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The map label for this gene is mro [H]

Identifier: 119773675

GI number: 119773675

Start: 659093

End: 660118

Strand: Reverse

Name: mro [H]

Synonym: Sama_0535

Alternate gene names: 119773675

Gene position: 660118-659093 (Counterclockwise)

Preceding gene: 119773676

Following gene: 119773668

Centisome position: 15.33

GC content: 55.85

Gene sequence:

>1026_bases
ATGGTGCGTCACTCAGTGCTCGACGCCTGGAAGGATCCCAGGGGCGGAGAAATTGAACGGGTTCGATTGGACAACGGCCA
GTTGGCCATCGAAGTACTGAGTCTGGGCGGTATTATTCGCTCACTATGGGCTCCTGACAGCCGGGGCGAGCGCGCCAATC
TGGTACTTGGGTGTGACAGTCTTGAAGACTATCTCGCCCAGAATGCGCACCTTGGCGCCATTGCCGGACGCTATGCCAAC
CGTATCGCCCTCGGCAAATTGCACTATGACGGTGAAGACTTCCAACTGGATATCAATCAGGCAACCAACTGCCTCCATGG
TGGCCATGAGGGTTTTAATCGCAAACAATGGGCGCTGGGATTGCTTCCCGACGGTGTGCGTCTGAGCCTTAGCAGCCCAG
ATGGCGATATGGGGTTTCCAGGCAATTGCTCGGTCCAGCTGGATTACCGGCTAGCGGGCAATAACCTCTACGTGGAAATC
ATGGCGATGACCGATAGGCCCTGCCCGGTCAACCTTACCCAGCACAGCTACTTTAACCTTGACGGACGTGCCGATTGTCT
CGATCACACAGTGACCATGCACGCCAGGGCGTTTCTGCGCTGTAACGAGGCAGGGATACCCACAGGACGCGCCACCACCG
CAGGCACACCGCTGGCATTGCAGGATGTTCGCCTTGGTGACCGGGTACAACACCCGGACCTTGCCAGCACACGCGGTTTT
GACCACTGTTTTATTATCGATAAGACACAGGACGAGCTGGCGTTGGCAGCCGAGCTACACAGCCCACACTCGGGCAGACT
CCTTAAACTCTATACCAATCAGCCGGGCGTACAGCTCTACGGGGCGAATTTTCTCGATGGCGAACGGGGCAGGCAGGGCA
AAATTTATCGACCCTATCAGGGTGTTTGCCTCGAACCACAGCTGTTTCCCGATGCACCAAATCAACCCGATTTGGGCAAG
GCCTGGTTAATGCCGGGGGAGATTTATCATCATATCAGTCGTTATCAGTTCGAGGTAAAAGACTGA

Upstream 100 bases:

>100_bases
GCTGATTTTTTCAGCCAAAACATACGAATGCAATCACTGTTTCGCGCCTGGGCTATCGTTTATAGTGCATTGACTTTAAT
ACAGATAAGGCAATCTATTC

Downstream 100 bases:

>100_bases
ACCGGGCTGACCGCAAGCGCCATTAACGAGACTCAGCGCCCTATTGCCGACAATATGAGTGAAGGTGCAAAAGCAGGTGA
TGCTGCTGGGTGAGAGCTAA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MVRHSVLDAWKDPRGGEIERVRLDNGQLAIEVLSLGGIIRSLWAPDSRGERANLVLGCDSLEDYLAQNAHLGAIAGRYAN
RIALGKLHYDGEDFQLDINQATNCLHGGHEGFNRKQWALGLLPDGVRLSLSSPDGDMGFPGNCSVQLDYRLAGNNLYVEI
MAMTDRPCPVNLTQHSYFNLDGRADCLDHTVTMHARAFLRCNEAGIPTGRATTAGTPLALQDVRLGDRVQHPDLASTRGF
DHCFIIDKTQDELALAAELHSPHSGRLLKLYTNQPGVQLYGANFLDGERGRQGKIYRPYQGVCLEPQLFPDAPNQPDLGK
AWLMPGEIYHHISRYQFEVKD

Sequences:

>Translated_341_residues
MVRHSVLDAWKDPRGGEIERVRLDNGQLAIEVLSLGGIIRSLWAPDSRGERANLVLGCDSLEDYLAQNAHLGAIAGRYAN
RIALGKLHYDGEDFQLDINQATNCLHGGHEGFNRKQWALGLLPDGVRLSLSSPDGDMGFPGNCSVQLDYRLAGNNLYVEI
MAMTDRPCPVNLTQHSYFNLDGRADCLDHTVTMHARAFLRCNEAGIPTGRATTAGTPLALQDVRLGDRVQHPDLASTRGF
DHCFIIDKTQDELALAAELHSPHSGRLLKLYTNQPGVQLYGANFLDGERGRQGKIYRPYQGVCLEPQLFPDAPNQPDLGK
AWLMPGEIYHHISRYQFEVKD
>Mature_341_residues
MVRHSVLDAWKDPRGGEIERVRLDNGQLAIEVLSLGGIIRSLWAPDSRGERANLVLGCDSLEDYLAQNAHLGAIAGRYAN
RIALGKLHYDGEDFQLDINQATNCLHGGHEGFNRKQWALGLLPDGVRLSLSSPDGDMGFPGNCSVQLDYRLAGNNLYVEI
MAMTDRPCPVNLTQHSYFNLDGRADCLDHTVTMHARAFLRCNEAGIPTGRATTAGTPLALQDVRLGDRVQHPDLASTRGF
DHCFIIDKTQDELALAAELHSPHSGRLLKLYTNQPGVQLYGANFLDGERGRQGKIYRPYQGVCLEPQLFPDAPNQPDLGK
AWLMPGEIYHHISRYQFEVKD

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=330, Percent_Identity=42.4242424242424, Blast_Score=247, Evalue=9e-66,
Organism=Escherichia coli, GI1786971, Length=322, Percent_Identity=37.888198757764, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17557428, Length=324, Percent_Identity=30.2469135802469, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI115533334, Length=324, Percent_Identity=30.2469135802469, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319493, Length=310, Percent_Identity=27.4193548387097, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324399, Length=316, Percent_Identity=28.4810126582279, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=26.4044943820225, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24659048, Length=342, Percent_Identity=36.8421052631579, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24668278, Length=337, Percent_Identity=33.2344213649852, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583720, Length=326, Percent_Identity=33.1288343558282, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24641876, Length=347, Percent_Identity=30.835734870317, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24668282, Length=347, Percent_Identity=31.4121037463977, Blast_Score=157, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37808; Mature: 37808

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRHSVLDAWKDPRGGEIERVRLDNGQLAIEVLSLGGIIRSLWAPDSRGERANLVLGCDS
CCCCHHHHHHCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHCCCCCCCCCEEEEEECCH
LEDYLAQNAHLGAIAGRYANRIALGKLHYDGEDFQLDINQATNCLHGGHEGFNRKQWALG
HHHHHHCCCCCHHHHHHHHCEEEEEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCEEEEE
LLPDGVRLSLSSPDGDMGFPGNCSVQLDYRLAGNNLYVEIMAMTDRPCPVNLTQHSYFNL
ECCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEECCCCCCCEECCCEEECC
DGRADCLDHTVTMHARAFLRCNEAGIPTGRATTAGTPLALQDVRLGDRVQHPDLASTRGF
CCCCHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHCCCC
DHCFIIDKTQDELALAAELHSPHSGRLLKLYTNQPGVQLYGANFLDGERGRQGKIYRPYQ
CEEEEEECCCCCEEEEEHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCEECCCC
GVCLEPQLFPDAPNQPDLGKAWLMPGEIYHHISRYQFEVKD
CEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHEEEEECC
>Mature Secondary Structure
MVRHSVLDAWKDPRGGEIERVRLDNGQLAIEVLSLGGIIRSLWAPDSRGERANLVLGCDS
CCCCHHHHHHCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHCCCCCCCCCEEEEEECCH
LEDYLAQNAHLGAIAGRYANRIALGKLHYDGEDFQLDINQATNCLHGGHEGFNRKQWALG
HHHHHHCCCCCHHHHHHHHCEEEEEEEEECCCCEEEEHHHHHHHHCCCCCCCCCCEEEEE
LLPDGVRLSLSSPDGDMGFPGNCSVQLDYRLAGNNLYVEIMAMTDRPCPVNLTQHSYFNL
ECCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEECCCCCCCEECCCEEECC
DGRADCLDHTVTMHARAFLRCNEAGIPTGRATTAGTPLALQDVRLGDRVQHPDLASTRGF
CCCCHHHHHHHHEEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHCCCC
DHCFIIDKTQDELALAAELHSPHSGRLLKLYTNQPGVQLYGANFLDGERGRQGKIYRPYQ
CEEEEEECCCCCEEEEEHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCEECCCC
GVCLEPQLFPDAPNQPDLGKAWLMPGEIYHHISRYQFEVKD
CEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]