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The map label for this gene is clcA [H]

Identifier: 119773978

GI number: 119773978

Start: 1025735

End: 1027450

Strand: Reverse

Name: clcA [H]

Synonym: Sama_0841

Alternate gene names: 119773978

Gene position: 1027450-1025735 (Counterclockwise)

Preceding gene: 119773981

Following gene: 119773977

Centisome position: 23.86

GC content: 55.65

Gene sequence:

>1716_bases
ATGAAGATAAAGACCCGGCTCGAGGCGATGCGTCGACTCGCCCTCAGATATTTTCACACAGAACTCAGAGACAAGCTGTC
ACAGGCGCGGATCAGTCTGCAACTCTGTGGTTTGGCATTGTGTTTCGCGCTCATTGCCTCACTGGTCATTATTTTGTTCC
GCTTACTGCTGGAAGGCGCCAACCACTACTCCGGCATCGAACGTATGGACATGGAGGCCATGGTGTATGACTGGCGGGCG
CTGTTGCCGCTCTTGGGGGCTCTGCTGATTTGGCTGGTTGCAACCCTGGGCTCAAAACGTTACCGCCGGATGGGTATCGC
CTATGTGCTGCACCGCTTTAAACTGCACTACGGAAAAATTCCGCTGCAATCGGCTCCCGGTCAGTTTTTTCAGGCGCTGA
TTGCACTTGCCACTAACTTCTCTGTCGGCCGTGAAGGTCCGGCCATTCACCTTGGCGCCGTGAGCGCCAGTGTGCTAGCC
GAAAAATTCAAACTGCCCGATAATAGCGTGCGCATCATGTGTGCCAGTGGCATAGCCGCCGGGATTGCGGCCACCTTTAA
CGCCCCGCTGGCGGCGGTGGTATTTGTATTTGAAGTGGTGGTGCGGGAATACAAAATCCATTACTTCTTTCCTATCATGA
TTTCGGCCATCTGCGGCGCGCTCTCAAGCCAACTGGTATTCGGCAACGTGCACGAATACGATGCCATTCAGGTGTTTCAT
ATCCCGCTGGATCACTACCCCTTGCTGGCCTTGGGCGGGGTGGGACTGGGATGCGCAGCTGCCGCCTTTAACTGGACCCT
GCTCAAGGTAACCGCCACCGGCCAGCACTGGCCCTTAATAGTGCGGCTGCTGTTGGCTGGCAGTATCACTACGGTTGTCG
GTATCGCCCTGCCCCAAGCCCTGGGTTCCGGGGATTTGGCCATCAATGCAGTGATTGCCGAAAACCCGGGACTCTTGCTG
CTCATCGCCGTGCTCATTGGCAAAATGATTGCCACTATTGCCGCCATTGGTCTTGGCATCCCCGGCGGACTTATCGGCCC
GCTGTACGGCATTGGTGCTTTGCTGGGCGGTATTCTCGCGCTTATCAGCGCCATGTTGTTCCCTTCCATTGCACCCTACG
TGGGGCTCTACACCGTAATTGGCATGACGGCCATGATGGGAGTGTGCCTGAGCGCGCCGCTGGCGGCCCTGGTGGCGCTG
CTGGAACTTACCAACGATGCCTCCATTATTTTGCCTGCCATGTTCGTGACCATTCCCGCCTTCCTGGTGGCTTATCAGTG
GTTTCAAACCGAGTCGGTGTTTTTCCGCCAGTTGGACATCATGGGCCTGGGTTACAAGGTGCCACCGGTGAATCAGGGGC
TGCAAAAAACCGGCGTCCGTGCCCTGATGGACCGGCGCTTTGTGGTGGTGAAAAACGATGACGAGCTGCTGCTTGAAGTG
ATGAAGCGTGCCGAGGGTCGTCCTGTGATGGTGCGAAGCGCTGAGGGAGAAATCCAGATGCTGCGCCTGGAAATGCAATC
CTTTGAAGACAACACCACACTATCTCGCCAACCGATGCAGGGCTTGCCCGATACCGCCACCTTAAACGAAGCCTATGAGA
TCCTCTCACCGAAACGGACTGGCGAAGTTTATATTTATCAAGGAGATAAAGATAATCTAGTGGGCGTTATCGGCTGGACC
AAACTACAACAGGAAATTCGTTCCGGTCAGGTGTGA

Upstream 100 bases:

>100_bases
GCCTCTTAGTAACTTTCGGTCCGCCGGACCGTCGACGGGGCAGAATAACAGCATAAGCATGGCAAAGGCCAGCACCCCGG
GGCCTATGCACAGGGCAGGC

Downstream 100 bases:

>100_bases
TGGGCAGCAGGTAATTTAGCTGCTGCCATTTCAAAGCGCTGCCCCTTCTGCTATAGTTGCGCCTCAGCCAAACCCTACAT
AAACCAGGGGCGGAAAGGCC

Product: chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MKIKTRLEAMRRLALRYFHTELRDKLSQARISLQLCGLALCFALIASLVIILFRLLLEGANHYSGIERMDMEAMVYDWRA
LLPLLGALLIWLVATLGSKRYRRMGIAYVLHRFKLHYGKIPLQSAPGQFFQALIALATNFSVGREGPAIHLGAVSASVLA
EKFKLPDNSVRIMCASGIAAGIAATFNAPLAAVVFVFEVVVREYKIHYFFPIMISAICGALSSQLVFGNVHEYDAIQVFH
IPLDHYPLLALGGVGLGCAAAAFNWTLLKVTATGQHWPLIVRLLLAGSITTVVGIALPQALGSGDLAINAVIAENPGLLL
LIAVLIGKMIATIAAIGLGIPGGLIGPLYGIGALLGGILALISAMLFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVAL
LELTNDASIILPAMFVTIPAFLVAYQWFQTESVFFRQLDIMGLGYKVPPVNQGLQKTGVRALMDRRFVVVKNDDELLLEV
MKRAEGRPVMVRSAEGEIQMLRLEMQSFEDNTTLSRQPMQGLPDTATLNEAYEILSPKRTGEVYIYQGDKDNLVGVIGWT
KLQQEIRSGQV

Sequences:

>Translated_571_residues
MKIKTRLEAMRRLALRYFHTELRDKLSQARISLQLCGLALCFALIASLVIILFRLLLEGANHYSGIERMDMEAMVYDWRA
LLPLLGALLIWLVATLGSKRYRRMGIAYVLHRFKLHYGKIPLQSAPGQFFQALIALATNFSVGREGPAIHLGAVSASVLA
EKFKLPDNSVRIMCASGIAAGIAATFNAPLAAVVFVFEVVVREYKIHYFFPIMISAICGALSSQLVFGNVHEYDAIQVFH
IPLDHYPLLALGGVGLGCAAAAFNWTLLKVTATGQHWPLIVRLLLAGSITTVVGIALPQALGSGDLAINAVIAENPGLLL
LIAVLIGKMIATIAAIGLGIPGGLIGPLYGIGALLGGILALISAMLFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVAL
LELTNDASIILPAMFVTIPAFLVAYQWFQTESVFFRQLDIMGLGYKVPPVNQGLQKTGVRALMDRRFVVVKNDDELLLEV
MKRAEGRPVMVRSAEGEIQMLRLEMQSFEDNTTLSRQPMQGLPDTATLNEAYEILSPKRTGEVYIYQGDKDNLVGVIGWT
KLQQEIRSGQV
>Mature_571_residues
MKIKTRLEAMRRLALRYFHTELRDKLSQARISLQLCGLALCFALIASLVIILFRLLLEGANHYSGIERMDMEAMVYDWRA
LLPLLGALLIWLVATLGSKRYRRMGIAYVLHRFKLHYGKIPLQSAPGQFFQALIALATNFSVGREGPAIHLGAVSASVLA
EKFKLPDNSVRIMCASGIAAGIAATFNAPLAAVVFVFEVVVREYKIHYFFPIMISAICGALSSQLVFGNVHEYDAIQVFH
IPLDHYPLLALGGVGLGCAAAAFNWTLLKVTATGQHWPLIVRLLLAGSITTVVGIALPQALGSGDLAINAVIAENPGLLL
LIAVLIGKMIATIAAIGLGIPGGLIGPLYGIGALLGGILALISAMLFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVAL
LELTNDASIILPAMFVTIPAFLVAYQWFQTESVFFRQLDIMGLGYKVPPVNQGLQKTGVRALMDRRFVVVKNDDELLLEV
MKRAEGRPVMVRSAEGEIQMLRLEMQSFEDNTTLSRQPMQGLPDTATLNEAYEILSPKRTGEVYIYQGDKDNLVGVIGWT
KLQQEIRSGQV

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=308, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62064; Mature: 62064

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKTRLEAMRRLALRYFHTELRDKLSQARISLQLCGLALCFALIASLVIILFRLLLEGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NHYSGIERMDMEAMVYDWRALLPLLGALLIWLVATLGSKRYRRMGIAYVLHRFKLHYGKI
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
PLQSAPGQFFQALIALATNFSVGREGPAIHLGAVSASVLAEKFKLPDNSVRIMCASGIAA
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEECCHHH
GIAATFNAPLAAVVFVFEVVVREYKIHYFFPIMISAICGALSSQLVFGNVHEYDAIQVFH
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEE
IPLDHYPLLALGGVGLGCAAAAFNWTLLKVTATGQHWPLIVRLLLAGSITTVVGIALPQA
ECCCCCCHHHCCCCCHHHHHHHHCEEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHH
LGSGDLAINAVIAENPGLLLLIAVLIGKMIATIAAIGLGIPGGLIGPLYGIGALLGGILA
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LISAMLFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVALLELTNDASIILPAMFVTIPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FLVAYQWFQTESVFFRQLDIMGLGYKVPPVNQGLQKTGVRALMDRRFVVVKNDDELLLEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHH
MKRAEGRPVMVRSAEGEIQMLRLEMQSFEDNTTLSRQPMQGLPDTATLNEAYEILSPKRT
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GEVYIYQGDKDNLVGVIGWTKLQQEIRSGQV
CEEEEEECCCCCEEEEEHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIKTRLEAMRRLALRYFHTELRDKLSQARISLQLCGLALCFALIASLVIILFRLLLEGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NHYSGIERMDMEAMVYDWRALLPLLGALLIWLVATLGSKRYRRMGIAYVLHRFKLHYGKI
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCC
PLQSAPGQFFQALIALATNFSVGREGPAIHLGAVSASVLAEKFKLPDNSVRIMCASGIAA
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEEECCHHH
GIAATFNAPLAAVVFVFEVVVREYKIHYFFPIMISAICGALSSQLVFGNVHEYDAIQVFH
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEE
IPLDHYPLLALGGVGLGCAAAAFNWTLLKVTATGQHWPLIVRLLLAGSITTVVGIALPQA
ECCCCCCHHHCCCCCHHHHHHHHCEEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHH
LGSGDLAINAVIAENPGLLLLIAVLIGKMIATIAAIGLGIPGGLIGPLYGIGALLGGILA
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LISAMLFPSIAPYVGLYTVIGMTAMMGVCLSAPLAALVALLELTNDASIILPAMFVTIPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FLVAYQWFQTESVFFRQLDIMGLGYKVPPVNQGLQKTGVRALMDRRFVVVKNDDELLLEV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHHH
MKRAEGRPVMVRSAEGEIQMLRLEMQSFEDNTTLSRQPMQGLPDTATLNEAYEILSPKRT
HHHCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
GEVYIYQGDKDNLVGVIGWTKLQQEIRSGQV
CEEEEEECCCCCEEEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA