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The map label for this gene is gltT [H]

Identifier: 119774192

GI number: 119774192

Start: 1276475

End: 1277728

Strand: Reverse

Name: gltT [H]

Synonym: Sama_1055

Alternate gene names: 119774192

Gene position: 1277728-1276475 (Counterclockwise)

Preceding gene: 119774198

Following gene: 119774191

Centisome position: 29.67

GC content: 55.18

Gene sequence:

>1254_bases
ATGATAATTCAAACATTAAATAAAATTCCCTTCTGGCAGAAAGTGCTGGCTGGTTTTGCCCTGGGGATACTCACAGGGGT
ACTGCTGGGCGAATCGGCCACTGTGCTCAAGCCCCTTGGCGATCTCTTTATTGCCGCTATCAAGATGCTGGTTGCACCAC
TGGTCCTGTGCGCCATCGTGGTCAGTATCACCTCCCTGGGCAGCTCATCCAACCTTAAGCGCCTGAGCTTCAAGACACTG
GCGCTCTTCATGCTGACCGGTACCCTTGCCTCGTTGATTGGTCTGGCAGTCGGCAGCAGCTTCGATATGGGCGGCAGCAT
GCAACTGGCCAGTACCGAAGTGCGCGAACGCGTTGTACCGGGCTTTGCTCAGGTGCTGCTGGATATGATCCCGGTGAACC
CCTTTGCCTCGCTGACCAACGGCAAAGTACTGCAAATCATTGTATTTGCGGCCTTGGTGGGTATTGCCATCAACGCTGTG
GGCGAGAAAGCCGAGCCTCTGAAAAAGGTATTTGATGCCGGAGCCGAGGTGATGTTCCAGCTGACCCGTATGGTGCTGAA
ACTCACTCCAATCGGTGTATTTGGCCTGATGGCTTGGGTGGTGGGCGAATATGGCCTCTCAACCCTGCTGCCGCTGGGTA
AATTTATTATCGCCATCTACGTGGCAGCGCTTATCCACATAGTGTTTGTCTACGGCGGCCTGGTGAAGTTTGCTGCCCGC
TTAAGCCCTCTGCAGTTTTTCCGTAAGGCAATGCCAGCGCAGCTGGTTGCCTTTAGCACGGCGTCGAGCTTTGGCACCCT
GCCGGTCACCACCAAGTGTGCCGAGTCCATGGGTGTTTCCAAGCGTTACAGTGCGTTTGTGCTGCCCATGGGCGCCACCA
TGAACATGGATGGCTGTGGTGGTATTTATCCTGCCATTGCGGCCATTTTCATCGCGCAAATCTACGGAATTCCGCTGGAT
ATGACCGACTATATGCTGATTGCCGTTACCGCGACCGTGGCCTCAGTGGGCACCGCCGGCGTACCAGGCAGCGCCATGGT
GATGCTTACCGTCACCCTGGGAGTGGTTGGTTTACCGCTGGAAGGTATTGCCTTTATCGCGGCCATTGACCGGGTGATTG
ATATGATACGGACCTGCACCAACGTTACCGGCGATATGATGACCGCCGTAGTGGTGGGCAATTCCGAGGGTGAGCTGGAC
CGCGAGCGATTTTATAAGGCGGAAGAAGATAAAATCGTCGCAGACAACGCCTGA

Upstream 100 bases:

>100_bases
ACTGCCAGAGTGCACGGGCTAGCGCAGTTTTGCCCCATCGTCTTTTTTTGGGCAAGGTAGCTTCGTTGTGGGCCACTGAT
TTAGAAAATTCGGAAAATTC

Downstream 100 bases:

>100_bases
GCCACTGTGCACCAACTGAGACGCCACCTCTCGTTGAAGGCCATTCCACACGGAATGGCCTTTTTGTTTACCTTATCCGT
AGTTTACCTTGGTAGGCAAA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIIQTLNKIPFWQKVLAGFALGILTGVLLGESATVLKPLGDLFIAAIKMLVAPLVLCAIVVSITSLGSSSNLKRLSFKTL
ALFMLTGTLASLIGLAVGSSFDMGGSMQLASTEVRERVVPGFAQVLLDMIPVNPFASLTNGKVLQIIVFAALVGIAINAV
GEKAEPLKKVFDAGAEVMFQLTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIIAIYVAALIHIVFVYGGLVKFAAR
LSPLQFFRKAMPAQLVAFSTASSFGTLPVTTKCAESMGVSKRYSAFVLPMGATMNMDGCGGIYPAIAAIFIAQIYGIPLD
MTDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLEGIAFIAAIDRVIDMIRTCTNVTGDMMTAVVVGNSEGELD
RERFYKAEEDKIVADNA

Sequences:

>Translated_417_residues
MIIQTLNKIPFWQKVLAGFALGILTGVLLGESATVLKPLGDLFIAAIKMLVAPLVLCAIVVSITSLGSSSNLKRLSFKTL
ALFMLTGTLASLIGLAVGSSFDMGGSMQLASTEVRERVVPGFAQVLLDMIPVNPFASLTNGKVLQIIVFAALVGIAINAV
GEKAEPLKKVFDAGAEVMFQLTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIIAIYVAALIHIVFVYGGLVKFAAR
LSPLQFFRKAMPAQLVAFSTASSFGTLPVTTKCAESMGVSKRYSAFVLPMGATMNMDGCGGIYPAIAAIFIAQIYGIPLD
MTDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLEGIAFIAAIDRVIDMIRTCTNVTGDMMTAVVVGNSEGELD
RERFYKAEEDKIVADNA
>Mature_417_residues
MIIQTLNKIPFWQKVLAGFALGILTGVLLGESATVLKPLGDLFIAAIKMLVAPLVLCAIVVSITSLGSSSNLKRLSFKTL
ALFMLTGTLASLIGLAVGSSFDMGGSMQLASTEVRERVVPGFAQVLLDMIPVNPFASLTNGKVLQIIVFAALVGIAINAV
GEKAEPLKKVFDAGAEVMFQLTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIIAIYVAALIHIVFVYGGLVKFAAR
LSPLQFFRKAMPAQLVAFSTASSFGTLPVTTKCAESMGVSKRYSAFVLPMGATMNMDGCGGIYPAIAAIFIAQIYGIPLD
MTDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLEGIAFIAAIDRVIDMIRTCTNVTGDMMTAVVVGNSEGELD
RERFYKAEEDKIVADNA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=274, Percent_Identity=36.4963503649635, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4827012, Length=285, Percent_Identity=35.0877192982456, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI40254478, Length=274, Percent_Identity=36.1313868613139, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI66773030, Length=263, Percent_Identity=35.7414448669202, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI21314632, Length=423, Percent_Identity=29.0780141843972, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI194239697, Length=256, Percent_Identity=34.765625, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI223468564, Length=276, Percent_Identity=34.7826086956522, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI223468566, Length=276, Percent_Identity=34.7826086956522, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI5032093, Length=404, Percent_Identity=30.4455445544554, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI301601644, Length=168, Percent_Identity=37.5, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI262359914, Length=200, Percent_Identity=34, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790514, Length=420, Percent_Identity=36.1904761904762, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1789947, Length=402, Percent_Identity=32.5870646766169, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788024, Length=455, Percent_Identity=26.1538461538462, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1789473, Length=372, Percent_Identity=24.7311827956989, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71983106, Length=429, Percent_Identity=29.1375291375291, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71983099, Length=429, Percent_Identity=29.1375291375291, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=453, Percent_Identity=28.6975717439294, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=444, Percent_Identity=28.8288288288288, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=420, Percent_Identity=26.6666666666667, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193206505, Length=444, Percent_Identity=26.1261261261261, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=444, Percent_Identity=27.9279279279279, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24583025, Length=444, Percent_Identity=25.9009009009009, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17137668, Length=444, Percent_Identity=25.9009009009009, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583023, Length=444, Percent_Identity=25.9009009009009, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360481, Length=299, Percent_Identity=32.1070234113712, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360483, Length=300, Percent_Identity=32, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137666, Length=300, Percent_Identity=32, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43927; Mature: 43927

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHCCCCCCCCEECCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCCHHHCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]