Click here to switch to the map view.

The map label for this gene is kefC [H]

Identifier: 119773677

GI number: 119773677

Start: 661514

End: 663121

Strand: Reverse

Name: kefC [H]

Synonym: Sama_0537

Alternate gene names: 119773677

Gene position: 663121-661514 (Counterclockwise)

Preceding gene: 119773678

Following gene: 119773676

Centisome position: 15.4

GC content: 56.53

Gene sequence:

>1608_bases
ATGGAGCCGGCCATTCTCGTCATCACCCTCGCTTGCGGCCTCTTGGTCAACCGCGTCGGTTTGCCGCCATTGATAGGATA
TCTGGCCGCTGGCTTTGTGCTCTTTATGTTTGGCATTGAAGAATCCAGTTTGCCCATGCTTCAGCAATTTGCCGATCTCG
GTGTGACCCTGCTGCTGTTTGCCATTGGCCTGAAACTGGATATTCGCAGCCTGTTCAAGGCCGAAGTCTGGGCCGGCGCC
AGCCTGCATCTCGTCGGCACCATGCTGTTTTTGGTTCCCATCCTCAAGCTGCTGGGCATTCTGGGCCTGAGCCAGCTTAC
CGACCTCAGTCTCAATCAACTGTCGCTGCTGGCCTTTGCCCTGAGCTTCTCTTCCACTGTCTTTGCCGTGAAAGTGCTGG
AAGACAAAGGGGATATGCAAACCCTCTATGGCCGGGTCGCCATTGGTATCCTCATCATGCAGGATATCTTTGCGGTGGGC
TTCCTGACGGTTTCAAAGGGAGAATGGCCCTCAATCTGGGCACTGACACTGCTGTTGCTGCCAATCGCCAGACCACTGAT
TTACCGCGCCTTTGACCGGGTCGGCCATGGTGAACTCCTGGTGCTCTTCGGTTTGGTGATGGCACTGGTGCTTGGCGCCT
GGCTCTTTGAAGCCGTAGGGCTCAAGCCCGATTTGGGCGCCCTGATTGTCGGTGTGTTACTGGCGGGCCACCCCAAGGCA
TCCGAACTCGCCAAGTCACTGTTTTATTTTAAAGAATTATTCCTCGTCGCCTTCTTCCTCACCATAGGCCTCAATGGGTT
GCCAAGCCTGGAGGATGTGGCGCTGGCCGGGCTCTTGGTGGCGCTCATCCCCTTCAAGGTCGCTCTGTTTGTGGTACTGC
TGACCCGCTTCAAGCTGCGCTCCCGTACCTCAATGCTGGCTTCGTTCAATCTGGGCAACTACAGCGAATTCGGCCTGATA
GTTGCGGCGGTAGCCGCATCCAAAGGATGGTTGCCGTCTCAGTGGCTCATTATTATCGCCGTGGCGCTGAGCTTCAGCTT
TTTGCTGGCCGCCCCCCTCAACAACATGGTGGGTAAGATTTACCAGCGATACCAGCAGCCCCTCAGACGCATGGAGCGTC
CGCCCCTGCATCCGGAAGACAGACCCATCCCTATTGGTAACCCCCGTTTCCTGATTTTGGGTATGGGCCGTATTGGTTCG
GGTGCCTACGATGAGCTCAAACTCCGATTCGAAGGTGAAATCCTTGGCATTGAGCACAAGCAGGAACTGGTGGACTTCCA
CCGGGCTCAGGGCCGTAACGTGGTACAGGGCGATGCCTCGGATACCGACTTCTGGGAAAAGCTCGACAGGGCACCCAACC
TGGATCTTGTGCTGCTGGCCATGCCCCATCACGCGGGCAACCTGTTTGCGGTAGAACAACTGAAAAAGCAGGACTATCAG
GGTAAGATCAGCGCCATTGTCCAGTACGCAGAACACACCGACTCCCTGAAAGAGAGTGGCGTGCACAGTGTCTACAATCT
CTATGAAGCCGCGGGTGCGGGTTTTGTGGAGCACGTCGCCACAGAGTTGATGCCCGCAGAGGGTGAACTGGCCCAGGCCA
GAGGCTGA

Upstream 100 bases:

>100_bases
AGGCAAAGATTTCACTGAAATCTTTGCCTTTTTCATCTCACATTAAATAAAGTCCGCTAAGATACCTGATTTATAGCTGA
ATTATCTTTTAAGGAGTTTC

Downstream 100 bases:

>100_bases
TTTGAAACGCCGCGAATTCGCGGCGTTTTTGTTTGTTCACGTATCGCAAAAATCTCAGTTTTCCGGCTTTTTAAGACGTG
GTATAACTCAGGGAAGCCGC

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MEPAILVITLACGLLVNRVGLPPLIGYLAAGFVLFMFGIEESSLPMLQQFADLGVTLLLFAIGLKLDIRSLFKAEVWAGA
SLHLVGTMLFLVPILKLLGILGLSQLTDLSLNQLSLLAFALSFSSTVFAVKVLEDKGDMQTLYGRVAIGILIMQDIFAVG
FLTVSKGEWPSIWALTLLLLPIARPLIYRAFDRVGHGELLVLFGLVMALVLGAWLFEAVGLKPDLGALIVGVLLAGHPKA
SELAKSLFYFKELFLVAFFLTIGLNGLPSLEDVALAGLLVALIPFKVALFVVLLTRFKLRSRTSMLASFNLGNYSEFGLI
VAAVAASKGWLPSQWLIIIAVALSFSFLLAAPLNNMVGKIYQRYQQPLRRMERPPLHPEDRPIPIGNPRFLILGMGRIGS
GAYDELKLRFEGEILGIEHKQELVDFHRAQGRNVVQGDASDTDFWEKLDRAPNLDLVLLAMPHHAGNLFAVEQLKKQDYQ
GKISAIVQYAEHTDSLKESGVHSVYNLYEAAGAGFVEHVATELMPAEGELAQARG

Sequences:

>Translated_535_residues
MEPAILVITLACGLLVNRVGLPPLIGYLAAGFVLFMFGIEESSLPMLQQFADLGVTLLLFAIGLKLDIRSLFKAEVWAGA
SLHLVGTMLFLVPILKLLGILGLSQLTDLSLNQLSLLAFALSFSSTVFAVKVLEDKGDMQTLYGRVAIGILIMQDIFAVG
FLTVSKGEWPSIWALTLLLLPIARPLIYRAFDRVGHGELLVLFGLVMALVLGAWLFEAVGLKPDLGALIVGVLLAGHPKA
SELAKSLFYFKELFLVAFFLTIGLNGLPSLEDVALAGLLVALIPFKVALFVVLLTRFKLRSRTSMLASFNLGNYSEFGLI
VAAVAASKGWLPSQWLIIIAVALSFSFLLAAPLNNMVGKIYQRYQQPLRRMERPPLHPEDRPIPIGNPRFLILGMGRIGS
GAYDELKLRFEGEILGIEHKQELVDFHRAQGRNVVQGDASDTDFWEKLDRAPNLDLVLLAMPHHAGNLFAVEQLKKQDYQ
GKISAIVQYAEHTDSLKESGVHSVYNLYEAAGAGFVEHVATELMPAEGELAQARG
>Mature_535_residues
MEPAILVITLACGLLVNRVGLPPLIGYLAAGFVLFMFGIEESSLPMLQQFADLGVTLLLFAIGLKLDIRSLFKAEVWAGA
SLHLVGTMLFLVPILKLLGILGLSQLTDLSLNQLSLLAFALSFSSTVFAVKVLEDKGDMQTLYGRVAIGILIMQDIFAVG
FLTVSKGEWPSIWALTLLLLPIARPLIYRAFDRVGHGELLVLFGLVMALVLGAWLFEAVGLKPDLGALIVGVLLAGHPKA
SELAKSLFYFKELFLVAFFLTIGLNGLPSLEDVALAGLLVALIPFKVALFVVLLTRFKLRSRTSMLASFNLGNYSEFGLI
VAAVAASKGWLPSQWLIIIAVALSFSFLLAAPLNNMVGKIYQRYQQPLRRMERPPLHPEDRPIPIGNPRFLILGMGRIGS
GAYDELKLRFEGEILGIEHKQELVDFHRAQGRNVVQGDASDTDFWEKLDRAPNLDLVLLAMPHHAGNLFAVEQLKKQDYQ
GKISAIVQYAEHTDSLKESGVHSVYNLYEAAGAGFVEHVATELMPAEGELAQARG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG4651

COG function: function code P; Kef-type K+ transport system, predicted NAD-binding component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=511, Percent_Identity=25.8317025440313, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786685, Length=533, Percent_Identity=24.765478424015, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789749, Length=448, Percent_Identity=25, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 58470; Mature: 58470

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPAILVITLACGLLVNRVGLPPLIGYLAAGFVLFMFGIEESSLPMLQQFADLGVTLLLF
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AIGLKLDIRSLFKAEVWAGASLHLVGTMLFLVPILKLLGILGLSQLTDLSLNQLSLLAFA
HHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHH
LSFSSTVFAVKVLEDKGDMQTLYGRVAIGILIMQDIFAVGFLTVSKGEWPSIWALTLLLL
HHHCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
PIARPLIYRAFDRVGHGELLVLFGLVMALVLGAWLFEAVGLKPDLGALIVGVLLAGHPKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCH
SELAKSLFYFKELFLVAFFLTIGLNGLPSLEDVALAGLLVALIPFKVALFVVLLTRFKLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRTSMLASFNLGNYSEFGLIVAAVAASKGWLPSQWLIIIAVALSFSFLLAAPLNNMVGKI
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQRYQQPLRRMERPPLHPEDRPIPIGNPRFLILGMGRIGSGAYDELKLRFEGEILGIEHK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHEEEEECCCEECCHHH
QELVDFHRAQGRNVVQGDASDTDFWEKLDRAPNLDLVLLAMPHHAGNLFAVEQLKKQDYQ
HHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
GKISAIVQYAEHTDSLKESGVHSVYNLYEAAGAGFVEHVATELMPAEGELAQARG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MEPAILVITLACGLLVNRVGLPPLIGYLAAGFVLFMFGIEESSLPMLQQFADLGVTLLLF
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AIGLKLDIRSLFKAEVWAGASLHLVGTMLFLVPILKLLGILGLSQLTDLSLNQLSLLAFA
HHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHH
LSFSSTVFAVKVLEDKGDMQTLYGRVAIGILIMQDIFAVGFLTVSKGEWPSIWALTLLLL
HHHCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
PIARPLIYRAFDRVGHGELLVLFGLVMALVLGAWLFEAVGLKPDLGALIVGVLLAGHPKA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCH
SELAKSLFYFKELFLVAFFLTIGLNGLPSLEDVALAGLLVALIPFKVALFVVLLTRFKLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRTSMLASFNLGNYSEFGLIVAAVAASKGWLPSQWLIIIAVALSFSFLLAAPLNNMVGKI
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQRYQQPLRRMERPPLHPEDRPIPIGNPRFLILGMGRIGSGAYDELKLRFEGEILGIEHK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHEEEEECCCEECCHHH
QELVDFHRAQGRNVVQGDASDTDFWEKLDRAPNLDLVLLAMPHHAGNLFAVEQLKKQDYQ
HHHHHHHHHCCCCEEECCCCCCHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
GKISAIVQYAEHTDSLKESGVHSVYNLYEAAGAGFVEHVATELMPAEGELAQARG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA