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The map label for this gene is galK [H]

Identifier: 119773676

GI number: 119773676

Start: 660214

End: 661362

Strand: Reverse

Name: galK [H]

Synonym: Sama_0536

Alternate gene names: 119773676

Gene position: 661362-660214 (Counterclockwise)

Preceding gene: 119773677

Following gene: 119773675

Centisome position: 15.36

GC content: 57.96

Gene sequence:

>1149_bases
ATGTCGAACCCTGCGCAGCGCGCCACCAAGCTGTTTGTCCAAACTTTCGGAACCAAGGCCGATGCCTATTACCAGGCGCC
GGGCCGGGTCAATATCATTGGTGAACACACAGACTATAACGATGGGTTTGTTCTGCCGGCAGCCATTAATTTTCATACGG
TTATCGCCGTAAAAAAGCGTGAAGATGATCGCTTTCGGGTGGTCACTGAGGCCTTTCCCGGTGAGCTAAGGGAGTGGCGT
TTCGGCGAAGAAGGCGAAGTCACTGCCGGTGGTGACTGGGTTAATTACCTTAAAGGTTTCACCCAGGCAGTGGGCCAGGC
CGGACTCAAAGCCAAGGGGCTGGATCTTGCGGTGGTGAGCAGCATCCCCATGGGAGCAGGCTTTTCATCCTCAGGCGCAC
TGGAAATTGCCTTTGGCACGGCCCTGAATGACACCTGTCAGCTTCACCTTTCCCCCATGGCCATTGCCCAACTGGCACAG
CGCGGCGAGAGCCGTTTCCACGGCAGTACCTGCGGCGTGATGGACCATATGACCAGCGCCCTGGCCGAGGCTGATTCAGC
CCTGCTGATTGACTGCCTGGATCTGGATATAGAAGCTGTGCTTATTCCGGATAACCTAAGCCTTATCATCGTGCATTCGC
CACTGGACCCCAAGCTACTGGAAGAGGCCTATAAGGCCCGGGCCGATGAGTGCCGCGATGCCGCCGAATTTTTCGGGCTC
GACTCCTTACGGGACCTGGAACTGGACGAGCTCAAGGCCGCCAGCGATGTGCTGGACGAAACCCTCTATAAGCGCGCCCG
ACATGTCATAAGCGAAAACCTGCGCACCCAGAGTGCTGGCCGGGCGCTGAAACGCGGTGATGTCGCCCGCCTGTCTGAAC
TGATGGCACTCTCCCATGCCTCGCTTCGGGATGACTTTGAACTTATGGTCCCGGAAGTTGAGACTCTGGTGCAAATCATG
GCCCAGGCCATTGGCGACCGTGGCGGTGTCCGTATGACAGACGGCTGCAGTGTCGTTGCGCTGGTGGAGCATGATTTGAC
CGATGCCGTCGTGCACGCAGTCGAGTCAGAATACCCTGCCAAAACCGGGCTGGAGCCCGTGCTGTACATGTGTGCCCCAA
GCGCAGGTGCAGGACGTATCGACGGCTGA

Upstream 100 bases:

>100_bases
ATCTCAGTTTTCCGGCTTTTTAAGACGTGGTATAACTCAGGGAAGCCGCCATTTCGTGCGGCAATTCAGAATAACCCGGT
TATCAATGGGATCAGTGAGC

Downstream 100 bases:

>100_bases
TTTTTTCAGCCAAAACATACGAATGCAATCACTGTTTCGCGCCTGGGCTATCGTTTATAGTGCATTGACTTTAATACAGA
TAAGGCAATCTATTCATGGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSNPAQRATKLFVQTFGTKADAYYQAPGRVNIIGEHTDYNDGFVLPAAINFHTVIAVKKREDDRFRVVTEAFPGELREWR
FGEEGEVTAGGDWVNYLKGFTQAVGQAGLKAKGLDLAVVSSIPMGAGFSSSGALEIAFGTALNDTCQLHLSPMAIAQLAQ
RGESRFHGSTCGVMDHMTSALAEADSALLIDCLDLDIEAVLIPDNLSLIIVHSPLDPKLLEEAYKARADECRDAAEFFGL
DSLRDLELDELKAASDVLDETLYKRARHVISENLRTQSAGRALKRGDVARLSELMALSHASLRDDFELMVPEVETLVQIM
AQAIGDRGGVRMTDGCSVVALVEHDLTDAVVHAVESEYPAKTGLEPVLYMCAPSAGAGRIDG

Sequences:

>Translated_382_residues
MSNPAQRATKLFVQTFGTKADAYYQAPGRVNIIGEHTDYNDGFVLPAAINFHTVIAVKKREDDRFRVVTEAFPGELREWR
FGEEGEVTAGGDWVNYLKGFTQAVGQAGLKAKGLDLAVVSSIPMGAGFSSSGALEIAFGTALNDTCQLHLSPMAIAQLAQ
RGESRFHGSTCGVMDHMTSALAEADSALLIDCLDLDIEAVLIPDNLSLIIVHSPLDPKLLEEAYKARADECRDAAEFFGL
DSLRDLELDELKAASDVLDETLYKRARHVISENLRTQSAGRALKRGDVARLSELMALSHASLRDDFELMVPEVETLVQIM
AQAIGDRGGVRMTDGCSVVALVEHDLTDAVVHAVESEYPAKTGLEPVLYMCAPSAGAGRIDG
>Mature_381_residues
SNPAQRATKLFVQTFGTKADAYYQAPGRVNIIGEHTDYNDGFVLPAAINFHTVIAVKKREDDRFRVVTEAFPGELREWRF
GEEGEVTAGGDWVNYLKGFTQAVGQAGLKAKGLDLAVVSSIPMGAGFSSSGALEIAFGTALNDTCQLHLSPMAIAQLAQR
GESRFHGSTCGVMDHMTSALAEADSALLIDCLDLDIEAVLIPDNLSLIIVHSPLDPKLLEEAYKARADECRDAAEFFGLD
SLRDLELDELKAASDVLDETLYKRARHVISENLRTQSAGRALKRGDVARLSELMALSHASLRDDFELMVPEVETLVQIMA
QAIGDRGGVRMTDGCSVVALVEHDLTDAVVHAVESEYPAKTGLEPVLYMCAPSAGAGRIDG

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=358, Percent_Identity=37.9888268156425, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1786972, Length=378, Percent_Identity=42.8571428571429, Blast_Score=323, Evalue=9e-90,
Organism=Caenorhabditis elegans, GI71989053, Length=411, Percent_Identity=26.7639902676399, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319494, Length=201, Percent_Identity=28.8557213930348, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24661292, Length=429, Percent_Identity=27.5058275058275, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355577, Length=429, Percent_Identity=27.5058275058275, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24661285, Length=429, Percent_Identity=27.5058275058275, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41255; Mature: 41124

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00106 GALACTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPAQRATKLFVQTFGTKADAYYQAPGRVNIIGEHTDYNDGFVLPAAINFHTVIAVKKR
CCCHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECEEEEEEEEEC
EDDRFRVVTEAFPGELREWRFGEEGEVTAGGDWVNYLKGFTQAVGQAGLKAKGLDLAVVS
CCCCEEEEEHHCCCHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
SIPMGAGFSSSGALEIAFGTALNDTCQLHLSPMAIAQLAQRGESRFHGSTCGVMDHMTSA
CCCCCCCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHCCHHCCCCCHHHHHHHHHH
LAEADSALLIDCLDLDIEAVLIPDNLSLIIVHSPLDPKLLEEAYKARADECRDAAEFFGL
HHHCCCEEEEEEECCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
DSLRDLELDELKAASDVLDETLYKRARHVISENLRTQSAGRALKRGDVARLSELMALSHA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SLRDDFELMVPEVETLVQIMAQAIGDRGGVRMTDGCSVVALVEHDLTDAVVHAVESEYPA
HHCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCCC
KTGLEPVLYMCAPSAGAGRIDG
CCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SNPAQRATKLFVQTFGTKADAYYQAPGRVNIIGEHTDYNDGFVLPAAINFHTVIAVKKR
CCHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEEEEEECEEEEEEEEEC
EDDRFRVVTEAFPGELREWRFGEEGEVTAGGDWVNYLKGFTQAVGQAGLKAKGLDLAVVS
CCCCEEEEEHHCCCHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
SIPMGAGFSSSGALEIAFGTALNDTCQLHLSPMAIAQLAQRGESRFHGSTCGVMDHMTSA
CCCCCCCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHCCHHCCCCCHHHHHHHHHH
LAEADSALLIDCLDLDIEAVLIPDNLSLIIVHSPLDPKLLEEAYKARADECRDAAEFFGL
HHHCCCEEEEEEECCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
DSLRDLELDELKAASDVLDETLYKRARHVISENLRTQSAGRALKRGDVARLSELMALSHA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
SLRDDFELMVPEVETLVQIMAQAIGDRGGVRMTDGCSVVALVEHDLTDAVVHAVESEYPA
HHCCCHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHCCCC
KTGLEPVLYMCAPSAGAGRIDG
CCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA