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The map label for this gene is sdhB [H]

Identifier: 119774563

GI number: 119774563

Start: 1735622

End: 1736329

Strand: Direct

Name: sdhB [H]

Synonym: Sama_1426

Alternate gene names: 119774563

Gene position: 1735622-1736329 (Clockwise)

Preceding gene: 119774562

Following gene: 119774564

Centisome position: 40.31

GC content: 53.95

Gene sequence:

>708_bases
ATGAAGTTGGAGTTTTCAGTTTATCGTTACAATCCTGACGTAGATACCAAGCCACGTATGCAGGATTACAGCTTCGACGT
GCCTGATGGCTCAGACATGATGGTGCTTGATGCGCTGCTGAAGCTGAAAGAAATCGATCCGACACTGTCGTTCCGCCGTT
CATGCCGTGAAGGTGTGTGTGGTTCTGACGGTATGAACATGAATGGTAAGAACGGCCTGGCTTGTATCACGCCTATCTCT
ACCTTCAAGGGCAAGAAGATTGAAATCCGCCCACTGCCCGGTATGCCCGTGGTACGTGACCTGGTGGTCGATCTTTCCCA
GTTCTACAAGCAGTACGAGAAGATCAAGCCATACCTCATCAACGATGAGAAGAAGCCTGCCCGTGAACACCTGCAGAGCC
CTGAGGAGCGTGCGCACCTCGACGGTCTGTATGAATGTATCATGTGCGCCTGCTGCTCGACCGCCTGTCCATCGTTCTGG
TGGAACCCCGACAAGTTCGTGGGGCCAAGTGGTTTGCTGCATGCCTATCGCTTCCTTATCGACAGCCGCGATACTGCGAC
TGAAGAGCGTCTGGCCGAGCTTGACGACGCCTACAGCGTGTTCCGTTGCCACGGCATCATGAACTGCGTAGACGTGTGTC
CGAAAGGACTGAACCCGACCAAGGCGATTGGACACATCAAGTCCATGCTGCTGAAGCGGGCCGTGTAA

Upstream 100 bases:

>100_bases
CCCCGTGACTGAGGCTATGTCCAAGCGCGAAGTGAACATGTCACCCAAGCACCGTGAAGCCTTCCCACCGAAGAAGCGTA
CCTACTAAGGAGTTGCGAAG

Downstream 100 bases:

>100_bases
ATGCAAGACAATGAGCTAACGATAATAATGATATAGCTCAGCGAGAGTCACTGTCCCTTTCGGGGGATGGTGGCTCTTTT
GTGTAAAGGAACTACTTGAA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKLEFSVYRYNPDVDTKPRMQDYSFDVPDGSDMMVLDALLKLKEIDPTLSFRRSCREGVCGSDGMNMNGKNGLACITPIS
TFKGKKIEIRPLPGMPVVRDLVVDLSQFYKQYEKIKPYLINDEKKPAREHLQSPEERAHLDGLYECIMCACCSTACPSFW
WNPDKFVGPSGLLHAYRFLIDSRDTATEERLAELDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV

Sequences:

>Translated_235_residues
MKLEFSVYRYNPDVDTKPRMQDYSFDVPDGSDMMVLDALLKLKEIDPTLSFRRSCREGVCGSDGMNMNGKNGLACITPIS
TFKGKKIEIRPLPGMPVVRDLVVDLSQFYKQYEKIKPYLINDEKKPAREHLQSPEERAHLDGLYECIMCACCSTACPSFW
WNPDKFVGPSGLLHAYRFLIDSRDTATEERLAELDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV
>Mature_235_residues
MKLEFSVYRYNPDVDTKPRMQDYSFDVPDGSDMMVLDALLKLKEIDPTLSFRRSCREGVCGSDGMNMNGKNGLACITPIS
TFKGKKIEIRPLPGMPVVRDLVVDLSQFYKQYEKIKPYLINDEKKPAREHLQSPEERAHLDGLYECIMCACCSTACPSFW
WNPDKFVGPSGLLHAYRFLIDSRDTATEERLAELDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=231, Percent_Identity=57.5757575757576, Blast_Score=274, Evalue=4e-74,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=77.1186440677966, Blast_Score=392, Evalue=1e-111,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=39.3013100436681, Blast_Score=157, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=53.8793103448276, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322987, Length=229, Percent_Identity=56.7685589519651, Blast_Score=263, Evalue=2e-71,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=55.793991416309, Blast_Score=273, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24643156, Length=231, Percent_Identity=53.6796536796537, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26656; Mature: 26656

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
8.9 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
8.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEFSVYRYNPDVDTKPRMQDYSFDVPDGSDMMVLDALLKLKEIDPTLSFRRSCREGVC
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCC
GSDGMNMNGKNGLACITPISTFKGKKIEIRPLPGMPVVRDLVVDLSQFYKQYEKIKPYLI
CCCCCCCCCCCCEEEECCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEE
NDEKKPAREHLQSPEERAHLDGLYECIMCACCSTACPSFWWNPDKFVGPSGLLHAYRFLI
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
DSRDTATEERLAELDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLEFSVYRYNPDVDTKPRMQDYSFDVPDGSDMMVLDALLKLKEIDPTLSFRRSCREGVC
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCC
GSDGMNMNGKNGLACITPISTFKGKKIEIRPLPGMPVVRDLVVDLSQFYKQYEKIKPYLI
CCCCCCCCCCCCEEEECCHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEE
NDEKKPAREHLQSPEERAHLDGLYECIMCACCSTACPSFWWNPDKFVGPSGLLHAYRFLI
CCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
DSRDTATEERLAELDDAYSVFRCHGIMNCVDVCPKGLNPTKAIGHIKSMLLKRAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]