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The map label for this gene is apr [H]

Identifier: 119867192

GI number: 119867192

Start: 1226281

End: 1227618

Strand: Reverse

Name: apr [H]

Synonym: Mkms_1141

Alternate gene names: 119867192

Gene position: 1227618-1226281 (Counterclockwise)

Preceding gene: 119867193

Following gene: 119867190

Centisome position: 21.4

GC content: 74.14

Gene sequence:

>1338_bases
ATGACCGGCCGACTCACCGCGGCGACCCTCACCGGACTGCTCGTGGCGGCGGTTCCGTTGGCGACGGCCCCGGAGGTGTC
GGCGGTGACCCCACCCGCCGTCGACGACGCGTTCCTTCCCGCCGCCGCACCACCGGCACCGCCGCAGCGCACCGAACAAC
GCGCGGAGTGCTCCGGCGCCGAACGCGACCGGGACCCGCCTGCGGACGCACGCCAGTTGGACATGCTGAACCTGCAGAGC
GTGTGGCCGCTGACCCGGGGCGCGGGCCAGACGGTCGCCGTCATCGACACCGGCGTGGCCAGGCACCGGCTCCTCCCCCG
ACTCATGCCCGGCGGTGACTACGTGTCGACCGGCGACGGAACCGACGACTGCGACGGGCACGGCACGCTGGTGGCCGGGA
TCGTCGCGGCGACAGGAGAATTCACCGGCGTGGCGCCGGATGCCGCGCTGCTGGGCATCCGTCAGTCGAGCAACAAGTTC
GGGGCGGCCGACGATCCGGGCGTCACGGGGTACGGCGATGTGCAGACACTCGCGACGGCGGTGCGCGCCGCGGCGGACCT
CGGTGCGACGGTGATCAACGTGTCGTCGGTGGCCTGTCTGGCTGCGGCCGATGCGCTCGACGACCGCGCGCTGGGCGCCG
CCCTCGCCTATGCCGTCGACGTGCGCAATGCGGTCGTGGTGACCGCGGCGGGCAACGTCGGCGGTCCGGGCCAGTGCCCG
ACGCAGAACGCCACCCAACCGGGCCGACCGGATTGGCAGAGCGTCGAATCCGTTGCCAGCCCGGCCTGGTACGACGATCT
GGTGCTCACCGTCGGATCGGTGCGCACCGACGGCGCCCCGTCGGAGTTCAGCCTCGCCGGACCGTGGGTCGACGTCGCCG
CGCCGGGTGAGCACGTGGTGTCGCTGGACCCCGATGGTGACGGCCTGGTCGATGCCCTGCCGACCGCCGACGGCGACGCG
TCGATCGCCGGCACCAGTTACGCCGCGCCGGTGGTCTCGGGGGTCGCGGCGCTGGTGCGCTCGCGCTGGCCGCACCTGAC
CGCCCGCCAGGTGATGCAGCGCATCGAGGACACCGCGCACCGGCCACCTGCGGGCTGGGATTCCGTCGTCGGCCACGGTG
TCGTGGACGTGGCGGCCGCCGTGAGCGGCGGCGTACCCGCCGACACGACCGAGACCCCAGCGCGGTCACTGCACGCACCG
GCCGACGTCCCGCACGACGGGCGGCCCCGCCGGGTCGCCATGGCCGGAGCGGGGATCTGCGTGGCGATCACGGTGCTCGT
CGCGCTGAGCGCCTCATCGCACCGGCGCGGCCACTCCGACCGCGTCGCGCGTCACTGA

Upstream 100 bases:

>100_bases
GCTCCGTCGAGGTGCTCGAGTACGCCGTCCTGGCGGCGGTGGTGCCGGTCGCCTGCGCGGCACTCGACCTGTTCGCCATG
GTCCGCACCTCGGACCTGAT

Downstream 100 bases:

>100_bases
CGCTGCGGCACGGCTCAGTTCGGGTCCGCGGGGCAGCCGGGCCAGCACCGGCCACGGCGCAGGCACCGGCGACGACCCCA
CGCCGAGCGTGCGGGCGGTG

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTGRLTAATLTGLLVAAVPLATAPEVSAVTPPAVDDAFLPAAAPPAPPQRTEQRAECSGAERDRDPPADARQLDMLNLQS
VWPLTRGAGQTVAVIDTGVARHRLLPRLMPGGDYVSTGDGTDDCDGHGTLVAGIVAATGEFTGVAPDAALLGIRQSSNKF
GAADDPGVTGYGDVQTLATAVRAAADLGATVINVSSVACLAAADALDDRALGAALAYAVDVRNAVVVTAAGNVGGPGQCP
TQNATQPGRPDWQSVESVASPAWYDDLVLTVGSVRTDGAPSEFSLAGPWVDVAAPGEHVVSLDPDGDGLVDALPTADGDA
SIAGTSYAAPVVSGVAALVRSRWPHLTARQVMQRIEDTAHRPPAGWDSVVGHGVVDVAAAVSGGVPADTTETPARSLHAP
ADVPHDGRPRRVAMAGAGICVAITVLVALSASSHRRGHSDRVARH

Sequences:

>Translated_445_residues
MTGRLTAATLTGLLVAAVPLATAPEVSAVTPPAVDDAFLPAAAPPAPPQRTEQRAECSGAERDRDPPADARQLDMLNLQS
VWPLTRGAGQTVAVIDTGVARHRLLPRLMPGGDYVSTGDGTDDCDGHGTLVAGIVAATGEFTGVAPDAALLGIRQSSNKF
GAADDPGVTGYGDVQTLATAVRAAADLGATVINVSSVACLAAADALDDRALGAALAYAVDVRNAVVVTAAGNVGGPGQCP
TQNATQPGRPDWQSVESVASPAWYDDLVLTVGSVRTDGAPSEFSLAGPWVDVAAPGEHVVSLDPDGDGLVDALPTADGDA
SIAGTSYAAPVVSGVAALVRSRWPHLTARQVMQRIEDTAHRPPAGWDSVVGHGVVDVAAAVSGGVPADTTETPARSLHAP
ADVPHDGRPRRVAMAGAGICVAITVLVALSASSHRRGHSDRVARH
>Mature_444_residues
TGRLTAATLTGLLVAAVPLATAPEVSAVTPPAVDDAFLPAAAPPAPPQRTEQRAECSGAERDRDPPADARQLDMLNLQSV
WPLTRGAGQTVAVIDTGVARHRLLPRLMPGGDYVSTGDGTDDCDGHGTLVAGIVAATGEFTGVAPDAALLGIRQSSNKFG
AADDPGVTGYGDVQTLATAVRAAADLGATVINVSSVACLAAADALDDRALGAALAYAVDVRNAVVVTAAGNVGGPGQCPT
QNATQPGRPDWQSVESVASPAWYDDLVLTVGSVRTDGAPSEFSLAGPWVDVAAPGEHVVSLDPDGDGLVDALPTADGDAS
IAGTSYAAPVVSGVAALVRSRWPHLTARQVMQRIEDTAHRPPAGWDSVVGHGVVDVAAAVSGGVPADTTETPARSLHAPA
DVPHDGRPRRVAMAGAGICVAITVLVALSASSHRRGHSDRVARH

Specific function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.62 [H]

Molecular weight: Translated: 44982; Mature: 44851

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRLTAATLTGLLVAAVPLATAPEVSAVTPPAVDDAFLPAAAPPAPPQRTEQRAECSGA
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
ERDRDPPADARQLDMLNLQSVWPLTRGAGQTVAVIDTGVARHRLLPRLMPGGDYVSTGDG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEECCCC
TDDCDGHGTLVAGIVAATGEFTGVAPDAALLGIRQSSNKFGAADDPGVTGYGDVQTLATA
CCCCCCCCHHHHHHHHHCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
VRAAADLGATVINVSSVACLAAADALDDRALGAALAYAVDVRNAVVVTAAGNVGGPGQCP
HHHHHHHCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
TQNATQPGRPDWQSVESVASPAWYDDLVLTVGSVRTDGAPSEFSLAGPWVDVAAPGEHVV
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEE
SLDPDGDGLVDALPTADGDASIAGTSYAAPVVSGVAALVRSRWPHLTARQVMQRIEDTAH
EECCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
RPPAGWDSVVGHGVVDVAAAVSGGVPADTTETPARSLHAPADVPHDGRPRRVAMAGAGIC
CCCCCHHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCHH
VAITVLVALSASSHRRGHSDRVARH
HHHHHHHHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TGRLTAATLTGLLVAAVPLATAPEVSAVTPPAVDDAFLPAAAPPAPPQRTEQRAECSGA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCC
ERDRDPPADARQLDMLNLQSVWPLTRGAGQTVAVIDTGVARHRLLPRLMPGGDYVSTGDG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEECCCC
TDDCDGHGTLVAGIVAATGEFTGVAPDAALLGIRQSSNKFGAADDPGVTGYGDVQTLATA
CCCCCCCCHHHHHHHHHCCCCCCCCCCHHHEEEECCCCCCCCCCCCCCCCCCHHHHHHHH
VRAAADLGATVINVSSVACLAAADALDDRALGAALAYAVDVRNAVVVTAAGNVGGPGQCP
HHHHHHHCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
TQNATQPGRPDWQSVESVASPAWYDDLVLTVGSVRTDGAPSEFSLAGPWVDVAAPGEHVV
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCEEE
SLDPDGDGLVDALPTADGDASIAGTSYAAPVVSGVAALVRSRWPHLTARQVMQRIEDTAH
EECCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
RPPAGWDSVVGHGVVDVAAAVSGGVPADTTETPARSLHAPADVPHDGRPRRVAMAGAGIC
CCCCCHHHHHHCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEECCCHH
VAITVLVALSASSHRRGHSDRVARH
HHHHHHHHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6420308; 9826175 [H]