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The map label for this gene is menA [H]

Identifier: 119866770

GI number: 119866770

Start: 761005

End: 761874

Strand: Reverse

Name: menA [H]

Synonym: Mkms_0716

Alternate gene names: 119866770

Gene position: 761874-761005 (Counterclockwise)

Preceding gene: 119866776

Following gene: 119866764

Centisome position: 13.28

GC content: 73.79

Gene sequence:

>870_bases
GTGGCAACTTTCGCCGAATGGGTCGAGGGCGCGCGCCCCCGCACGCTGCCCAACGCCGTCGCACCGGTGATCGCCGGTAC
CGGGGCGGCGGCGTGGCTGGACGGTGCGGTGTGGTGGAAAGCGCTGCTGGCGTTCGTCGTCGCGGTCGCGCTGATCATCG
GGGTCAACTACGCCAACGACTACTCCGACGGTATCCGCGGCACCGACGACGTGCGGTCCGGGCCGCTGCGCCTGGTGGGC
TCCAGGCTGGCGTCCCCGCGGGCGGTGCTCACGGCGGCGATCGCCAGCCTCGCGGTGGGGGCGGTGGCCGGTTTGGCGCT
CGCGGTGGCCAGCGCCCCGTGGCTGATCGCCGTCGGCGCCGTCTGCATCGCGGGCGCGTGGCTCTACACCGGGGGTTCGA
AGCCCTACGGCTACCTCGGGCTCGGCGAGGTCGCGGTGTTCGTCTTCTTCGGCCTGGTCGCGGTGCTCGGCACGCAGTAC
ACCCAGGCGCTGCGCGTCGACTGGGTCGGGCTGGCCCTGGCCGTCGCGATGGGTGCGCTGTCGTCGGCGGTGCTGGTCGC
CAACAACCTGCGCGACATCCCCACCGACCGCGAGTCGGGCAAGATCACGCTGGCCGTCCGGCTCGGCGACGCCCGCACCC
GGCTGCTGTACCAGGCGCTGCTGGCCACCGCGTTCGCGCTCACGCTGGTGCTGATGCTCGCCACGCCCTGGTGTGCGGTC
GGTCTGGTGGCGCTGCCGCTGGCGGTGCGGGCGGCCCGTCCGGTGCGCGGCGGGCTCGGCGGTAAGGACCTGATCCCCGT
GCTTCGCGACACCGGGCTGACCATGCTGGTGTGGGCGGTCGCCGTCGCGCTCGCGCTCGCCCTCGGTTAG

Upstream 100 bases:

>100_bases
CCCAGCATTCAGATGCTCCTCACGTGCGCGGGCATGGGACCATTCTCGACCATCGCGCACCGCGCAGGGCGGACGGACCG
GCCGTGCGACGATTGCGGTC

Downstream 100 bases:

>100_bases
GGCGAGCCCGCGTCAGGCGGCCCGGTCGAGCAGGGCCACGATGTCGGCGCGCAGCCACGCGGCATCGACGCGCTCGGTGA
TCAGGCCGACGGCCACCTCG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MATFAEWVEGARPRTLPNAVAPVIAGTGAAAWLDGAVWWKALLAFVVAVALIIGVNYANDYSDGIRGTDDVRSGPLRLVG
SRLASPRAVLTAAIASLAVGAVAGLALAVASAPWLIAVGAVCIAGAWLYTGGSKPYGYLGLGEVAVFVFFGLVAVLGTQY
TQALRVDWVGLALAVAMGALSSAVLVANNLRDIPTDRESGKITLAVRLGDARTRLLYQALLATAFALTLVLMLATPWCAV
GLVALPLAVRAARPVRGGLGGKDLIPVLRDTGLTMLVWAVAVALALALG

Sequences:

>Translated_289_residues
MATFAEWVEGARPRTLPNAVAPVIAGTGAAAWLDGAVWWKALLAFVVAVALIIGVNYANDYSDGIRGTDDVRSGPLRLVG
SRLASPRAVLTAAIASLAVGAVAGLALAVASAPWLIAVGAVCIAGAWLYTGGSKPYGYLGLGEVAVFVFFGLVAVLGTQY
TQALRVDWVGLALAVAMGALSSAVLVANNLRDIPTDRESGKITLAVRLGDARTRLLYQALLATAFALTLVLMLATPWCAV
GLVALPLAVRAARPVRGGLGGKDLIPVLRDTGLTMLVWAVAVALALALG
>Mature_288_residues
ATFAEWVEGARPRTLPNAVAPVIAGTGAAAWLDGAVWWKALLAFVVAVALIIGVNYANDYSDGIRGTDDVRSGPLRLVGS
RLASPRAVLTAAIASLAVGAVAGLALAVASAPWLIAVGAVCIAGAWLYTGGSKPYGYLGLGEVAVFVFFGLVAVLGTQYT
QALRVDWVGLALAVAMGALSSAVLVANNLRDIPTDRESGKITLAVRLGDARTRLLYQALLATAFALTLVLMLATPWCAVG
LVALPLAVRAARPVRGGLGGKDLIPVLRDTGLTMLVWAVAVALALALG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=266, Percent_Identity=28.1954887218045, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1790365, Length=275, Percent_Identity=38.5454545454545, Blast_Score=152, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17737429, Length=253, Percent_Identity=28.0632411067194, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 29622; Mature: 29491

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATFAEWVEGARPRTLPNAVAPVIAGTGAAAWLDGAVWWKALLAFVVAVALIIGVNYAND
CCCHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDVRSGPLRLVGSRLASPRAVLTAAIASLAVGAVAGLALAVASAPWLIAVGA
CCCCCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VCIAGAWLYTGGSKPYGYLGLGEVAVFVFFGLVAVLGTQYTQALRVDWVGLALAVAMGAL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSAVLVANNLRDIPTDRESGKITLAVRLGDARTRLLYQALLATAFALTLVLMLATPWCAV
HHHHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLVALPLAVRAARPVRGGLGGKDLIPVLRDTGLTMLVWAVAVALALALG
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATFAEWVEGARPRTLPNAVAPVIAGTGAAAWLDGAVWWKALLAFVVAVALIIGVNYAND
CCHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YSDGIRGTDDVRSGPLRLVGSRLASPRAVLTAAIASLAVGAVAGLALAVASAPWLIAVGA
CCCCCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VCIAGAWLYTGGSKPYGYLGLGEVAVFVFFGLVAVLGTQYTQALRVDWVGLALAVAMGAL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSAVLVANNLRDIPTDRESGKITLAVRLGDARTRLLYQALLATAFALTLVLMLATPWCAV
HHHHHHHHCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
GLVALPLAVRAARPVRGGLGGKDLIPVLRDTGLTMLVWAVAVALALALG
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]