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The map label for this gene is aceA [C]

Identifier: 119944089

GI number: 119944089

Start: 399941

End: 401536

Strand: Direct

Name: aceA [C]

Synonym: Ping_0304

Alternate gene names: 119944089

Gene position: 399941-401536 (Clockwise)

Preceding gene: 119944088

Following gene: 119944090

Centisome position: 8.77

GC content: 39.97

Gene sequence:

>1596_bases
ATGAACTATAATACTGAAAAAACTAATGCTAGCAATGTTATTGCACAACAGGGTGATGCTTGGAAGGCGATTAATCCTGA
GTATGTTGCCCGTTTGCGCTCACAAAACCGCTTTAAAACAGGTATTGATATTGCTAAATATACAGCGAAGATAATGCGCG
AAGATATGGATTCATATGATATCGACAGTAAAAATTATACTCAGTCTCTAGGTTGCTGGCATGGATTTGTCGGTCAGCAA
AAAATGATCTCTATTAAAAAGCATTTTACGACGACTAAAGGTACTTATTTATACCTTTCCGGTTGGATGGTTGCGGCAAT
GCGCTCTGAATTTGGCCCGCTTCCTGATCAGTCAATGCATGAAAAGACCAGTGTTCCGTTGTTAATAGAAGAGCTTTATA
CTTTCTTAAAACAAGCTGATGCCCGTGAACTTGGTCATGTCTTTCAAGAGTTAGATGCAGCCAATGATAAAGGTGATCAA
GTAGCAGCGCAGGCGGCTCTAAAGAAAATCAATGAATTTGAAACACATGTTGTGCCGATTATCGCCGATATTGATGCGGG
TTTTGGTAATGAAGAAGCAACTTACCTACTAGCTAAAAAAATGATTGAAGCCGGTGCTTGTTGTATTCAGATTGAAAACC
AGGTATCCGATGCTAAACAGTGTGGTCACCAGGATGGCAAAGTAACTGTCCCGCATGAAGACTTCCTCGCTAAGATTAAT
GCAGTACGTTATGCATTTATGGAGTTGGGTGTTGACGATGGCGTTATTGTTGCGCGAACTGATTCTTTAGGTGCTGGTTT
AACTCAAAAAATTCCAGTATCCCAAGAGCCAGGCGATCTTGCTGATCAGTATAATAACTATATTGACGGCGAAGTAATCA
ACTCTTTAGATCAGTTGAAATCGGGAGATCTCGTACTGAGTCGTGGTGGAGAATTGATTATACCAAACCGTTTAGCCAAT
GGCCTGGTACGTTTTAAACCTGATACTGGCGAAGACAGAGTAGTACTTGATTGTATTACTTCTCTACAAAATGGTGCTGA
TTTATTGTGGATTGAAACGGAACAACCTAACGTTGGGCAAATTGCTGGTATGGTTAACCGTATCCGCGAAGCGGTTCCAA
ATGCCAAGCTTGTTTATAATAACAGTCCATCATTTAACTGGACATTAAGCTTTAGACAGCAGATTTTTGATACTTGGAAT
AAAGATGGTATTGATGTTTCAGCTTATAACCGTGCAGATTTGATGAGCCCAATCTATGATGAGACTAAATTAGCTCTTGA
AGCTGACCAACAAATTCAGAACTTCCAGAAAGATGCGGCAAGAGAAGCAGGTATTTTCCATCACTTGATAACTTTACCGA
CTTACCATACTGCAGCTTTGTCGACTGATAATCTTGCTAAAGATTACTTTGGTGAAATGGGTATGCTGGCTTATGTTAAA
AATGTACAGAGAGAAGAAATTCGTCAGGGTCTTGCATGTGTAAAACATCAGGATATGTCCGGCTCTAATATGGGCGATGA
TCACAAAGAATATTTCTCTGGAGAGCAGGCGCTGAAAGCTTCTGGTGAAAATAATACGATGAGTCAATTTTCATAA

Upstream 100 bases:

>100_bases
CATGAGTACAGAATGTTCGCAAAAATTTCCTAGAAATAATAGGTTTTAGGAATATTAATCTAACCACTAATTGATTCAAC
TACTGAGAGAGACGTTTATC

Downstream 100 bases:

>100_bases
CGGATAACTAATCGGCGGTATCAAAATTGCCTGATTATAATCGAATAAAGCATACTGGGTTGTTAACGGTATGCTTTTTT
TGGGTTTTTATTTTTGTCCA

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MNYNTEKTNASNVIAQQGDAWKAINPEYVARLRSQNRFKTGIDIAKYTAKIMREDMDSYDIDSKNYTQSLGCWHGFVGQQ
KMISIKKHFTTTKGTYLYLSGWMVAAMRSEFGPLPDQSMHEKTSVPLLIEELYTFLKQADARELGHVFQELDAANDKGDQ
VAAQAALKKINEFETHVVPIIADIDAGFGNEEATYLLAKKMIEAGACCIQIENQVSDAKQCGHQDGKVTVPHEDFLAKIN
AVRYAFMELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLADQYNNYIDGEVINSLDQLKSGDLVLSRGGELIIPNRLAN
GLVRFKPDTGEDRVVLDCITSLQNGADLLWIETEQPNVGQIAGMVNRIREAVPNAKLVYNNSPSFNWTLSFRQQIFDTWN
KDGIDVSAYNRADLMSPIYDETKLALEADQQIQNFQKDAAREAGIFHHLITLPTYHTAALSTDNLAKDYFGEMGMLAYVK
NVQREEIRQGLACVKHQDMSGSNMGDDHKEYFSGEQALKASGENNTMSQFS

Sequences:

>Translated_531_residues
MNYNTEKTNASNVIAQQGDAWKAINPEYVARLRSQNRFKTGIDIAKYTAKIMREDMDSYDIDSKNYTQSLGCWHGFVGQQ
KMISIKKHFTTTKGTYLYLSGWMVAAMRSEFGPLPDQSMHEKTSVPLLIEELYTFLKQADARELGHVFQELDAANDKGDQ
VAAQAALKKINEFETHVVPIIADIDAGFGNEEATYLLAKKMIEAGACCIQIENQVSDAKQCGHQDGKVTVPHEDFLAKIN
AVRYAFMELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLADQYNNYIDGEVINSLDQLKSGDLVLSRGGELIIPNRLAN
GLVRFKPDTGEDRVVLDCITSLQNGADLLWIETEQPNVGQIAGMVNRIREAVPNAKLVYNNSPSFNWTLSFRQQIFDTWN
KDGIDVSAYNRADLMSPIYDETKLALEADQQIQNFQKDAAREAGIFHHLITLPTYHTAALSTDNLAKDYFGEMGMLAYVK
NVQREEIRQGLACVKHQDMSGSNMGDDHKEYFSGEQALKASGENNTMSQFS
>Mature_531_residues
MNYNTEKTNASNVIAQQGDAWKAINPEYVARLRSQNRFKTGIDIAKYTAKIMREDMDSYDIDSKNYTQSLGCWHGFVGQQ
KMISIKKHFTTTKGTYLYLSGWMVAAMRSEFGPLPDQSMHEKTSVPLLIEELYTFLKQADARELGHVFQELDAANDKGDQ
VAAQAALKKINEFETHVVPIIADIDAGFGNEEATYLLAKKMIEAGACCIQIENQVSDAKQCGHQDGKVTVPHEDFLAKIN
AVRYAFMELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLADQYNNYIDGEVINSLDQLKSGDLVLSRGGELIIPNRLAN
GLVRFKPDTGEDRVVLDCITSLQNGADLLWIETEQPNVGQIAGMVNRIREAVPNAKLVYNNSPSFNWTLSFRQQIFDTWN
KDGIDVSAYNRADLMSPIYDETKLALEADQQIQNFQKDAAREAGIFHHLITLPTYHTAALSTDNLAKDYFGEMGMLAYVK
NVQREEIRQGLACVKHQDMSGSNMGDDHKEYFSGEQALKASGENNTMSQFS

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=447, Percent_Identity=27.7404921700224, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17561814, Length=414, Percent_Identity=28.5024154589372, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71982926, Length=414, Percent_Identity=28.5024154589372, Blast_Score=129, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6320908, Length=487, Percent_Identity=27.5154004106776, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325263, Length=421, Percent_Identity=25.41567695962, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59146; Mature: 59146

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYNTEKTNASNVIAQQGDAWKAINPEYVARLRSQNRFKTGIDIAKYTAKIMREDMDSYD
CCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCC
IDSKNYTQSLGCWHGFVGQQKMISIKKHFTTTKGTYLYLSGWMVAAMRSEFGPLPDQSMH
CCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCCHHH
EKTSVPLLIEELYTFLKQADARELGHVFQELDAANDKGDQVAAQAALKKINEFETHVVPI
HHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEE
IADIDAGFGNEEATYLLAKKMIEAGACCIQIENQVSDAKQCGHQDGKVTVPHEDFLAKIN
EEECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCEEECCHHHHHHHHH
AVRYAFMELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLADQYNNYIDGEVINSLDQLK
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHC
SGDLVLSRGGELIIPNRLANGLVRFKPDTGEDRVVLDCITSLQNGADLLWIETEQPNVGQ
CCCEEEECCCCEEECHHHHCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHH
IAGMVNRIREAVPNAKLVYNNSPSFNWTLSFRQQIFDTWNKDGIDVSAYNRADLMSPIYD
HHHHHHHHHHHCCCCEEEECCCCCEEEEHHHHHHHHHCCCCCCCEEECCCHHHHHCCHHH
ETKLALEADQQIQNFQKDAAREAGIFHHLITLPTYHTAALSTDNLAKDYFGEMGMLAYVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCHHHHHHH
NVQREEIRQGLACVKHQDMSGSNMGDDHKEYFSGEQALKASGENNTMSQFS
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCHHCCC
>Mature Secondary Structure
MNYNTEKTNASNVIAQQGDAWKAINPEYVARLRSQNRFKTGIDIAKYTAKIMREDMDSYD
CCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCC
IDSKNYTQSLGCWHGFVGQQKMISIKKHFTTTKGTYLYLSGWMVAAMRSEFGPLPDQSMH
CCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCCHHH
EKTSVPLLIEELYTFLKQADARELGHVFQELDAANDKGDQVAAQAALKKINEFETHVVPI
HHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEE
IADIDAGFGNEEATYLLAKKMIEAGACCIQIENQVSDAKQCGHQDGKVTVPHEDFLAKIN
EEECCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCEEECCHHHHHHHHH
AVRYAFMELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLADQYNNYIDGEVINSLDQLK
HHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHC
SGDLVLSRGGELIIPNRLANGLVRFKPDTGEDRVVLDCITSLQNGADLLWIETEQPNVGQ
CCCEEEECCCCEEECHHHHCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHH
IAGMVNRIREAVPNAKLVYNNSPSFNWTLSFRQQIFDTWNKDGIDVSAYNRADLMSPIYD
HHHHHHHHHHHCCCCEEEECCCCCEEEEHHHHHHHHHCCCCCCCEEECCCHHHHHCCHHH
ETKLALEADQQIQNFQKDAAREAGIFHHLITLPTYHTAALSTDNLAKDYFGEMGMLAYVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCHHHHHHH
NVQREEIRQGLACVKHQDMSGSNMGDDHKEYFSGEQALKASGENNTMSQFS
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]