Click here to switch to the map view.

The map label for this gene is menA [H]

Identifier: 119944138

GI number: 119944138

Start: 458186

End: 459100

Strand: Direct

Name: menA [H]

Synonym: Ping_0356

Alternate gene names: 119944138

Gene position: 458186-459100 (Clockwise)

Preceding gene: 119944130

Following gene: 119944139

Centisome position: 10.05

GC content: 38.8

Gene sequence:

>915_bases
ATGAGTAATATTTCAGTTTGGCTAAGCGAATTACGTTTACGTACATTACCGCTTGCAGCAGCTTCAATTATTTTAGGGGC
TGGGATAGCCATTCAAGCACAAATATTTGACCTGTTGATTTTTAGTTTATCGCTTATTACCGCTTTGTTATTACAGATTT
TATCAAATCTTGCCAATGATTATGGTGATGCCATCTCCGGGGTAGACAATGGCAAGCGTGTTGGTCCGTTACGCGCAATG
CAGAGCGGTGCTATCAGCCAAAAAAGCCTGAAAATTGCGATCCTGTTAACGACTAGTTTAGTGGTGGTGTCGGGCATCAC
TTTACTGGTTATTGCATTAGGTTCAAATTCAACGAGTTGGGTAGTTTTTTTGTTGCTTGGTTTATTAGCTATTGTCGCTG
CGATAACCTATACAATGGGAAAATTACATTATGGATACAGAGCGATGGGCGATCTTGCTGTGTTTCTGTTTTTTGGCTTA
GTAGGAGTAGTCGGCAGTTATTACCTTTATGGTTTAACTTTTAGCTGGTCCTTACTTTTACCGGCAACCAGTGTCGGGCT
TTTATCCGCAGCTGTTTTAAATATTAATAATATGCGTGATATTTATACGGATAAAGAGGCCCATAAAACAACTTTGGTGG
TTTTATGGGGGCTGAAAAATGCTTTTATCTATCACTTGTCCCTTATTGTCGGTGCTTTTATCTGTGCCGTTTACTATTTT
AGTCAGCTTGAAAATGTACAAGCCTGGCAATTTATTTTTTTGCTTAGCTTTAGTCCGCTAATCAAGAGTTGTCTGATATT
AAAGGAGGCGATCTCCAAAGATATTCGTGACGGTCAGGTATTTAATGATGAGCTTAAAAACACGGCATTATCCACCTTTG
TTTTTAGTCTTTTATTTGCGCTGGTATTAATTTAG

Upstream 100 bases:

>100_bases
GCTCATGATATATTGACGGATTAAGGTTTGTTAATGTAGCGCGATTAACAGCCGATTCCTAGCGGAACCGCGTATAACCA
CACTTTTTTAGGATATTTAG

Downstream 100 bases:

>100_bases
ATGCATTAAACCCATTTTTAGTTTCTTACCACTTTCAGAACTTGGATAAGCGCGCTTTTGTACGCTTATTTTAACCGGAG
CTTAGCTGTTTTTATAAAAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSNISVWLSELRLRTLPLAAASIILGAGIAIQAQIFDLLIFSLSLITALLLQILSNLANDYGDAISGVDNGKRVGPLRAM
QSGAISQKSLKIAILLTTSLVVVSGITLLVIALGSNSTSWVVFLLLGLLAIVAAITYTMGKLHYGYRAMGDLAVFLFFGL
VGVVGSYYLYGLTFSWSLLLPATSVGLLSAAVLNINNMRDIYTDKEAHKTTLVVLWGLKNAFIYHLSLIVGAFICAVYYF
SQLENVQAWQFIFLLSFSPLIKSCLILKEAISKDIRDGQVFNDELKNTALSTFVFSLLFALVLI

Sequences:

>Translated_304_residues
MSNISVWLSELRLRTLPLAAASIILGAGIAIQAQIFDLLIFSLSLITALLLQILSNLANDYGDAISGVDNGKRVGPLRAM
QSGAISQKSLKIAILLTTSLVVVSGITLLVIALGSNSTSWVVFLLLGLLAIVAAITYTMGKLHYGYRAMGDLAVFLFFGL
VGVVGSYYLYGLTFSWSLLLPATSVGLLSAAVLNINNMRDIYTDKEAHKTTLVVLWGLKNAFIYHLSLIVGAFICAVYYF
SQLENVQAWQFIFLLSFSPLIKSCLILKEAISKDIRDGQVFNDELKNTALSTFVFSLLFALVLI
>Mature_303_residues
SNISVWLSELRLRTLPLAAASIILGAGIAIQAQIFDLLIFSLSLITALLLQILSNLANDYGDAISGVDNGKRVGPLRAMQ
SGAISQKSLKIAILLTTSLVVVSGITLLVIALGSNSTSWVVFLLLGLLAIVAAITYTMGKLHYGYRAMGDLAVFLFFGLV
GVVGSYYLYGLTFSWSLLLPATSVGLLSAAVLNINNMRDIYTDKEAHKTTLVVLWGLKNAFIYHLSLIVGAFICAVYYFS
QLENVQAWQFIFLLSFSPLIKSCLILKEAISKDIRDGQVFNDELKNTALSTFVFSLLFALVLI

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=303, Percent_Identity=44.8844884488449, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33030; Mature: 32898

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNISVWLSELRLRTLPLAAASIILGAGIAIQAQIFDLLIFSLSLITALLLQILSNLAND
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGDAISGVDNGKRVGPLRAMQSGAISQKSLKIAILLTTSLVVVSGITLLVIALGSNSTSW
HHHHHCCCCCCCCCCHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHEEEEECCCCCHH
VVFLLLGLLAIVAAITYTMGKLHYGYRAMGDLAVFLFFGLVGVVGSYYLYGLTFSWSLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PATSVGLLSAAVLNINNMRDIYTDKEAHKTTLVVLWGLKNAFIYHLSLIVGAFICAVYYF
HHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
SQLENVQAWQFIFLLSFSPLIKSCLILKEAISKDIRDGQVFNDELKNTALSTFVFSLLFA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVLI
HHHC
>Mature Secondary Structure 
SNISVWLSELRLRTLPLAAASIILGAGIAIQAQIFDLLIFSLSLITALLLQILSNLAND
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGDAISGVDNGKRVGPLRAMQSGAISQKSLKIAILLTTSLVVVSGITLLVIALGSNSTSW
HHHHHCCCCCCCCCCHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHEEEEECCCCCHH
VVFLLLGLLAIVAAITYTMGKLHYGYRAMGDLAVFLFFGLVGVVGSYYLYGLTFSWSLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PATSVGLLSAAVLNINNMRDIYTDKEAHKTTLVVLWGLKNAFIYHLSLIVGAFICAVYYF
HHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
SQLENVQAWQFIFLLSFSPLIKSCLILKEAISKDIRDGQVFNDELKNTALSTFVFSLLFA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LVLI
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]