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The map label for this gene is trxB [H]

Identifier: 119867138

GI number: 119867138

Start: 1170690

End: 1172354

Strand: Reverse

Name: trxB [H]

Synonym: Mkms_1086

Alternate gene names: 119867138

Gene position: 1172354-1170690 (Counterclockwise)

Preceding gene: 119867140

Following gene: 119867137

Centisome position: 20.43

GC content: 69.13

Gene sequence:

>1665_bases
ATGACAGGCCCTACCGCGGTACCCCGCAAACCCGTGATCCTCACCGTCGACGACGACCCTGCGGTCTCGCGTGCGGTGGC
GCGCGACCTGCGCCGCCACTACGGCGAGACCTTCCGCATCGTGCGGGCCGAATCCGGCCCGGATGCGCTCGAGACACTCA
ACGAACTGAAGCTGCGCGGCGAGACCGTCGCGGTGTTCGTCGCCGACTACCGGATGCCGCAGATGAGCGGTATCGAATTC
CTCGAAGAGGCGATGGACCTCTACCCCATGGCGCGCCGCGTACTGCTCACCGCGTACGCCGACACCCACGCGGCCATCGA
CGCGATCAACGTCGTCGACCTGGACCACTACCTGCTCAAACCGTGGGACCCCCCGGAGGAGAAGCTCTACCCGGTCATCG
ACGCGCTGATCGAGGCGTGGCGCGCCACCGGGGACCGGGCCATCCCGCACACCAAGATCATCGGCCATCCGTGGAACGCC
AGATCGTCGGAGGTGCGCGAGTTCCTGGCCCGGAACCGGTTGTACTACACCTGGTTTCGCGCCGACGAAGCCAAGGGCAG
ACAGCTGCTGGAGGCGGCCGGCCAGGACGGGATGACGCTGCCGGTGGTGATCACCGAACAGGGTGAGACGCTGGTCGACC
CCTCCGACGCCGAACTGGGCGCCACGCTCGGGCTCACCACGACCCCGGCCGAGGACTTCTACGACCTGGTGGTGATCGGT
GGCGGGCCCGCCGGGCTGGCCGCCGCCGTGTACGGCGCGTCCGAGGGTCTCAAGACGGTGCTCATCGAACGCACCGCCAC
CGGCGGGCAGGCCGGGCAGAGCTCCCGCATCGAGAACTACCTGGGCTTCCCCGACGGCCTGTCGGGTTCTCAGCTCGCCG
AGCGGGCGCGCAGGCAGGCCGAGAAGTTCGACGCCGAACTGATCACCGCGGCGGAGGTGACGGCGTTGGAGGTCGACGGG
TCGGCCCGCACCGTGCGGCTGTCCGACGGCCGGTCGATCGGTGCGCGGGCGGTGATCCTGGCGATGGGCGTCGAGTACCG
CCAGCTGCCGGCCGAGGGTTGCGACGGGTTGACCGGCGCCGGGGTGTACTACGGCGCGACGTCGTCGGTGGCGGCCGACT
GCGAGGACGACGAGGTGTACGTGATCGGCGGCGCGAACTCCGCCGGCCAGGCCGCGATGTACCTGTCGCGCAGCGCCAAG
CAGGTCACGATCGTCAGCAGGCGCCGGCTCGAGGACTCGATGTCGCACTACCTGATCCAGCAGATCAGGGCCAACGACAA
GATCCGGGAGCTGCCGAACACCGTCGTGCACGCGGTCAAGGGCGACGGCCACCTCGAGGGCATCTGCCTGGAGAACACCC
TGACCGGGGCGCGCGAGGAGCACCACTGCGGCCGCATGTTCATCTTCATCGGCGCCGAACCGCGCACCGACTGGCTCGAC
GGCATCGTGGTCCGCGACGACCACGGGTTCATCCTGGCCGGGCCCGATCTGCGCGACGTCTCGGGCTGGATGCTGGACCG
CCCGCCGCACCACCTGGAAACAAGTGTGCCGGGTGTTTTTGTTGCAGGTGATGTGCGCGCGGAATCCGCCAAACGGGTGG
CCGCCGCCGTCGGCGAAGGATCGATGGCGGTGATGCTGGTGCACCGGTATCTGGCGGAAGCCTGA

Upstream 100 bases:

>100_bases
AACGCGTACACGGCCTCCGGCTCCCGCGCCACGTACACCGAATCGGAGTATTGGAGATCGACCACGGGTCGAAGCCTAAG
ACGGCGCATACTTGATCGCG

Downstream 100 bases:

>100_bases
AAGGGGTCACGATGGGCGAGACATGCCTGCGCGACGAACTGCGCACCCTGTTCCTGTTCGAGGCGCTCTCCGACGAACAA
CTCGACATGCTGTGCGCCGA

Product: response regulator receiver modulated FAD-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTGPTAVPRKPVILTVDDDPAVSRAVARDLRRHYGETFRIVRAESGPDALETLNELKLRGETVAVFVADYRMPQMSGIEF
LEEAMDLYPMARRVLLTAYADTHAAIDAINVVDLDHYLLKPWDPPEEKLYPVIDALIEAWRATGDRAIPHTKIIGHPWNA
RSSEVREFLARNRLYYTWFRADEAKGRQLLEAAGQDGMTLPVVITEQGETLVDPSDAELGATLGLTTTPAEDFYDLVVIG
GGPAGLAAAVYGASEGLKTVLIERTATGGQAGQSSRIENYLGFPDGLSGSQLAERARRQAEKFDAELITAAEVTALEVDG
SARTVRLSDGRSIGARAVILAMGVEYRQLPAEGCDGLTGAGVYYGATSSVAADCEDDEVYVIGGANSAGQAAMYLSRSAK
QVTIVSRRRLEDSMSHYLIQQIRANDKIRELPNTVVHAVKGDGHLEGICLENTLTGAREEHHCGRMFIFIGAEPRTDWLD
GIVVRDDHGFILAGPDLRDVSGWMLDRPPHHLETSVPGVFVAGDVRAESAKRVAAAVGEGSMAVMLVHRYLAEA

Sequences:

>Translated_554_residues
MTGPTAVPRKPVILTVDDDPAVSRAVARDLRRHYGETFRIVRAESGPDALETLNELKLRGETVAVFVADYRMPQMSGIEF
LEEAMDLYPMARRVLLTAYADTHAAIDAINVVDLDHYLLKPWDPPEEKLYPVIDALIEAWRATGDRAIPHTKIIGHPWNA
RSSEVREFLARNRLYYTWFRADEAKGRQLLEAAGQDGMTLPVVITEQGETLVDPSDAELGATLGLTTTPAEDFYDLVVIG
GGPAGLAAAVYGASEGLKTVLIERTATGGQAGQSSRIENYLGFPDGLSGSQLAERARRQAEKFDAELITAAEVTALEVDG
SARTVRLSDGRSIGARAVILAMGVEYRQLPAEGCDGLTGAGVYYGATSSVAADCEDDEVYVIGGANSAGQAAMYLSRSAK
QVTIVSRRRLEDSMSHYLIQQIRANDKIRELPNTVVHAVKGDGHLEGICLENTLTGAREEHHCGRMFIFIGAEPRTDWLD
GIVVRDDHGFILAGPDLRDVSGWMLDRPPHHLETSVPGVFVAGDVRAESAKRVAAAVGEGSMAVMLVHRYLAEA
>Mature_553_residues
TGPTAVPRKPVILTVDDDPAVSRAVARDLRRHYGETFRIVRAESGPDALETLNELKLRGETVAVFVADYRMPQMSGIEFL
EEAMDLYPMARRVLLTAYADTHAAIDAINVVDLDHYLLKPWDPPEEKLYPVIDALIEAWRATGDRAIPHTKIIGHPWNAR
SSEVREFLARNRLYYTWFRADEAKGRQLLEAAGQDGMTLPVVITEQGETLVDPSDAELGATLGLTTTPAEDFYDLVVIGG
GPAGLAAAVYGASEGLKTVLIERTATGGQAGQSSRIENYLGFPDGLSGSQLAERARRQAEKFDAELITAAEVTALEVDGS
ARTVRLSDGRSIGARAVILAMGVEYRQLPAEGCDGLTGAGVYYGATSSVAADCEDDEVYVIGGANSAGQAAMYLSRSAKQ
VTIVSRRRLEDSMSHYLIQQIRANDKIRELPNTVVHAVKGDGHLEGICLENTLTGAREEHHCGRMFIFIGAEPRTDWLDG
IVVRDDHGFILAGPDLRDVSGWMLDRPPHHLETSVPGVFVAGDVRAESAKRVAAAVGEGSMAVMLVHRYLAEA

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=327, Percent_Identity=31.4984709480122, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI87081763, Length=330, Percent_Identity=30, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320560, Length=336, Percent_Identity=33.0357142857143, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321898, Length=339, Percent_Identity=32.7433628318584, Blast_Score=140, Evalue=5e-34,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 60091; Mature: 59959

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPTAVPRKPVILTVDDDPAVSRAVARDLRRHYGETFRIVRAESGPDALETLNELKLRG
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
ETVAVFVADYRMPQMSGIEFLEEAMDLYPMARRVLLTAYADTHAAIDAINVVDLDHYLLK
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCHHHCC
PWDPPEEKLYPVIDALIEAWRATGDRAIPHTKIIGHPWNARSSEVREFLARNRLYYTWFR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEEEE
ADEAKGRQLLEAAGQDGMTLPVVITEQGETLVDPSDAELGATLGLTTTPAEDFYDLVVIG
CCCHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCCEEECCCCCCCCCCEEEEEEC
GGPAGLAAAVYGASEGLKTVLIERTATGGQAGQSSRIENYLGFPDGLSGSQLAERARRQA
CCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHH
EKFDAELITAAEVTALEVDGSARTVRLSDGRSIGARAVILAMGVEYRQLPAEGCDGLTGA
HHHCHHHEEEEEEEEEEECCCEEEEEECCCCCCCCEEEEEEECCHHHHCCCCCCCCCCCC
GVYYGATSSVAADCEDDEVYVIGGANSAGQAAMYLSRSAKQVTIVSRRRLEDSMSHYLIQ
CEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHH
QIRANDKIRELPNTVVHAVKGDGHLEGICLENTLTGAREEHHCGRMFIFIGAEPRTDWLD
HHHCCCHHHHCCHHHHEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCC
GIVVRDDHGFILAGPDLRDVSGWMLDRPPHHLETSVPGVFVAGDVRAESAKRVAAAVGEG
CEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCC
SMAVMLVHRYLAEA
CHHHHHHHHHHHCC
>Mature Secondary Structure 
TGPTAVPRKPVILTVDDDPAVSRAVARDLRRHYGETFRIVRAESGPDALETLNELKLRG
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
ETVAVFVADYRMPQMSGIEFLEEAMDLYPMARRVLLTAYADTHAAIDAINVVDLDHYLLK
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCHHHCC
PWDPPEEKLYPVIDALIEAWRATGDRAIPHTKIIGHPWNARSSEVREFLARNRLYYTWFR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCEEEEEEE
ADEAKGRQLLEAAGQDGMTLPVVITEQGETLVDPSDAELGATLGLTTTPAEDFYDLVVIG
CCCHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCCEEECCCCCCCCCCEEEEEEC
GGPAGLAAAVYGASEGLKTVLIERTATGGQAGQSSRIENYLGFPDGLSGSQLAERARRQA
CCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHH
EKFDAELITAAEVTALEVDGSARTVRLSDGRSIGARAVILAMGVEYRQLPAEGCDGLTGA
HHHCHHHEEEEEEEEEEECCCEEEEEECCCCCCCCEEEEEEECCHHHHCCCCCCCCCCCC
GVYYGATSSVAADCEDDEVYVIGGANSAGQAAMYLSRSAKQVTIVSRRRLEDSMSHYLIQ
CEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHH
QIRANDKIRELPNTVVHAVKGDGHLEGICLENTLTGAREEHHCGRMFIFIGAEPRTDWLD
HHHCCCHHHHCCHHHHEEECCCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCC
GIVVRDDHGFILAGPDLRDVSGWMLDRPPHHLETSVPGVFVAGDVRAESAKRVAAAVGEG
CEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCC
SMAVMLVHRYLAEA
CHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9795994 [H]