78

GC content: 43.19

Gene sequence:

>1278_bases
ATGAGCATATCTAACCAACTTTTCGATCGGGCACAAGCAATTATTCCAGGTGGTGTTAACTCTCCAGCTCGCGCATTCAA
TGGCGTTGGTGGTGACCCTCTATTTATTGAAAAAGCACAAGGTGCTTACATTTATGATGTTGATAAAAAAAGCTATATTG
ATTATGTCGGGTCATGGGGACCGATGATTTTAGGACATAATCATCCGGAGATTAAAGCGGCGGTTATTGCAGCTGTTGAA
AATGGCTTAAGTTTTGGTGCCCCAACCGAAATAGAAATCATCATGGCAGAAAAAGTAAAAAGTTTAGTGCCGTCAATGGA
GCAGGTGCGCATGGTAAGCTCAGGGACTGAAGCCACCATGAGTGCAATACGTTTAGCCCGAGGTTACACAGGTCGTGACA
AGATTTTAAAGTTTGAAGGTAATTATCACGGCCACTCCGATTCATTATTGGTAAAAGCAGGATCCGGCGCACTTACATTA
GGCCAACCAAGCTCTCCCGGTATTCCAGCTGATTTTGCAAAACACACTCTAACAGCCACCTATAACGACTTAGCCTCTGT
ACAACAACTGTTTACTGAGTATAAAGATCAGATCGCCTGCATCATCGTTGAACCGGTTGCAGGTAACATGAACTGTATTC
TTCCTCAAGAAGGGTTTTTACAGGGATTAAGAGAGATTTGTGACGCTAATGATGCATTGTTAATTTTAGATGAAGTCATG
ACAGGTTTCCGGGTTGCGCTCGGTGGCGCACAAGCTTATTACGATATCAAACCAGATTTAACCACTTTAGGCAAAGTGAT
CGGCGGTGGCATGCCGGTTGGGGCATTTGGTGGCAGTAAAAAAGTCATGCAGCATATCGCCCCTACGGGTCCGGTATATC
AAGCAGGCACACTGTCGGGTAACCCCATTGCTATGCATGCGGGTTTAGCGGCTCTGACCGCCCTTGATAGACCTGAATAT
GCACAGCTTGCCGAAAAAACAAAAAAATTAGCATTAGGTTTAAAGCGCGTCGCAAAAGAAGAAAATGTACCGTTAGCTAT
CAATTATGCTGGCGGAATGTTTGGTTTCTTTTTTACCGAAGCGGAACAGGTTAGCAATTACACACAAGCTTGTGCCTGTG
ACATAGAAAAATTTAAAAAATTCTTTCATTTGATGCTTGAACAAGGCATTTATCTCGCCCCTTCTGCCTTTGAAGCTGGA
TTTTTATCTTTAGCCCATAGCGATCAAGATATTGAAGATACGTTAACGGCTGCTAAAAAAGCCTTCTCAATGCTTTAA

Upstream 100 bases:

>100_bases
TTAGGAAACGAATAAAAAGCCATGATCAACTCTCATATATACTTAAATAGAGGATTTGTTATTATAGCGGACTAATTTAA
TGATCTTTGATAGGACTTTT

Downstream 100 bases:

>100_bases
AAAAGATAAGAGCTTAAGCGGGTGTTCGTTTAAGCTCTTAATATAAAATTCCATCACTAGTAAGTTCTTATTATTAATGT
CGATACACCTATTATTTTAA

Product: glutamate-1-semialdehyde-2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSISNQLFDRAQAIIPGGVNSPARAFNGVGGDPLFIEKAQGAYIYDVDKKSYIDYVGSWGPMILGHNHPEIKAAVIAAVE
NGLSFGAPTEIEIIMAEKVKSLVPSMEQVRMVSSGTEATMSAIRLARGYTGRDKILKFEGNYHGHSDSLLVKAGSGALTL
GQPSSPGIPADFAKHTLTATYNDLASVQQLFTEYKDQIACIIVEPVAGNMNCILPQEGFLQGLREICDANDALLILDEVM
TGFRVALGGAQAYYDIKPDLTTLGKVIGGGMPVGAFGGSKKVMQHIAPTGPVYQAGTLSGNPIAMHAGLAALTALDRPEY
AQLAEKTKKLALGLKRVAKEENVPLAINYAGGMFGFFFTEAEQVSNYTQACACDIEKFKKFFHLMLEQGIYLAPSAFEAG
FLSLAHSDQDIEDTLTAAKKAFSML

Sequences:

>Translated_425_residues
MSISNQLFDRAQAIIPGGVNSPARAFNGVGGDPLFIEKAQGAYIYDVDKKSYIDYVGSWGPMILGHNHPEIKAAVIAAVE
NGLSFGAPTEIEIIMAEKVKSLVPSMEQVRMVSSGTEATMSAIRLARGYTGRDKILKFEGNYHGHSDSLLVKAGSGALTL
GQPSSPGIPADFAKHTLTATYNDLASVQQLFTEYKDQIACIIVEPVAGNMNCILPQEGFLQGLREICDANDALLILDEVM
TGFRVALGGAQAYYDIKPDLTTLGKVIGGGMPVGAFGGSKKVMQHIAPTGPVYQAGTLSGNPIAMHAGLAALTALDRPEY
AQLAEKTKKLALGLKRVAKEENVPLAINYAGGMFGFFFTEAEQVSNYTQACACDIEKFKKFFHLMLEQGIYLAPSAFEAG
FLSLAHSDQDIEDTLTAAKKAFSML
>Mature_424_residues
SISNQLFDRAQAIIPGGVNSPARAFNGVGGDPLFIEKAQGAYIYDVDKKSYIDYVGSWGPMILGHNHPEIKAAVIAAVEN
GLSFGAPTEIEIIMAEKVKSLVPSMEQVRMVSSGTEATMSAIRLARGYTGRDKILKFEGNYHGHSDSLLVKAGSGALTLG
QPSSPGIPADFAKHTLTATYNDLASVQQLFTEYKDQIACIIVEPVAGNMNCILPQEGFLQGLREICDANDALLILDEVMT
GFRVALGGAQAYYDIKPDLTTLGKVIGGGMPVGAFGGSKKVMQHIAPTGPVYQAGTLSGNPIAMHAGLAALTALDRPEYA
QLAEKTKKLALGLKRVAKEENVPLAINYAGGMFGFFFTEAEQVSNYTQACACDIEKFKKFFHLMLEQGIYLAPSAFEAGF
LSLAHSDQDIEDTLTAAKKAFSML

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=316, Percent_Identity=29.1139240506329, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI284507298, Length=234, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI13994255, Length=319, Percent_Identity=25.705329153605, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=68.5446009389671, Blast_Score=614, Evalue=1e-177,
Organism=Escherichia coli, GI1789016, Length=364, Percent_Identity=29.9450549450549, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1787560, Length=346, Percent_Identity=30.0578034682081, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788044, Length=296, Percent_Identity=31.4189189189189, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI145693181, Length=329, Percent_Identity=29.483282674772, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1789759, Length=332, Percent_Identity=30.1204819277108, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1786991, Length=312, Percent_Identity=28.2051282051282, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=296, Percent_Identity=28.0405405405405, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=23.6658932714617, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=328, Percent_Identity=27.1341463414634, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25144274, Length=141, Percent_Identity=34.0425531914894, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=312, Percent_Identity=28.2051282051282, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=353, Percent_Identity=28.0453257790368, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357415, Length=311, Percent_Identity=28.2958199356913, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_PSYIN (A1ST92)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_942306.1
- ProteinModelPortal:   A1ST92
- SMR:   A1ST92
- STRING:   A1ST92
- GeneID:   4624579
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0865
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   VGCFGGK
- PhylomeDB:   A1ST92
- BioCyc:   PING357804:PING_0865-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45432; Mature: 45300

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISNQLFDRAQAIIPGGVNSPARAFNGVGGDPLFIEKAQGAYIYDVDKKSYIDYVGSWG
CCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCEEEECCCHHHHHHHCCCC
PMILGHNHPEIKAAVIAAVENGLSFGAPTEIEIIMAEKVKSLVPSMEQVRMVSSGTEATM
CEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHCCHHHHH
SAIRLARGYTGRDKILKFEGNYHGHSDSLLVKAGSGALTLGQPSSPGIPADFAKHTLTAT
HHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHH
YNDLASVQQLFTEYKDQIACIIVEPVAGNMNCILPQEGFLQGLREICDANDALLILDEVM
HHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHCCCCCEEEHHHHH
TGFRVALGGAQAYYDIKPDLTTLGKVIGGGMPVGAFGGSKKVMQHIAPTGPVYQAGTLSG
HHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMHAGLAALTALDRPEYAQLAEKTKKLALGLKRVAKEENVPLAINYAGGMFGFFFTE
CCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
AEQVSNYTQACACDIEKFKKFFHLMLEQGIYLAPSAFEAGFLSLAHSDQDIEDTLTAAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
AFSML
HHHCC
>Mature Secondary Structure 
SISNQLFDRAQAIIPGGVNSPARAFNGVGGDPLFIEKAQGAYIYDVDKKSYIDYVGSWG
CCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEEECCCCEEEECCCHHHHHHHCCCC
PMILGHNHPEIKAAVIAAVENGLSFGAPTEIEIIMAEKVKSLVPSMEQVRMVSSGTEATM
CEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHCCHHHHH
SAIRLARGYTGRDKILKFEGNYHGHSDSLLVKAGSGALTLGQPSSPGIPADFAKHTLTAT
HHHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCEEECCCCCCCCCCHHHHHHHHHHH
YNDLASVQQLFTEYKDQIACIIVEPVAGNMNCILPQEGFLQGLREICDANDALLILDEVM
HHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEECCCHHHHHHHHHHHCCCCCEEEHHHHH
TGFRVALGGAQAYYDIKPDLTTLGKVIGGGMPVGAFGGSKKVMQHIAPTGPVYQAGTLSG
HHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMHAGLAALTALDRPEYAQLAEKTKKLALGLKRVAKEENVPLAINYAGGMFGFFFTE
CCEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHH
AEQVSNYTQACACDIEKFKKFFHLMLEQGIYLAPSAFEAGFLSLAHSDQDIEDTLTAAKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCCHHHHHHHHHH
AFSML
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA