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The map label for this gene is parC [H]

Identifier: 119944625

GI number: 119944625

Start: 1080504

End: 1082783

Strand: Reverse

Name: parC [H]

Synonym: Ping_0864

Alternate gene names: 119944625

Gene position: 1082783-1080504 (Counterclockwise)

Preceding gene: 119944626

Following gene: 119944624

Centisome position: 23.75

GC content: 42.85

Gene sequence:

>2280_bases
ATGAGTAATCTATTAGATTTAAGCTTAGAAGGTGTTGAAAAACTGCCTCTAACTAAATTTACCGAGGAAGCCTATCTCAA
CTATGCCATGTATGTGATCATGGACAGAGCACTACCGCATATTAGTGATGGCTTAAAACCCGTTCAAAGACGCATCATAT
ATGCTATGTCTGAACTGGGATTATCGGCACTTTCCAAACATAAAAAATCAGCCCGTACCGTCGGGGATGTATTAGGTAAA
TACCATCCACACGGTGATAGCGCCTGTTATGAAGCCATGGTATTAATGGCACAACCCTTTTCCTACCGTTACCCTTTAAT
AGATGGGCAGGGAAACTGGGGCGCACCGGATGATCCTAAGTCGTTTGCTGCTATGCGTTACACTGAATCCCGTTTATCCG
CCTTTTCAGAATTATTGCTCTCGGAAGTAGCCTTAGGTACCACGGATTGGAAACCCAATTTTGATGGCACCATGAAAGAG
CCGGTGTTATTACCGGCACGTTTACCTCATATACTGTTAAATGGTATTAGCGGTATTGCGGTTGGTATGGCAACCGATAT
TCCGCCTCATAACGTCCGCGAAGTAGCCGCTGCTTGTTGTCATTTGATTGACCATCCTAAAGCAAACCTGATTGATTTAA
TGGCCTTTGTACAGGGACCTGATTATCCCACTGAAGCTGAAATCATCACCCCTAACAGTGATATAAAGAAAATTTACGAA
ACCGGCCGTGGTAGCTTCAAAAGTCGCGCCGTTTATACGGTAGAAAATGGTGAAATCGTTATTACGGCCCTTCCCCATCG
CGTGTCTGGTGGCAAAATTCTCAAAGAAATAGCCAAACAGATGCAGGATAAAAAATTACCCATGATTGCAGATTTACGCG
ATGAATCTGATCATGAAAACCCGACCCGACTCGTTATCATCCCGCGTTCAAATCGAATTGATATTGAAGGGTTAATGCAC
CACCTGTTTGCTTCAACGGATTTAGAGGTTAATCATAAAGTTAACCTCAATATGTTGGGATTAGACCAGCGTCCACAAGT
TAAAGGTTTAGTGACCATTTTAAACGAGTGGTTAGTGTACCGGATGAAGACAGTGCGTCGCCGTTTGCAGTTTCGATTAG
ACAAAATTTTAGCGCGCCTGCATATTTTAGAAGGTTTATTAGCCGCCTATTTAAACATAGATGAAGTCATTGAAATCATT
AGAACTTGTGATGATGCAAAAGCCGAATTAATGTCTCGTTTTGAGCTTTCAGCAATACAAGCACATGCTATTTTAGAAAT
CAAACTTCGCCAACTCGCCAAGTTAGAAGAGATCCAAATCCGCGCTGAGATGGATACGCTTACCGATGAGCAAACAAAAC
TAGAACGTTTATTAAGCTCAGAGCGACGCTTAAACACACTGGTTAAAAAAGAAATTCAGGCAGATGCGCTAAAATATGGC
GATGATCGTCGCTCTCCGCTTATTGAACGTATTGAAGCAAAAGCACTCACTGAAAAAGAATTAATGCCCAGTGAAACTGT
GACGGTCGTATTATCAACCCAAGGTTGGGTGCGCTCGGCCAAGGGATTGGATGTTGACGCACAGGCATTAAATTATAAAT
CCGGTGATGAGTTCCTGACCAAGGCACAAGGGCGAAGTAATCAAAGTTGTATTTTTATTGATGCAAGTGGCCGGGCCTAT
TCATTAGATGTACACTCCCTGCCATCAGCGCGTTCACAGGGCGAGCCGCTAACGGGGCGATTTAATCAAAATGAAAATGT
TCCTTTTGTCTGTGCATTGATAGGGGATGATGATGATCGTTATCTTATCAGCAGTGATCATGGTTATGGATTTATTGCCA
AATTTAGCGATATTAATAGCCGCAACAAAAACGGTAAAACACTTATTAACCTCACCCCCAACGCACAATTAATGCCGCCG
AAAAAAATGACCGCAGCTGATGATGATTGGTGTTTAACCATCAGCAATGAGGGACGTTTATTACTCTTCCCGGTAAACAG
TTTACCAAGCCTCAGCAAAGGTAAAGGAAATAGGATGCTCAACATCATCTCTGCCAAAGCGACTAAACGTGAAGAGTTTG
TTACTATGCTTGAAATTATCCCGCAGGCAAGTTCGGTCACGCTGCATGCAGGAAAACGTAAATTGACTTTAAAGCCCAGT
GATTTGGTACATTATCAAGGCGAACGAGGCCGGCGTGGCAGCAAACTGCCGCGCGGTTTACAACGTGTAGATAAAATCGA
AATTATTGAAGCTGCGCAAATACATTCAAGAGACTCTTAA

Upstream 100 bases:

>100_bases
ATTTTCTTTTATAATACTATATGTCATTTGTATTTTTTCCTTAGAATGCATTTACGTTATAATAAGCGTTTTTGCACGCC
AATAAACAGGGTCGTTTCAC

Downstream 100 bases:

>100_bases
TATTATGTTATTTATTATCCGCGTTATAATGCTTTTTGTGATAGTTATATTGATGACCGTCTATTCATTATTTTATTGCT
TATTCAGCCCCCGCAATCCC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MSNLLDLSLEGVEKLPLTKFTEEAYLNYAMYVIMDRALPHISDGLKPVQRRIIYAMSELGLSALSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESRLSAFSELLLSEVALGTTDWKPNFDGTMKE
PVLLPARLPHILLNGISGIAVGMATDIPPHNVREVAAACCHLIDHPKANLIDLMAFVQGPDYPTEAEIITPNSDIKKIYE
TGRGSFKSRAVYTVENGEIVITALPHRVSGGKILKEIAKQMQDKKLPMIADLRDESDHENPTRLVIIPRSNRIDIEGLMH
HLFASTDLEVNHKVNLNMLGLDQRPQVKGLVTILNEWLVYRMKTVRRRLQFRLDKILARLHILEGLLAAYLNIDEVIEII
RTCDDAKAELMSRFELSAIQAHAILEIKLRQLAKLEEIQIRAEMDTLTDEQTKLERLLSSERRLNTLVKKEIQADALKYG
DDRRSPLIERIEAKALTEKELMPSETVTVVLSTQGWVRSAKGLDVDAQALNYKSGDEFLTKAQGRSNQSCIFIDASGRAY
SLDVHSLPSARSQGEPLTGRFNQNENVPFVCALIGDDDDRYLISSDHGYGFIAKFSDINSRNKNGKTLINLTPNAQLMPP
KKMTAADDDWCLTISNEGRLLLFPVNSLPSLSKGKGNRMLNIISAKATKREEFVTMLEIIPQASSVTLHAGKRKLTLKPS
DLVHYQGERGRRGSKLPRGLQRVDKIEIIEAAQIHSRDS

Sequences:

>Translated_759_residues
MSNLLDLSLEGVEKLPLTKFTEEAYLNYAMYVIMDRALPHISDGLKPVQRRIIYAMSELGLSALSKHKKSARTVGDVLGK
YHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESRLSAFSELLLSEVALGTTDWKPNFDGTMKE
PVLLPARLPHILLNGISGIAVGMATDIPPHNVREVAAACCHLIDHPKANLIDLMAFVQGPDYPTEAEIITPNSDIKKIYE
TGRGSFKSRAVYTVENGEIVITALPHRVSGGKILKEIAKQMQDKKLPMIADLRDESDHENPTRLVIIPRSNRIDIEGLMH
HLFASTDLEVNHKVNLNMLGLDQRPQVKGLVTILNEWLVYRMKTVRRRLQFRLDKILARLHILEGLLAAYLNIDEVIEII
RTCDDAKAELMSRFELSAIQAHAILEIKLRQLAKLEEIQIRAEMDTLTDEQTKLERLLSSERRLNTLVKKEIQADALKYG
DDRRSPLIERIEAKALTEKELMPSETVTVVLSTQGWVRSAKGLDVDAQALNYKSGDEFLTKAQGRSNQSCIFIDASGRAY
SLDVHSLPSARSQGEPLTGRFNQNENVPFVCALIGDDDDRYLISSDHGYGFIAKFSDINSRNKNGKTLINLTPNAQLMPP
KKMTAADDDWCLTISNEGRLLLFPVNSLPSLSKGKGNRMLNIISAKATKREEFVTMLEIIPQASSVTLHAGKRKLTLKPS
DLVHYQGERGRRGSKLPRGLQRVDKIEIIEAAQIHSRDS
>Mature_758_residues
SNLLDLSLEGVEKLPLTKFTEEAYLNYAMYVIMDRALPHISDGLKPVQRRIIYAMSELGLSALSKHKKSARTVGDVLGKY
HPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPKSFAAMRYTESRLSAFSELLLSEVALGTTDWKPNFDGTMKEP
VLLPARLPHILLNGISGIAVGMATDIPPHNVREVAAACCHLIDHPKANLIDLMAFVQGPDYPTEAEIITPNSDIKKIYET
GRGSFKSRAVYTVENGEIVITALPHRVSGGKILKEIAKQMQDKKLPMIADLRDESDHENPTRLVIIPRSNRIDIEGLMHH
LFASTDLEVNHKVNLNMLGLDQRPQVKGLVTILNEWLVYRMKTVRRRLQFRLDKILARLHILEGLLAAYLNIDEVIEIIR
TCDDAKAELMSRFELSAIQAHAILEIKLRQLAKLEEIQIRAEMDTLTDEQTKLERLLSSERRLNTLVKKEIQADALKYGD
DRRSPLIERIEAKALTEKELMPSETVTVVLSTQGWVRSAKGLDVDAQALNYKSGDEFLTKAQGRSNQSCIFIDASGRAYS
LDVHSLPSARSQGEPLTGRFNQNENVPFVCALIGDDDDRYLISSDHGYGFIAKFSDINSRNKNGKTLINLTPNAQLMPPK
KMTAADDDWCLTISNEGRLLLFPVNSLPSLSKGKGNRMLNIISAKATKREEFVTMLEIIPQASSVTLHAGKRKLTLKPSD
LVHYQGERGRRGSKLPRGLQRVDKIEIIEAAQIHSRDS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=747, Percent_Identity=63.855421686747, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=726, Percent_Identity=33.4710743801653, Blast_Score=366, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84952; Mature: 84821

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLLDLSLEGVEKLPLTKFTEEAYLNYAMYVIMDRALPHISDGLKPVQRRIIYAMSELG
CCCCHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHH
LSALSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCH
SFAAMRYTESRLSAFSELLLSEVALGTTDWKPNFDGTMKEPVLLPARLPHILLNGISGIA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCHHHHHHHHHCCCHHE
VGMATDIPPHNVREVAAACCHLIDHPKANLIDLMAFVQGPDYPTEAEIITPNSDIKKIYE
EEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHH
TGRGSFKSRAVYTVENGEIVITALPHRVSGGKILKEIAKQMQDKKLPMIADLRDESDHEN
HCCCCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCC
PTRLVIIPRSNRIDIEGLMHHLFASTDLEVNHKVNLNMLGLDQRPQVKGLVTILNEWLVY
CEEEEEEECCCCCCHHHHHHHHHHCCCCEECCEEEEEEECCCCCCCHHHHHHHHHHHHHH
RMKTVRRRLQFRLDKILARLHILEGLLAAYLNIDEVIEIIRTCDDAKAELMSRFELSAIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHAILEIKLRQLAKLEEIQIRAEMDTLTDEQTKLERLLSSERRLNTLVKKEIQADALKYG
HHHHHHHHHHHHHHHHHHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DDRRSPLIERIEAKALTEKELMPSETVTVVLSTQGWVRSAKGLDVDAQALNYKSGDEFLT
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHCCCCCCCHHHCCCCCCHHHHH
KAQGRSNQSCIFIDASGRAYSLDVHSLPSARSQGEPLTGRFNQNENVPFVCALIGDDDDR
HCCCCCCCCEEEEECCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
YLISSDHGYGFIAKFSDINSRNKNGKTLINLTPNAQLMPPKKMTAADDDWCLTISNEGRL
EEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEE
LLFPVNSLPSLSKGKGNRMLNIISAKATKREEFVTMLEIIPQASSVTLHAGKRKLTLKPS
EEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCH
DLVHYQGERGRRGSKLPRGLQRVDKIEIIEAAQIHSRDS
HHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNLLDLSLEGVEKLPLTKFTEEAYLNYAMYVIMDRALPHISDGLKPVQRRIIYAMSELG
CCCHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHH
LSALSKHKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLIDGQGNWGAPDDPK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCH
SFAAMRYTESRLSAFSELLLSEVALGTTDWKPNFDGTMKEPVLLPARLPHILLNGISGIA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCHHHHHHHHHCCCHHE
VGMATDIPPHNVREVAAACCHLIDHPKANLIDLMAFVQGPDYPTEAEIITPNSDIKKIYE
EEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHH
TGRGSFKSRAVYTVENGEIVITALPHRVSGGKILKEIAKQMQDKKLPMIADLRDESDHEN
HCCCCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCC
PTRLVIIPRSNRIDIEGLMHHLFASTDLEVNHKVNLNMLGLDQRPQVKGLVTILNEWLVY
CEEEEEEECCCCCCHHHHHHHHHHCCCCEECCEEEEEEECCCCCCCHHHHHHHHHHHHHH
RMKTVRRRLQFRLDKILARLHILEGLLAAYLNIDEVIEIIRTCDDAKAELMSRFELSAIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHAILEIKLRQLAKLEEIQIRAEMDTLTDEQTKLERLLSSERRLNTLVKKEIQADALKYG
HHHHHHHHHHHHHHHHHHHEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DDRRSPLIERIEAKALTEKELMPSETVTVVLSTQGWVRSAKGLDVDAQALNYKSGDEFLT
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHCCCCCCCHHHCCCCCCHHHHH
KAQGRSNQSCIFIDASGRAYSLDVHSLPSARSQGEPLTGRFNQNENVPFVCALIGDDDDR
HCCCCCCCCEEEEECCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
YLISSDHGYGFIAKFSDINSRNKNGKTLINLTPNAQLMPPKKMTAADDDWCLTISNEGRL
EEEECCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEE
LLFPVNSLPSLSKGKGNRMLNIISAKATKREEFVTMLEIIPQASSVTLHAGKRKLTLKPS
EEEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCH
DLVHYQGERGRRGSKLPRGLQRVDKIEIIEAAQIHSRDS
HHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]