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The map label for this gene is prs [H]

Identifier: 119775702

GI number: 119775702

Start: 3076087

End: 3077034

Strand: Direct

Name: prs [H]

Synonym: Sama_2570

Alternate gene names: 119775702

Gene position: 3076087-3077034 (Clockwise)

Preceding gene: 119775701

Following gene: 119775706

Centisome position: 71.43

GC content: 54.85

Gene sequence:

>948_bases
GTGCCCGACATCAAGCTCTTTGCTGGGAATGCTACCCCCAGTCTCGCGAAAAAGATTGCCGACCGTTTATTTTGCAAACT
TGGAGAGGCTGAGGTAGGCCGTTTCAGTGACGGTGAAATCAGTGTCCAGATCAACGAAAATGTACGTGGTGCTGATGTTT
TCATCATTCAATCCACCTGCGCCCCCACCAATGACAACCTGATGGAACTCATTGTGATGGTCGATGCTCTGCGCCGCGCC
TCTGCAGGTCGTATCACTGCCGTAATCCCATACTTCGGTTATGCCCGTCAGGATCGCCGTGTGCGCTCTGCCCGTGTGCC
TATTACCGCCAAAGTGGTTGCCGACTTCCTGTCAAGCGTTGGTGTTGACCGCGTACTGACCTGTGACCTGCACGCCGAGC
AGATCCAGGGCTTCTTCGACGTGCCGGTAGACAACGTGTTCGGTAGCCCAGTGCTGCTGGAAGACATGGTTGCCAAGAAG
CTGGACAACCCTGTGGTTGTGTCTCCGGACATCGGTGGCGTTGTCCGCGCCCGCGCCGTTGCCAAGCTGCTGAACGATTC
CGATCTGGCCATTATCGACAAGCGTCGCCCACAGGCCAACGTGGCTCAGGTCATGCACATTATCGGTGACGTTGAAGGTC
GTGACTGCATCATCGTTGACGACATGATTGATACCGGTGGCACCCTGTGTAAAGCCGCCGAAGCCCTGAAAGAACATGGT
GCCAACCGCGTATTCGCTTACGCCACTCACCCAGTGTTCTCCGGCAAGGCCGCTGAAAACATCAAAAACTCTGTGATTGA
TGAAGTGATAGTGACCGACACTGTGCCTCTGAGCGAAGAGATGATGAAAGTAGGTAAAGTCAGTCAGCTGACCATGTCTG
CCCTGCTCGCCGAAGCCATTCGCCGTGTGAGCAACGAAGAATCCATCTCTGCCATGTTCCAGCACTGA

Upstream 100 bases:

>100_bases
TTGAGACTCGCTCAGCTTTAAACTACTTCTGCGCTGCACGCCAGGGAACGCGCGGCAGCAGCTACACTAAAATATCAAGC
AAACGCCTGAGGTTCATACA

Downstream 100 bases:

>100_bases
TAGCTCAGGTACCGGACAACAAGCCGGTAACCGCTGTCTGCCCATGGCAAAAAACGCACCCTCAGGGGTGCGTTTTTTTA
TGCCGGCACTCTTTGAAACC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDIKLFAGNATPSLAKKIADRLFCKLGEAEVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMVAKK
LDNPVVVSPDIGGVVRARAVAKLLNDSDLAIIDKRRPQANVAQVMHIIGDVEGRDCIIVDDMIDTGGTLCKAAEALKEHG
ANRVFAYATHPVFSGKAAENIKNSVIDEVIVTDTVPLSEEMMKVGKVSQLTMSALLAEAIRRVSNEESISAMFQH

Sequences:

>Translated_315_residues
MPDIKLFAGNATPSLAKKIADRLFCKLGEAEVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMVAKK
LDNPVVVSPDIGGVVRARAVAKLLNDSDLAIIDKRRPQANVAQVMHIIGDVEGRDCIIVDDMIDTGGTLCKAAEALKEHG
ANRVFAYATHPVFSGKAAENIKNSVIDEVIVTDTVPLSEEMMKVGKVSQLTMSALLAEAIRRVSNEESISAMFQH
>Mature_314_residues
PDIKLFAGNATPSLAKKIADRLFCKLGEAEVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMVAKKL
DNPVVVSPDIGGVVRARAVAKLLNDSDLAIIDKRRPQANVAQVMHIIGDVEGRDCIIVDDMIDTGGTLCKAAEALKEHGA
NRVFAYATHPVFSGKAAENIKNSVIDEVIVTDTVPLSEEMMKVGKVSQLTMSALLAEAIRRVSNEESISAMFQH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=48.5804416403785, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=47.6340694006309, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=47.3354231974922, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=47.6340694006309, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=36.8115942028986, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=36.231884057971, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=31.7241379310345, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=31.7241379310345, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=31.7241379310345, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=31.7241379310345, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=83.1746031746032, Blast_Score=553, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17554702, Length=318, Percent_Identity=46.8553459119497, Blast_Score=297, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI25149168, Length=318, Percent_Identity=46.8553459119497, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI71989924, Length=318, Percent_Identity=46.8553459119497, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=313, Percent_Identity=46.3258785942492, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=35.0148367952522, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=46.5189873417722, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=46.3492063492063, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=320, Percent_Identity=47.5, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=40.5797101449275, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=45.2173913043478, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=46.3722397476341, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=43.3628318584071, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24651458, Length=357, Percent_Identity=34.453781512605, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651456, Length=357, Percent_Identity=34.453781512605, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI281362873, Length=357, Percent_Identity=34.453781512605, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651454, Length=357, Percent_Identity=34.453781512605, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24651462, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24651464, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45552010, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34120; Mature: 33989

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFAGNATPSLAKKIADRLFCKLGEAEVGRFSDGEISVQINENVRGADVFIIQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMVAKKLDNPVVVSPDIGGVVRARAV
CCCEEEEECCCHHHCCCEECCCHHHHCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHH
AKLLNDSDLAIIDKRRPQANVAQVMHIIGDVEGRDCIIVDDMIDTGGTLCKAAEALKEHG
HHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
ANRVFAYATHPVFSGKAAENIKNSVIDEVIVTDTVPLSEEMMKVGKVSQLTMSALLAEAI
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
RRVSNEESISAMFQH
HHHCCHHHHHHHHCC
>Mature Secondary Structure 
PDIKLFAGNATPSLAKKIADRLFCKLGEAEVGRFSDGEISVQINENVRGADVFIIQSTC
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMVAKKLDNPVVVSPDIGGVVRARAV
CCCEEEEECCCHHHCCCEECCCHHHHCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHH
AKLLNDSDLAIIDKRRPQANVAQVMHIIGDVEGRDCIIVDDMIDTGGTLCKAAEALKEHG
HHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
ANRVFAYATHPVFSGKAAENIKNSVIDEVIVTDTVPLSEEMMKVGKVSQLTMSALLAEAI
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHH
RRVSNEESISAMFQH
HHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]