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The map label for this gene is ipk

Identifier: 119775701

GI number: 119775701

Start: 3075156

End: 3076007

Strand: Direct

Name: ipk

Synonym: Sama_2569

Alternate gene names: 119775701

Gene position: 3075156-3076007 (Clockwise)

Preceding gene: 119775700

Following gene: 119775702

Centisome position: 71.41

GC content: 53.99

Gene sequence:

>852_bases
ATGATGTCTGTATCCCTTGCCTGGCCGGCACCGGCAAAGCTCAATCTGTTTTTGCACATCAATGGCCGCTTACCCAATGG
CTACCATGAACTGCAAACCCTGTTTCAGTTTATCGACTACGGTGACTGGCTGGATTTTAAAATAACAGCAACACCAGAGT
TGAAACTGCACTCCAACCTCAGCCAAGTTGTCCCCGACAGCGATAACTTAATTCTGAAAGCCGCAAAATCTTTGCAGAGC
GTCACAGGTTGTATACAGGGCGCCGAGATCTGGCTCGACAAGCGCCTGCCCATGGGCGGCGGACTCGGCGGCGGTTCATC
GGATGCCGCTACCACACTGGTGGCGCTTAACGCCCTGTGGCAGCTGGGTTTGGACAAAAAAGCCCTGATGGATATCGGCC
TGACTCTCGGCGCTGATGTGCCTGTTTTTATTAACGGAATCGCGGCTTTCGCCGAAGGTGTCGGCGAAAAATTACAGCCC
GTGGACGTAGCAGAGCCTTGGTATTTGGTGTTGATACCAGACGCCCATGTATCCACCGCCGACGTATTTCAGCACCCTGA
TTTACCTAGGAATACGCCCAAGCTGGACATGTCATCACTAAGCCCGGAACGCTGGTCAAACGACTGCCAGGCATTGGTCA
GTGCCAAATACCCCCAAGTTGCCAATGCCTTAAGCTGGCTGGTAGAATATGCGCCGTCCAGAATGACCGGAACCGGTGCA
TGCGTGTTCGGGGAATTCGGCTCGCAGCAGGCCGCGCTGGAGGCGTTGGCTAAAAAGCCAGCTGAGATGCAGGGCTTTGT
TGCGAAAGGACTGAATCGTTCGCCGTTGGAGTTGAGACTCGCTCAGCTTTAA

Upstream 100 bases:

>100_bases
TTCCACGGATGCTGGAGCTTACCCACGCCAGCGCTGTTATCAAGCTGCAAACCAATGAATGGCAGGCACTGGCCAATGCC
ACAGGTTCGAAAGGAGCCCG

Downstream 100 bases:

>100_bases
ACTACTTCTGCGCTGCACGCCAGGGAACGCGCGGCAGCAGCTACACTAAAATATCAAGCAAACGCCTGAGGTTCATACAG
TGCCCGACATCAAGCTCTTT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MMSVSLAWPAPAKLNLFLHINGRLPNGYHELQTLFQFIDYGDWLDFKITATPELKLHSNLSQVVPDSDNLILKAAKSLQS
VTGCIQGAEIWLDKRLPMGGGLGGGSSDAATTLVALNALWQLGLDKKALMDIGLTLGADVPVFINGIAAFAEGVGEKLQP
VDVAEPWYLVLIPDAHVSTADVFQHPDLPRNTPKLDMSSLSPERWSNDCQALVSAKYPQVANALSWLVEYAPSRMTGTGA
CVFGEFGSQQAALEALAKKPAEMQGFVAKGLNRSPLELRLAQL

Sequences:

>Translated_283_residues
MMSVSLAWPAPAKLNLFLHINGRLPNGYHELQTLFQFIDYGDWLDFKITATPELKLHSNLSQVVPDSDNLILKAAKSLQS
VTGCIQGAEIWLDKRLPMGGGLGGGSSDAATTLVALNALWQLGLDKKALMDIGLTLGADVPVFINGIAAFAEGVGEKLQP
VDVAEPWYLVLIPDAHVSTADVFQHPDLPRNTPKLDMSSLSPERWSNDCQALVSAKYPQVANALSWLVEYAPSRMTGTGA
CVFGEFGSQQAALEALAKKPAEMQGFVAKGLNRSPLELRLAQL
>Mature_283_residues
MMSVSLAWPAPAKLNLFLHINGRLPNGYHELQTLFQFIDYGDWLDFKITATPELKLHSNLSQVVPDSDNLILKAAKSLQS
VTGCIQGAEIWLDKRLPMGGGLGGGSSDAATTLVALNALWQLGLDKKALMDIGLTLGADVPVFINGIAAFAEGVGEKLQP
VDVAEPWYLVLIPDAHVSTADVFQHPDLPRNTPKLDMSSLSPERWSNDCQALVSAKYPQVANALSWLVEYAPSRMTGTGA
CVFGEFGSQQAALEALAKKPAEMQGFVAKGLNRSPLELRLAQL

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=278, Percent_Identity=53.5971223021583, Blast_Score=271, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_SHEAM (A1S8R5)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_928441.1
- ProteinModelPortal:   A1S8R5
- SMR:   A1S8R5
- STRING:   A1S8R5
- GeneID:   4604816
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_2569
- NMPDR:   fig|326297.7.peg.2409
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- PhylomeDB:   A1S8R5
- ProtClustDB:   PRK00343
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 30507; Mature: 30507

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: ACT_SITE 13-13 ACT_SITE 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVSLAWPAPAKLNLFLHINGRLPNGYHELQTLFQFIDYGDWLDFKITATPELKLHSNL
CCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCH
SQVVPDSDNLILKAAKSLQSVTGCIQGAEIWLDKRLPMGGGLGGGSSDAATTLVALNALW
HHHCCCCCCHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QLGLDKKALMDIGLTLGADVPVFINGIAAFAEGVGEKLQPVDVAEPWYLVLIPDAHVSTA
HHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHH
DVFQHPDLPRNTPKLDMSSLSPERWSNDCQALVSAKYPQVANALSWLVEYAPSRMTGTGA
HHHCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCE
CVFGEFGSQQAALEALAKKPAEMQGFVAKGLNRSPLELRLAQL
EEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHEEEECC
>Mature Secondary Structure
MMSVSLAWPAPAKLNLFLHINGRLPNGYHELQTLFQFIDYGDWLDFKITATPELKLHSNL
CCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCH
SQVVPDSDNLILKAAKSLQSVTGCIQGAEIWLDKRLPMGGGLGGGSSDAATTLVALNALW
HHHCCCCCCHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
QLGLDKKALMDIGLTLGADVPVFINGIAAFAEGVGEKLQPVDVAEPWYLVLIPDAHVSTA
HHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHH
DVFQHPDLPRNTPKLDMSSLSPERWSNDCQALVSAKYPQVANALSWLVEYAPSRMTGTGA
HHHCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCE
CVFGEFGSQQAALEALAKKPAEMQGFVAKGLNRSPLELRLAQL
EEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA