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The map label for this gene is sdhA [H]

Identifier: 119774562

GI number: 119774562

Start: 1733843

End: 1735609

Strand: Direct

Name: sdhA [H]

Synonym: Sama_1425

Alternate gene names: 119774562

Gene position: 1733843-1735609 (Clockwise)

Preceding gene: 119774561

Following gene: 119774563

Centisome position: 40.26

GC content: 55.4

Gene sequence:

>1767_bases
GTGAGTATTCCAGTTCGCGAGTTTGATGCAGTCGTGATTGGTGCCGGCGGTGCCGGTATGCGCGCTGCACTGCAGATTTC
CAAAGAAGGCAAGAGCTGTGCGCTCCTGTCTAAAGTATTCCCAACCCGTTCTCACACTGTATCTGCCCAGGGTGGTATTA
CAGTAGCGCTGGGCAACGCCCACGAAGATAACTGGGAATACCACATGTACGATACCGTTAAGGGCTCCGACTTTATCGGT
GACCAAGACGCTATCGAATACATGTGTCAAACCGGTCCAGAAGCCATTATCGAGCTGGAGCATATGGGTCTGCCATTCTC
CCGTTTCGAAAACGGCAAGATTTACCAGCGTCCTTTTGGCGGTCAGTCCAAGAACTTTGGTGGTGAGCAGGCTGCTCGTA
CTGCCGCGGCTGCCGACCGTACCGGTCACGCCCTGCTGCACTGTCTGTATCAGCAGAACGTGAAGAACAAAACTCAGGTA
TTCTCTGAGTGGTACGCTCTTGACCTGGTGAAGAACGAAGATGGCGCCATCGTAGGCTGTACTGCCATCGACATTGAATC
CGGTGAAATTGTTTACTTCAAAGCCAAGGCCACTGTACTGGCTACCGGTGGTGCAGGTCGTATCTACGCATCTACCACCA
ACGCGCACATCAACACCGGTGACGGTGTGGGTATGGCTTACCGTGCCGGTGTGCAGCTGCAGGACATGGAAATGTGGCAG
TTCCACCCAACCGGTATTGCCGGTGCCGGTGTACTGGTAACCGAAGGTTGCCGCGGTGAGGGTGGCTACCTTTTGAACAA
AGACGGTGAGCGCTTTATGGAGCGTTACGCGCCAAACGCCAAGGACCTCGCGTCCCGTGACGTTGTGGCCCGTTCCATGA
TGACCGAAATCCGTGAAGGCCGTGGCTGTGATGGTCCTATGGGTCCACACATCAAGCTCAAGCTTGATCACCTGGGTAAA
GAAACCCTGGAAGCCCGTCTGCCAGGCGTGTGCGAACTGTCACGTACCTTTGCTCACATCGATCCGGCCGATGGCCCAAT
CCCTGTGATCCCAACCTGCCACTATATGATGGGTGGTCTGCCGACCAAGGTATCCGGTCAGGTAATCCGTAAGAACGACG
ACGGCAGCGAAACCGATATCGTCGGCCTGTTCGCTGTGGGCGAAATCGCTTGTGTATCTGTTCACGGTGCCAACCGTCTG
GGCGGTAACTCGCTGCTTGACCTGGTGGTATTCGGCCGTGCGGCTGGTCAGCACCTGGGTAAGGCGCTGGACGAGACTGC
CGATCCTAAAGCTGCTACCGACGCAGACATCGAGCAATCACTTGCCCGTCTGAAGCGTTGGGAAAGCAACAAAGACGGCG
AAGATCCTGCGCAAATCCGTAAAGACCTGCAAATGTGTATGCAGCTTAACTTCTCTGTGTTCCGTACCGGTGAAGCCATG
GCCGAAGGCCTCGAGCAACTGCAAGCCATCCGCAAGCGTCTGGAAAATGCCAAGCTGTCTGACAACTCCAAAGAGTTCAA
CACTCAGCGTATTGAGTGTCTGGAGCTGGATAACCTGATGGCCACCGCCATCGCGACTGCTTACGCTGCTAACTTCCGTA
CTGAGAGCCGTGGTGCCCACAGCCGTGAAGACTTCACCGAGCGTGATGATGACAACTGGCTGTGCCACAGCCTGTTCGAC
CCCGTGACTGAGGCTATGTCCAAGCGCGAAGTGAACATGTCACCCAAGCACCGTGAAGCCTTCCCACCGAAGAAGCGTAC
CTACTAA

Upstream 100 bases:

>100_bases
GTCAAGCAAACAGCGCTGCGTGGTGTATTACAGTTTACCTTTGTCGTGACTGCCTTCGCTTATCTGGCCGCCGGCATTGT
GATTGTGTGGGGGGTATAAG

Downstream 100 bases:

>100_bases
GGAGTTGCGAAGATGAAGTTGGAGTTTTCAGTTTATCGTTACAATCCTGACGTAGATACCAAGCCACGTATGCAGGATTA
CAGCTTCGACGTGCCTGATG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDNWEYHMYDTVKGSDFIG
DQDAIEYMCQTGPEAIIELEHMGLPFSRFENGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKNKTQV
FSEWYALDLVKNEDGAIVGCTAIDIESGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAYRAGVQLQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGCDGPMGPHIKLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVIPTCHYMMGGLPTKVSGQVIRKNDDGSETDIVGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETADPKAATDADIEQSLARLKRWESNKDGEDPAQIRKDLQMCMQLNFSVFRTGEAM
AEGLEQLQAIRKRLENAKLSDNSKEFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDFTERDDDNWLCHSLFD
PVTEAMSKREVNMSPKHREAFPPKKRTY

Sequences:

>Translated_588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDNWEYHMYDTVKGSDFIG
DQDAIEYMCQTGPEAIIELEHMGLPFSRFENGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKNKTQV
FSEWYALDLVKNEDGAIVGCTAIDIESGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAYRAGVQLQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGCDGPMGPHIKLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVIPTCHYMMGGLPTKVSGQVIRKNDDGSETDIVGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETADPKAATDADIEQSLARLKRWESNKDGEDPAQIRKDLQMCMQLNFSVFRTGEAM
AEGLEQLQAIRKRLENAKLSDNSKEFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDFTERDDDNWLCHSLFD
PVTEAMSKREVNMSPKHREAFPPKKRTY
>Mature_587_residues
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDNWEYHMYDTVKGSDFIGD
QDAIEYMCQTGPEAIIELEHMGLPFSRFENGKIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKNKTQVF
SEWYALDLVKNEDGAIVGCTAIDIESGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAYRAGVQLQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGCDGPMGPHIKLKLDHLGKE
TLEARLPGVCELSRTFAHIDPADGPIPVIPTCHYMMGGLPTKVSGQVIRKNDDGSETDIVGLFAVGEIACVSVHGANRLG
GNSLLDLVVFGRAAGQHLGKALDETADPKAATDADIEQSLARLKRWESNKDGEDPAQIRKDLQMCMQLNFSVFRTGEAMA
EGLEQLQAIRKRLENAKLSDNSKEFNTQRIECLELDNLMATAIATAYAANFRTESRGAHSREDFTERDDDNWLCHSLFDP
VTEAMSKREVNMSPKHREAFPPKKRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=546, Percent_Identity=53.8461538461538, Blast_Score=538, Evalue=1e-153,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=79.7619047619048, Blast_Score=939, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=41.0122164048866, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788928, Length=569, Percent_Identity=28.8224956063269, Blast_Score=208, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17505833, Length=592, Percent_Identity=49.3243243243243, Blast_Score=542, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=49.0662139219015, Blast_Score=533, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71986328, Length=78, Percent_Identity=50, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322701, Length=594, Percent_Identity=51.8518518518518, Blast_Score=578, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=54.1516245487365, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6320788, Length=490, Percent_Identity=27.7551020408163, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322511, Length=487, Percent_Identity=24.435318275154, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=53.2110091743119, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=53.2110091743119, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=53.2110091743119, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24663005, Length=549, Percent_Identity=49.3624772313297, Blast_Score=516, Evalue=1e-146,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64160; Mature: 64029

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDNWEYHMYDTVKGSDFIGDQDAIEYMCQTGPEAIIELEHMGLPFSRFENGKIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHEEEHHHCCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKNKTQVFSEWYALDLVKNEDGAIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCEEEE
TAIDIESGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAYRAGVQLQDMEMWQ
EEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCCEECCCEEEECCEEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGCDGPMGPHIKLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVIPTCHYMMGGL
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PTKVSGQVIRKNDDGSETDIVGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEEECCCCCCCEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETADPKAATDADIEQSLARLKRWESNKDGEDPAQIRKDLQMCMQLNFSVFRTGEAM
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHEECCHHH
AEGLEQLQAIRKRLENAKLSDNSKEFNTQRIECLELDNLMATAIATAYAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
SREDFTERDDDNWLCHSLFDPVTEAMSKREVNMSPKHREAFPPKKRTY
CCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDNWEYHMYDTVKGSDFIGDQDAIEYMCQTGPEAIIELEHMGLPFSRFENGKIYQRPFG
CCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHEEEHHHCCCCHHHCCCCEEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHCLYQQNVKNKTQVFSEWYALDLVKNEDGAIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCEEEE
TAIDIESGEIVYFKAKATVLATGGAGRIYASTTNAHINTGDGVGMAYRAGVQLQDMEMWQ
EEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCCEECCCEEEECCEEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGCDGPMGPHIKLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVIPTCHYMMGGL
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PTKVSGQVIRKNDDGSETDIVGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEEECCCCCCCEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETADPKAATDADIEQSLARLKRWESNKDGEDPAQIRKDLQMCMQLNFSVFRTGEAM
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHEECCHHH
AEGLEQLQAIRKRLENAKLSDNSKEFNTQRIECLELDNLMATAIATAYAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHCCCCCCCCCC
SREDFTERDDDNWLCHSLFDPVTEAMSKREVNMSPKHREAFPPKKRTY
CCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]