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The map label for this gene is resD [H]

Identifier: 119866777

GI number: 119866777

Start: 768175

End: 768888

Strand: Reverse

Name: resD [H]

Synonym: Mkms_0723

Alternate gene names: 119866777

Gene position: 768888-768175 (Counterclockwise)

Preceding gene: 119866781

Following gene: 119866776

Centisome position: 13.4

GC content: 69.19

Gene sequence:

>714_bases
GTGACACGCGTCCTGATCGCCGACGACGACTCCGTCGTGCGGGATGTCGTGCGCCGATACCTCGAACGCGACGGCCTCGA
AGTGGCCATCGCCCGCGACGGCACCGAGGCGCTGCGACTGCTCGGCACCGAGCGGATCGACGTCGCCGTACTCGACGTGA
TGATGCCCGGACCCGACGGGGTGACGCTGTGCCGCACCCTGCGCCAGCGCGGCGAGCACACCGTCCCGGTCATCCTGTTG
ACCGCCCTCGGCGAGGAGGACGACCGCATCGCCGGACTGGAAGCCGGCGCGGACGACTACCTGACCAAACCGTTCAGCCC
GCGGGAACTGGCCCTGCGGGTGCGTTCGGTGCTGCGCCGTTCACCGACACCGGTCGGGGTGACCCCGGTCGACCTGACGG
TCGGCGCCCTCACGATCTCTGCGGCCGCCCGCTCGGTCACCGTCGACGGCCGGCCGGTCAGCCTCACCAACCGCGAATTC
GACCTGCTGCTGTTCTTCATCACCCACGCCGACACCGTGTTCACCCGCGAAGAGCTGCTCAAGCAGGTGTGGCGGTGGGA
TTTCGGCGATCTGTCCACGGTGACCGTGCACGTCAAACGGTTGCGTTCCAAGCTCGGCGACCAGCACCGGGTGCAGACGG
TGTGGGGCCGCGGCTACATGTGGAGCGACACCGCAGGCGCCCTTGAAGGCCTGGCCAGCGGTGCCGTCAACTGA

Upstream 100 bases:

>100_bases
GCACCGAGGCTAACCACCCCCACCGGGGGCCATCTGGGGCAACAGTGACGAATCTCTGACATCGGCGCAGGTGGCGGGCG
CCGACGGCTAACCTCGAAGG

Downstream 100 bases:

>100_bases
CCTCTGGGAGATCGGCGCCTGGGCGCTGGCCTGCTCGATTCCGGTGGTGCTGGCCGGTGCGCTCGTCATCCGGCTGGCCC
GCACGTGGTCGCTGGCGGTC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTRVLIADDDSVVRDVVRRYLERDGLEVAIARDGTEALRLLGTERIDVAVLDVMMPGPDGVTLCRTLRQRGEHTVPVILL
TALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRSPTPVGVTPVDLTVGALTISAAARSVTVDGRPVSLTNREF
DLLLFFITHADTVFTREELLKQVWRWDFGDLSTVTVHVKRLRSKLGDQHRVQTVWGRGYMWSDTAGALEGLASGAVN

Sequences:

>Translated_237_residues
MTRVLIADDDSVVRDVVRRYLERDGLEVAIARDGTEALRLLGTERIDVAVLDVMMPGPDGVTLCRTLRQRGEHTVPVILL
TALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRSPTPVGVTPVDLTVGALTISAAARSVTVDGRPVSLTNREF
DLLLFFITHADTVFTREELLKQVWRWDFGDLSTVTVHVKRLRSKLGDQHRVQTVWGRGYMWSDTAGALEGLASGAVN
>Mature_236_residues
TRVLIADDDSVVRDVVRRYLERDGLEVAIARDGTEALRLLGTERIDVAVLDVMMPGPDGVTLCRTLRQRGEHTVPVILLT
ALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRRSPTPVGVTPVDLTVGALTISAAARSVTVDGRPVSLTNREFD
LLLFFITHADTVFTREELLKQVWRWDFGDLSTVTVHVKRLRSKLGDQHRVQTVWGRGYMWSDTAGALEGLASGAVN

Specific function: Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=39.5555555555556, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.0877192982456, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=37.3873873873874, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=37.3913043478261, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=34.061135371179, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786911, Length=206, Percent_Identity=38.8349514563107, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=32.4444444444444, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=35.6828193832599, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.4841628959276, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=33.9449541284404, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=34.2465753424658, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=31.6017316017316, Blast_Score=113, Evalue=8e-27,
Organism=Escherichia coli, GI145693140, Length=243, Percent_Identity=31.6872427983539, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=27.6785714285714, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=36.1344537815126, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=102, Percent_Identity=39.2156862745098, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=103, Percent_Identity=39.8058252427184, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=104, Percent_Identity=32.6923076923077, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26173; Mature: 26042

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVLIADDDSVVRDVVRRYLERDGLEVAIARDGTEALRLLGTERIDVAVLDVMMPGPDG
CCEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEEECCCCH
VTLCRTLRQRGEHTVPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
HHHHHHHHHCCCCCCEEEEEEECCCCCCCEECCCCCCCHHHCCCCCHHHHHHHHHHHHHC
SPTPVGVTPVDLTVGALTISAAARSVTVDGRPVSLTNREFDLLLFFITHADTVFTREELL
CCCCCCCCCHHHHHHHHEEEHHHEEEEECCCEEEECCCCCEEEEEEEHHCCHHHHHHHHH
KQVWRWDFGDLSTVTVHVKRLRSKLGDQHRVQTVWGRGYMWSDTAGALEGLASGAVN
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHCCCCEEECCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRVLIADDDSVVRDVVRRYLERDGLEVAIARDGTEALRLLGTERIDVAVLDVMMPGPDG
CEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEEECCCCH
VTLCRTLRQRGEHTVPVILLTALGEEDDRIAGLEAGADDYLTKPFSPRELALRVRSVLRR
HHHHHHHHHCCCCCCEEEEEEECCCCCCCEECCCCCCCHHHCCCCCHHHHHHHHHHHHHC
SPTPVGVTPVDLTVGALTISAAARSVTVDGRPVSLTNREFDLLLFFITHADTVFTREELL
CCCCCCCCCHHHHHHHHEEEHHHEEEEECCCEEEECCCCCEEEEEEEHHCCHHHHHHHHH
KQVWRWDFGDLSTVTVHVKRLRSKLGDQHRVQTVWGRGYMWSDTAGALEGLASGAVN
HHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHCCCCEEECCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934829; 9384377; 8631715; 8682783 [H]