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The map label for this gene is panB [H]

Identifier: 119773913

GI number: 119773913

Start: 958810

End: 959649

Strand: Reverse

Name: panB [H]

Synonym: Sama_0776

Alternate gene names: 119773913

Gene position: 959649-958810 (Counterclockwise)

Preceding gene: 119773914

Following gene: 119773912

Centisome position: 22.29

GC content: 56.07

Gene sequence:

>840_bases
TTGGCTTATAACTCCACTTCACACTCGCTGGTAGAGAAACGCATTATGTCCAAAGTCACCACCTCAACCCTGATGAAGTT
TAAACAGGAAGGGAAAAAGTTCACCGCGCTGACCGCTTATGATGCCAGTTTTGCCGCCGCTTTTGACAGTGAGGGCGTTG
ATGTCCTGCTGGTGGGCGACTCACTGGGCATGGTACTGCAGGGGCACGAGGATACCTTGCCGGTTACTGTGCAAGACATT
GCCTATCACACCCGCTGTGTGCGTCGCGGTATTTCCCGCGCACTGCTGATAGCCGATCTGCCCTTTATGAGTTACGCCAC
CGTGGAGCAGACCATGACCACGGCCACCGCCCTGATGCAGGCCGGTGCCAACATGGTGAAACTGGAAGGCGGTGAATGGC
TGCTGGAAAGCGTGAAAAAGCTCACCGAGCGTGGCGTGCCCGTGTGTGCCCACATCGGCCTGACGCCTCAGTCTGTGCAC
GTGTTTGGTGGCTTTAAGGTACAGGGCCGCGATGCCGACAACGCCCAGCGTATCTTGAATGAAGCCAAGGCACTGGAAGC
CGCAGGCGCCCAGCTGCTGGTAATTGAATGTATTCCGGCGTCGCTGGCAAAGGCCATTACCGAGGCCCTGAGCATTCCTG
TGATTGGTATTGGTGCCGGCAAAGACACCGATGGCCAGATTTTGGTAATGCACGATGTGCTTGGCATCTCCAGCGGCTAT
ATTCCGCGCTTCTCCAAGAATTACCTCAAGCAGACCGGTGAGATCCGCGCTGCGGTACGCGCCTTTATTGACGAAGTGGC
CGATGGCAGCTTCCCTGGCCCAGAACATACCTTTAATTGA

Upstream 100 bases:

>100_bases
CTGATGTTGCCCTGTGGCACCCCAGTCCAGAGCCTTATCACCCAGGCAATGCGGGACGAGCTTCACCAACTGACACCCTG
CGATTGAAGTCAGACCTCAG

Downstream 100 bases:

>100_bases
GACACAGATGTACACAACCGCTGTAATCGATGAAATCAGACAACAGGTGCGTCAGTGGCGCGCCAGTGGCGAAACCGTGG
CCTTTGTCCCCACCATGGGT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MAYNSTSHSLVEKRIMSKVTTSTLMKFKQEGKKFTALTAYDASFAAAFDSEGVDVLLVGDSLGMVLQGHEDTLPVTVQDI
AYHTRCVRRGISRALLIADLPFMSYATVEQTMTTATALMQAGANMVKLEGGEWLLESVKKLTERGVPVCAHIGLTPQSVH
VFGGFKVQGRDADNAQRILNEAKALEAAGAQLLVIECIPASLAKAITEALSIPVIGIGAGKDTDGQILVMHDVLGISSGY
IPRFSKNYLKQTGEIRAAVRAFIDEVADGSFPGPEHTFN

Sequences:

>Translated_279_residues
MAYNSTSHSLVEKRIMSKVTTSTLMKFKQEGKKFTALTAYDASFAAAFDSEGVDVLLVGDSLGMVLQGHEDTLPVTVQDI
AYHTRCVRRGISRALLIADLPFMSYATVEQTMTTATALMQAGANMVKLEGGEWLLESVKKLTERGVPVCAHIGLTPQSVH
VFGGFKVQGRDADNAQRILNEAKALEAAGAQLLVIECIPASLAKAITEALSIPVIGIGAGKDTDGQILVMHDVLGISSGY
IPRFSKNYLKQTGEIRAAVRAFIDEVADGSFPGPEHTFN
>Mature_278_residues
AYNSTSHSLVEKRIMSKVTTSTLMKFKQEGKKFTALTAYDASFAAAFDSEGVDVLLVGDSLGMVLQGHEDTLPVTVQDIA
YHTRCVRRGISRALLIADLPFMSYATVEQTMTTATALMQAGANMVKLEGGEWLLESVKKLTERGVPVCAHIGLTPQSVHV
FGGFKVQGRDADNAQRILNEAKALEAAGAQLLVIECIPASLAKAITEALSIPVIGIGAGKDTDGQILVMHDVLGISSGYI
PRFSKNYLKQTGEIRAAVRAFIDEVADGSFPGPEHTFN

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=264, Percent_Identity=64.3939393939394, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319653, Length=258, Percent_Identity=35.2713178294574, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29918; Mature: 29787

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYNSTSHSLVEKRIMSKVTTSTLMKFKQEGKKFTALTAYDASFAAAFDSEGVDVLLVGD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCCEEEEECC
SLGMVLQGHEDTLPVTVQDIAYHTRCVRRGISRALLIADLPFMSYATVEQTMTTATALMQ
CCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
AGANMVKLEGGEWLLESVKKLTERGVPVCAHIGLTPQSVHVFGGFKVQGRDADNAQRILN
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECEEEECCCCHHHHHHHH
EAKALEAAGAQLLVIECIPASLAKAITEALSIPVIGIGAGKDTDGQILVMHDVLGISSGY
HHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEHHCCCCCC
IPRFSKNYLKQTGEIRAAVRAFIDEVADGSFPGPEHTFN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AYNSTSHSLVEKRIMSKVTTSTLMKFKQEGKKFTALTAYDASFAAAFDSEGVDVLLVGD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHCCCCCCEEEEECC
SLGMVLQGHEDTLPVTVQDIAYHTRCVRRGISRALLIADLPFMSYATVEQTMTTATALMQ
CCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
AGANMVKLEGGEWLLESVKKLTERGVPVCAHIGLTPQSVHVFGGFKVQGRDADNAQRILN
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECEEEECCCCHHHHHHHH
EAKALEAAGAQLLVIECIPASLAKAITEALSIPVIGIGAGKDTDGQILVMHDVLGISSGY
HHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEHHCCCCCC
IPRFSKNYLKQTGEIRAAVRAFIDEVADGSFPGPEHTFN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA