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The map label for this gene is copR [H]

Identifier: 119776435

GI number: 119776435

Start: 3929286

End: 3929960

Strand: Direct

Name: copR [H]

Synonym: Sama_3303

Alternate gene names: 119776435

Gene position: 3929286-3929960 (Clockwise)

Preceding gene: 119776434

Following gene: 119776436

Centisome position: 91.25

GC content: 59.85

Gene sequence:

>675_bases
ATGCGCCTGTTACTGGTTGAAGACGATGCGGCCCTGGCCGCCAATTTGGGGGATCACCTCAGAGAAAACCTCTACAGCGT
GGATGTGGCCGCCGACGGCGAGCTGGGGCTGTTTCAGGGGCTGGAGTACGACTACGACGCCGCCATTATCGACGTAGGCC
TGCCCAAGCTCGATGGCATCAGTCTGGTCACCAAGCTCAGGGCCGAAGGCCGTGAGTTCCCCATTCTTATCCTCACCGCC
CGGGACAGCTGGGAAGACAAGGTCGAAGGCCTGGATGCCGGTGCCGACGACTACCTCACCAAGCCGTTCCATCCCCGGGA
ACTGGCCTCGCGCTTAAAGGCACTGATTCGCCGCAGCGCCGGTAAGGCCAGCCCCGTTATCGAAAACGGCCCTGTTACCC
TCAATACCGCCAGCGGCGAAGTATTGCTTAACGGCGAGCGGGTCAGCCTGTCGGCTTCCGAGTTCCGGCTGCTGCAATTT
TTGATGATGCACCGGGGCGAGGTGCAATCCAAAACCATGCTCACCGAGCATATTTACGATCAGGACTTCGACCTCGACTC
CAACGTGATTGAAGTCTTTATCCGCCGGTTGCGTAAAAAGCTCGACCCGGACAACGAGCTCGGGCTGATTGAAACCCTGC
GCGGCCAGGGCTACCGGCTGAACCTGCTGACCTGA

Upstream 100 bases:

>100_bases
GTGGCAACCCCGGCTACCGGGTCAAGATGGTCAGCGACGACGGTAAAGTCTTTTACGTATCTGTGGATGCCCGTACCGGA
CGGGTTGGGAGAGACTGACA

Downstream 100 bases:

>100_bases
TGTCACACTCAGCCTCTACGCCCAAGCCAGTGCCTGCAGCCGCACCGGCCCACAAGCAGGCGGCGGCCTTTATCGATCGC
CTATCCCTGAAAACACGCCT

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRLLLVEDDAALAANLGDHLRENLYSVDVAADGELGLFQGLEYDYDAAIIDVGLPKLDGISLVTKLRAEGREFPILILTA
RDSWEDKVEGLDAGADDYLTKPFHPRELASRLKALIRRSAGKASPVIENGPVTLNTASGEVLLNGERVSLSASEFRLLQF
LMMHRGEVQSKTMLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNELGLIETLRGQGYRLNLLT

Sequences:

>Translated_224_residues
MRLLLVEDDAALAANLGDHLRENLYSVDVAADGELGLFQGLEYDYDAAIIDVGLPKLDGISLVTKLRAEGREFPILILTA
RDSWEDKVEGLDAGADDYLTKPFHPRELASRLKALIRRSAGKASPVIENGPVTLNTASGEVLLNGERVSLSASEFRLLQF
LMMHRGEVQSKTMLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNELGLIETLRGQGYRLNLLT
>Mature_224_residues
MRLLLVEDDAALAANLGDHLRENLYSVDVAADGELGLFQGLEYDYDAAIIDVGLPKLDGISLVTKLRAEGREFPILILTA
RDSWEDKVEGLDAGADDYLTKPFHPRELASRLKALIRRSAGKASPVIENGPVTLNTASGEVLLNGERVSLSASEFRLLQF
LMMHRGEVQSKTMLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNELGLIETLRGQGYRLNLLT

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=41.4414414414414, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=39.3805309734513, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=37.6146788990826, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.7713004484305, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=37.10407239819, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.1351351351351, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=32.1266968325792, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.4444444444444, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.9285714285714, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=33.4782608695652, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=31.7180616740088, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=28.695652173913, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24993; Mature: 24993

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLVEDDAALAANLGDHLRENLYSVDVAADGELGLFQGLEYDYDAAIIDVGLPKLDGI
CEEEEEECCCHHHHHHHHHHHHHHEEEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCCH
SLVTKLRAEGREFPILILTARDSWEDKVEGLDAGADDYLTKPFHPRELASRLKALIRRSA
HHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GKASPVIENGPVTLNTASGEVLLNGERVSLSASEFRLLQFLMMHRGEVQSKTMLTEHIYD
CCCCCCCCCCCEEEEECCCEEEECCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
QDFDLDSNVIEVFIRRLRKKLDPDNELGLIETLRGQGYRLNLLT
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECC
>Mature Secondary Structure
MRLLLVEDDAALAANLGDHLRENLYSVDVAADGELGLFQGLEYDYDAAIIDVGLPKLDGI
CEEEEEECCCHHHHHHHHHHHHHHEEEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCCH
SLVTKLRAEGREFPILILTARDSWEDKVEGLDAGADDYLTKPFHPRELASRLKALIRRSA
HHHHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GKASPVIENGPVTLNTASGEVLLNGERVSLSASEFRLLQFLMMHRGEVQSKTMLTEHIYD
CCCCCCCCCCCEEEEECCCEEEECCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
QDFDLDSNVIEVFIRRLRKKLDPDNELGLIETLRGQGYRLNLLT
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]