Click here to switch to the map view.

The map label for this gene is panC

Identifier: 119773912

GI number: 119773912

Start: 957957

End: 958802

Strand: Reverse

Name: panC

Synonym: Sama_0775

Alternate gene names: 119773912

Gene position: 958802-957957 (Counterclockwise)

Preceding gene: 119773913

Following gene: 119773911

Centisome position: 22.27

GC content: 58.27

Gene sequence:

>846_bases
ATGTACACAACCGCTGTAATCGATGAAATCAGACAACAGGTGCGTCAGTGGCGCGCCAGTGGCGAAACCGTGGCCTTTGT
CCCCACCATGGGTAACCTCCATGCCGGGCATATCACCCTGATAAAAGAAGCCAAACAACGTGCCGACCACGTGGTGGCCT
CGATTTTCGTCAACCCCATGCAGTTTGGTAAAAATGAGGATTTGGACGCCTATCCTCGTACTCTGGCAGAAGATCAGGCT
GCGCTGACGGCCGCCGGTTGTGAGCTGCTGTTTACCCCAACGCCTGACATCATTTATCCCAAGGGACTGGATGCCCAGAC
CTTTGTGGAAGTGCCGGGCATTTCAGATGAGCTCTGCGGTGCCAGCCGTCCGGGCCATTTCCGTGGCGTGGCCACCATAG
TGCTGAAGCTCTTTAACATAGTGCAGCCCGACGTAGCCCTGTTTGGCCGCAAGGATTACCAGCAGCTTTTGGTCATTCGT
ACCATGGTGGAAGACCTGTCATTGCCGCTGGAAATCGTGGGTGTTGAAACCGTGCGTGAAGCCAGCGGCCTTGCCATGAG
CTCCCGCAATGGTTACCTGACCGCCGATGAAAAGGCCCGCGCCGCCGCCCTCAAGGCCGCTCTGGATGCCCTTGCGATGC
AAATCGGCGCTGGCACTGCTATTGATGCCGCCATCACTGAAGCCAATGCGGCCCTGGTGACAGCCGGTTTCCGCCCGGAC
TATCTGGAAGTGCGCAGCGCCACCACCCTGGCTCTGCCCACGGATGCCGACAAGGAACTGGTGGTACTCGCCGCCGCCTA
CCTTGGCAAGGCCCGCCTGATTGATAATCTGGTGTTCAGCCGCTAA

Upstream 100 bases:

>100_bases
AAGCAGACCGGTGAGATCCGCGCTGCGGTACGCGCCTTTATTGACGAAGTGGCCGATGGCAGCTTCCCTGGCCCAGAACA
TACCTTTAATTGAGACACAG

Downstream 100 bases:

>100_bases
GGTTAAACACACATACGAAGGGAGCCAAGGCTCCCTTTTTTATTGTCAACAAGACGGTAAACTCATCACCAAGTACATAT
TTTAACTGGTGTTTTTTGTT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MYTTAVIDEIRQQVRQWRASGETVAFVPTMGNLHAGHITLIKEAKQRADHVVASIFVNPMQFGKNEDLDAYPRTLAEDQA
ALTAAGCELLFTPTPDIIYPKGLDAQTFVEVPGISDELCGASRPGHFRGVATIVLKLFNIVQPDVALFGRKDYQQLLVIR
TMVEDLSLPLEIVGVETVREASGLAMSSRNGYLTADEKARAAALKAALDALAMQIGAGTAIDAAITEANAALVTAGFRPD
YLEVRSATTLALPTDADKELVVLAAAYLGKARLIDNLVFSR

Sequences:

>Translated_281_residues
MYTTAVIDEIRQQVRQWRASGETVAFVPTMGNLHAGHITLIKEAKQRADHVVASIFVNPMQFGKNEDLDAYPRTLAEDQA
ALTAAGCELLFTPTPDIIYPKGLDAQTFVEVPGISDELCGASRPGHFRGVATIVLKLFNIVQPDVALFGRKDYQQLLVIR
TMVEDLSLPLEIVGVETVREASGLAMSSRNGYLTADEKARAAALKAALDALAMQIGAGTAIDAAITEANAALVTAGFRPD
YLEVRSATTLALPTDADKELVVLAAAYLGKARLIDNLVFSR
>Mature_281_residues
MYTTAVIDEIRQQVRQWRASGETVAFVPTMGNLHAGHITLIKEAKQRADHVVASIFVNPMQFGKNEDLDAYPRTLAEDQA
ALTAAGCELLFTPTPDIIYPKGLDAQTFVEVPGISDELCGASRPGHFRGVATIVLKLFNIVQPDVALFGRKDYQQLLVIR
TMVEDLSLPLEIVGVETVREASGLAMSSRNGYLTADEKARAAALKAALDALAMQIGAGTAIDAAITEANAALVTAGFRPD
YLEVRSATTLALPTDADKELVVLAAAYLGKARLIDNLVFSR

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=268, Percent_Identity=54.4776119402985, Blast_Score=288, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322046, Length=301, Percent_Identity=38.8704318936877, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_SHEAM (A1S3M6)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_926652.1
- ProteinModelPortal:   A1S3M6
- SMR:   A1S3M6
- STRING:   A1S3M6
- GeneID:   4603027
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0775
- NMPDR:   fig|326297.7.peg.727
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   A1S3M6
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30227; Mature: 30227

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTTAVIDEIRQQVRQWRASGETVAFVPTMGNLHAGHITLIKEAKQRADHVVASIFVNPM
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QFGKNEDLDAYPRTLAEDQAALTAAGCELLFTPTPDIIYPKGLDAQTFVEVPGISDELCG
HCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCEEECCCCCHHHCC
ASRPGHFRGVATIVLKLFNIVQPDVALFGRKDYQQLLVIRTMVEDLSLPLEIVGVETVRE
CCCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHH
ASGLAMSSRNGYLTADEKARAAALKAALDALAMQIGAGTAIDAAITEANAALVTAGFRPD
HCCCEEECCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCC
YLEVRSATTLALPTDADKELVVLAAAYLGKARLIDNLVFSR
CEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYTTAVIDEIRQQVRQWRASGETVAFVPTMGNLHAGHITLIKEAKQRADHVVASIFVNPM
CCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QFGKNEDLDAYPRTLAEDQAALTAAGCELLFTPTPDIIYPKGLDAQTFVEVPGISDELCG
HCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCCCCCCEEECCCCCHHHCC
ASRPGHFRGVATIVLKLFNIVQPDVALFGRKDYQQLLVIRTMVEDLSLPLEIVGVETVRE
CCCCCCHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHH
ASGLAMSSRNGYLTADEKARAAALKAALDALAMQIGAGTAIDAAITEANAALVTAGFRPD
HCCCEEECCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCC
YLEVRSATTLALPTDADKELVVLAAAYLGKARLIDNLVFSR
CEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA