Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 119866776

GI number: 119866776

Start: 767154

End: 768188

Strand: Reverse

Name: phoR [H]

Synonym: Mkms_0722

Alternate gene names: 119866776

Gene position: 768188-767154 (Counterclockwise)

Preceding gene: 119866777

Following gene: 119866770

Centisome position: 13.39

GC content: 70.82

Gene sequence:

>1035_bases
GTGCCGTCAACTGACCTCTGGGAGATCGGCGCCTGGGCGCTGGCCTGCTCGATTCCGGTGGTGCTGGCCGGTGCGCTCGT
CATCCGGCTGGCCCGCACGTGGTCGCTGGCGGTCAGCATGGTCGTGCTGGTGCTGATTCCCGTGATCGCGACCTTCACCG
GCGTGCTGGGCGCCAGCGGATTCATGATCACCGAGACCTTCGAACCGATCGCCGTCGTGCTCGTGGTCGTGGCGGTGGTC
ACCATCCCCGGGGCCGTGATGCTCGGCCGCTACCAGGCCCGCCGCACGGTGTGGGAACAGGAGATCCGCGACTCCGAACG
GGCCGCCGAGATGTCGCGACGCCAGCTGGTCGCGTTCGTCAGCCACGATCTGCGGACCCCGCTGGCCGGGATCCGGGCGG
TGTCCGAAGCCATCGCCGACGGTCTGGTCGGCGGCGACGAGGTGCGGGCCCACGCCAAGCACATCGAACAGGAGTCCATC
CGCCTCTCGGAGATGGTCGACGACCTGTTCGAGATGAGCAAGATCAACGCCGGGGCGGTGCAGCCCACCTTCGACCGGGT
CGCGCTCGACGAGGTGGTCGACGACGTGCTGGCCGCCCACCGCATCGCCGCCGAACGCGCGGGAGTGCAACTACGGGCCG
AACTGCCCGACGAACCCGTGCGGGTGCTGGGCAGCGACCGCGCGCTGGTGCGGGTGCTGTCCAATCTGGTGGCCAACGCC
ATCGCGCACACCCCGGAGGGCGGGCGCGTGCAGTTGGCGCTCGGATCCGACGAGAACGTGGCCTGGGCCCGTGTCGACGA
CACCGGGGTCGGCATCGACGAGGCCGACCTGCCGCGGGTGTTCGACGTCGCCTACCGCGGATCGAACGACCGTGTGCCGC
GCGAGGATTCGTCGTTGCCGAGCGGTTCGGGGCTGGGGCTGGCCATCGCCGCGGGTCTGGTGCAGGCGCACCGGGGCACG
CTGTCGGCGCACAACCTGGACACCGGCGCGCGCTTCGAGGTGCGGCTGCCGCTGGCCTCGGACGTCTCCGACTGA

Upstream 100 bases:

>100_bases
TTGCGTTCCAAGCTCGGCGACCAGCACCGGGTGCAGACGGTGTGGGGCCGCGGCTACATGTGGAGCGACACCGCAGGCGC
CCTTGAAGGCCTGGCCAGCG

Downstream 100 bases:

>100_bases
CCGAGCGGGCCGGATCCGGTCTAGTTGCCCTCGGGGGCGGGTTCCGCGAGGTCCCACGAGGAGTAGGTGTACCGCTGATC
GTGACGGTCCCCGGCCCCGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPSTDLWEIGAWALACSIPVVLAGALVIRLARTWSLAVSMVVLVLIPVIATFTGVLGASGFMITETFEPIAVVLVVVAVV
TIPGAVMLGRYQARRTVWEQEIRDSERAAEMSRRQLVAFVSHDLRTPLAGIRAVSEAIADGLVGGDEVRAHAKHIEQESI
RLSEMVDDLFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANA
IAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREDSSLPSGSGLGLAIAAGLVQAHRGT
LSAHNLDTGARFEVRLPLASDVSD

Sequences:

>Translated_344_residues
MPSTDLWEIGAWALACSIPVVLAGALVIRLARTWSLAVSMVVLVLIPVIATFTGVLGASGFMITETFEPIAVVLVVVAVV
TIPGAVMLGRYQARRTVWEQEIRDSERAAEMSRRQLVAFVSHDLRTPLAGIRAVSEAIADGLVGGDEVRAHAKHIEQESI
RLSEMVDDLFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANA
IAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREDSSLPSGSGLGLAIAAGLVQAHRGT
LSAHNLDTGARFEVRLPLASDVSD
>Mature_343_residues
PSTDLWEIGAWALACSIPVVLAGALVIRLARTWSLAVSMVVLVLIPVIATFTGVLGASGFMITETFEPIAVVLVVVAVVT
IPGAVMLGRYQARRTVWEQEIRDSERAAEMSRRQLVAFVSHDLRTPLAGIRAVSEAIADGLVGGDEVRAHAKHIEQESIR
LSEMVDDLFEMSKINAGAVQPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANAI
AHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREDSSLPSGSGLGLAIAAGLVQAHRGTL
SAHNLDTGARFEVRLPLASDVSD

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=32.2448979591837, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789149, Length=270, Percent_Identity=30.7407407407407, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=28.6324786324786, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=31.6239316239316, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=30.4347826086957, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=30.4526748971193, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=29.6747967479675, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=287, Percent_Identity=25.4355400696864, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=257, Percent_Identity=27.2373540856031, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=25.8928571428571, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788279, Length=252, Percent_Identity=21.8253968253968, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=209, Percent_Identity=30.1435406698565, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=26.2948207171315, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790551, Length=237, Percent_Identity=29.1139240506329, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 36706; Mature: 36575

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTDLWEIGAWALACSIPVVLAGALVIRLARTWSLAVSMVVLVLIPVIATFTGVLGASG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FMITETFEPIAVVLVVVAVVTIPGAVMLGRYQARRTVWEQEIRDSERAAEMSRRQLVAFV
CEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLRTPLAGIRAVSEAIADGLVGGDEVRAHAKHIEQESIRLSEMVDDLFEMSKINAGAV
HHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHH
IAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREDSSLP
HHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCC
SGSGLGLAIAAGLVQAHRGTLSAHNLDTGARFEVRLPLASDVSD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
PSTDLWEIGAWALACSIPVVLAGALVIRLARTWSLAVSMVVLVLIPVIATFTGVLGASG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FMITETFEPIAVVLVVVAVVTIPGAVMLGRYQARRTVWEQEIRDSERAAEMSRRQLVAFV
CEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHDLRTPLAGIRAVSEAIADGLVGGDEVRAHAKHIEQESIRLSEMVDDLFEMSKINAGAV
HHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
QPTFDRVALDEVVDDVLAAHRIAAERAGVQLRAELPDEPVRVLGSDRALVRVLSNLVANA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCHHHHHHHHHHHHHH
IAHTPEGGRVQLALGSDENVAWARVDDTGVGIDEADLPRVFDVAYRGSNDRVPREDSSLP
HHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCC
SGSGLGLAIAAGLVQAHRGTLSAHNLDTGARFEVRLPLASDVSD
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]